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Browse the failure-mode index

21,681 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessArts and Humanities

The Impact of Peer Scaffolding through Process Approach on EFL Learners’ Academic Writing Fluency

Masoud Khalili Sabet, Abdorreza Tahriri, Parastou Gholami Pasand · 2013 · Theory and Practice in Language Studies

This paper aimed to examine the impact of peer scaffolding through process approach on writing fluency of EFL learners. To this end, a Nelson Proficiency Test was administered to 49 EFL learners studying at University of Guilan, based on…

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Negative / Null Result ReportOpen accessEnvironmental Science

Variability in Fitness Trade-Offs Amongst Coral Juveniles With Mixed Genetic Backgrounds Held in the Wild

Kate M. Quigley, Magena R. Marzonie, Blake D. Ramsby et al. · 2021 · Frontiers in Marine Science

Novel restoration methods are currently under consideration worldwide to help coral reefs recover or become more resilient to higher temperature stress. Critical field-based information concerning the paradigm of “local is best” is lacking for many methods; information which is essential to determine the risk and feasibility associated with restoration. One method involves breeding corals from different reef regions with expected variation in heat tolerance and moving those offspring to new locations to enhance offspring survival; thereby augmenting local stock to enhance survival for anticipa

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Negative / Null Result ReportOpen accessMedicine

Positron Emission Tomography Scan for a Hepatic Mass

Boris Blechacz, Gregory J. Gores · 2010 · Hepatology

A 66-year-old male patient who is hepatitis C RNA–positive without cirrhosis has been found to have a mass on ultrasound examination of the liver. The physical examination is unremarkable. The hemoglobin, white cell count, and platelet…

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Negative / Null Result ReportOpen accessMedicine

Measured GFR: not a gold, but a gold-plated standard

Elise Boele-Schutte, Ron T. Gansevoort · 2016 · Nephrology Dialysis Transplantation

Because of the circadian rhythm in kidney function the true glomerular filtration rate (GFR) is historically considered to be the average GFR measured by urinary inulin clearance over a 24-h period [1]. In clinical practice, it is…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Intensifying cropping systems through doubled-up legumes in Eastern Zambia

Mulundu Mwila, Blessing Mhlanga, Christian Thierfelder · 2021 · Scientific Reports

Abstract Declining soil fertility and negative impacts of climate effects threaten the food security of millions in Africa. Conservation Agriculture (CA) is a promising strategy to address these challenges. However, lack of viable economic entry points and short-term benefits for smallholders limit its adoption. Legume intensification can possibly increase the output per unit area, thus making the system more attractive. Rotations of maize with intensified legume systems were tested for three consecutive years under ridge and furrow (RF) tillage and CA to investigate: (a) increases in producti

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Negative / Null Result ReportOpen accessPsychology

Community-based randomized controlled trial of psychological first aid with crime victims.

Michael R. McCart, Jason E. Chapman, Kristyn Zajac et al. · 2020 · Journal of Consulting and Clinical Psychology

OBJECTIVE: The first randomized controlled trial of psychological first aid (PFA) was conducted, using crime victims as participants. For study Aim 1, investigators tested whether paraprofessional victim advocates could be trained to…

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Negative / Null Result ReportEconomics, Econometrics and Finance

Wettbewerb als Norm der Wettbewerbspolitik

Erich Hoppmann · 2026 · ORDO

Der Wirtschaftspolitische Ausschus des Deutschen Bundestages erklarte bei Erlas des Kartellgesetzes, er konne und wolle den Wettbewerbsbegriff nicht definieren, das sei eine Angelegen heit der zustandigen Fachdisziplin1. Diese Aufforderung…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

How to interpret a discovery or null result of the $$0\nu 2\beta $$ 0 ν 2 β decay

Zhi-zhong Xing, Zhen-hua Zhao, Ye-Ling Zhou · 2015 · The European Physical Journal C

The Majorana nature of massive neutrinos will be crucially probed in the next-generation experiments of the neutrinoless double-beta ( $$0\nu 2\beta $$ ) decay. The effective mass term of this process, $$\langle m\rangle _{ee}$$ , may be contaminated by new physics. So how to interpret a discovery or null result of the $$0\nu 2\beta $$ decay in the foreseeable future is highly nontrivial. In this paper we introduce a novel three-dimensional description of $$|\langle m\rangle _{ee}|$$ , which allows us to see its sensitivity to the lightest neutrino mass and two Majorana phases in a transparent

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Negative / Null Result ReportOpen accessMedicine

Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation

Matthias Diebold, Hannes Vietzen, Andreas Heinzel et al. · 2023 · American Journal of Transplantation

Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically determined NK cell functionality on ABMR development and activity. The study included 86 kidney transplant recipients subjected to systematic biopsies triggered by donor-specific antibody detection. We performed killer immunoglobulin-like receptor typing to predict missing self and genotyped polymorphisms determining NK cell functionality (FCGR3AV/F158 [rs39699

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Negative / Null Result ReportEngineering

Systematic Strategy for Obtaining a Dividing-Wall Column Applied to an Extractive Distillation Process

Gardênia Marinho Cordeiro, M.F. Figueirêdo, Wagner Brandão Ramos et al. · 2017 · Industrial & Engineering Chemistry Research

Currently, process intensification using dividing-wall columns (DWCs) is one of the most promising alternatives for reducing the costs of the distillation process. However, for extractive distillation, there are still questions regarding…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Yeast Species, Strains, and Growth Media Mediate Attraction of Drosophila suzukii (Diptera: Drosophilidae)

