Replication Failure
Brian Chin, Andrea Copeland, Lucas Gallo et al. · 2019 · Plastic & Reconstructive Surgery
Background: The fragility index has been proposed as a metric to evaluate the robustness of statistically significant findings in randomized controlled trials. It measures the number of events that a trial result relies on to maintain…
View details →Negative / Null Result ReportOpen accessMaterials Science
Kimberly M. Sogi, Zev J. Gartner, Mark A. Breidenbach et al. · 2013 · PLoS ONE
The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate-dependent dioxygenase that catalyzes the oxidation and subsequent cleavage of alkyl sulfate esters. Rv3406 was identified based on its homology to the alkyl sulfatase AtsK from Pseudomonas putida. Using an in vitro biochemical assay, we confirmed that Rv3406 is a sulfatase with a preference for alkyl sulfate substrates similar to those processed by Ats
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Irina Travkina, Manuela Tvaronavičienė · 2015 · Journal of Entrepreneurship and Sustainability Issues
The research paper discusses the relationship between international trade, especially export, and the economic growth, presented by GDP, in Lithuania over the period of 2000-2015 years. The analysis is started by the historical review of possible types of relationships between exports and economic growth. Furthermore, the paper presents four theoretical propositions as export-led growth (1), growth-driven export (2), a feedback relationship (3) and simple contemporaneous relationship (4). This study examines the importance of the export-led growth hypothesis for Lithuania. The testing is based
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
John F. Krisko, Nurjahan Begum, Caroline E. Baker et al. · 2016 · Journal of Virology
UNLABELLED: The multifunctional HIV-1 accessory protein Vif counters the antiviral activities of APOBEC3G (A3G) and APOBEC3F (A3F), and some Vifs counter stable alleles of APOBEC3H (A3H). Studies in humanized mice have shown that HIV-1…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Neil D. Clarke, James R. Thomas, Marion Kagka et al. · 2016 · The Journal of Strength and Conditioning Research
Clarke, ND, Thomas, JR, Kagka, M, Ramsbottom, R, and Delextrat, A. No dose-response effect of carbohydrate mouth rinse concentration on 5-km running performance in recreational athletes. J Strength Cond Res 31(3): 715-720, 2017-Oral…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rebecca Fisher, David R. Fox · 2023 · Environmental Toxicology and Chemistry
The no-effect concentration (NEC) is the preferred threshold metric for single-species toxicity tests applied to derive safe concentration thresholds for contaminants in the environment for use in species sensitivity distributions.…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Wei Hu · 2013 · Social Networking
Various networks exist in the world today including biological, social, information, and communication networks with the Internet as the largest network of all. One salient structural feature of these networks is the formation of groups or communities of vertices that tend to be more connected to each other within the same group than to those outside. Therefore, the detection of these communities is a topic of great interest and importance in many applications and different algorithms including label propagation have been developed for such purpose. Speaker-listener label propagation algorithm
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Benjamin L. Rambo‐Martin, Jennifer G. Mulle, David J. Cutler et al. · 2017 · G3 Genes Genomes Genetics
One in five people with Down syndrome (DS) are born with an atrioventricular septal defect (AVSD), an incidence 2000 times higher than in the euploid population. The genetic loci that contribute to this risk are poorly understood. In this study, we tested two hypotheses: (1) individuals with DS carrying chromosome 21 copy number variants (CNVs) that interrupt exons may be protected from AVSD, because these CNVs return AVSD susceptibility loci back to disomy, and (2) individuals with DS carrying chromosome 21 genes spanned by microduplications are at greater risk for AVSD because these microdup
View details →Negative / Null Result ReportOpen accessMedicine
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish et al. · 2021 · Journal of Psychiatry and Neuroscience
Background: Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH…
View details →Negative / Null Result ReportOpen accessNeuroscience
Adam Maxwell Sparks, Pat Barclay · 2015 · Letters on Evolutionary Behavioral Science
The effect of exposure to eye images on various behaviors has been explained as a response to an invalid cue of observation. This interpretation has been supported by an experiment showing that a short exposure to eye images increased…
View details →Negative / Null Result Report
Pamela Laird, Roz Walker, Mary Lane et al. · 2019 · Respirology
ABSTRACT Background and objective Chronic lung disease is prevalent among Australian Aboriginal children. Chronic wet cough is an early marker of disease but often goes undetected. Currently, no studies have examined health practitioner…
View details →Negative / Null Result Report
Clarin Collins · 2014 · Education Policy Analysis Archives
This study examined the SAS Education Value-Added Assessment System (EVAAS®) in practice, as perceived and experienced by teachers in the Southwest School District (SSD). To evaluate teacher effectiveness, SSD is using SAS EVAAS® for…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Yawen Chen · 2017 · Modern Economy
Based on the annual data of China from 2000 to 2014, this paper applies the dynamic panel model to study the relationship between inbound tourism and foreign direct investment (FDI). Compared with previous literatures, our analysis is not limited to the study of FDI in single tourism sectors such as hotels and restaurants, but takes general FDI into consideration. The empirical results show that the growth of inbound tourism can not only promote FDI flow into the tourism industries, but also increase the inflows of FDI to other sectors. In other words, the flourished inbound tourism may have s
