Negative / Null Result ReportOpen accessMedicine
Anna Katri, Aneta Dąbrowska, Henrik Löfvall et al. · 2019 · Arthritis Research & Therapy
BACKGROUND: Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on salmon calcitonin and are expected to inhibit bone resorption and to be chondroprotective. In this study, we investigated if combining a standard of care NSAID (naproxen) with a KBP resulted in improvement in pain
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Daniel Doyle, Gerald McDonald, Claire Pratt et al. · 2021 · PLoS ONE
OBJECTIVES: Inappropriate antibiotic use contributes to antimicrobial resistance. The SpectrumTM app provides antibiotic decision support, based on local antimicrobial resistance rates. We determined the impact of regional implementation of the app on inpatient antimicrobial appropriateness, inpatient antimicrobial usage (AMU), population-based Clostridioides difficile infection (CDI) rates and cost, using a retrospective, before and after quasi-experimental design, including a one-year study period. METHODS: The SpectrumTM app was released to prescribers in February, 2019. We performed two on
View details →Negative / Null Result ReportOpen accessMedicine
Manjusha Kulkarni, Sanjay Varikuti, César Terrazas et al. · 2014 · Immunology
The control of Trypanosoma cruzi infection is related to interferon-γ (IFN-γ) activation leading to intracellular clearance of parasites. The transcription factor signal transducer and activator of transcription 1 (STAT-1) is a key…
View details →Negative / Null Result ReportOpen accessMedicine
Thiago Pereira Diniz, Wilson Luiz da Costa, Victor Hugo Fonseca de Jesus et al. · 2019 · Journal of Surgical Oncology
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been associated with improved survival when compared with surgery alone for non-metastatic gastric cancer patients in randomized trials and meta-analyses. However, little evidence is available regarding the use of HIPEC in nonmetastatic patients who are treated with perioperative chemotherapy and radical surgery. The aim of this study was to investigate the putative survival benefit of HIPEC in the subgroup of gastric cancer patients treated with perioperative chemotherapy and surgery. PATIENTS AND METHODS: This was a retrospect
View details →Negative / Null Result ReportOpen accessMedicine
Stefanie G. Beesems, Jocelyn Berdowski, Michiel Hulleman et al. · 2016 · Resuscitation
BACKGROUND: Previous large retrospective analyses have found an association between duration of peri-shock pauses in cardiopulmonary resuscitation (CPR) and survival. In a randomized trial, we tested whether shortening these pauses…
View details →Negative / Null Result ReportOpen accessMedicine
Jonathan Tucci, Waseem Alhushki, Ting Chen et al. · 2018 · Cancer & Metabolism
BACKGROUND: It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. METHODS: Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from A
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Martin Boegemann, Katrin Schlack, Ann-Kathrin Fischer et al. · 2016 · PLoS ONE
OBJECTIVE: Even though the exact mechanism is largely unknown until now, statins are supposed to improve survival outcomes in various malignancies. For prostate cancer however, statins are known to compete with dehydroepiandrosterone (DHEAS) for the transport into the cytosol both using the cell by the Solute Carrier Transporter and thus diminish the cellular uptake of DHEAS as a precursor of androgens. Abiraterone inhibits CYP17A1 and thus effectively decreases the production of all relevant androgens including DHEAS. In this study we examined whether statins still affect survival outcome in
View details →Negative / Null Result ReportOpen accessMedicine
Toshiki Kuno, Takahisa Mikami, Yuki Sahashi et al. · 2022 · Scientific Reports
Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. We evaluated 19,222 consecutive patients undergoing PCI between 2008 and 2019 in a Ja
View details →Negative / Null Result Report
E. S. Skordas, N. V. Sarlis, P. A. Varotsos · 2010 · Chaos: An Interdisciplinary Journal of Nonlinear Science
Electric field variations that appear before rupture have been recently studied by employing the detrended fluctuation analysis (DFA) to quantify their long-range temporal correlations. These studies revealed that seismic electric signal…
View details →Negative / Null Result Report
R. G. Waruna Jinadasa, Bihong Li, Benjamin Schmitz et al. · 2016 · ChemSusChem
Abstract A series of monobenzoporphyrins ( WH1 – WH4 ) bearing different conjugated spacer groups were designed and synthesized as sensitizers for dye‐sensitized solar cells. Although a phenyl spacer only has a minimal impact on the…
View details →Negative / Null Result Report
Thomas Milic · 2015 · Swiss Political Science Review
Abstract After the vote of 9 February 2014, many attributed the surprising result to voter ignorance. The basic claim was that the majority of those voting in favour of the initiative possessed only a weak understanding of what the likely…
View details →Negative / Null Result ReportOpen accessMedicine
Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…
View details →Negative / Null Result ReportSocial Sciences
Holger Hopp, Teresa Kieseier, Jenny Jakisch et al. · 2021 · Multilingua
Abstract This paper reports findings of a project on pedagogical translanguaging (PTL) among 128 fourth-grade students learning English as a foreign language (EFL) in German primary schools. Over a period of six months, 20% of lesson time…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shaharudin Jakpar, Michael Tinggi, Akmal Hisham Tak et al. · 2018 · UNIMAS Review of Accounting and Finance
This study is conducted to analyse the credibility of the fundamental analysis and technical analysis on predicting the stock return and compare both models to determine which model is more credible to be used as a good trading strategy by…
View details →Negative / Null Result ReportComputer Science
Anton Kotelyanskii, Gregory M. Kapfhammer · 2014
