Negative / Null Result ReportOpen accessSocial Sciences
Irene Mosca, Bláithín Ní Bhuachalla, Rose Anne Kenny · 2013 · BMC Cardiovascular Disorders
BACKGROUND: To assess prevalence rates of subjective and objective reports of two cardiovascular disorders (hypertension and hypercholesterolemia) for the same subset of respondents in a large-scale study. To determine whether and the extent to which the socioeconomic health gradient differed in the subjective and objective reports of the two cardiovascular disorders. METHODS: Data from the first wave (2009/2011) of The Irish Longitudinal Study on Ageing were used (n = 4,179). This is a nationally representative study of community-dwelling adults aged 50+ residing in Ireland. Subjective measur
View details →Negative / Null Result ReportOpen accessMedicine
Maria L.V. Dizon, Rakesh Rao, Shannon E. G. Hamrick et al. · 2019 · BMC Pediatrics
BACKGROUND: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with H
View details →Negative / Null Result ReportOpen accessMedicine
Weikun Li, Murat Yalçın, Dhruba J. Bharali et al. · 2019 · Scientific Reports
Abstract The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vi
View details →Negative / Null Result ReportOpen accessMedicine
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson et al. · 2022 · European Heart Journal - Cardiovascular Pharmacotherapy
AIMS: Most trials showing benefit of beta-blocker treatment after myocardial infarction (MI) included patients with large MIs and are from an era before modern biomarker-based MI diagnosis and reperfusion treatment. The aim of the…
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Bisakha Sen, Justin Blackburn, Michael A. Morrisey et al. · 2012 · Health Services Research
Objective To explore whether health care utilization changed among enrollees in Alabama's CHIP program, ALL Kids, following copayment increases at the beginning of fiscal year 2004. Data Sources Data on all ALL Kids enrollees over…
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Verônica Belchior, Bruno G. Botelho, Adriana S. Franca · 2022 · Foods
The Specialty Coffee Association (SCA) sensory analysis protocol is the methodology that is used to classify specialty coffees. However, because the sensory analysis is sensitive to the taster’s training, cognitive psychology, and…
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Austin Clyde, Xuefeng Liu, Thomas Brettin et al. · 2023 · Scientific Reports
Abstract Protein-ligand docking is a computational method for identifying drug leads. The method is capable of narrowing a vast library of compounds down to a tractable size for downstream simulation or experimental testing and is widely…
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Leon Deutsch, Damjan Osredkar, Janez Plavec et al. · 2021 · Metabolites
Spinal muscular atrophy (SMA) is a genetically heterogeneous group of rare neuromuscular diseases and was until recently the most common genetic cause of death in children. The effects of 2-month nusinersen therapy on urine, serum, and…
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Rune Strand Ødegård, Atle Nesje, Ketil Isaksen et al. · 2017 · The Cryosphere
Abstract. Despite numerous spectacular archaeological discoveries worldwide related to melting ice patches and the emerging field of glacial archaeology, governing processes related to ice patch development during the Holocene and their…
View details →Negative / Null Result ReportMedicine
Þórunn Rafnar, Patrick Sulem, Søren Besenbacher et al. · 2011 · Cancer Research
Genome-wide association studies (GWAS) have identified 3 genomic regions, at 15q24-25.1, 5p15.33, and 6p21.33, which associate with the risk of lung cancer. Large meta-analyses of GWA data have failed to find additional associations of…
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Erik Litonius, Tomohisa Niiya, Pertti J. Neuvonen et al. · 2011 · Basic & Clinical Pharmacology & Toxicology
Abstract: Intravenous lipid emulsion has been used in the resuscitative treatment of intoxications caused by local anaesthetics and tricyclic antidepressants with seemingly beneficial results. We studied the effect of intravenous lipid…
View details →Negative / Null Result ReportOpen accessNeuroscience
Huaxin Fan, Hewei Wang, Zhengxu Lian et al. · 2026 · Journal of Stroke
BACKGROUND AND PURPOSE: Therapeutic target selection in noninvasive brain stimulation for poststroke motor recovery typically relies on the interhemispheric inhibition model, which is effective for mildly affected patients but offers…
View details →Negative / Null Result ReportOpen accessComputer Science
Shervin Malmasi, Joel Tetreault, Mark Dras · 2015
We examine different ensemble methods, including an oracle, to estimate the upper-limit of classification accuracy for Native Language Identification (NLI). The oracle outperforms state-of-the-art systems by over 10% and results indicate that for many misclassified texts the correct class label receives a significant portion of the ensemble votes, often being the runner-up. We also present a pilot study of human performance for NLI, the first such experiment. While some participants achieve modest results on our simplified setup with 5 L1s, they did not outperform our NLI system, and this perf
