Negative / Null Result ReportOpen accessEnvironmental Science
IREC, CSIC–UCLM–JCCM, Ciudad Real, Spain, Ainhoa Mateo-Moriones, Rafael Villafuerte et al. · 2012 · Animal Biodiversity and Conservation
This work evaluates the effectiveness of fox control as a method to improve the survival of red–legged partridge (Alectoris rufa). We radio–tracked 89 adult partridges and their chicks (62 few days old chicks and 46 over one–month–old chicks) and monitored their nests (N = 45) on two hunting estates in northern Spain over two years. Generalist predators (red fox, Vulpes vulpes, and magpie, Pica pica) were selectively controlled on one half of each estate during the first year, and on the other half in the second year. We estimated the effect of predator control on survival rates. Predator cont
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ayca Gucalp, Tiffany A. Traina · 2017 · Cancer
Patients with triple-negative breast cancer (TNBC) generally are considered a single clinical subgroup, defined by the lack of receptor expression, and are uniformly treated with cytotoxic chemotherapy. However, the advent of molecular…
View details →Negative / Null Result ReportOpen accessMedicine
Guillaume Millot, Pauline Boddaert, Erika Parmentier-Decrucq et al. · 2018 · Annals of Translational Medicine
Background: Microaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence. Methods: Single-center prospective observational study, performed…
View details →Negative / Null Result ReportOpen accessMedicine
Shipeng Gong, Ying-Ting Zhao, Yanhong Yu · 2011 · PubMed
AIM: To construct and examine models of the vascular networks using the technique of vascular corrosion casting in placentas collected from normal pregnancies and from pregnancies complicated by fetal growth restriction (FGR). METHODS:…
View details →Negative / Null Result ReportOpen accessNeuroscience
Jasmine C. Huynh, May Cho, Arta M. Monjazeb et al. · 2023 · Investigational New Drugs
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) helps orchestrate immune suppression and checkpoint inhibitor resistance in hepatocellular carcinoma (HCC). BMS-986,205 is a novel oral drug that potently and selectively inhibits IDO. This Phase I/II study evaluated the safety and tolerability of BMS-986,205 in combination with nivolumab as first-line therapy in advanced HCC. METHODS: IV on Day 1 of each 14-day cycle). The primary objective was to determine the safety and tolerability of this combination; secondary objectives were to obtain preliminary efficacy. RESULTS: Eight patients received a
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Melissa A. Snyder, Kieran McCann, Maryline J. Lalande et al. · 2016 · Journal of Neurochemistry
Abstract The sigma‐1 receptor (σ‐1R) is a chaperone protein located at the endoplasmic reticulum ( ER ) mitochondrial interface with roles in neuroprotection and cognition. Increasing evidence suggests that loss of σ‐1R function could…
View details →Negative / Null Result Report
Johan P. Mackenbach, Marina Karanikolos, Jamie Lopez Bernal et al. · 2015 · Scandinavian Journal of Public Health
Background: The upturn of life expectancy in Central and Eastern Europe in the 1990s, after a period of stagnation or even decline, is one of the main events in European population history of the late 20th century, but has not been…
View details →Negative / Null Result Report
Juliana Chen, Harpreet Kaur, Joanna Jaques et al. · 2022 · Clinical Obesity
Summary Despite the obesity epidemic, there are relatively few multidisciplinary obesity services in Australia, and only limited data on the effectiveness of these services. The aim of this study was to evaluate the effectiveness of a…
View details →Negative / Null Result Report
Jorge G. Ruiz, Allen D. Andrade, Ramanakumar Anam et al. · 2013 · The Diabetes Educator
Purpose The purpose of this study was to investigate whether computer-based programmed instruction (CPI) with a dynamic avatar (DA) improves retention of medication information better than text (controls) or better than CPI with text…
View details →Negative / Null Result Report
Lauren N. Forrest, Ross C. Jacobucci, Carlos M. Grilo · 2020 · Psychological Medicine
Abstract Background Eating-disorder severity indicators should theoretically index symptom intensity, impairment, and level of needed treatment. Two severity indicators for binge-eating disorder (BED) have been proposed (categories of…
View details →Negative / Null Result Report
A.R.J.V. Vossen, H.H. van der Zee, N. Davelaar et al. · 2018 · Journal of the European Academy of Dermatology and Venereology
Abstract Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa ( HS ). Objective To evaluate the change in expression of inflammatory markers in lesional skin…
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Anne M Rowat, Catriona Graham, Martin Dennis · 2018 · BMJ Open Gastroenterology
Objective To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement. Methods This prospective observational study included a convenience sample of adult…
View details →Negative / Null Result Report
Yoshitaka Shimada, Yoshihito Takahashi, Hiroyoshi Iguchi et al. · 2013 · Journal of Medical Case Reports
Abstract Introduction Liver cavernous hemangioma is the most common noncystic hepatic lesion, and a hemangioma that undergoes degeneration and fibrous replacement is called a hepatic sclerosed hemangioma. Case presentation A 63-year-old…
View details →Negative / Null Result Report
Winston A. Haynes, Kathy Kamath, Rebecca Waitz et al. · 2021 · Frontiers in Immunology
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader identification of…
View details →Negative / Null Result Report
