Negative / Null Result ReportOpen accessEnergy
Casey M. Godwin, David C. Hietala, Aubrey R. Lashaway et al. · 2017 · Environmental Science & Technology
For algal biofuels to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and processing must maximize rates of biofuel production while simultaneously minimizing the consumption of nitrogen (N) and…
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Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta et al. · 2021 · Nature Communications
Abstract A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and…
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Andrea Riboli, Fabio Esposito, Giuseppe Coratella · 2022 · Journal of Strength & Conditioning Research
Abstract Riboli, A, Esposito, F, and Coratella, G. Small-sided games in elite football: practical solutions to replicate the 4-min match-derived maximal intensities. J Strength Cond Res 37(2): 366–374, 2023—The purpose of the study was to…
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Ruella Rouf, Sara M. Karaba, Jenny Dao et al. · 2011 · Microbiology
The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of…
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Marie R. Johnston, Nick J. Balster, Anita M. Thompson · 2020 · Water
Rain gardens are residential bioretention practices widely used to manage urban runoff, yet their design as plant-soil systems lacks understanding. We hypothesized that vegetative treatment (turfgrass, prairie, and shrubs, plus a…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Boshu Ru, Dingcheng Li, Yueqi Hu et al. · 2019 · IEEE Transactions on NanoBioscience
Serendipitous drug usage refers to the unexpected relief of comorbid diseases or symptoms when taking medication for a different known indication. Historically, serendipity has contributed significantly to identifying many new drug…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars et al. · 2020 · Scientific Reports
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four
View details →Negative / Null Result ReportOpen accessMedicine
Yen‐Jen Chen, Hsien‐Te Chen, Horng‐Chaung Hsu · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Survival is a key factor physicians consider when selecting a treatment modality for the treatment of spinal metastases. Various assessment systems can predict length of survival and facilitate selection of the most appropriate treatment. Spinal palsy is a prognostic parameter in the Tokuhashi scoring system but not in the Tomita scoring system. A limitation of these scoring systems is that studies of them have included different tumor types. The aim of this study was to evaluate the usefulness of preoperative neurological status as a prognostic factor in non-small-cell lung cancer
View details →Negative / Null Result ReportOpen accessSocial Sciences
Amanda Rotella, Adam Maxwell Sparks, Sandeep Mishra et al. · 2021 · PLoS ONE
Some evidence suggests that people behave more cooperatively and generously when observed or in the presence of images of eyes (termed the 'watching eyes' effect). Eye images are thought to trigger feelings of observation, which in turn motivate people to behave more cooperatively to earn a good reputation. However, several recent studies have failed to find evidence of the eyes effect. One possibility is that inconsistent evidence in support of the eyes effect is a product of individual differences in sensitivity or susceptibility to the cue. In fact, some evidence suggests that people who ar
View details →Negative / Null Result ReportOpen accessMedicine
Mats Enlund, Anders Berglund, Anna Enlund et al. · 2022 · Anesthesiology
BACKGROUND: Several retrospective studies using administrative or single-center data have failed to show any difference between general anesthesia using propofol versus inhaled volatiles on long-term survival after breast cancer surgery.…
View details →Negative / Null Result ReportOpen accessMedicine
Josef S. Smolen, Christopher J. Edwards, Victoria Konzett et al. · 2026 · Annals of the Rheumatic Diseases
OBJECTIVES: This study aims to provide an update of the European Alliance of Associations for Rheumatology (EULAR) rheumatoid arthritis (RA) management recommendations addressing the most recent insights. METHODS: An International Task…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Adrian Abac, I. Abouelfettouh, F. Acernese et al. · 2026 · The Astrophysical Journal Letters
Abstract We detail the population properties of binary neutron star, neutron star–black hole binary, and binary black hole mergers using 158 events from the cumulative Gravitational-Wave Transient Catalog 4.0. The black hole primary mass distribution consists of a power-law-like continuum that steepens above 35 M ⊙ with overdensities at 10 M ⊙ and 35 M ⊙ . Binary black holes with primary masses near 10 M ⊙ are more likely to have less massive secondaries, with a mass ratio distribution peaking at q = 0.7 1 − 0.11 + 0.12 , potentially a signature of stable mass transfer during binary evolution.
