MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium–Pilocarpine Model of Epilepsy
A. V. Dyomina; Anna A. Kovalenko; Maria V. Zakharova; Tatyana Y. Postnikova; Alexandra V. Griflyuk; Ilya V. Smolensky; Irina Antonova; Aleksey V. Zaitsev · 2022 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases. Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear. In the present study, we aimed to clarify the effect of treatment with the selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on epile
Abstract by A. V. Dyomina; Anna A. Kovalenko; Maria V. Zakharova; Tatyana Y. Postnikova; Alexandra V. Griflyuk; Ilya V. Smolensky; Irina Antonova; Aleksey V. Zaitsev, International Journal of Molecular Sciences (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms23010497