Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model
Anna Katri; Aneta Dąbrowska; Henrik Löfvall; Ming Ding; M.A. Karsdal; Kim Vietz Andreassen; Christian S. Thudium; Kim Henriksen · 2019 · Arthritis Research & Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on salmon calcitonin and are expected to inhibit bone resorption and to be chondroprotective. In this study, we investigated if combining a standard of care NSAID (naproxen) with a KBP resulted in improvement in pain
Abstract by Anna Katri; Aneta Dąbrowska; Henrik Löfvall; Ming Ding; M.A. Karsdal; Kim Vietz Andreassen; Christian S. Thudium; Kim Henriksen, Arthritis Research & Therapy (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13075-019-1819-9