Negative / Null Result ReportMedicine
Matthew R. Quigley, Nicholas R. Bello, Diana H. Jho et al. · 2015 · Neurosurgery
BACKGROUND: There are limited data on the benefits of surgical tumor resection plus stereotactic radiosurgery (SRS) in comparison with SRS alone for patients with oligometastatic brain disease. OBJECTIVE: To determine the benefit of adding…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaozhun Huang, Lin Xu, Teng Ma et al. · 2021 · Frontiers in Oncology
BACKGROUND: Nivolumab and pembrolizumab disrupt the programmed cell death-1 immune checkpoint and display promising efficacy and safety results in advanced hepatocellular carcinoma (HCC). However, the benefits remain limited. The preliminary results of lenvatinib (LEN) combined with immune checkpoint inhibitors (ICIs) reveal that the combinations were well-tolerated and encouraging. This study aimed to analyze the safety and efficacy of LEN plus ICIs in a real-world cohort of patients with advanced HCC. METHOD: Between June 4, 2017, and June 30, 2019, 16 patients received LEN plus nivolumab, a
View details →Negative / Null Result Report
Tom Stafford · 2018 · Psychological Science
Stereotype threat has been offered as a potential explanation of differential performance between men and women in some cognitive domains. Questions remain about the reliability and generality of the phenomenon. Previous studies have found…
View details →Negative / Null Result ReportOpen accessMedicine
Joshua A. Beckman, Allison B. Goldfine, Alison Goldin et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Antagonism of protein kinase Cbeta (PKCbeta) restores endothelial function in experimental models of diabetes and prevents vascular dysfunction in response to hyperglycemia in healthy humans. OBJECTIVE: We tested the hypothesis…
View details →Negative / Null Result ReportOpen accessMedicine
Carlos Farkas, Andy Mella, Maxime Turgeon et al. · 2021 · Frontiers in Microbiology
An unprecedented amount of SARS-CoV-2 sequencing has been performed, however, novel bioinformatic tools to cope with and process these large datasets is needed. Here, we have devised a bioinformatic pipeline that inputs SARS-CoV-2 genome sequencing in FASTA/FASTQ format and outputs a single Variant Calling Format file that can be processed to obtain variant annotations and perform downstream population genetic testing. As proof of concept, we have analyzed over 229,000 SARS-CoV-2 viral sequences up until November 30, 2020. We have identified over 39,000 variants worldwide with increased polymo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
I. Krzyzewska, Judith Ensink, Laura Nawijn et al. · 2018 · European Journal of Human Genetics
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder that may develop after a traumatic event. Here we aimed to identify epigenetic and genetic loci associated with PTSD. We included 73 traumatized police officers…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Mona Ghannad, Bada Yang, Mariska Leeflang et al. · 2020 · Journal of Clinical Epidemiology
OBJECTIVE: To estimate the effect of an intervention compared to the usual peer-review process on reducing spin in the abstract's conclusion of biomedical study reports. STUDY DESIGN AND SETTING: We conducted a two-arm, parallel-group RCT in a sample of primary research manuscripts submitted to BMJ Open. The authors received short instructions alongside the peer reviewers' comments in the intervention group. We assessed the presence of spin (primary outcome), types of spin, and wording change in the revised abstract's conclusion. Outcome assessors were blinded to the intervention assignment. R
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Madeleine P. J. White, Chris Johnston, John R. Grainger et al. · 2020 · Frontiers in Immunology
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimise excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases. Multiple sclerosis (MS) is a severe autoimmune disease characterised by inflammatory lesions within the central nervous system; there are very limited therapeutic options for the progressive forms of the disease and none are curative. Here, we used the experimental autoimmune encephalomyelitis (EAE) model to examine if the intestinal helminth He
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
W-J Xiao, J-W He, H Zhang et al. · 2010 · International Journal of Obesity
OBJECTIVE: Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids. The products of ALOX12 reactions serve as endogenous…
View details →Negative / Null Result ReportOpen accessPsychology
Robert Young, Daniel Vincent Riordan, Cameron Stark · 2011 · BMC Public Health
BACKGROUND: Past studies using large population based datasets link certain perinatal circumstances (birth weight, parity, etc) with mental health outcomes such as suicide, self-harm and psychiatric problems. Problematically, population datasets omit a number of social confounds. The aim of this study is to replicate past research linking perinatal circumstances and mental health (suicidality and use of psychiatric services) and to determine if such associations remain after adjusting for social circumstances. METHODS: A longitudinal school-based survey of 2157 young people (surveyed at age 11
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jaehwan Park, Byungkwon Lim · 2018 · International Journal of Financial Studies
This paper explores the market efficiency of the six base metals traded on the LME (London Metal Exchange) using daily data from January 2000 to June 2016. The hypothesis that futures prices 3M (3-month) are unbiased predictors of spot prices (cash) in the LME is rejected based on the false premise that the financialization of commodities has been growing. For the robustness check, monthly data is analyzed using ordinary least squares (OLS) and GARCH (1,1) models. We reject the null hypothesis for all metals except for zinc.
