Failed Experiment ReportOpen accessImmunology and Microbiology
Carl Christoph Schimanski, Stefan Kasper, Susanna Hegewisch‐Becker et al. · 2020 · OncoImmunology
= .2141), respectively. Cox regression models revealed no dependence of RFS or OS on MUC1 expression. The most common tecemotide-related grade 3/4 adverse events were diarrhea, injection site reaction, intestinal perforation, peritonitis…
View details →Negative / Null Result ReportMedicine
Ryan G. Overmayer, Matthew Driller · 2017 · International Journal of Sports Physiology and Performance
PURPOSE: To examine the efficacy of intermittent sequential pneumatic compression (ISPC) on exercise recovery and subsequent performance, when implemented between a 20-min cycling bout (simulated scratch race) and a 4-min cycling test…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ahmad Karimi, Yuna Min, C. Lu et al. · 2012 · Poultry Science
A total of 540 one-day-old male broiler chicks were used to evaluate the potential enhancing effects of a mixture of 2 commercial carbohydrase preparations on phytase efficacy. A nonphytate phosphorus (nPP) deficient diet (0.15%) was…
View details →Negative / Null Result ReportOpen accessPsychology
Nori Jacoby, Merav Ahissar · 2015 · Journal of Vision
In the 1980s to 1990s, studies of perceptual learning focused on the specificity of training to basic visual attributes such as retinal position and orientation. These studies were considered scientifically innovative since they suggested…
View details →Negative / Null Result ReportEnvironmental Science
Amber White, Michelle Nault, Katherine D. McMahon et al. · 2022 · Environmental Science & Technology
Laboratory studies used to assess the environmental fate of organic chemicals such as pesticides fail to replicate environmental conditions, resulting in large errors in predicted transformation rates. We combine laboratory and field data…
View details →Negative / Null Result ReportOpen accessPsychology
Bartosz Sobczyk, Paweł Dobrowolski, Maciek Skorko et al. · 2015 · Frontiers in Psychology
The impact of video game playing on cognitive abilities has been the focus of numerous studies over the last 10 years. Some cross-sectional comparisons indicate the cognitive advantages of video game players (VGPs) over non-players (NVGPs) and the benefits of video game trainings, while others fail to replicate these findings. Though there is an ongoing discussion over methodological practices and their impact on observable effects, some elementary issues, such as the representativeness of recruited VGP groups and lack of genre differentiation have not yet been widely addressed. In this articl
View details →Negative / Null Result ReportOpen accessPsychology
John F. Magnotti, Michael S. Beauchamp · 2018 · PLoS ONE
A common measure of multisensory integration is the McGurk effect, an illusion in which incongruent auditory and visual speech are integrated to produce an entirely different percept. Published studies report that participants who differ in age, gender, culture, native language, or traits related to neurological or psychiatric disorders also differ in their susceptibility to the McGurk effect. These group-level differences are used as evidence for fundamental alterations in sensory processing between populations. Using empirical data and statistical simulations tested under a range of conditio
View details →Negative / Null Result ReportOpen accessMedicine
Samuel Antwi‐Baffour, Jonathan Kofi Adjei, Peter Owadee Forson et al. · 2019 · Anemia
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. SCD patients are prone to haemolysis due to the shape of their red blood cells and if they are deficient in G6PD, the haemolysis may escalate. Repo
View details →Negative / Null Result ReportOpen accessMedicine
Kimberly L. Armstrong, Tun‐Hou Lee, Max Essex · 2011 · Antimicrobial Agents and Chemotherapy
Single-dose nevirapine (NVP) is quite effective in preventing transmission of the human immunodeficiency virus (HIV) from mother to child; however, many women develop resistance to NVP in this setting. Comparing outcomes of clinical studies reveals an increased amount of resistance in subtype C relative to that in other subtypes. This study investigates how nonnucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations of subtype C affect replication capacity. The 103N, 106A, 106M, 181C, 188C, 188L, and 190A drug resistance mutations were placed in a reverse transcriptase (RT)
View details →Negative / Null Result ReportMedicine
Christopher J. Green, Jeffrey M P Holly, Antony Bayer et al. · 2014 · Journal of Alzheimer s Disease
