Negative / Null Result ReportOpen accessSocial Sciences
Elizabeth Ty Wilde, Zohn Rosen, Kenneth A. Couch et al. · 2013 · American Journal of Public Health
OBJECTIVES: We examined whether Jobs First, a multicenter randomized trial of a welfare reform program conducted in Connecticut, demonstrated increases in employment, income, and health insurance relative to traditional welfare (Aid to…
View details →Negative / Null Result ReportOpen accessMedicine
Ian Roberts · 2016 · Transfusion
Administration of tranexamic acid (TXA) to bleeding trauma patients who are within 3 hours of injury has been shown to safely reduce mortality in bleeding trauma patients. However, some believe that thromboelastography (TEG or ROTEM) can…
View details →Negative / Null Result ReportOpen accessMedicine
Bradford L. McRae, Alon D. Levin, Manon E. Wildenberg et al. · 2015 · Journal of Crohn s and Colitis
BACKGROUND AND AIMS: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of patients with Crohn's disease whereas a TNF receptor fusion protein [etanercept] is…
View details →Negative / Null Result ReportMedicine
Mauro Cignarelli, Ettore Cicinelli, Mónica Corso et al. · 2010 · Gynecologic and Obstetric Investigation
Thermocutaneous, vascular, metabolic and hormonal changes were investigated during 11 hot flashes from 6 postmenopausal women. The first detectable change was an increase in finger blood flow with a concomitant enhancement of skin…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jie Shen, Gary N. Landis, John Tower · 2016 · The Journals of Gerontology Series A
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for…
View details →Negative / Null Result ReportOpen accessMedicine
Valérie Fonteyne, Piet Dirix, Charles Van Praet et al. · 2021 · European Urology Focus
BACKGROUND: High-risk muscle-invasive bladder cancer (MIBC) has a poor prognosis. Old trials showed that external beam radiotherapy (EBRT) after radical cystectomy (RC) decreases the incidence of local recurrences but induces severe…
View details →Negative / Null Result ReportOpen accessMedicine
Lindsay Rosenbeck, Patrick J. Kiel, Iftekhar Kalsekar et al. · 2010 · Biology of Blood and Marrow Transplantation
Methotrexate (MTX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared…
View details →Negative / Null Result ReportMedicine
Gonçalo N. Petrucci, Joaquim Henriques, Luís Lobo et al. · 2020 · Veterinary and Comparative Oncology
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical…
View details →Negative / Null Result ReportOpen accessEngineering
Tien‐Yu Yang, Tsan-Wen Huang, Po‐Yao Chuang et al. · 2018 · BMC Musculoskeletal Disorders
BACKGROUND: Displaced transverse fractures of the body of the patella are usually associated with disruption of extensor mechanism and should be fixed surgically. The most common method is a tension band wiring (TBW) technique. Some surgeons concurrently employ an augmented circumferential cerclage wiring (ACCW) technique to help fracture stabilization and aid in fracture healing; however, its role and effect on the treatment outcomes is unclear. METHODS: We performed a STROBE-compliant retrospective observational cohort study on all cases of acute closed patella fracture that were treated at
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marjorie L. McCullough, Rebecca A. Hodge, Peter T. Campbell et al. · 2021 · Metabolites
Untargeted metabolomic studies have identified potential biomarkers of colorectal cancer risk, but evidence is still limited and broadly inconsistent. Among 39,239 Cancer Prevention Study II Nutrition cohort participants who provided a blood sample between 1998–2001, 517 newly diagnosed colorectal cancers were identified through 30 June 2015. In this nested case–control study, controls were matched 1:1 to cases on age, sex, race and date of blood draw. Mass spectroscopy-based metabolomic analyses of pre-diagnostic plasma identified 886 named metabolites, after quality control exclusions. Condi
View details →Negative / Null Result ReportOpen accessMedicine
Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jade Chapman, Elliott Rees, Denise Harold et al. · 2012 · Human Molecular Genetics
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study (GWAS) conducted by the Genetic and…
View details →Negative / Null Result ReportOpen accessEngineering
Anna A. Stec, T. Richard Hull, David Purser et al. · 2014 · Fire Safety Science
In a fire, normally non-hazardous thermoplastic materials can produce lethal concentrations of toxic effluents in the smoke. The toxic product yields of the asphyxiants carbon monoxide (CO) and hydrogen cyanide (HCN) from developed fires…
View details →Negative / Null Result ReportOpen accessMedicine
Yumiko Matsuoka, Amorsolo L. Suguitan, Marlene S. Orandle et al. · 2014 · Journal of Virology
