Negative / Null Result ReportOpen accessMedicine
Sonia Tejada, Ricardo Díez-Valle, Guillermo Aldave et al. · 2013 · Journal of Neuro-Oncology
Our purpose was to analyze the pattern of failure in glioblastoma (GBM) patients at first recurrence after radiotherapy and temozolomide and its relationship with different factors. From 77 consecutive GBM patients treated at our institution with fluorescence guided surgery and standard radiochemotherapy, 58 first recurrences were identified and included in a retrospective review. Clinical data including age, Karnofsky performance score, preoperative tumor volume and location, extend of resection, MGMT promoter methylation status, time to progression (PFS), overall survival (OS) and adjuvant t
View details →Negative / Null Result ReportOpen accessMedicine
Romelia Barba Bernal, Bryan W. Ferrigno, Esli Medina Morales et al. · 2023 · The Turkish Journal of Gastroenterology
Primary biliary cholangitis is an autoimmune cholestatic liver disease characterized by progressive destruction of bile ducts, which can ultimately progress to chronic liver disease and cirrhosis. Ursodeoxycholic acid and obeticholic acid are the only 2 Food and Drug Administration (FDA)-approved medications for primary biliary cholangitis. Unfortunately, up to 40% of patients with primary biliary cholangitis have an incomplete response to ursodeoxycholic acid, warranting an essential need for additional therapeutics. Peroxisome proliferator-activated receptor agonists have shown promising dat
View details →Negative / Null Result ReportOpen accessSocial Sciences
Elizabeth Ty Wilde, Zohn Rosen, Kenneth A. Couch et al. · 2013 · American Journal of Public Health
OBJECTIVES: We examined whether Jobs First, a multicenter randomized trial of a welfare reform program conducted in Connecticut, demonstrated increases in employment, income, and health insurance relative to traditional welfare (Aid to…
View details →Negative / Null Result ReportOpen accessMedicine
Ian Roberts · 2016 · Transfusion
Administration of tranexamic acid (TXA) to bleeding trauma patients who are within 3 hours of injury has been shown to safely reduce mortality in bleeding trauma patients. However, some believe that thromboelastography (TEG or ROTEM) can…
View details →Negative / Null Result ReportOpen accessMedicine
Bradford L. McRae, Alon D. Levin, Manon E. Wildenberg et al. · 2015 · Journal of Crohn s and Colitis
BACKGROUND AND AIMS: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of patients with Crohn's disease whereas a TNF receptor fusion protein [etanercept] is…
View details →Negative / Null Result ReportMedicine
Mauro Cignarelli, Ettore Cicinelli, Mónica Corso et al. · 2010 · Gynecologic and Obstetric Investigation
Thermocutaneous, vascular, metabolic and hormonal changes were investigated during 11 hot flashes from 6 postmenopausal women. The first detectable change was an increase in finger blood flow with a concomitant enhancement of skin…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jie Shen, Gary N. Landis, John Tower · 2016 · The Journals of Gerontology Series A
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for…
View details →Negative / Null Result ReportOpen accessMedicine
Valérie Fonteyne, Piet Dirix, Charles Van Praet et al. · 2021 · European Urology Focus
BACKGROUND: High-risk muscle-invasive bladder cancer (MIBC) has a poor prognosis. Old trials showed that external beam radiotherapy (EBRT) after radical cystectomy (RC) decreases the incidence of local recurrences but induces severe…
View details →Negative / Null Result ReportOpen accessMedicine
Lindsay Rosenbeck, Patrick J. Kiel, Iftekhar Kalsekar et al. · 2010 · Biology of Blood and Marrow Transplantation
Methotrexate (MTX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared…
View details →Negative / Null Result ReportMedicine
Gonçalo N. Petrucci, Joaquim Henriques, Luís Lobo et al. · 2020 · Veterinary and Comparative Oncology
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical…
View details →Negative / Null Result ReportOpen accessEngineering
Tien‐Yu Yang, Tsan-Wen Huang, Po‐Yao Chuang et al. · 2018 · BMC Musculoskeletal Disorders
BACKGROUND: Displaced transverse fractures of the body of the patella are usually associated with disruption of extensor mechanism and should be fixed surgically. The most common method is a tension band wiring (TBW) technique. Some surgeons concurrently employ an augmented circumferential cerclage wiring (ACCW) technique to help fracture stabilization and aid in fracture healing; however, its role and effect on the treatment outcomes is unclear. METHODS: We performed a STROBE-compliant retrospective observational cohort study on all cases of acute closed patella fracture that were treated at
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marjorie L. McCullough, Rebecca A. Hodge, Peter T. Campbell et al. · 2021 · Metabolites
