21,234 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Osea Giuntella, Johannes König, Luca Stella · 2025 · Scientific Reports
This study explores the relationship between artificial intelligence (AI) and workers' well-being and health using longitudinal survey data from Germany (2000-2020). Using a measure of occupational exposure to AI, we explore an event study…
View details →André Luiz Souza, Arthur B. Markman · 2013 · eScholarship (California Digital Library)
A recent paper by Lev-Ari and Keysar (2010) reported that the processing fluency associated with non-native speech causes non-native speakers to sound less credible.The authors found that the same trivia statements were rated as less…
View details →Paul A. Gilbert, Scott D. Rhodes · 2012 · Hispanic Journal of Behavioral Sciences
Social support is protective for a variety of health outcomes, and individuals living outside their country of origin ("sojourners") might use social support in distinctive ways. The authors performed a confirmatory factor analysis of the…
View details →Jason M. Schon, Jacob D. Mikula, Jonathon D. Backus et al. · 2016 · Foot & Ankle International
BACKGROUND: The effect of ankle positioning during suture-button fixation for syndesmosis repair on range of motion (ROM) and anatomic reduction has yet to be investigated. The purpose of this cadaveric study was to compare the effects of…
View details →Shane J. J. McCrea · 2017 · International Journal of Dentistry
Here we present an analysis of patient perceptions and expectations to dental implant placement and their prosthetic reconstruction, to then consider whether they have an effect on long-term satisfaction levels. A Post-Treatment Completion Questionnaire was designed to analyse whether patient satisfaction is influenced by age and/or gender; has an effect on patient-reported self-confidence levels; contributes to increased levels of oral hygiene; provides further insight into the average pain levels during and after the surgical intervention; or influences further acceptance of dental implant s
View details →Qingyu Shi, Fang Wang, Dan Feng · 2020 · IEEE Transactions on Network and Service Management
Datacenter network load balancing schemes handle network traffic generated by massive different applications. Some packet-based or flowlet-based schemes capture traffic bursts for load balancing. But frequent rerouting within a flow can…
View details →Jorma J. de Ronde, Christiaan Klijn, Arno Velds et al. · 2010 · BMC Research Notes
BACKGROUND: Most approaches used to find recurrent or differential DNA Copy Number Alterations (CNA) in array Comparative Genomic Hybridization (aCGH) data from groups of tumour samples depend on the discretization of the aCGH data to gain, loss or no-change states. This causes loss of valuable biological information in tumour samples, which are frequently heterogeneous. We have previously developed an algorithm, KC-SMART, that bases its estimate of the magnitude of the CNA at a given genomic location on kernel convolution (Klijn et al., 2008). This accounts for the intensity of the probe sign
View details →Veronika V. Odintsova, Fiona A. Hagenbeek, Matthew Suderman et al. · 2019 · Nutrients
Breastfeeding has long-term benefits for children that may be mediated via the epigenome. This pathway has been hypothesized, but the number of empirical studies in humans is small and mostly done by using peripheral blood as the DNA source. We performed an epigenome-wide association study (EWAS) in buccal cells collected around age nine (mean = 9.5) from 1006 twins recruited by the Netherlands Twin Register (NTR). An age-stratified analysis examined if effects attenuate with age (median split at 10 years; n<10 = 517, mean age = 7.9; n>10 = 489, mean age = 11.2). We performed replication
View details →Mark A. Straccia, Adam R. Teed, Perri L. Katzman et al. · 2021 · Psychological Medicine
BACKGROUND: Although potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically, most studies have included all male samples, and few have demonstrated consistent effects of either neuropeptide on mentalizing (i.e. understanding the mental states of others). To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP on mentalizing in healthy individuals. METHODS: = 186) of healthy individuals, we exa
View details →Per Pfeiffer, Maryam B. Lustberg, Jacques Näsström et al. · 2022 · JNCI Cancer Spectrum
