Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice

Abstract

BACKGROUND: It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. METHODS: Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from A

Abstract by Jonathan Tucci; Waseem Alhushki; Ting Chen; Xia Sheng; Yong‐Mi Kim; Steven D. Mittelman, Cancer & Metabolism (2018) — licensed CC BY 4.0.

Related failures