Untargeted metabolomic studies have identified potential biomarkers of colorectal cancer risk, but evidence is still limited and broadly inconsistent. Among 39,239 Cancer Prevention Study II Nutrition cohort participants who provided a blood sample between 1998–2001, 517 newly diagnosed colorectal cancers were identified through 30 June 2015. In this nested case–control study, controls were matched 1:1 to cases on age, sex, race and date of blood draw. Mass spectroscopy-based metabolomic analyses of pre-diagnostic plasma identified 886 named metabolites, after quality control exclusions. Condi
View details →Negative / Null Result ReportOpen accessMedicine
Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jade Chapman, Elliott Rees, Denise Harold et al. · 2012 · Human Molecular Genetics
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the Genetic and…
View details →Negative / Null Result ReportOpen accessEngineering
Anna A. Stec, T. Richard Hull, David Purser et al. · 2014 · Fire Safety Science
In a fire, normally non-hazardous thermoplastic materials can produce lethal concentrations of toxic effluents in the smoke. The toxic product yields of the asphyxiants carbon monoxide (CO) and hydrogen cyanide (HCN) from developed fires…
View details →Negative / Null Result ReportOpen accessMedicine
Yumiko Matsuoka, Amorsolo L. Suguitan, Marlene S. Orandle et al. · 2014 · Journal of Virology
Live attenuated cold-adapted (ca) H5N1, H7N3, H6N1, and H9N2 influenza vaccine viruses replicated in the respiratory tract of mice and ferrets, and 2 doses of vaccines were immunogenic and protected these animals from challenge infection…
View details →Negative / Null Result ReportOpen accessMedicine
Constance Wose Kinge, Christine Espiritu, Nishi Prabdial‐Sing et al. · 2014 · Antimicrobial Agents and Chemotherapy
Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In…
View details →Negative / Null Result ReportOpen accessNeuroscience
Tomer Fekete, Andrey R. Nikolaev, Floris De Knijf et al. · 2018 · Frontiers in Neuroscience
Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-electrode arrangements needed to direct currents into precise brain loci. We set out to explore these questions by administering alternating current through a multi-electrode montage (mtACS), while va
View details →Negative / Null Result ReportMedicine
Cyril Messaraa, Nicola J. Robertson, Melissa Walsh et al. · 2019 · Journal of Cosmetic Dermatology
BACKGROUND: The use of a skin care routine is commonly promoted by the cosmetic industry, yet there is a lack of clinical evidence to support this practice over the use of a single skin care product. AIMS: In the present study, we aimed at…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Bo Zou, Dan Zhao, Shuang Zhou et al. · 2025 · Frontiers in Nutrition
Emerging evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) are essential structural and functional nutrients that significantly influence the composition and function of the gut microbiota, a key mediator of host health. Although evidence suggests that increasing tissue Omega-3 levels through dietary intervention may optimize gut microbiota-host interaction through modulation of composition, metabolite production, and the intestinal mucus barrier, some studies have reported inconsistent findings regarding these protective effects. Studies indicate that a high Omega-6/Omega-3 r
View details →Negative / Null Result ReportOpen accessComputer Science
Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov et al. · 2025 · Nature Communications
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals' cancer progression for effective personalized care. However, AI's imperfections can lead to suboptimal therapeutics if clinicians over or under rely on AI. To investigate such collaborative decision-making process, we conducted a Human-AI interaction study on response-adaptive radiotherapy for non-small cell lung cancer and hepatocellular carcinoma. We investigated two levels of collaborative behavior: model-agnostic and model-specific; and found that Human-AI
View details →Negative / Null Result ReportOpen accessComputer Science
J. M. Górriz, R. Martin-Clemente, F. Segovia et al. · 2026 · Information Fusion
As a technique that can compactly represent complex patterns, machine learning has significant potential for predictive inference in multi-source and heterogeneous information fusion scenarios. K-fold cross-validation (CV) is the most common approach for ascertaining the likelihood that a machine learning outcome is generated by chance and frequently outperforms conventional hypothesis testing. This improvement arises from measures directly obtained from machine learning classifications, such as accuracy, that do not have a parametric description. To approach a frequentist analysis within fusi
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
K.E. Giller, Euan K. James, Julie Ardley et al. · 2024 · Plant and Soil