Although search-based test-data generators, like EvoSuite, efficiently and automatically create effective JUnit test suites for Java classes, these tools are often difficult to configure. Prior work by Arcuri and Fraser revealed that the…
View details →Negative / Null Result ReportOpen accessMedicine
Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…
View details →Negative / Null Result ReportOpen accessNeuroscience
Shan-Chuan Teng, Yunn-Wen Lien · 2022 · PLoS ONE
Mind wandering has been argued to be beneficial for breaking through mental impasses, which leads to better creative performance upon a second attempt (i.e., the incubation effect). However, the evidence is inconsistent. Different from the propensity for mind wandering that has been the focus of past studies, in this study we further examined the role of diversity (i.e., non-repetitiveness of mind wandering respective to its content) and types of mind wandering along the dimensions of intentionality and awareness during incubation when engaging in a 0-back task (a mind wandering-prone conditio
View details →Negative / Null Result ReportPsychology
Mark van Veen, Inge van Weeghel, Bauke Koekkoek et al. · 2014 · International Journal of Social Psychiatry
BACKGROUND: Risk of suicide is notoriously difficult to assess, and no gold standard is available, in terms of an instrument of first choice. Many different instruments are in use, among which are some that are not properly…
View details →Negative / Null Result ReportOpen accessMedicine
Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry
BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…
View details →Negative / Null Result ReportOpen accessMedicine
Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…
View details →Negative / Null Result ReportOpen accessMedicine
Charlotte Lindblad Wollmann, Kyle D. Hart, Can Liu et al. · 2020 · Acta Obstetricia Et Gynecologica Scandinavica
INTRODUCTION: Predicting a woman's probability of vaginal birth after cesarean could facilitate the antenatal decision-making process. Having a previous vaginal birth strongly predicts vaginal birth after cesarean. Delivery outcome in…
View details →Negative / Null Result ReportOpen accessMedicine
Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology
<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…
View details →Negative / Null Result Report
Xinyang Zhang, Alexander Palevski, Aharon Kapitulnik · 2022 · Proceedings of the National Academy of Sciences
Resistivity saturation is found on both superconducting and insulating sides of an “avoided” magnetic-field-tuned superconductor-to-insulator transition (H-SIT) in a two-dimensional In/InO x composite, where the anomalous metallic behavior…
View details →Negative / Null Result Report
David Curtis · 2014 · The Psychiatric Bulletin
Summary In the Oxford Community Treatment Order Evaluation Trial (OCTET), patients were randomised either to be made subject to a community treatment order (CTO) or to be managed with Section 17 leave and discharge. No differences in…
View details →Negative / Null Result Report
Falko Dahm, Hassan Syed, Sebastian Tomescu et al. · 2022 · Arthroscopy
Purpose The purpose of this study was to investigate biomechanical differences of medial patellofemoral ligament (MPFL) reconstruction, medial quadriceps tendon femoral ligament (MQTFL) reconstruction, and a combination of these techniques…
View details →Negative / Null Result Report
Tom Burns · 2010 · The Psychiatrist
Summary UK mental healh services have been distinguished by their continuity of care but recently there has been a move to separating consultant responsibility for in-patient and out-patient care. Local examples of the success of this…
View details →Negative / Null Result Report
Rachael Storo, Cole Easson, Mahmood Shivji et al. · 2021 · Frontiers in Microbiology
Profiles of symbiotic microbial communities (“microbiomes”) can provide insight into the natural history and ecology of their hosts. Using high throughput DNA sequencing of the 16S rRNA V4 region, microbiomes of five shark species in South…
View details →Negative / Null Result ReportOpen accessMedicine
Sergio Luis‐Lima, Tomás H. Higuera Linares, Laura Henríquez-Gómez et al. · 2019 · Journal of Clinical Medicine
Type 2 diabetes mellitus represents 30-50% of the cases of end stage renal disease worldwide. Thus, a correct evaluation of renal function in patients with diabetes is crucial to prevent or ameliorate diabetes-associated kidney disease. The reliability of formulas to estimate renal function is still unclear, in particular, those new equations based on cystatin-C or the combination of creatinine and cystatin-C. We aimed to assess the error of the available formulas to estimate glomerular filtration rate in diabetic patients. We evaluated the error of creatinine and/or cystatin-C based formulas
View details →Negative / Null Result ReportOpen accessMedicine
Yan Tong, Peter Jezzard, Thomas W. Okell et al. · 2020 · Magnetic Resonance in Medicine
PURPOSE: To improve the labeling efficiency of pseudo-continuous arterial spin labeling (PCASL) at 7T using parallel transmission (pTx). METHODS: maps were acquired in the labeling plane for tagging pulse design. Complex weights of the labeling pulses for each of the 8 transmit channels were calculated to produce a homogenous radiofrequency (RF) -shimmed labeling across the ROIs. Variable-Rate Selective Excitation (VERSE) pulses were also implemented as a part of the labeling pulse train. Whole-brain perfusion-weighted images were acquired under conditions of RF shimming, VERSE with RF shimmin
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Takeshi Kuroda, Naohito Tanabe, Daisuke Kobayashi et al. · 2012 · BMC Nephrology
BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters. METHODS: Fifty-eight patients with an established diagnosis of AL amyloidosis participated in the study. All patients showed amyloid deposits in renal biopsies. We retrospectively investigated the correlation between clinical data
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