BACKGROUND: Calmangafodipir (CaM, PledOx) demonstrated efficacy in preventing patient-reported chemotherapy-induced peripheral neuropathy (CIPN) in a randomized phase 2 study in patients with metastatic colorectal cancer. The Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy (POLAR) program aimed to assess efficacy and safety of CaM in the prevention of CIPN in patients treated with oxaliplatin in adjuvant (POLAR-A, ClinicalTrials.gov.NCT04034355) or metastatic (POLAR-M, ClinicalTrials.gov.NCT03654729) settings. METHODS: Two randomized, placebo-controlled phase 3 trials investi
View details →Yasushi Tojo, Yasuhiro Koh, Masayuki Amano et al. · 2010 · Antimicrobial Agents and Chemotherapy
Natural products with macrocyclic structural features often display intriguing biological properties. Molecular design incorporating macrocycles may lead to molecules with unique protein-ligand interactions. We generated novel human…
View details →Donghyok Kwon, Kyeong‐Cheol Shin, Seungtae Kim et al. · 2010 · The Journal of Microbiology
This study aimed to characterize the replication and pathogenic properties of a Korean pandemic (H1N1) 2009 influenza virus isolate in ferrets and mice. Ferrets infected with A/Korea/01/2009 (H1N1) virus showed mild clinical signs. The…
View details →Adrienne L. Romer, Diego A. Pizzagalli · 2021 · Biological Psychiatry Global Open Science
A general psychopathology factor (p factor) captures shared variance across mental disorders in diverse samples and may partly reflect executive dysfunction. Higher p factor scores have been related to structural alterations within the…
View details →Brittany N. Neilson, Curtis M. Craig, Raelyn Y. Curiel et al. · 2020 · Human Factors The Journal of the Human Factors and Ergonomics Society
OBJECTIVE: The aim of this study is to replicate Berto's (2005) heavily cited work on attention restoration. BACKGROUND: Nature interventions have gained increased interest for improving performance of attentionally demanding tasks. Berto…
View details →Mark O. Goodarzi, Nicholette D Palmer, Jinrui Cui et al. · 2019 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Genome-wide association studies have identified more than 450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). OBJECTIVE: To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed…
View details →Lawrence Grierson, Samantha Winemaker, Alan Taniguchi et al. · 2020 · Perspectives on Medical Education
INTRODUCTION: The medical education community has implemented writing exercises that foster critical analysis and nurture reflective capacity. The REFLECT rubric (Wald et al. 2012) was developed to address the challenge of assessing these written reflections. The objective of this replication work is to explore the reproducibility of the reliability characteristics presented by the REFLECT developers. METHODS: Five raters evaluated narratives written by medical students and experienced clinicians using the REFLECT rubric. Reliability across rubric domains was determined via intraclass correlat
View details →Yuli Wang · 2019 · UNC Libraries
The human small intestinal epithelium possesses a distinct crypt-villus architecture and tissue polarity in which proliferative cells reside inside crypts while differentiated cells are localized to the villi. Indirect evidence has shown…
View details →Manou Sommen, Guy Van Camp, Balázs Liktor et al. · 2014 · Otology & Neurotology
BACKGROUND/HYPOTHESIS: Otosclerosis is a frequent cause of hearing impairment characterized by abnormal resorption and deposition of bone in the human otic capsule. It is a disease of complex etiopathogenesis that is caused by both…
View details →Samantha J. Heintzelman, Jason Trent, Laura A. King · 2014 · The Journal of Positive Psychology
Growing popular interest in positive psychology may have important implications for the measurement of well-being. Five studies tested the prediction that well-being ratings are influenced by desirability bias. In Study 1, participants (N…
View details →Dinggang Zhou, Liping Xu, Shiwu Gao et al. · 2016 · Frontiers in Plant Science
Cry1Ac transgenic sugarcane provides a promising way to control stem-borer pests. Biosafety assessment of soil ecosystem for cry1Ac transgenic sugarcane is urgently needed because of the important role of soil microorganisms in nutrient transformations and element cycling, however little is known. This study aimed to explore the potential impact of cry1Ac transgenic sugarcane on rhizosphere soil enzyme activities and microbial community diversity, and also to investigate whether the gene flow occurs through horizontal gene transfer. We found no horizontal gene flow from cry1Ac sugarcane to soi
View details →Waldemar Siemens, Joerg J. Meerpohl, Miriam S. Rohe et al. · 2022 · Research Synthesis Methods
