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Browse the failure-mode index

21,234 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessArts and Humanities

Prognosis of Patients with Esophageal Carcinoma following Routine Thoracic Duct Resection: A Propensity-matched Analysis of 12,237 Patients based on the Comprehensive Registry of Esophageal Cancer in Japan

Taro Oshikiri, 押切, 太郎, オシキリ, タロウ et al. · 2023 · Kobe University Repository Kernel (Kobe University)

Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. Summary Background Data: Although TD resection can cause nutritional disadvantage and…

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Negative / Null Result ReportOpen accessMedicine

No Significant Differences in Clinical and Radiographic Outcomes between PCL Retained or Sacrificed Kinematic Aligned Medial Pivot Total Knee Arthroplasty in Varus Knee

Fortunato Giustra, Francesco Bosco, Giorgio Cacciola et al. · 2022 · Journal of Clinical Medicine

In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excl

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Negative / Null Result ReportOpen accessMedicine

Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis

Chao Yang, Jianqing Zhao, Lan Lin et al. · 2015 · Frontiers in Cellular and Infection Microbiology

Streptococcus suis (S.suis), a major swine pathogen, is also a severe threat to human health. Infection with highly virulent strains of S. suis can cause human Streptococcal toxic-shock-like syndrome (STSLS), which is associated with high serum pro-inflammatory cytokine levels and a high mortality rate. Our previous study indicated that highly virulent S. suis infection could activate the TREM-1 signaling pathway, which promotes host clearance of S. suis during early infection. However, it remained to be elicited whether TREM-1 signaling could be a target against STSLS in the presence of antib

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Negative / Null Result ReportOpen accessMedicine

Ten-Year Results of Laparoscopic Sleeve Gastrectomy: Retrospective Matched Comparison with Laparoscopic Adjustable Gastric Banding—Is There a Significant Difference in Long Term?

Mario Musella, Giovanna Berardi, Nunzio Velotti et al. · 2021 · Obesity Surgery

BACKGROUND: The laparoscopic sleeve gastrectomy (LSG) is the most common bariatric procedure performed worldwide while the laparoscopic adjustable gastric banding (LAGB) has been almost abandoned. Aim of this study was to retrospectively assess 10-year outcomes of LSG through a matched comparison with LAGB. MATERIALS AND METHODS: Retrospective search of prospectively maintained database of our university was carried out to find all patients that underwent LSG before December 2010. Each subject with LSG was matched one-to-one with a patient that had undergone LAGB in the same period with corres

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota

Jin‐Yi Wan, Chong‐Zhi Wang, Qi‐Hui Zhang et al. · 2016 · Biomedical Chromatography

Abstract After ingestion of ginseng, the bioavailability of its parent compounds is low and enteric microbiota plays an important role in parent compound biotransformation to their metabolites. Diet type can influence the enteric…

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Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics

Acute liver failure

Laura Blackmore, William Bernal · 2015 · Clinical Medicine

Acute liver failure (ALF) is a rare critical illness with high mortality whose successful management requires early recognition and effective initial management. Though it may result from a wide variety of causes, in the UK and much of the…

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Negative / Null Result ReportOpen accessMedicine

Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits

Matilde Negrini, Giuseppe Tomasello, Marcus Davidsson et al. · 2022 · Journal of Parkinson s Disease

BACKGROUND: Preclinical rodent models for Parkinson's disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell loss and additional synucleinopathy in cortical and subcortical structures. Recent studies have combined viral vector-based overexpression of human wild-type αSyn with the sequential or simultaneous inoculation of preformed fibrils (PFFs) derived from human αSyn. OBJECTIVE: The goal of the study was to investigate whether sequential or combined delivery of the AAV vector

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Negative / Null Result ReportOpen accessMedicine

Bronchiectasis: Phenotyping a Complex Disease

James D. Chalmers · 2017 · COPD Journal of Chronic Obstructive Pulmonary Disease

Bronchiectasis is a long-neglected disease currently experiencing a surge in interest. It is a highly complex condition with numerous aetiologies, co-morbidities and a heterogeneous disease presentation and clinical course. The past few…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells

Makoto Miyara, Driss Chader, Aude Burlion et al. · 2016 · Oncotarget

// Makoto Miyara 1,2 , Driss Chader 1,2 , Aude Burlion 2 , Jérémie Goldstein 2 , Delphine Sterlin 1,2 , Françoise Norol 3 , Hélène Trebeden-Nègre 3 , Laetitia Claër 1,2 , Shimon Sakaguchi 4,* , Gilles Marodon 2,* , Zahir Amoura 1,2,5,6,* and Guy Gorochov 1,2,6 1 Department of immunology, AP-HP Pitié Salpêtrière, Paris, France 2 Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France 3 Cell Therapy, AP-HP Pitié Salpêtri&egrave

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Negative / Null Result Report

A Decade of Evidence-Based Education

Ronnie Detrich, Teri Lewis · 2012 · Journal of Positive Behavior Interventions

It has been 10 years since No Child Left Behind (NCLB), with its emphasis on scientifically based instruction as a means for improving the educational outcomes of students, was signed into law. In this article, we review the basic tenets…

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Negative / Null Result ReportOpen accessArts and Humanities

The Impact of Peer Scaffolding through Process Approach on EFL Learners’ Academic Writing Fluency

Masoud Khalili Sabet, Abdorreza Tahriri, Parastou Gholami Pasand · 2013 · Theory and Practice in Language Studies

This paper aimed to examine the impact of peer scaffolding through process approach on writing fluency of EFL learners. To this end, a Nelson Proficiency Test was administered to 49 EFL learners studying at University of Guilan, based on…

