Effect of Zinc Supplementation vs Placebo on Mortality Risk and HIV Disease Progression Among HIV-Positive Adults With Heavy Alcohol Use
Matthew S. Freiberg; Debbie M. Cheng; Natalia Gnatienko; Elena Blokhina; S. M. Coleman; Margaret F. Doyle; T. V. Yaroslavtseva; Carly Bridden · 2020 · JAMA Network Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Importance: Zinc supplementation can reduce alcohol-related microbial translocation and inflammation. Objective: To assess whether zinc supplementation reduces markers of mortality and risk of cardiovascular disease, reduces levels of inflammation and microbial translocation, and slows HIV disease progression in people with heavy alcohol use who are living with HIV/AIDS. Design, Setting, and Participants: This study is a double-blinded placebo-controlled randomized clinical trial of zinc supplementation among participants recruited from 2013 to 2015. Participants were recruited from HIV and ad
Abstract by Matthew S. Freiberg; Debbie M. Cheng; Natalia Gnatienko; Elena Blokhina; S. M. Coleman; Margaret F. Doyle; T. V. Yaroslavtseva; Carly Bridden, JAMA Network Open (2020) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia
Replication FailureRandomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
Negative / Null Result ReportAgricultural commercialization and nutrition revisited: Empirical evidence from three African countries
Negative / Null Result ReportEffect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders
Negative / Null Result ReportThe diversity and function of sourdough starter microbiomes
Replication FailureSelenium supplementation for the primary prevention of cardiovascular disease
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1001/jamanetworkopen.2020.4330