Negative / Null Result ReportOpen accessMedicine
Nan Bi, Jun Liang, Zongmei Zhou et al. · 2019 · JAMA Network Open
Importance: Treatment of locally advanced non-small cell lung cancer (NSCLC) remains challenging. The rationale of combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results of preclinical research and prospective clinical studies; however, no randomized clinical trial has provided evidence of a direct comparison with CCRT alone. Objective: To determine the effect of combined selective COX-2 inhibition with standard CCRT on survival among patients with unresectable stage III NSCLC. Design, Setting, and Participants: A single-center, open-label, ra
View details →Negative / Null Result ReportOpen accessMedicine
Kennichi Kakudo · 2022 · Cancers
Histopathological diagnosis of papillary thyroid carcinomas (PTCs) is prone to significant observer variation due to different thresholds of RAS-like nuclear changes among pathologists. This gap recently widened due to a defensive attitude by Western pathologists where malpractice litigation is significant. Cases with delicate RAS-like nuclear changes are follicular adenomas when they are noninvasive, follicular carcinomas when invasive, and follicular variant PTCs when they have fully developed PTC-type nuclear features in Asian practice. The different diagnostic threshold of PTC nuclear feat
View details →Negative / Null Result ReportOpen accessMedicine
Francesca Faustini, Nicky Dunn, Nastya Kharlamova et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used for ANCA-associated vasculitis (AAV) and as off-label therapy for systemic lupus erythematosus (SLE), but data on occurrence and predisposing factors to ADAs in these diseases is limited. OBJECTIVES: To elucidate the rate of occurrence, and risk factors for ADAs against rituximab in SLE and AAV. METHODS: ADAs were detected using a bridging electrochemilumi
View details →Negative / Null Result ReportMedicine
Brintha K. Enestvedt, M. Brian Fennerty, A. Zaman et al. · 2011 · Alimentary Pharmacology & Therapeutics
BACKGROUND: In recent clinical trials (RCT) of bowel preparation, Golytely was more efficacious than MiraLAX. We hypothesised that there is a difference in adenoma detection between Golytely and MiraLAX. AIMS: To compare the adenoma…
View details →Negative / Null Result ReportOpen accessNeuroscience
A. V. Dyomina, Anna A. Kovalenko, Maria V. Zakharova et al. · 2022 · International Journal of Molecular Sciences
Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases. Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear. In the present study, we aimed to clarify the effect of treatment with the selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on epile
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Juan Zeng, Yukun Li, Feifei Quan et al. · 2020 · Molecular Medicine Reports
Propofol, a commonly used intravenous anesthetic agent during surgery, has relatively widespread pharmacological actions. Previous studies have reported that propofol may act as an antitumor drug in several cancer types, such as pancreatic…
View details →Negative / Null Result ReportOpen accessNeuroscience
Sean Coulborn, Howard Bowman, R. Chris Miall et al. · 2020 · Frontiers in Human Neuroscience
Mind-wandering is associated with switching our attention to internally directed thoughts and is by definition an intrinsic, self-generated cognitive function. Interestingly, previous research showed that it may be possible to modulate its propensity externally, with transcranial direct current stimulation (tDCS) targeting different regions in the default mode and executive control networks. However, these studies used highly heterogeneous montages (targeting the dorsolateral prefrontal cortex (DLPFC), the right inferior parietal lobule (IPL), or both concurrently), often showed contradicting
View details →Negative / Null Result ReportOpen accessNeuroscience
Klára Marečková, Amy Miles, Zhijie Liao et al. · 2022 · NeuroImage Clinical
BACKGROUND: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Fumitaka Furuoka · 2016 · Applied Economics Letters
This article proposes a new unit root test to analyse unemployment hysteresis. The test is able to incorporate cross-sectional dependence, unattended nonlinearity and unknown structural breaks in the time-series data. This study used data…
View details →Negative / Null Result ReportOpen accessMedicine
Freija Verdoodt, Susanne K. Kjær, Christian Dehlendorff et al. · 2018 · British Journal of Cancer
BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a…
