Replicative Fitness Costs of Nonnucleoside Reverse Transcriptase Inhibitor Drug Resistance Mutations on HIV Subtype C
Kimberly L. Armstrong; Tun‐Hou Lee; Max Essex · 2011 · Antimicrobial Agents and Chemotherapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Single-dose nevirapine (NVP) is quite effective in preventing transmission of the human immunodeficiency virus (HIV) from mother to child; however, many women develop resistance to NVP in this setting. Comparing outcomes of clinical studies reveals an increased amount of resistance in subtype C relative to that in other subtypes. This study investigates how nonnucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations of subtype C affect replication capacity. The 103N, 106A, 106M, 181C, 188C, 188L, and 190A drug resistance mutations were placed in a reverse transcriptase (RT)
Abstract by Kimberly L. Armstrong; Tun‐Hou Lee; Max Essex, Antimicrobial Agents and Chemotherapy (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1128/aac.01505-10