21,234 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Julia D. Hur, Loran F. Nordgren · 2016 · Journal of Personality and Social Psychology
The current research examines how exposure to performance incentives affects one's desire for the reward object. We hypothesized that the flexible nature of performance incentives creates an attentional fixation on the reward object (e.g.,…
View details →Kyung‐No Son, Yong-kwan Kim, Jae‐Ku Oem et al. · 2017 · Transboundary and Emerging Diseases
Outbreaks of highly pathogenic avian influenza (HPAI) have been reported worldwide. Wild waterfowl play a major role in the maintenance and transmission of HPAI. Highly pathogenic avian influenza subtype H5N6 and H5N8 viruses simultaneously emerged in South Korea. In this study, the comparative pathogenicity and infectivity of Clade 2.3.4.4 Group B H5N8 and Group C H5N6 viruses were evaluated in Mandarin duck (Aix galericulata). None of the ducks infected with H5N6 or H5N8 viruses showed clinical signs or mortality. Serological assays revealed that the HA antigenicity of H5N8 and H5N6 viruses
View details →Mark Alfano · 2018 · PhilPapers (PhilPapers Foundation)
Virtues are dispositions that make their bearers admirable. Dispositions can be studied scientifically by systematically varying whether their alleged bearers are in (or take themselves to be in) the dispositions' eliciting conditions. In…
View details →Pengyu Gong, Fei Wang, Yixin Hua et al. · 2025 · Journal of Nanobiotechnology
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated…
View details →Zhi-zhong Xing, Zhen-hua Zhao, Ye-Ling Zhou · 2015 · The European Physical Journal C
The Majorana nature of massive neutrinos will be crucially probed in the next-generation experiments of the neutrinoless double-beta ( $$0\nu 2\beta $$ ) decay. The effective mass term of this process, $$\langle m\rangle _{ee}$$ , may be contaminated by new physics. So how to interpret a discovery or null result of the $$0\nu 2\beta $$ decay in the foreseeable future is highly nontrivial. In this paper we introduce a novel three-dimensional description of $$|\langle m\rangle _{ee}|$$ , which allows us to see its sensitivity to the lightest neutrino mass and two Majorana phases in a transparent
View details →Xiaona Yang, Hong Guo, Min Zou · 2026 · Molecular Biomedicine
Inflammatory bowel disease (IBD) is a heterogeneous group of disorders characterized primarily by chronic relapsing intestinal inflammation, encompassing Crohn's disease (CD) and ulcerative colitis (UC), affecting individuals across age groups with variable clinical manifestations. With the advancement of global industrialization, its incidence continues to rise, particularly in newly industrialized regions, which not only severely impairs patients' quality of life but also emerges as a major public health concern threatening digestive system health, accompanied by a substantial healthcare bur
View details →Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar et al. · 2025 · MedComm
Chronic wounds-such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)-pose a serious clinical challenge due to their prolonged inflammatory phase and impaired healing. Increasing evidence reveals that dysregulated immune responses are central to the pathogenesis of chronic wounds. A complex interplay between innate and adaptive immune cells, including macrophages, neutrophils, and T cells, contributes to chronic inflammation, extracellular matrix (ECM) degradation, and tissue repair failure. While current treatments target symptoms, they often overlook the und
View details →Marelisa Albelo-Martínez, Syed Rizvi · 2025 · Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa
View details →John K. Forrest, Steven J. Yakubov, G. Michael Deeb et al. · 2026 · Journal of the American College of Cardiology
BACKGROUND: The Evolut Low Risk trial enrolled patients with severe aortic stenosis at low surgical risk. Annual follow-up is planned for 10 years, evaluating the composite of all-cause mortality or disabling stroke and key secondary…
View details →Bram Van Bockstaele, Elske Salemink, Susan M. Bögels et al. · 2015 · Cognition & Emotion
Although attentional bias modification (ABM) can change anxiety, recent studies failed to replicate such effects, possibly because the visual probe ABM failed to induce changes in attentional bias (AB). We investigated whether visual probe…
View details →Marta Celorrio, Kirill Shumilov, Camryn Payne et al. · 2022 · Acta Neuropathologica Communications
Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation, has been shown to be neuroprotective when administered early after experimental TBI but detrimental when administered chronically to human TBI survivors. Rather than focusing on the rescue of primary injury with early administration of therapeutics which may not be clinically feasible, we hypothesiz
View details →Sophie E. Field, Annabel J. Curle, Roger A. Barker · 2024 · Expert Opinion on Investigational Drugs
INTRODUCTION: Huntington's Disease (HD) is a genetic neurodegenerative disease for which there is currently no disease-modifying treatment. One of several underlying mechanisms proposed to be involved in HD pathogenesis is inflammation;…
View details →Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
View details →Maurizio Agelli, Nicola Corona, Fabio Maggio et al. · 2024 · Machines
Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports auton
View details →James D. Doecke, Giovanni Bellomo, Lisa Vermunt et al. · 2025 · Alzheimer s & Dementia
INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) were collected from six international centers. Aβ40, Aβ42, GFAP, NfL, and p-tau181 were measured using single molecule array. In each group, AD diagnosis/co-pathology was defined according to cerebrosp
View details →Preesha Premsagar, Colleen Aldous, Tonya M. Esterhuizen et al. · 2022 · Informatics in Medicine Unlocked