Jingran Zhang, Wukui Wang, Lei Gao et al. · 2022 · Atmosphere
Air pollution caused by coal burning not only increases the cost of environmental pollution but also harms human health. It is urgent for China to change the practice of coal-fired central heating. Therefore, the effectiveness and…
View details →Negative / Null Result Report
Shan Ren, Wenjing Wang, Junfeng Lu et al. · 2022 · Frontiers in Immunology
Objective In clinical practice, a substantial proportion of chronic hepatitis B virus (HBV) infections that do not fit into any of the usual immune states are considered to be in the “grey zone (GZ)”. This study aimed to investigate the…
View details →Negative / Null Result Report
Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo et al. · 2021 · PLOS ONE
Background and purpose The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases ( MMPs ) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia. Methods The 781…
View details →Negative / Null Result Report
Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology
Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…
View details →Negative / Null Result Report
Aydin Demircioğlu · 2023 · Diagnostics
In radiomics, utilizing features extracted from pretrained deep networks could result in models with a higher predictive performance than those relying on hand-crafted features. This study compared the predictive performance of models…
View details →Negative / Null Result Report
Veeral Ajmera, Na Wang, Hanfei Xu et al. · 2023 · Alimentary Pharmacology & Therapeutics
Summary Background Adiposity amplifies the genetic risk of non‐alcoholic fatty liver disease (NAFLD). Aim We evaluated the association between overweight‐years, a cumulative exposure based on the product of the duration and severity of…
View details →Replication FailureMedicine
Luca Testa, J M De La Torre Hernandez, Giovanni Luigi De Maria et al. · 2026 · New England Journal of Medicine
BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used for revascularization of unprotected left main coronary artery disease. Whether intravascular ultrasonographic (IVUS) guidance during PCI results in better clinical…
View details →Negative / Null Result ReportOpen accessMedicine
Jiacheng Ma, Shengrui Liu, Yuting Pei · 2025 · Scientific Reports
Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability. Using the Kaggle "University Football Injury Prediction Dataset"…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roberta Ottria, Susan Mirmajidi, Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences
This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key
View details →Negative / Null Result ReportOpen accessSocial Sciences
Luísa Sório Flor, Cory N Spencer, Jack Cagney et al. · 2025 · The Lancet
BACKGROUND: Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both nat
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid, Nesrine Gafsi · 2025 · International Journal of Energy Economics and Policy
The purpose of this research paper is to examine the long-term dynamics between economic growth, technological integration, and environmental sustainability in Saudi Arabia from 1995 to 2023. It aims to identify the impact of key economic, technological, and environmental indicators, including GDP, ICT sector performance, foreign direct investment (FDI), trade, and ecological footprint, on the country’s development trajectory. The research employs a quantitative approach, using VAR-VECM models to analyze time-series data. The study applies Granger causality tests and impulse response functions
View details →Negative / Null Result ReportOpen accessEngineering
Takahiro Ezaki, Kazumichi Ohtsuka, Mohcine Chraibi et al. · 2026 · Qucosa (Saxon State and University Library Dresden)
To better design safe and comfortable urban spaces, understanding the nature of human crowd movement is important. However, precise interactions among pedestrians are difficult to measure in the presence of their complex decision-making processes and many related factors. While extensive studies on pedestrian flow through bottlenecks and corridors have been conducted, the dominant mode of interaction in these scenarios may not be relevant in different scenarios. Here, we attempt to decipher the factors that affect human reactions to other individuals from a different perspective. We conducted
View details →Negative / Null Result ReportOpen accessChemistry
Andrew T. Rajczewski, J. Alfredo Blakeley‐Ruiz, Annaliese Meyer et al. · 2025 · PROTEOMICS
Mass spectrometry (MS)-based metaproteomics is used to identify and quantify proteins in microbiome samples, with the frequently used methodology being data-dependent acquisition mass spectrometry (DDA-MS). However, DDA-MS is limited in…
View details →Negative / Null Result ReportOpen accessMedicine
Anna Kankaanpää, Asko Tolvanen, Laura Joensuu et al. · 2025 · European Journal of Epidemiology
OBJECTIVES: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association. METHODS: Study participants were twins from the older Finnish Twin Cohort (n = 22,750; 18-50 years at baseline). LTPA was assessed using questionnaires in 1975, 1981 and 1990. The mortality follow-up lasted until 2020 and biol
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhiyu Yang, Fanny‐Dhelia Pajuste, Kristina Zguro et al. · 2025 · Nature Genetics
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Claudia Monaco, Coleen A. McNamara, Bram Slütter et al. · 2025 · Physiological Reviews
Cardiovascular disease is the global number one cause of mortality and morbidity. The majority of cardiovascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The…
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