Negative / Null Result ReportOpen accessMedicine
Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open
•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…
View details →Negative / Null Result ReportMedicine
Susan Rowell, Eric N. Meier, Tatiana Hoyos Gomez et al. · 2024 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In the prehospital tranexamic acid (TXA) for traumatic brain injury (TBI) trial, TXA administered within 2 hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Emanuela Colombo, Rosaria Pascente, Daniela Triolo et al. · 2020 · Molecules
Astrocytes greatly participate to inflammatory and neurotoxic reactions occurring in neurodegenerative diseases and are valuable pharmacological targets to support neuroprotection. Here we used human astrocytes generated from reprogrammed fibroblasts as a cellular model to study the effect of the compound Laquinimod and its active metabolite de-Laquinimod on astrocyte functions and the astrocyte-neuron interaction. We show that human iAstrocytes expressed the receptor for the inflammatory mediator IL1 and responded to it via nuclear translocation of NFκB, an event that did not occur if cells w
View details →Negative / Null Result ReportOpen accessMedicine
Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology
OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
View details →Negative / Null Result ReportOpen accessEngineering
Denis A. Zadkov, Nikita MARTYUSHEV, Boris V. Malozyomov et al. · 2026 · Mathematics
In this study, a comprehensive mathematical method for modeling the operational reliability of mine hoisting equipment under conditions of incomplete and heavily censored data is developed. The analyzed dataset includes 259 observations collected over a five-year period for six critical components, with the overall level of censoring reaching 62% and exceeding 70% for long life mechanical subsystems. Considering right, left, and interval censoring, the paper proposes a unified statistical procedure that combines empirical estimation of failure rates with parametric identification using Weibull
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Aras Fahrettin Korkmaz, Fatih Ekinci, Şehmus Altaş et al. · 2025 · Biology
This study presents a novel approach for classifying Discomycetes species using deep learning and explainable artificial intelligence (XAI) techniques. The EfficientNet-B0 model achieved the highest performance, reaching 97% accuracy, a 97% F1-score, and a 99% AUC, making it the most effective model. MobileNetV3-L followed closely, with 96% accuracy, a 96% F1-score, and a 99% AUC, while ShuffleNet also showed strong results, reaching 95% accuracy and a 95% F1-score. In contrast, the EfficientNet-B4 model exhibited lower performance, achieving 89% accuracy, an 89% F1-score, and a 93% AUC. These
View details →Negative / Null Result ReportOpen accessMedicine
Elisa Alonso‐Perez, Marian Suarez-Gestal, Manuel Calaza et al. · 2014 · Arthritis Research & Therapy
INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not r
View details →Negative / Null Result ReportOpen accessMedicine
Rickard Strandberg, Fredrik Åberg, Juho Asteljoki et al. · 2025 · BMJ
OBJECTIVE: To develop and validate a novel risk prediction model for incident major adverse liver outcomes (MALO) in a primary care setting. DESIGN: Population based cohort study. SETTING: Sweden, with validation in Finland and the UK.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nicolás Fragoso-Bargas, Hannah R. Elliott, Sindre Lee-Ødegård et al. · 2022 · Diabetes
Although there are some epigenome-wide association studies (EWAS) of insulin resistance, for most of them authors did not replicate their findings, and most are focused on populations of European ancestry, limiting the generalizability. In…
View details →Negative / Null Result ReportOpen accessNursing
Newton Cao, Warda Merchant, Laurent Gautron · 2024 · Scientific Reports
The communication between intestinal Glucagon like peptide 1 (GLP-1)-producing cells and the peripheral nervous system has garnered renewed interest considering the availability of anti-obesity and anti-diabetic approaches targeting GLP-1…
View details →Negative / Null Result ReportOpen accessMedicine
Yuting Tan, Rui Xue, Yuwei Pan et al. · 2026 · Signal Transduction and Targeted Therapy
The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on m
View details →Negative / Null Result ReportOpen accessHealth Professions
Claire Henderson, Yasuhiro Kotera, Brynmor Lloyd‐Evans et al. · 2026 · World Psychiatry
Social inclusion means being able to participate in activities valued within one's community or wider society as one would wish. People with severe mental illness (i.e., psychoses, bipolar disorder, and severe depression) experience some…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Francesco D’Eugenio, Ignas Juodžbalis, Xihan Ji et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present a ‘Little Red Dot’ (LRD) broad-line active galactic nucleus (AGN) at $z=5.077 $, observed with NIRSpec/MSA (micro-shutter assembly) and NIRSpec/IFU (integral-field unit) by the JADES (JWST Advanced Deep Extragalactic Survey) and BlackTHUNDER (Black holes in THe early Universe aNd their DensE surRoundings) surveys. Combining spatially resolved and high-resolution spectroscopy, we characterize its central engine, host, and environment. H$\alpha $ has multiple components, including two broad Gaussians, yielding a black-hole mass $\log (M_{\bullet }/{\rm M}_\odot) = 7.65 $, whi
View details →Negative / Null Result ReportOpen accessMedicine