View details →Negative / Null Result ReportOpen accessEngineering
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos et al. · 2022 · Pharmaceutics
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Rouven Doran, Daniel Hanss, Torvald Øgaard · 2017 · Sustainability
Two online experiments explored the effects of social comparison feedback on indicators of eco-friendly travel choices. It was tested whether the chosen indicators are sensitive to the information conveyed, and if this varies as a function of in-group identification. Study 1 (N = 134) focused on unfavourable feedback (i.e., being told that one has a larger ecological footprint than the average member of a reference group). People who received unfavourable feedback reported stronger intentions to choose eco-friendly travel options than those who received nondiscrepant feedback, when in-group id
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jeni L. Burnette, Crystal L. Hoyt, Nicholas R. Buttrick et al. · 2021 · International Journal of Psychology
Communications about the Coronavirus Disease 2019 (COVID-19) often employ metaphors, which can help people understand complex issues. For example, public health messages may focus on "fighting" the disease, attempting to rouse people to…
View details →Negative / Null Result ReportOpen accessComputer Science
Christian Bock, Thomas Gumbsch, Michael Moor et al. · 2018 · Bioinformatics
Motivation: Most modern intensive care units record the physiological and vital signs of patients. These data can be used to extract signatures, commonly known as biomarkers, that help physicians understand the biological complexity of…
View details →Replication FailureOpen accessSocial Sciences
Joseph Workman, Paul von Hippel, Joseph J. Merry · 2023 · Sociological Science
It is widely believed that (1) children lose months of reading and math skills over summer vacation and that (2) inequality in skills grows much faster during summer than during school. Concerns have been raised about the replicability of evidence for these claims, but an impression may exist that nonreplicable findings are limited to older studies. After reviewing the 100-year history of nonreplicable results on summer learning, we compared three recent data sources (ECLS- K:2011, NWEA, and Renaissance) that tracked U.S. elementary students' skills through school years and summers in the 2010
View details →Negative / Null Result ReportSocial Sciences
Odis Johnson · 2012 · Review of Educational Research
Since 1976, the U.S. Department of Housing and Urban Development (HUD) has relocated low-income children of color from public housing communities to less racially and economically isolated neighborhoods in an effort to improve their…
View details →Negative / Null Result ReportPsychology
John G. McCabe, Daniel A. Krauss · 2011 · Behavioral Sciences & the Law
An intervention designed to correct affective and cognitive biases was tested in the context of a civil commitment hearing of a sexually violent predator. Potential differences between a college student mock jury sample and a more…
View details →Negative / Null Result ReportEngineering
John Keane, Wei Zhang, Chris H. Kim · 2010
We present an array-based system to accurately study variations in ROSC aging. Microsecond measurements for minimal BTI recovery, and frequency shift measurement resolution ranging down to the error floor of 0.07% are achieved with three…
View details →Negative / Null Result ReportOpen accessPsychology
Eike Kofi Buabang, Yannick Boddez, Oliver T. Wolf et al. · 2022 · Behavioral Neuroscience
People are more likely to engage in various suboptimal behaviors such as overeating, addictive behaviors, and short-sighted financial decision-making when they are under stress. Traditional dual-process models propose that stress can…
View details →Negative / Null Result ReportMathematics
Kevin D. Floate, Paul C. Coghlin · 2010 · The Canadian Entomologist
Abstract Fluctuating asymmetries (FAs) are small random deviations between left- and right-side measurements of normally symmetrical traits in a given organism. Changes in FA have frequently been proposed as biomarkers for organisms…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna L. Guyatt, Kimberley Burrows, Philip A. I. Guthrie et al. · 2017 · Mitochondrion
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69.4 (5.5) years (N=2872). Mitochondrial DNA copy number was assayed by qua
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Bart de Boer · 2010 · Journal of Evolutionary Psychology
