Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model
Michael Schütt; Connor O’Farrell; Konstantinos Stamatopoulos; Caroline L. Hoad; Luca Marciani; Sarah Sulaiman; Mark Simmons; Hannah Batchelor · 2022 · Pharmaceutics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade
Abstract by Michael Schütt; Connor O’Farrell; Konstantinos Stamatopoulos; Caroline L. Hoad; Luca Marciani; Sarah Sulaiman; Mark Simmons; Hannah Batchelor, Pharmaceutics (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/pharmaceutics14010184