Rodrigo Lasa, Laura Navarro-de-la-Fuente, Anne Gschaedler et al. · 2019 · Insects

Specific ecological interactions between insects and microbes have potential in the development of targeted pest monitoring or control techniques for the spotted wing drosophilid, Drosophila suzukii (Matsumura), an exotic invasive pest of soft fruit. To evaluate D. suzukii attraction to yeast species from preferred types of fruit, three yeasts were isolated from blackberry fruit and two yeasts from raspberry fruit and used to bait simple plastic bottle traps. Saccharomyces cerevisiae and Hanseniaspora uvarum were identified from blackberries, whereas a different H. uvarum strain was identified

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Negative / Null Result ReportOpen accessEnvironmental Science

Across Date Species Detection Using Airborne Imaging Spectroscopy

Anthony Laybros, Daniel Schläpfer, Jean‐Baptiste Féret et al. · 2019 · Remote Sensing

Imaging spectroscopy is a promising tool for airborne tree species recognition in hyper-diverse tropical canopies. However, its widespread application is limited by the signal sensitivity to acquisition parameters, which may require new training data in every new area of application. This study explores how various pre-processing steps may improve species discrimination and species recognition under different operational settings. In the first experiment, a classifier was trained and applied on imaging spectroscopy data acquired on a single date, while in a second experiment, the classifier wa

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Negative / Null Result Report

An intraoperative load sensor did not improve the early postoperative results of posterior‐stabilized TKA for osteoarthritis with varus deformities

Sang Jun Song, Se Gu Kang, Yeon Je Lee et al. · 2018 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose In the present study, the early results of sensor‐assisted versus manually balanced posterior‐stabilized total knee arthroplasty (TKA) for osteoarthritis with varus deformities were prospectively compared. Methods Fifty…

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Negative / Null Result Report

Intracranial Pressure Changes following Traumatic Brain Injury in Rats: Lack of Significant Change in the Absence of Mass Lesions or Hypoxia

Levon Gabrielian, Luke W. Willshire, Stephen C. Helps et al. · 2011 · Journal of Neurotrauma

Traumatic brain injury (TBI) often causes raised intracranial pressure (ICP), with >50% of all TBI- related deaths being associated with this increase in ICP. To date, there is no effective pharmacological treatment for TBI, partly because…

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Negative / Null Result Report

Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized, Controlled Trial

Jean-Philippe Hauzeur, Chantal Lechanteur, Etienne Baudoux et al. · 2019 · Clinical Orthopaedics & Related Research

Abstract Background In patients with nontraumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow aspirate concentrate (BMAC) could delay the progression of osteonecrosis and improve symptoms in pre-fracture ONFH.…

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Negative / Null Result ReportOpen accessMedicine

Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis

Eleni Frangou, Panagiotis Garantziotis, Maria Grigoriou et al. · 2022 · Annals of the Rheumatic Diseases

OBJECTIVES: Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched in affected kidneys. METHODS: We used mRNA-sequencing in effector (spleen) and target (kidneys, brain) tissues from lupus and control mice at sequential time points, and in the blood from 367 individuals (261 systemic lupus erythematosus (SLE) patients and 106 healthy individuals). Comparative cross-tissue and cross-species analyses were performed. The human dataset was split into training and validation sets and machine learning was

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Negative / Null Result ReportMedicine

Complete Atrioventricular Block does not Reduce Long-Term Mortality in Patients with Permanent Atrial Fibrillation Treated with Cardiac Resynchronization Therapy

José Marı́a Tolosana, Emilce Trucco, Malek Khatib et al. · 2013 · European Journal of Heart Failure

AIMS: A maximum percentage of ventricular pacing is mandatory to obtain a good response to CRT. Atrioventricular junction (AVJ) ablation has been recommended to attain this objective in patients with AF. THE AIMS OF OUR STUDY WERE: (i) to…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant Therapeutic Modalities in Primary Small Cell Carcinoma of Esophagus Patients

Bingwen Zou, Tao Li, Qiang Zhou et al. · 2016 · Medicine

To evaluate the treatment pattern and survival of patients receiving radical resection for primary small cell carcinoma of the esophagus (PSCCE).This retrospective study included 150 patients who received radical resection of PSCCE. Data were retrieved from 4 centers in Western China. Thirty-nine of 150 patients received postoperative chemo-radiotherapy, 62 received postoperative chemotherapy, and 49 received radical resection only. The median radiation dosage was 50 Gy. The chemotherapeutic regimen was platinum-based and lasted for 2 to 6 cycles (median, 3).Median disease-free survival (mDFS)

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Negative / Null Result ReportOpen accessNursing

Effect of Zinc Supplementation vs Placebo on Mortality Risk and HIV Disease Progression Among HIV-Positive Adults With Heavy Alcohol Use

Matthew S. Freiberg, Debbie M. Cheng, Natalia Gnatienko et al. · 2020 · JAMA Network Open

Importance: Zinc supplementation can reduce alcohol-related microbial translocation and inflammation. Objective: To assess whether zinc supplementation reduces markers of mortality and risk of cardiovascular disease, reduces levels of inflammation and microbial translocation, and slows HIV disease progression in people with heavy alcohol use who are living with HIV/AIDS. Design, Setting, and Participants: This study is a double-blinded placebo-controlled randomized clinical trial of zinc supplementation among participants recruited from 2013 to 2015. Participants were recruited from HIV and ad

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