This paper investigates the effect of larynx position on the articulatory abilities of a human-like vocal tract. Previous work has investigated models that were built to resemble the anatomy of existing species or fossil ancestors. This…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anarkali Mahmood, Zdeněk Otruba, Alan W. Weisgerber et al. · 2023 · Biophysical Journal
When multivesicular endosomes (MVEs) fuse with the plasma membrane, exosomes are released into the extracellular space where they can affect other cells. The ability of exosomes to regulate cells nearby or further away depends on whether…
View details →Negative / Null Result ReportOpen accessMedicine
Brahim Aı̈ssani, Kui Zhang, Howard W. Wiener · 2015 · Frontiers in Genetics
We evaluated the association of 56 candidate SNPs identified in two published genome-wide association studies (GWAS) of uterine leiomyoma (UL), or fibroids, with the risk and tumor size in the multi-ethnic uterine fibroid study (NIEHS-UFS). The selected SNPs were genotyped in 916 premenopausal women of African American (AA) and European American (EA) descents and their association with the outcomes was evaluated in race-stratified models and in meta-analysis of risk in NIEHS-UFS and discovery and replication GWAS in the Japanese population. We report moderate associations of variant rs4954368
View details →Negative / Null Result ReportOpen accessMedicine
Liv Cecilie Vestrheim Thomsen, Nina S. McCarthy, Phillip E. Melton et al. · 2016 · Journal of Hypertension
OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life.…
View details →Failed Experiment ReportOpen accessMedicine
Kui Yang, Elizabeth Wills, Joel D. Baines · 2011 · Journal of Virology
Herpesvirus genomic DNA is cleaved from concatemers that accumulate in infected cell nuclei. Genomic DNA is inserted into preassembled capsids through a unique portal vertex. Extensive analyses of viral mutants have indicated that intact…
View details →Negative / Null Result ReportOpen accessMedicine
Helena Canhão, Ana Maria Rodrigues, María José Santos et al. · 2015 · BioMed Research International
BACKGROUND: The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. METHODS: We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to con
View details →Negative / Null Result ReportOpen accessEngineering
Yaser Maddahi, Kourosh Zareinia, Liu Shi Gan et al. · 2016 · BioMed Research International
The use of robotic technology in the surgical treatment of brain tumour promises increased precision and accuracy in the performance of surgery. Robotic manipulators may allow superior access to narrow surgical corridors compared to freehand or conventional neurosurgery. This paper reports values and ranges of tool-tissue interaction forces during the performance of glioma surgery using an MR compatible, image-guided neurosurgical robot called neuroArm. The system, capable of microsurgery and stereotaxy, was used in the surgical resection of glioma in seven cases. neuroArm is equipped with for
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
E. M. Dunne, Lindsay Lee, Carly Reddington et al. · 2012 · Atmospheric chemistry and physics
Abstract. Observed correlations between short-term decreases in cosmic ray ionisation and cloud and aerosol properties have been attributed to short-term decreases in the ion-induced nucleation rate. We use a global aerosol microphysics model to determine whether a 10 day reduction of 15% in the nucleation rate could generate a statistically significant response in aerosol concentrations and optical properties. As an upper limit to the possible effect of changes in ion-induced nucleation rate, we perturb the total nucleation rate, which has been shown to generate particle concentrations and nu
View details →Negative / Null Result ReportOpen accessMedicine
Antonija Perović, Nora Nikolac, Marina Njire Bratičević et al. · 2017 · Biochemia Medica
INTRODUCTION: Scuba diving represents a combination of exercise and changes in environmental conditions. This study aimed to evaluate changes in haematological parameters after recreational scuba diving in order to identify clinically significant changes. MATERIALS AND METHODS: The study included males, 17 recreational divers, median age (range) 41 (30-52) years. Blood samples were taken before diving, immediately after diving to 30 meters for 30 minutes, 3 hours and 6 hours after diving. Complete blood counts were analyzed on the Cell Dyn Ruby haematology analyzer. Statistical significance be
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