View details →Negative / Null Result ReportOpen accessNeuroscience
Yves‐Alain Barde · 2025 · Physiological Reviews
BDNF is synthesized and secreted by excitatory neurons. Decades of work with animal models prepared the ground for interpreting the results of human genome analyses associating polymorphisms with memory deficits, mood disorders and…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sue Maguire, Jo Thompson · 2026 · Warwick Research Archive Portal (University of Warwick)
Young people who are "not in education, employment or training" (NEET) were brought firmly within the political agenda in 1999 with the publication of the Social Exclusion Unit's (SEU) report "Bridging the Gap" (SEU, 1999). The SEU report…
View details →Replication FailureOpen accessPsychology
Michael D. Pullmann, Julien Rouvere, Patrick J. Raue et al. · 2025 · JAMA Network Open
Importance: There is a need to determine the relative effect of message-based psychotherapy (MBP), an asynchronous approach that uses emails, texts, or voice or video messages to permit therapeutic exchanges, compared with video-based psychotherapy (VBP) and whether a combination of modalities would result in better outcomes for those who do not respond to either treatment alone. Objectives: To compare MBP with VBP on a commercial digital mental health platform and test combinations of modalities for participants who did not respond to single-modality treatment. Design, Setting, and Participan
View details →Negative / Null Result ReportOpen accessMedicine
Chiara Corti, Beyza Koca, Tasnim Rahman et al. · 2025 · ImmunoTargets and Therapy
While immunotherapy has transformed treatment across various cancers, its impact on breast cancer is relatively limited. Recent advances have established immunotherapy as an effective approach for triple-negative breast cancer (TNBC), an…
View details →Negative / Null Result ReportOpen accessMedicine
Hüseyin Alperen Yıldız, Emrullah Söğütdelen · 2025 · Journal of Medical Systems
BACKGROUND: Artificial intelligence (AI) chatbots are increasingly used for medical inquiries, including sensitive topics like sexually transmitted diseases (STDs). However, concerns remain regarding the reliability and readability of the information they provide. This study aimed to assess the reliability and readability of AI chatbots in providing information on STDs. The key objectives were to determine (1) the reliability of STD-related information provided by AI chatbots, and (2) whether the readability of this information meets the recommended standarts for patient education materials. M
View details →Negative / Null Result ReportOpen accessMedicine
Carmen Fiuza‐Luces, Nuria Garatachea, Nathan A. Berger et al. · 2026 · PubMed
Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data availabl
View details →Negative / Null Result ReportOpen accessNeuroscience
Jonathan Daume, Jan Kamiński, Yousef Salimpour et al. · 2024 · Neuron
Working Memory (WM) and Long-Term Memory (LTM) are often viewed as separate cognitive systems. Little is known about how these systems interact when forming memories. We recorded single neurons in the human medial temporal lobe while…
View details →Negative / Null Result ReportOpen accessNursing
Ivana Djuričić, Philip C. Calder · 2025 · Current Atherosclerosis Reports
PURPOSE OF REVIEW: We synthesize the latest evidence (published 2020 to 2025) on the role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular health, emphasizing biological mechanisms and key findings from observational studies and clinical trials related to cardiovascular disease (CVD) risk and outcomes. RECENT FINDINGS: EPA and DHA modulate lipid metabolism, inflammation, platelet and endothelial function, the gut-heart axis, ion channels and autonomic function via vagal tone, supporting cardiovascular health. While individual RCTs have produced variable results,
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Gillian D. Pullinger, Marc Guimerà Busquets, Kyriaki Nomikou et al. · 2016 · PLoS ONE
Bluetongue virus (BTV) can infect most ruminant species and is usually transmitted by adult, vector-competent biting midges (Culicoides spp.). Infection with BTV can cause severe clinical signs and can be fatal, particularly in naïve sheep and some deer species. Although 24 distinct BTV serotypes were recognized for several decades, additional 'types' have recently been identified, including BTV-25 (from Switzerland), BTV-26 (from Kuwait) and BTV-27 from France (Corsica). Although BTV-25 has failed to grow in either insect or mammalian cell cultures, BTV-26 (isolate KUW2010/02), which can be t
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Thomas Farmer, Gary Brook, John McSorley et al. · 2013 · International Journal of STD & AIDS
‘Did not attend’ and cancellation rates were compared for two 12-month periods before (2009) and after (2012/2013) the introduction of routine short message service text reminders being sent to patients who have pre-booked appointments.…
View details →Methods Dead-End
Rachel Kennedy, John Scriven, Magda Nenycz-Thiel · 2014 · International Journal of Market Research
Big data is here for some and coming for many. It promises access to new knowledge along with some challenges, but let's not forget the important lessons of the past to ensure that we are advancing knowledge and making the right decisions…
View details →Negative / Null Result ReportOpen accessMathematics
Fırat Soylu, David Raymond, Arianna Gutierrez et al. · 2018 · Journal of Numerical Cognition
The impact of fingers on numerical cognition has received a great deal of attention recently. One sub-set of these studies focus on the relation between finger gnosis (also called finger sense or finger gnosia), the ability to identify and individuate fingers, and mathematical development. Studies in this subdomain have reported mixed findings so far. While some studies reported that finger gnosis correlates with or predicts mathematics abilities in younger children, others failed to replicate these results. The current study explores the relationship between finger gnosis and two arithmetic o
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Panagiotis Kerezoudis, Kathleen J Yost, Nicole M Tombers et al. · 2018 · Neurosurgery
Abstract BACKGROUND The diagnosis of vestibular schwannomas (VS) is associated with reduced patient quality of life (QOL). Minimal clinically important difference (MCID) was introduced as the lowest improvement in a patient-reported…
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Kenneth Button · 2012 · Transportation Journal
Abstract The article examines the sustainability of the low-cost, or no-frills, airline business model. It looks at the background to the development of this managerial approach within the context of some prevailing business theories and…
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Jianjun Liu, Zhanqing Li · 2018 · Geophysical Research Letters
Abstract Aerosol optical quantities have been widely employed as the proxy variables of cloud condensation nuclei concentration to study aerosol indirect effects (AIE). Due to the aerosol swelling effect, cloud condensation nuclei and…
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Tao Zhang, Dan Gieseler, Rainer Jordan · 2016 · Polymer Chemistry
The influence of ambient laboratory light from common fluorescent lamps on AGET, ARGET, and classical ATRP reactions was investigated and significant differences were found except for ARGET ATRP.
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Jean C C Vila, Yang-Yu Liu, Alvaro Sanchez · 2020 · The ISME Journal
Abstract The taxonomic composition of microbial communities can vary substantially across habitats and within the same habitat over time. Efforts to build quantitative and predictive models of microbial population dynamics are underway,…
View details →Negative / Null Result Report
Francisca Alves-Cardoso, Vanessa Campanacho · 2022 · Heritage
Advancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely…
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