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jan G. Voelkel, Mark J. Brandt, Matteo Colombo · 2018 · Comprehensive Results in Social Psychology
People are prejudiced toward groups they perceive as having a worldview dissimilar from their own. This link between perceived attitudinal dissimilarity and prejudice is so stable that it has been described as a psychological law. The current research tests whether reducing people’s (over-)confidence in their own understanding of policies by puncturing their illusion of explanatory depth in the political domain will reduce the link between perceived attitudinal dissimilarity and prejudice. In an initial pre-registered experiment (N = 296), we did not find support for our hypothesis, but explor
View details →Negative / Null Result ReportOpen accessDecision Sciences
Gillian Pepper, Deirdre Corby, Rachel Bamber et al. · 2017 · PeerJ
Here, we report three attempts to replicate a finding from an influential psychological study (Griskevicius et al., 2011b). The original study found interactions between childhood SES and experimental mortality-priming condition in predicting risk acceptance and delay discounting outcomes. The original study used US student samples. We used British university students (replication 1) and British online samples (replications 2 and 3) with a modified version of the original priming material, which was tailored to make it more credible to a British audience. We did not replicate the interaction b
View details →Negative / Null Result ReportOpen accessMedicine
Tamara Beres Lederer Goldberg, Carla Cristiane da Silva, Luciana Peres et al. · 2026 · Archivos Latinoamericanos de Nutrición
Adolescents' eating habits are determined by social, psychological, economic, political, and educational influences. They tend to prefer foods with inadequate nutritional value and high fat and carbohydrate content which leads to excessive…
View details →Negative / Null Result ReportOpen accessMedicine
Dae-Sang Lee, Mi Yeon Lee, Chi-Min Park et al. · 2018 · PLoS ONE
Delirium is a common complication of vascular surgery. The protective effect of preoperative statins on delirium after vascular surgery is controversial. The authors hypothesized that preoperative statin administration would decrease the incidence of delirium after vascular surgery. From May 2010 to May 2015, 1,132 patients underwent vascular surgery. Postoperative delirium was diagnosed from patients' medical records. The incidence of delirium was 11.5%. The preoperative statin exposure was not associated with reduced delirium in the univariate analysis. After adjusting for covariates, preope
View details →Negative / Null Result ReportOpen accessPsychology
Hilmar Zech, Philip A. Gable, W. van Dijk et al. · 2022 · Behavior Research Methods
The approach-avoidance task (AAT) is an implicit task that measures people's behavioral tendencies to approach or avoid stimuli in the environment. In recent years, it has been used successfully to help explain a variety of health problems (e.g., addictions and phobias). Unfortunately, more recent AAT studies have failed to replicate earlier promising findings. One explanation for these replication failures could be that the AAT does not reliably measure approach-avoidance tendencies. Here, we first review existing literature on the reliability of various versions of the AAT. Next, we examine
View details →Negative / Null Result ReportOpen accessNeuroscience
Annelies Spek, Evert Scholte, Ina A. van Berckelaer‐Onnes · 2010 · Journal of Autism and Developmental Disorders
Local information processing in 42 adults with high functioning autism, 41 adults with Asperger syndrome and 41 neurotypical adults was examined. Contrary to our expectations, the disorder groups did not outperform the neurotypical group…
View details →Negative / Null Result ReportOpen accessPsychology
Leon Y. Xiao, Tullia C. Fraser, Philip Newall · 2022 · Journal of Gambling Studies
Loot boxes are quasi-gambling virtual products in video games that provide randomised rewards of varying value. Previous studies in Western contexts have identified a positive correlation between loot box purchasing and problem gambling severity. A preregistered survey of People's Republic of China (PRC) video game players (N = 879) failed to replicate this correlation. We observed statistically significant but weak positive correlations between loot box expenditure and past-year gambling participation, and between loot box expenditure and impulsiveness. This study cannot prove that loot boxes
View details →Negative / Null Result ReportOpen accessPsychology
Basil Wahn, Artur Czeszumski, Peter König · 2018 · PLoS ONE