Machine learning is used to process big data volumes with complex non-linear relationships between predictive variables and predictions. Research into the usefulness of machine learning in small data volumes remains limited. To compare…
View details →Rachael L. Brown · 2017 · Animal Sentience
Birch’s formulation is persuasive but not nuanced enough to capture at least one situation where it is reasonable to invoke the precautionary principle (PP): when we have multiple, weak, but convergent, lines of evidence that a species is…
View details →Fabienne Marcellin, C. Lions, Éric Rosenthal et al. · 2016 · Drug and Alcohol Review
INTRODUCTION AND AIMS: Despite cannabis use being very common in patients co-infected with HIV and hepatitis C virus (HCV), its effect on these patients' immune systems remains undocumented. Documenting the potential effect of cannabis use…
View details →Sang‐Rae Lee, Hong J. Lee, Sang-Hoon Cha et al. · 2015 · Cell Transplantation
Cellular fate of human neural stem cells (hNSCs) transplanted in the brain of nonhuman primates (NHPs) with no immunosuppression was determined at 22 and 24 months posttransplantation (PTx) regarding survival, differentiation, and tumorigenesis. Survival of hNSCs labeled with magnetic nanoparticles was successfully detected around injection sites in the brain at 22 months PTx by MRI. Histological examination of brain sections with H&E and Prussian blue staining at 24 months revealed that most of the grafted hNSCs were found located along the injection tract. Grafted hNSCs were found to differe
View details →Suzanne Birner, Elizabeth Cottrell, J. M. Warren et al. · 2021 · Earth and Planetary Science Letters
Mid-ocean ridge peridotites record significantly greater variability in major and trace elements, isotopic compositions, and thermodynamic properties such as oxygen fugacity (fO2) than do their basaltic counterparts. This variability may derive from modern ridge processes related to melting and melt-rock interaction or from long-lived source heterogeneity related to recycled material or ancient melting events. In this study, we investigate variations in spinel geochemistry as well as silicate major and trace element chemistry and oxygen fugacity of a suite of peridotites from a single segment
View details →Nicole Harlaar, Emma L. Meaburn, Marianna E. Hayiou‐Thomas et al. · 2014 · Journal of Speech Language and Hearing Research
PURPOSE: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the…
View details →Nivedita Mani, Melanie S. Schreiner, Julia Brase et al. · 2021 · Developmental Science
Developmental research, like many fields, is plagued by low sample sizes and inconclusive findings. The problem is amplified by the difficulties associated with recruiting infant participants for research as well as the increased variability in infant responses. With sequential testing designs providing a viable alternative to paradigms facing such issues, the current study implemented a Sequential Bayes Factor (SBF) design on three findings in the developmental literature. In particular, using the framework described by Schönbrödt and colleagues (2017), we examined infants' sensitivity to mis
View details →Matthew D. Wadge, Bryan W. Stuart, Kathryn G. Thomas et al. · 2018 · Materials & Design
Infection negation and biofilm prevention are necessary developments needed for implant materials. Furthermore, an increase in publications regarding gallium (Ga) as an antimicrobial ion has resulted in bacterial-inhibitory surfaces incorporating gallium as opposed to silver (Ag). The authors present the production of novel gallium titanate surfaces through hydrothermal ion-exchange reactions. Commercially-pure Ti (S0: Cp-Ti) was initially suspended in NaOH solutions to obtain sodium titanate (S1: Na2TiO3) layers ca. 0.5–1 μm in depth (2.4 at.% Na). Subsequent suspension in Ga(NO3)3 (S2: Ga2(T
View details →Vitória Piai, Kristoffer Dahlslätt, Eric Maris · 2014 · Psychophysiology
Abstract When making statistical comparisons, the temporal dimension of the EEG signal introduces problems. Guthrie and Buchwald (1991) proposed a formally correct statistical approach that deals with these problems: comparing waveforms by…
View details →Tom Koeman, Pauline Slottje, Hans Kromhout et al. · 2013 · Occupational and Environmental Medicine
OBJECTIVES: Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies…
View details →Yeoh Kai Qing, Suhal Kusairi · 2019 · WIDYAKALA JOURNAL OF PEMBANGUNAN JAYA UNIVERSITY
The stock market has become a significant role in the economy and has attracted investor's attention, as it is to generate funds and make an investment decision for companies and investors as well. Therefore, the objective of this study is…
View details →Priyanka Lahiri, Kenneth B. Wiberg, Patrick H. Vaccaro · 2013 · The Journal of Physical Chemistry A
The optical rotatory dispersion of two monocyclic ketones, (R)-3-methylcyclopentanone [R-3MCP] and (R)-3-methylcyclohexanone [R-3MCH], has been investigated under isolated and solvated conditions to explore the role of ring size/morphology…
View details →David R. Roalf, Martijn Figee, Desmond J. Oathes · 2024 · Translational Psychiatry
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level. Ultra-high field magnetic resonance imaging is developing as a sensitive measure of neurometabolic processes of particular relevance that holds promise as a new way to characterize patient abnormalities as well as variability
View details →Kariem Ezzat, Andrea Sturchio, Alberto J. Espay · 2022 · Biology
Protein aggregation into amyloid fibrils affects many proteins in a variety of diseases, including neurodegenerative disorders, diabetes, and cancer. Physicochemically, amyloid formation is a phase transition process, where soluble…
View details →Oliver Shutkever, David J. Gracie, Caroline Young et al. · 2018 · Inflammatory Bowel Diseases
Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD…
View details →