BACKGROUND: The increasing incidence of cognitive impairment and dementia in an aging population poses a significant burden on healthcare. Consequently, identifying modifiable physiological factors which may influence the onset of…
View details →Negative / Null Result ReportMaterials Science
Chun Zhu, Jinxia Liang, Binju Wang et al. · 2012 · Physical Chemistry Chemical Physics
The electronic and structural features of (oxo)manganese(V) corroles and their catalyzed oxygen atom transfers to thioanisole in different spin states have been investigated by the B3LYP functional calculations. Calculations show that…
View details →Negative / Null Result ReportMedicine
Alexandra Calmy, Mark Bloch, Handan Wand et al. · 2010 · HIV Medicine
BACKGROUND: Lipoatrophy can complicate thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI)-based antiretroviral therapy (ART). Lipoatrophy may be less likely with ART including ritonavir-boosted lopinavir (LPV/r). Small,…
View details →Negative / Null Result ReportMedicine
Sindu Vivekanandan, Richard Breene, Ramya Ramanujachar et al. · 2015 · Pediatric Blood & Cancer
BACKGROUND: Historically, the 5-year overall survival (OS) for metastatic medulloblastoma (MMB) was less than 40%. The strategy of post-operative induction chemotherapy (IC) followed by hyperfractionated accelerated radiotherapy (HART) and…
View details →Negative / Null Result ReportOpen accessNeuroscience
Recep A. Ozdemir, Sofia Kirkman, Justine R. Magnuson et al. · 2022 · Neuroimage Reports
Prior studies have suggested that oscillatory activity in cortical networks can modulate stimulus-evoked responses through time-varying fluctuations in neural excitation-inhibition dynamics. Studies combining transcranial magnetic…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shahzad Ahmad, Adelina Orellana, Isabelle Köhler et al. · 2020 · Alzheimer s Research & Therapy
BACKGROUND: Lysophosphatidic acids (LPAs) are bioactive signaling phospholipids that have been implicated in Alzheimer's disease (AD). It is largely unknown whether LPAs are associated with AD pathology and progression from mild cognitive impairment (MCI) to AD. METHODS: The current study was performed on cerebrospinal fluid (CSF) and plasma samples of 182 MCI patients from two independent cohorts. We profiled LPA-derived metabolites using liquid chromatography-mass spectrometry. We evaluated the association of LPAs with CSF biomarkers of AD, Aβ-42, p-tau, and total tau levels overall and stra
View details →Negative / Null Result ReportOpen accessEnvironmental Science
William L. Baker, Mark A. Williams · 2018 · Ecological Applications
An understanding of how historical fire and structure in dry forests (ponderosa pine, dry mixed conifer) varied across the western United States remains incomplete. Yet, fire strongly affects ecosystem services, and forest restoration…
View details →Negative / Null Result ReportComputer Science
Lu Yu, Jason Schwier, Ryan Craven et al. · 2013 · IEEE Transactions on Knowledge and Data Engineering
Hidden Markov models (HMMs) are used to analyze real-world problems. We consider an approach that constructs minimum entropy HMMs directly from a sequence of observations. If an insufficient amount of observation data is used to generate…
View details →Negative / Null Result ReportOpen accessPsychology
Kathryn J. Lester, Susanna Roberts, Robert Keers et al. · 2015 · The British Journal of Psychiatry
BACKGROUND: We previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive…
View details →Negative / Null Result ReportMedicine
Cynthia Ciwei Lim, Chieh Suai Tan, Manish Kaushik et al. · 2014 · Nephrology
AIM: Optimal timing for acute renal replacement therapy (ARRT) initiation in critically ill patients with acute kidney injury (AKI) is unclear. We aimed to evaluate outcomes in patients who initiated ARRT for traditional indications versus…
View details →Negative / Null Result ReportOpen accessNeuroscience
Alba Di Pardo, Elena Ciaglia, Monica Cattaneo et al. · 2020 · Cell Death and Disease
Abstract The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington’s disease (HD), a neurodegenerative disorder caused by neural death due to expanded CAG repeats encoding a long polyglutamine tract in the huntingtin protein (Htt). Herein, we showed that striatal-derived cell lines with expanded Htt (STHdh Q 111/111 ) expressed and secreted lower levels of BPIFB4, when compared with Htt expressing cells (STHdh Q 7/
View details →Negative / Null Result ReportOpen accessArts and Humanities
Taro Oshikiri, 押切, 太郎, オシキリ, タロウ et al. · 2023 · Kobe University Repository Kernel (Kobe University)
Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. Summary Background Data: Although TD resection can cause nutritional disadvantage and…
View details →Negative / Null Result ReportOpen accessMedicine
Fortunato Giustra, Francesco Bosco, Giorgio Cacciola et al. · 2022 · Journal of Clinical Medicine
In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excl
View details →Negative / Null Result ReportOpen accessMedicine
Chao Yang, Jianqing Zhao, Lan Lin et al. · 2015 · Frontiers in Cellular and Infection Microbiology
Streptococcus suis (S.suis), a major swine pathogen, is also a severe threat to human health. Infection with highly virulent strains of S. suis can cause human Streptococcal toxic-shock-like syndrome (STSLS), which is associated with high serum pro-inflammatory cytokine levels and a high mortality rate. Our previous study indicated that highly virulent S. suis infection could activate the TREM-1 signaling pathway, which promotes host clearance of S. suis during early infection. However, it remained to be elicited whether TREM-1 signaling could be a target against STSLS in the presence of antib
View details →Negative / Null Result ReportOpen accessMedicine
Mario Musella, Giovanna Berardi, Nunzio Velotti et al. · 2021 · Obesity Surgery
BACKGROUND: The laparoscopic sleeve gastrectomy (LSG) is the most common bariatric procedure performed worldwide while the laparoscopic adjustable gastric banding (LAGB) has been almost abandoned. Aim of this study was to retrospectively assess 10-year outcomes of LSG through a matched comparison with LAGB. MATERIALS AND METHODS: Retrospective search of prospectively maintained database of our university was carried out to find all patients that underwent LSG before December 2010. Each subject with LSG was matched one-to-one with a patient that had undergone LAGB in the same period with corres
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jin‐Yi Wan, Chong‐Zhi Wang, Qi‐Hui Zhang et al. · 2016 · Biomedical Chromatography
Abstract After ingestion of ginseng, the bioavailability of its parent compounds is low and enteric microbiota plays an important role in parent compound biotransformation to their metabolites. Diet type can influence the enteric…
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Laura Blackmore, William Bernal · 2015 · Clinical Medicine
Acute liver failure (ALF) is a rare critical illness with high mortality whose successful management requires early recognition and effective initial management. Though it may result from a wide variety of causes, in the UK and much of the…
View details →Negative / Null Result ReportOpen accessMedicine
Matilde Negrini, Giuseppe Tomasello, Marcus Davidsson et al. · 2022 · Journal of Parkinson s Disease
BACKGROUND: Preclinical rodent models for Parkinson's disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell loss and additional synucleinopathy in cortical and subcortical structures. Recent studies have combined viral vector-based overexpression of human wild-type αSyn with the sequential or simultaneous inoculation of preformed fibrils (PFFs) derived from human αSyn. OBJECTIVE: The goal of the study was to investigate whether sequential or combined delivery of the AAV vector
View details →Negative / Null Result ReportOpen accessMedicine
James D. Chalmers · 2017 · COPD Journal of Chronic Obstructive Pulmonary Disease
Bronchiectasis is a long-neglected disease currently experiencing a surge in interest. It is a highly complex condition with numerous aetiologies, co-morbidities and a heterogeneous disease presentation and clinical course. The past few…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Makoto Miyara, Driss Chader, Aude Burlion et al. · 2016 · Oncotarget
// Makoto Miyara 1,2 , Driss Chader 1,2 , Aude Burlion 2 , Jérémie Goldstein 2 , Delphine Sterlin 1,2 , Françoise Norol 3 , Hélène Trebeden-Nègre 3 , Laetitia Claër 1,2 , Shimon Sakaguchi 4,* , Gilles Marodon 2,* , Zahir Amoura 1,2,5,6,* and Guy Gorochov 1,2,6 1 Department of immunology, AP-HP Pitié Salpêtrière, Paris, France 2 Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France 3 Cell Therapy, AP-HP Pitié Salpêtriè
View details →Negative / Null Result Report
Ronnie Detrich, Teri Lewis · 2012 · Journal of Positive Behavior Interventions
It has been 10 years since No Child Left Behind (NCLB), with its emphasis on scientifically based instruction as a means for improving the educational outcomes of students, was signed into law. In this article, we review the basic tenets…
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