Bethan Cracknell Daniels, Neil M. Ferguson, Ilaria Dorigatti · 2025 · Nature Medicine
Dengue is the most common arboviral infection, causing substantial morbidity and mortality globally. The licensing of Qdenga, a second-generation vaccine developed by Takeda Pharmaceuticals, is therefore timely, but the potential public health impact of vaccination across transmission settings needs to be evaluated. To address this, we characterized Qdenga's efficacy profile using mathematical models calibrated to published clinical trial data and estimated the public health impact of routine vaccine use. We find that efficacy against both virologically confirmed dengue and hospitalization dep
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Nikolaos P.E. Kadoglou, Konstantinos G. Moulakakis, George Mantas et al. · 2022 · Angiology
Arterial stiffness and its valid index, the cardio-ankle vascular index (CAVI), have emerged as predictors of adverse cardiovascular outcomes. We investigated the relationship of the CAVI with significant carotid stenosis (> 50%) and the…
View details →Negative / Null Result Report
Rachel Murchison, Catherine Gooday, Ketan Dhatariya · 2014 · Journal of the American Podiatric Medical Association
Medication to aid weight loss and weight loss surgery are becoming more commonly available for people with diabetes. As a result of profound weight loss, diabetes may go into remission and many biochemical and physical parameters improve.…
View details →Negative / Null Result Report
Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu et al. · 2022 · International Journal of Environmental Research and Public Health
The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline…
View details →Negative / Null Result Report
Robert Pontius · 2018 · Land
The Verified Carbon Standard (VCS) recommends the Figure of Merit (FOM) as a possible metric to confirm models that simulate deforestation baselines for Reducing Emissions from Deforestation and forest Degradation (REDD). The FOM ranges…
View details →Negative / Null Result Report
Anna Kuehne, Barbara Hauer, Bonita Brodhun et al. · 2018 · Eurosurveillance
Background Germany has a low tuberculosis (TB) incidence. A relevant and increasing proportion of TB cases is diagnosed among asylum seekers upon screening. Aim: We aimed to assess whether cases identified by screening asylum seekers had…
View details →Negative / Null Result Report
Jiajia Du, Zhiyong Huang, Erlei Zhang · 2024 · Frontiers in Immunology
Background Immunotherapy based on immune checkpoint inhibitors (ICIs) has become the first-line treatment for unresectable hepatocellular carcinoma (uHCC). However, only a small portion of patients are responsive to ICIs. It is important…
View details →Negative / Null Result Report
Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine
Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…
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Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International
Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience
OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:
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Charles M. Reigeluth, Peter Honebein · 2020 · Revista de Educación a Distancia (RED)
La mayoría de los investigadores que diseñan experiencias innovadoras de aprendizaje digital y luego realizan investigaciones que investigan la utilidad de esas experiencias de aprendizaje, no aplican completamente la teoría de la…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mohamad Saad, Ayman El‐Menyar, Khalid Kunji et al. · 2022 · Circulation Genomic and Precision Medicine
Background: Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about their portability to diverse ancestry groups, thus motivating genome-wide association studies in non-European ancestry…
View details →Negative / Null Result ReportMedicine
Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering
Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jonathan E. Ramsay, Eddie M. W. Tong, Joyce S. Pang et al. · 2016 · PLoS ONE
Religious priming has been found to have both positive and negative consequences, and recent research suggests that the activation of God-related and community-related religious cognitions may cause outgroup prosociality and outgroup derogation respectively. The present research sought to examine whether reminders of God and religion have different effects on attitudes towards ingroup and outgroup members. Over two studies, little evidence was found for different effects of these two types of religious primes. In study 1, individuals primed with the words "religion", "God" and a neutral contro
View details →Negative / Null Result ReportOpen accessMedicine
Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology
Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ
View details →Negative / Null Result ReportPsychology
R. Garrett, Daniel Sude, Paolo Riva · 2019 · Political Communication
Research suggests that ostracism could promote endorsement of partisan falsehoods. Socially excluded individuals are uniquely attentive to distinctions between in-groups and out-groups, and act in ways intended to promote group belonging,…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jacqueline Ramı́rez, Tae Won Kim, Wanqing Liu et al. · 2013 · Pharmacogenetics and Genomics
XK469 (NSC 697887) is a selective topoisomerase II β inhibitor eliminated mainly by aldehyde oxidase I (AOX1). We performed a candidate gene study to investigate whether AOX1 genetic variation contributes to interindividual variability in…
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