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Rebecca C. Richmond, Carlos Sillero‐Rejon, Jasmine Khouja et al. · 2021 · Clinical Epigenetics
Abstract Background Little evidence exists on the health effects of e-cigarette use. DNA methylation may serve as a biomarker for exposure and could be predictive of future health risk. We aimed to investigate the DNA methylation profile of e-cigarette use. Results Among 117 smokers, 117 non-smokers and 116 non-smoking vapers, we evaluated associations between e-cigarette use and epigenome-wide methylation from saliva. DNA methylation at 7 cytosine-phosphate-guanine sites (CpGs) was associated with e-cigarette use at p < 1 × 10 –5 and none at p < 5.91 × 10 –8 . 13 CpGs were associated wi
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Zachary L. Pratt, Bingming Chen, Charles J. Czuprynski et al. · 2012 · Applied and Environmental Microbiology
Salmonella enterica forms aseptate filaments with multiple nucleoids when cultured in hyperosmotic conditions. These osmotic-induced filaments are viable and form single colonies on agar plates even though they contain multiple genomes and…
View details →Negative / Null Result ReportOpen accessMedicine
Hiroyuki Egami, Tomoya Matsumoto · 2020 · Sustainability
Lack of cash on hand is a significant obstacle in accessing healthcare services in developing countries. Many expectant mothers in the least developed countries do not receive sufficient care during pregnancy due to financial constraints. If such hurdles in accessing healthcare can be overcome, it will contribute to reduction in maternal and newborn mortality, which is a key target of Sustainable Development Goal 3. This study reports the first assessment of the impact of mobile money services on maternal care utilization. We hypothesize that mobile money adoption would motivate rural Ugandan
View details →Negative / Null Result ReportOpen accessNeuroscience
Jack Dempsey, Qiawen Liu, Kiel Christianson · 2020 · Journal of Experimental Psychology Learning Memory and Cognition
Previous work has ostensibly shown that readers rapidly adapt to less predictable ambiguity resolutions after repeated exposure to unbalanced statistical input (e.g., a high number of reduced relative-clause garden-path sentences), and…
View details →Negative / Null Result ReportOpen accessMedicine
Nina Bjerre Andersen, Lotte Dyhrberg O’Neill, Lise Kirstine Gormsen et al. · 2014 · BMC Medical Education
BACKGROUND: Reflection, the ability to examine critically one's own learning and functioning, is considered important for 'the good doctor'. The Groningen Reflection Ability Scale (GRAS) is an instrument measuring student reflection, which has not yet been validated beyond the original Dutch study. The aim of this study was to adapt GRAS for use in a Danish setting and to investigate the psychometric properties of GRAS-DK. METHODS: We performed a cross-cultural adaptation of GRAS from Dutch to Danish. Next, we collected primary data online, performed a retest, analysed data descriptively, esti
View details →Negative / Null Result ReportSocial Sciences
Martin Merkt, Sabrina Lux, Vincent Hoogerheide et al. · 2019 · Journal of Educational Psychology
Two experiments investigated the effects of an instructional video's setting on learners' retention and application of the video content. Experiment 1 explored competing hypotheses based on theoretical assumptions about whether an…
View details →Negative / Null Result ReportOpen accessPsychology
Aljoscha Rimpler, Henk A. L. Kiers, Don van Ravenzwaaij · 2025 · Behavior Research Methods
Interaction effects are very common in the psychological literature. However, interaction effects are typically very small and often fail to replicate. In this study, we conducted a simulation comparing the generalizability and estimability of two linear regression models: one correctly specified to account for interaction effects and one misspecified including simple effects only. We manipulated noise levels, predictor variable correlations, and different sets of regression weights, resulting in 9216 different conditions. From each dataset, we drew 1000 samples of N = 25, 50, 100, 250, 500, a
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mark P. Purdue, Yuanqing Ye, Zhaoming Wang et al. · 2013 · Cancer Epidemiology Biomarkers & Prevention
Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) in populations of European ancestry have identified four susceptibility loci. No GWAS has been conducted among African Americans (AA), who experience a higher incidence…
View details →Negative / Null Result ReportPharmacology, Toxicology and Pharmaceutics
Anne‐Sophie Jannot, Xavier Vuillemin, Isabelle Étienne et al. · 2016 · Therapeutic Drug Monitoring
BACKGROUND: POR*28 is a recently newly described allelic variant of the cytochrome P450 oxidoreductase (POR), which might be associated with an increased metabolic activity of P450 cytochromes (CYP) 3A5 and 3A4. Consequently, carriers of…