When humans perform tasks together, they may reach a higher performance in comparison to the best member of a group (i.e., a collective benefit). Earlier research showed that interindividual performance similarities predict collective benefits for several joint tasks. Yet, researchers did not test whether this is the case for joint visuospatial tasks. Also, researchers did not investigate whether dyads and triads reach a collective benefit when they are forbidden to exchange any information while performing a visuospatial task. In this study, participants performed a joint visual search task e
View details →Negative / Null Result ReportOpen accessMedicine
Amy Armstrong, Fleur Coburn, Yanyamba Nsereko et al. · 2025 · Journal of Peptide Science
Peptide-drug conjugates (PDCs) are advancing as targeted cancer therapies, leveraging lessons from antibody-drug conjugates (ADCs) to improve tumour specificity. These molecules combine a homing peptide with a cytotoxic payload via a linker, enabling precise drug delivery while sparing healthy tissue. Despite their potential, PDCs face challenges including metabolic instability, premature payload release and rapid clearance, limiting clinical success. Only Lutathera remains FDA-approved after Pepaxto's withdrawal, though Pepaxto retains EMA and MHRA approval-highlighting regulatory and technic
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Erich Hoppmann · 2026 · ORDO
Der Wirtschaftspolitische Ausschus des Deutschen Bundestages erklarte bei Erlas des Kartellgesetzes, er konne und wolle den Wettbewerbsbegriff nicht definieren, das sei eine Angelegen heit der zustandigen Fachdisziplin1. Diese Aufforderung…
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Talia Gonda, Frank P Deane, Ganapathi Murugesan · 2012 · Australian & New Zealand Journal of Psychiatry
Objective: The first aim of this study was to assess the proportion of patients who achieved reliable and clinically significant change over the course of treatment in an inpatient psychosocial rehabilitation program. The second aim was to…
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Takudzwa C. Madzivanzira, Josie South, Olaf L. F. Weyl · 2021 · Freshwater Biology
Abstract Data on ecological impacts of freshwater crayfish invasions in Africa are scarce but invasion history suggests the likelihood of negative implications for biodiversity. To evaluate the potential for ecological impacts we describe…
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Jacob Guinot, Sandra Miralles, Alma Rodríguez-Sánchez et al. · 2020 · Employee Relations: The International Journal
Purpose Based on a new management paradigm rooted on care and compassion, this study explores the consequences of compassion at work on organizational learning and firm performance. Design/methodology/approach Structural equation modeling…
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Markus Orsi, Jean-Louis Reymond · 2024 · Journal of Cheminformatics
Abstract Molecular fingerprints are indispensable tools in cheminformatics. However, stereochemistry is generally not considered, which is problematic for large molecules which are almost all chiral. Herein we report MAP4C, a chiral…
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Jessica Oi‐Ling Tsang, Jie Zhou, Xiaoyu Zhao et al. · 2021 · Biomedicines
Enteroviruses are important causes of hand, foot, and mouth disease, respiratory infections, and neurological infections in human. A major hurdle for the development of anti-enterovirus agents is the lack of physiologically relevant evaluation platforms that closely correlate with the in vivo state. We established the human small intestinal organoids as a novel platform for characterizing the viral replication kinetics and evaluating candidate antivirals for enteroviruses. The organoids supported productive replication of enterovirus (EV)-A71, coxsackievirus B2, and poliovirus type 3, as evide
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Albert J. Auguste, Rose M. Langsjoen, Danielle L. Porier et al. · 2021 · Virology
We describe the isolation and characterization of a novel insect-specific flavivirus (ISFV), tentatively named Aripo virus (ARPV), that was isolated from Psorophora albipes mosquitoes collected in Trinidad. The ARPV genome was determined…
View details →Negative / Null Result ReportOpen accessMedicine
Meghan A. Baker, Bethany Baer, Martin Kulldorff et al. · 2019 · PLoS Medicine
BACKGROUND: Kawasaki disease is an acute vasculitis that primarily affects children younger than 5 years of age. Its etiology is unknown. The United States Vaccine Safety Datalink conducted postlicensure safety surveillance for 13-valent pneumococcal conjugate vaccine (PCV13), comparing the risk of Kawasaki disease within 28 days of PCV13 vaccination with the historical risk after 7-valent PCV (PCV7) vaccination and using chart-validation. A relative risk (RR) of 2.38 (95% CI 0.92-6.38) was found. Concurrently, the Food and Drug Administration (FDA) conducted a postlicensure safety review that
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