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Negative / Null Result ReportOpen accessEnvironmental Science

Variability in Fitness Trade-Offs Amongst Coral Juveniles With Mixed Genetic Backgrounds Held in the Wild

Kate M. Quigley, Magena R. Marzonie, Blake D. Ramsby et al. · 2021 · Frontiers in Marine Science

Novel restoration methods are currently under consideration worldwide to help coral reefs recover or become more resilient to higher temperature stress. Critical field-based information concerning the paradigm of “local is best” is lacking for many methods; information which is essential to determine the risk and feasibility associated with restoration. One method involves breeding corals from different reef regions with expected variation in heat tolerance and moving those offspring to new locations to enhance offspring survival; thereby augmenting local stock to enhance survival for anticipa

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Negative / Null Result ReportOpen accessMedicine

Positron Emission Tomography Scan for a Hepatic Mass

Boris Blechacz, Gregory J. Gores · 2010 · Hepatology

A 66-year-old male patient who is hepatitis C RNA–positive without cirrhosis has been found to have a mass on ultrasound examination of the liver. The physical examination is unremarkable. The hemoglobin, white cell count, and platelet…

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Negative / Null Result ReportOpen accessMedicine

Measured GFR: not a gold, but a gold-plated standard

Elise Boele-Schutte, Ron T. Gansevoort · 2016 · Nephrology Dialysis Transplantation

Because of the circadian rhythm in kidney function the true glomerular filtration rate (GFR) is historically considered to be the average GFR measured by urinary inulin clearance over a 24-h period [1]. In clinical practice, it is…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Intensifying cropping systems through doubled-up legumes in Eastern Zambia

Mulundu Mwila, Blessing Mhlanga, Christian Thierfelder · 2021 · Scientific Reports

Abstract Declining soil fertility and negative impacts of climate effects threaten the food security of millions in Africa. Conservation Agriculture (CA) is a promising strategy to address these challenges. However, lack of viable economic entry points and short-term benefits for smallholders limit its adoption. Legume intensification can possibly increase the output per unit area, thus making the system more attractive. Rotations of maize with intensified legume systems were tested for three consecutive years under ridge and furrow (RF) tillage and CA to investigate: (a) increases in producti

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Negative / Null Result ReportOpen accessPsychology

Community-based randomized controlled trial of psychological first aid with crime victims.

Michael R. McCart, Jason E. Chapman, Kristyn Zajac et al. · 2020 · Journal of Consulting and Clinical Psychology

OBJECTIVE: The first randomized controlled trial of psychological first aid (PFA) was conducted, using crime victims as participants. For study Aim 1, investigators tested whether paraprofessional victim advocates could be trained to…

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Negative / Null Result ReportOpen accessMedicine

Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation

Matthias Diebold, Hannes Vietzen, Andreas Heinzel et al. · 2023 · American Journal of Transplantation

Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically determined NK cell functionality on ABMR development and activity. The study included 86 kidney transplant recipients subjected to systematic biopsies triggered by donor-specific antibody detection. We performed killer immunoglobulin-like receptor typing to predict missing self and genotyped polymorphisms determining NK cell functionality (FCGR3AV/F158 [rs39699

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Negative / Null Result ReportEngineering

Systematic Strategy for Obtaining a Dividing-Wall Column Applied to an Extractive Distillation Process

Gardênia Marinho Cordeiro, M.F. Figueirêdo, Wagner Brandão Ramos et al. · 2017 · Industrial & Engineering Chemistry Research

Currently, process intensification using dividing-wall columns (DWCs) is one of the most promising alternatives for reducing the costs of the distillation process. However, for extractive distillation, there are still questions regarding…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Yeast Species, Strains, and Growth Media Mediate Attraction of Drosophila suzukii (Diptera: Drosophilidae)

Rodrigo Lasa, Laura Navarro-de-la-Fuente, Anne Gschaedler et al. · 2019 · Insects

Specific ecological interactions between insects and microbes have potential in the development of targeted pest monitoring or control techniques for the spotted wing drosophilid, Drosophila suzukii (Matsumura), an exotic invasive pest of soft fruit. To evaluate D. suzukii attraction to yeast species from preferred types of fruit, three yeasts were isolated from blackberry fruit and two yeasts from raspberry fruit and used to bait simple plastic bottle traps. Saccharomyces cerevisiae and Hanseniaspora uvarum were identified from blackberries, whereas a different H. uvarum strain was identified

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Negative / Null Result ReportOpen accessEnvironmental Science

Across Date Species Detection Using Airborne Imaging Spectroscopy

Anthony Laybros, Daniel Schläpfer, Jean‐Baptiste Féret et al. · 2019 · Remote Sensing

Imaging spectroscopy is a promising tool for airborne tree species recognition in hyper-diverse tropical canopies. However, its widespread application is limited by the signal sensitivity to acquisition parameters, which may require new training data in every new area of application. This study explores how various pre-processing steps may improve species discrimination and species recognition under different operational settings. In the first experiment, a classifier was trained and applied on imaging spectroscopy data acquired on a single date, while in a second experiment, the classifier wa

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Negative / Null Result Report

An intraoperative load sensor did not improve the early postoperative results of posterior‐stabilized TKA for osteoarthritis with varus deformities

Sang Jun Song, Se Gu Kang, Yeon Je Lee et al. · 2018 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose In the present study, the early results of sensor‐assisted versus manually balanced posterior‐stabilized total knee arthroplasty (TKA) for osteoarthritis with varus deformities were prospectively compared. Methods Fifty…

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