Abstract Using the Hartung–Knapp method and 95% prediction intervals (PIs) in random‐effects meta‐analyses is recommended by experts but rarely applied. Therefore, we aimed to reevaluate statistically significant meta‐analyses using the…
View details →Andreas Ketterer, Satoya Imai, Nikolai Wyderka et al. · 2022 · Physical review. A/Physical review, A
We consider statistical methods based on finite samples of locally randomized measurements in order to certify different degrees of multiparticle entanglement in intermediate-scale quantum systems. We first introduce hierarchies of…
View details →C. M. Chang, Victoria M. Chia, Marc J. Gunter et al. · 2013 · Carcinogenesis
Inherited variation in genes that regulate innate immunity and inflammation may contribute to colorectal neoplasia risk. To evaluate this association, we conducted a nested case-control study of 451 colorectal cancer cases, 694 colorectal…
View details →Matthew R. Pearson, Mark A. Prince, Adrián J. Bravo · 2017 · Substance Use & Misuse
BACKGROUND: Protective behavioral strategies (PBS) can be used to reduce alcohol-related harm when drinking. Despite much research demonstrating that use of protective behavioral strategies (PBS) is associated with decreased alcohol…
View details →John Redmond, Helen O. McCarthy, Paul Buchanan et al. · 2022 · Biomaterials Advances
While 2D culture presents a useful tool for cancer research, it fails to replicate the tumor microenvironment as it lacks proper three-dimensional cell-cell/cell-matrix interactions, often resulting in exaggerated responses to therapeutic agents. 3D models that aim to overcome the issues associated with 2D culture research offer a new frontier for cancer research with cell growth, morphology and genetic properties that more closely match in vivo cancers. Herein, we aim to develop a collagen-based scaffold that supports the attachment and proliferation of breast cancer (BC) cells as a 3D cultur
View details →Magnus Bergquist, Andréas Nilsson, Emma Ejelöv · 2019 · Sustainability
Setting up a contest is a popular means to promote pro-environmental behaviors. Yet, research on contest-based interventions is scarce while norm-based interventions have gained much attention. In two field experiments, we randomly assigned 79 apartments to either a contest-based or a norm-based electricity conservation intervention and measured kWh usage for 2 and 4 weeks, respectively. Results from both studies showed that contest-based interventions promote intensive but short-lived electricity saving. In Study 1 apartments assigned to a norm-based intervention showed more stable electricit
View details →Minghua Wu, Shervin Assassi, Gloria A. Salazar et al. · 2016 · Arthritis Research & Therapy
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts. Thirteen IIP-related selected single nucleotide polymorphisms (SNPs) were genotyped and
View details →Michael A. Mooney, Peter Ryabinin, Hannah E. Morton et al. · 2023 · JCPP Advances
Abstract Background attention‐deficit/hyperactivity disorder (ADHD) is associated with both polygenic liability and environmental exposures, both intrinsic to the family, such as family conflict, and extrinsic, such as air pollution. However, much less is known about the interplay between environmental and genetic risks relevant to ADHD—a better understanding of which could inform both mechanistic models and clinical prediction algorithms. Methods Two independent data sets, the population‐based Adolescent Brain Cognitive Development Study (ABCD) ( N = 11,876) and the case‐control Oregon‐ADHD‐1
View details →Sarah Kunkle, Manny Yip, Justin Hunt et al. · 2020 · JMIR Formative Research
BACKGROUND: Anxiety is an extremely prevalent condition, and yet, it has received notably less attention than depression and other mental health conditions from a research, clinical, and public health perspective. The COVID-19 pandemic has only exacerbated growing concerns about the burden of anxiety due to the confluence of physical health risks, economic stressors, social isolation, and general disruption of daily activities. OBJECTIVE: This study examines differences in anxiety outcomes by care modality (coaching, teletherapy and telepsychiatry, and combined care) within an on-demand mental
View details →Marina Terkourafi, Benjamin Weissman, Joseph Roy · 2020 · International Review of Pragmatics
Abstract Research on the effect of face-orientation on scalar implicatures has claimed that face-threatening contexts are one type of context in which scalar implicatures are not warranted. However, that research has been based on the two…
View details →