Abstract Background Despite more than 50 years of research, no robust evidence suggests that inoculation of cereals and other non-legumes with free-living and/or endophytic bacteria leads to fixation of agronomically significant quantities of dinitrogen gas (N 2 ) from the atmosphere. A plethora of new products claims to increase the growth and yields of major cereals and other crops through stimulating N 2 -fixation by inoculating with bacteria. Scope We review the literature on N 2 -fixation by bacteria in the rhizosphere and as endophytes in non-legume plants. We find no unequivocal evidenc
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Walter Acevedo, Bijan Fallah, Sebastian Reich et al. · 2017 · Climate of the past
Abstract. Paleoclimate data assimilation (DA) is a promising technique to systematically combine the information from climate model simulations and proxy records. Here, we investigate the assimilation of tree-ring-width (TRW) chronologies into an atmospheric global climate model using ensemble Kalman filter (EnKF) techniques and a process-based tree-growth forward model as an observation operator. Our results, within a perfect-model experiment setting, indicate that the "online DA" approach did not outperform the "off-line" one, despite its considerable additional implementation complexity. On
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Han Wu, Xiang Zhao, Fei Wang et al. · 2017 · Frontiers in Immunology
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not fully understood. The present study showed that MuV infected the majority of testicular cells, including Leydig cells (LC), testicular macrophages, Sertoli cells (SC), and male germ cells (GC). MuV was replicated at relatively high efficiencies in SC compared with LC and testicular macrophages. In contrast, MuV did not replicate in male GC. Notably, testicular ce
View details →Negative / Null Result ReportOpen accessMedicine
Jung Sun Kim, Eun Joo Kang, Dae Sik Kim et al. · 2018 · BMC Cancer
BACKGROUND: This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated. METHODS: A total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated. RESULTS: VTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed p
View details →Negative / Null Result ReportOpen accessComputer Science
The First Waters · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper develops government structural reference infrastructure for AI and AGI environments. It addresses the need for public institutions to preserve reference continuity across public records, citizen submissions, administrative documents, authority-condition references, state histories, seal-reference contexts, role accountability records, economic references, and propagation-sensitive records without becoming dependent on a single AI provider, platform, model, or cloud environment. The framework does not perform public decision-making, grant authority, issue permits, approve benefits, c
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mohsen Mehrara, H Abrishami, Mostafa Boroujli et al. · 2013 · International Letters of Social and Humanistic Sciences
This paper examines causal relationships between Government Recurrent Expenditure (GRE) and GDP for Iran using annual data over the period 1970-2010. The Gregory-Hansen (1996) cointegration technique, allowing for the presence of potential structural breaks in data, is applied to empirically examine the long-run co-movement between these variables. The results suggest that there is a long-run relationship between these variables. The Granger Causality test indicates strong unidirectional effects from GDP to GRE. But there is no evidence that TRE promotes long-term economic growth. Moreover, th
View details →Negative / Null Result ReportOpen accessMathematics
Jeremy P. Gygi, Cole Maguire, Ravi K. Patel et al. · 2024 · Journal of Clinical Investigation
BACKGROUNDPatients hospitalized for COVID-19 exhibit diverse clinical outcomes, with outcomes for some individuals diverging over time even though their initial disease severity appears similar to that of other patients. A systematic evaluation of molecular and cellular profiles over the full disease course can link immune programs and their coordination with progression heterogeneity.METHODSWe performed deep immunophenotyping and conducted longitudinal multiomics modeling, integrating 10 assays for 1,152 Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study participants and identif
View details →Negative / Null Result ReportOpen accessPsychology
Janna N. Vrijsen, Ben Grafton, Ernst H. W. Koster et al. · 2024 · Behaviour Research and Therapy
Cognitive bias modification (CBM) has evolved from an experimental method testing cognitive mechanisms of psychopathology to a promising tool for accessible digital mental health care. While we are still discovering the conditions under which clinically relevant effects occur, the dire need for accessible, effective, and low-cost mental health tools underscores the need for implementation where such tools are available. Providing our expert opinion as Association for Cognitive Bias Modification members, we first discuss the readiness of different CBM approaches for clinical implementation, the
View details →