View details →Negative / Null Result ReportOpen accessMedicine
Leah Wetherill, Dongbing Lai, Emma C. Johnson et al. · 2019 · Genes Brain & Behavior
Abstract Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome‐wide association study (GWAS) of a phenotype representing alcohol or illicit…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Marina Reyne, Myles Nolan, Henry McGuiggan et al. · 2020 · Journal of Applied Ecology
Abstract Farmland ponds are a highly threatened freshwater habitat which has undergone dramatic losses during the last 200 years due to land drainage schemes and agricultural intensification. Agri‐environment schemes (AES) incentivize farmers to adopt farming methods to benefit biodiversity, yet there are a paucity of data evaluating the success of artificially created AES ponds as analogues of natural ponds in an attempt to recreate lost environments. We examined variation in environmental parameters and aquatic and terrestrial invertebrate communities between 38 natural ponds and 91 artifici
View details →Negative / Null Result ReportOpen accessNeuroscience
Shan-Chuan Teng, Yunn-Wen Lien · 2022 · PLoS ONE
Mind wandering has been argued to be beneficial for breaking through mental impasses, which leads to better creative performance upon a second attempt (i.e., the incubation effect). However, the evidence is inconsistent. Different from the propensity for mind wandering that has been the focus of past studies, in this study we further examined the role of diversity (i.e., non-repetitiveness of mind wandering respective to its content) and types of mind wandering along the dimensions of intentionality and awareness during incubation when engaging in a 0-back task (a mind wandering-prone conditio
View details →Negative / Null Result Report
R. G. Waruna Jinadasa, Bihong Li, Benjamin Schmitz et al. · 2016 · ChemSusChem
Abstract A series of monobenzoporphyrins ( WH1 – WH4 ) bearing different conjugated spacer groups were designed and synthesized as sensitizers for dye‐sensitized solar cells. Although a phenyl spacer only has a minimal impact on the…
View details →Negative / Null Result Report
Thomas Milic · 2015 · Swiss Political Science Review
Abstract After the vote of 9 February 2014, many attributed the surprising result to voter ignorance. The basic claim was that the majority of those voting in favour of the initiative possessed only a weak understanding of what the likely…
View details →Negative / Null Result ReportOpen accessMedicine
Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…
View details →Negative / Null Result ReportPsychology
Mark van Veen, Inge van Weeghel, Bauke Koekkoek et al. · 2014 · International Journal of Social Psychiatry
BACKGROUND: Risk of suicide is notoriously difficult to assess, and no gold standard is available, in terms of an instrument of first choice. Many different instruments are in use, among which are some that are not properly…
View details →Negative / Null Result ReportComputer Science
Anton Kotelyanskii, Gregory M. Kapfhammer · 2014
Although search-based test-data generators, like EvoSuite, efficiently and automatically create effective JUnit test suites for Java classes, these tools are often difficult to configure. Prior work by Arcuri and Fraser revealed that the…
View details →Negative / Null Result ReportOpen accessMedicine
Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…
View details →Negative / Null Result ReportOpen accessMedicine
Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology
<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…
View details →Negative / Null Result ReportOpen accessMedicine
Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…
View details →Negative / Null Result Report
E. S. Skordas, N. V. Sarlis, P. A. Varotsos · 2010 · Chaos: An Interdisciplinary Journal of Nonlinear Science
Electric field variations that appear before rupture have been recently studied by employing the detrended fluctuation analysis (DFA) to quantify their long-range temporal correlations. These studies revealed that seismic electric signal…
View details →Negative / Null Result ReportOpen accessMedicine
Charlotte Lindblad Wollmann, Kyle D. Hart, Can Liu et al. · 2020 · Acta Obstetricia Et Gynecologica Scandinavica
INTRODUCTION: Predicting a woman's probability of vaginal birth after cesarean could facilitate the antenatal decision-making process. Having a previous vaginal birth strongly predicts vaginal birth after cesarean. Delivery outcome in…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shaharudin Jakpar, Michael Tinggi, Akmal Hisham Tak et al. · 2018 · UNIMAS Review of Accounting and Finance
This study is conducted to analyse the credibility of the fundamental analysis and technical analysis on predicting the stock return and compare both models to determine which model is more credible to be used as a good trading strategy by…
View details →Negative / Null Result ReportSocial Sciences
Holger Hopp, Teresa Kieseier, Jenny Jakisch et al. · 2021 · Multilingua
Abstract This paper reports findings of a project on pedagogical translanguaging (PTL) among 128 fourth-grade students learning English as a foreign language (EFL) in German primary schools. Over a period of six months, 20% of lesson time…
View details →Negative / Null Result ReportOpen accessMedicine
Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry
BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…
View details →Negative / Null Result Report
Bo Christiansen · 2013 · Journal of Climate
Abstract The author investigates whether the increasing numbers of warm records and warm extremes in the extratropical Northern Hemisphere over the last decade are statistically significant. For the extremes, the focus is on summer mean…
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