View details →Negative / Null Result ReportNeuroscience
Julia D. Hur, Loran F. Nordgren · 2016 · Journal of Personality and Social Psychology
The current research examines how exposure to performance incentives affects one's desire for the reward object. We hypothesized that the flexible nature of performance incentives creates an attentional fixation on the reward object (e.g.,…
View details →Negative / Null Result ReportOpen accessMedicine
Kyung‐No Son, Yong-kwan Kim, Jae‐Ku Oem et al. · 2017 · Transboundary and Emerging Diseases
Outbreaks of highly pathogenic avian influenza (HPAI) have been reported worldwide. Wild waterfowl play a major role in the maintenance and transmission of HPAI. Highly pathogenic avian influenza subtype H5N6 and H5N8 viruses simultaneously emerged in South Korea. In this study, the comparative pathogenicity and infectivity of Clade 2.3.4.4 Group B H5N8 and Group C H5N6 viruses were evaluated in Mandarin duck (Aix galericulata). None of the ducks infected with H5N6 or H5N8 viruses showed clinical signs or mortality. Serological assays revealed that the HA antigenicity of H5N8 and H5N6 viruses
View details →Negative / Null Result ReportNeuroscience
Mark Alfano · 2018 · PhilPapers (PhilPapers Foundation)
Virtues are dispositions that make their bearers admirable. Dispositions can be studied scientifically by systematically varying whether their alleged bearers are in (or take themselves to be in) the dispositions' eliciting conditions. In…
View details →Negative / Null Result ReportOpen accessMedicine
Thibaut Vaulet, Priyanka Joseph Koshy, Karolien Wellekens et al. · 2025 · Nature Communications
The international Banff classification for kidney transplant pathology discretizes the rejection continuum into distinct diagnostic categories, introducing artificial dichotomization and threshold effects. To better reflect the underlying…
View details →Negative / Null Result ReportOpen accessMedicine
Marelisa Albelo-Martínez, Syed Rizvi · 2025 · Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Zhi-zhong Xing, Zhen-hua Zhao, Ye-Ling Zhou · 2015 · The European Physical Journal C
The Majorana nature of massive neutrinos will be crucially probed in the next-generation experiments of the neutrinoless double-beta ( $$0\nu 2\beta $$ ) decay. The effective mass term of this process, $$\langle m\rangle _{ee}$$ , may be contaminated by new physics. So how to interpret a discovery or null result of the $$0\nu 2\beta $$ decay in the foreseeable future is highly nontrivial. In this paper we introduce a novel three-dimensional description of $$|\langle m\rangle _{ee}|$$ , which allows us to see its sensitivity to the lightest neutrino mass and two Majorana phases in a transparent
View details →Negative / Null Result ReportOpen accessComputer Science
David Graber, Peter Stockinger, Fabian Meyer et al. · 2025 · Nature Machine Intelligence
The field of computational drug design requires accurate scoring functions to predict binding affinities for protein-ligand interactions. However, train-test data leakage between the PDBbind database and the Comparative Assessment of Scoring Function benchmark datasets has severely inflated the performance metrics of currently available deep-learning-based binding affinity prediction models, leading to overestimation of their generalization capabilities. Here we address this issue by proposing PDBbind CleanSplit, a training dataset curated by a new structure-based filtering algorithm that elim
View details →Negative / Null Result ReportOpen accessMedicine
John K. Forrest, Steven J. Yakubov, G. Michael Deeb et al. · 2026 · Journal of the American College of Cardiology
BACKGROUND: The Evolut Low Risk trial enrolled patients with severe aortic stenosis at low surgical risk. Annual follow-up is planned for 10 years, evaluating the composite of all-cause mortality or disabling stroke and key secondary…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xiaona Yang, Hong Guo, Min Zou · 2026 · Molecular Biomedicine
Inflammatory bowel disease (IBD) is a heterogeneous group of disorders characterized primarily by chronic relapsing intestinal inflammation, encompassing Crohn's disease (CD) and ulcerative colitis (UC), affecting individuals across age groups with variable clinical manifestations. With the advancement of global industrialization, its incidence continues to rise, particularly in newly industrialized regions, which not only severely impairs patients' quality of life but also emerges as a major public health concern threatening digestive system health, accompanied by a substantial healthcare bur
View details →Negative / Null Result ReportOpen accessMedicine
Pengyu Gong, Fei Wang, Yixin Hua et al. · 2025 · Journal of Nanobiotechnology
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated…
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