Live attenuated cold-adapted (ca) H5N1, H7N3, H6N1, and H9N2 influenza vaccine viruses replicated in the respiratory tract of mice and ferrets, and 2 doses of vaccines were immunogenic and protected these animals from challenge infection…
View details →Negative / Null Result ReportOpen accessMedicine
Constance Wose Kinge, Christine Espiritu, Nishi Prabdial‐Sing et al. · 2014 · Antimicrobial Agents and Chemotherapy
Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In…
View details →Negative / Null Result ReportOpen accessNeuroscience
Tomer Fekete, Andrey R. Nikolaev, Floris De Knijf et al. · 2018 · Frontiers in Neuroscience
Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-electrode arrangements needed to direct currents into precise brain loci. We set out to explore these questions by administering alternating current through a multi-electrode montage (mtACS), while va
View details →Negative / Null Result ReportMedicine
Cyril Messaraa, Nicola J. Robertson, Melissa Walsh et al. · 2019 · Journal of Cosmetic Dermatology
BACKGROUND: The use of a skin care routine is commonly promoted by the cosmetic industry, yet there is a lack of clinical evidence to support this practice over the use of a single skin care product. AIMS: In the present study, we aimed at…
View details →Negative / Null Result ReportOpen accessMathematics
Andreas Deutsch, Josué Manik Nava-Sedeño, Simon Syga et al. · 2021 · PLoS Computational Biology
Collective dynamics in multicellular systems such as biological organs and tissues plays a key role in biological development, regeneration, and pathological conditions. Collective tissue dynamics-understood as population behaviour arising from the interplay of the constituting discrete cells-can be studied with on- and off-lattice agent-based models. However, classical on-lattice agent-based models, also known as cellular automata, fail to replicate key aspects of collective migration, which is a central instance of collective behaviour in multicellular systems. To overcome drawbacks of class
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michelle G. Pitts, Tanya Myers‐Morales, Sarah E. F. D’Orazio · 2016 · The Journal of Immunology
Type I IFN (IFN-α/β) is thought to enhance growth of the foodborne intracellular pathogen Listeria monocytogenes by promoting mechanisms that dampen innate immunity to infection. However, the type I IFN response has been studied primarily…
View details →Negative / Null Result ReportPsychology
Paul A. Jewsbury, Stephen C. Bowden · 2016 · Journal of Psychoeducational Assessment
Fluency is an important construct in clinical assessment and in cognitive taxonomies. In the Cattell–Horn–Carroll (CHC) model, Fluency is represented by several narrow factors that form a subset of the long-term memory encoding and…
View details →Negative / Null Result ReportNeuroscience
William H.B. McAuliffe · 2018 · Thinking & Reasoning
The past few decades of moral psychology research have yielded empirical anomalies for rationalist theories of moral judgments. An increasing number of psychologists and philosophers argue that these anomalies are explained well by…
View details →Negative / Null Result ReportEngineering
Matthias Langer, Ashley Hall, Zhen He et al. · 2018 · IEEE Transactions on Parallel and Distributed Systems
Many distributed deep learning systems have been published over the past few years, often accompanied by impressive performance claims. In practice these figures are often achieved in high performance computing (HPC) environments with fast…
View details →Negative / Null Result Report
Frank Kreienkamp, Philip Lorenz, Tobias Geiger · 2020 · Atmosphere
Climate modelling output that was provided under the latest Coupled Model Intercomparison Project (CMIP6) shows significant changes in model-specific Equilibrium Climate Sensitivity (ECS) as compared to CMIP5. The newer versions of many…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Giovanna Morelli, Marco Mele · 2020 · International Journal of Energy Economics and Policy
This study will demonstrate, through an econometric approach, the relationship among per capita GDP, CO2 emissions, and energy use in Vietnam. Using annual data for years 1970-2014, stationarity, structural breaks, Toda-Yamamoto test, Johansen and Juselius approach, and Variance decomposition have been conducted. The causality results in our analysis highlight that the presence of unidirectional causality was running from economic growth to energy consumption. This result will be significant since it supports the conservation hypothesis for the economy of Vietnam. Finally, the results of the v
View details →Negative / Null Result ReportOpen accessMedicine
Federica Albanese, Daniela Mercatelli, Luca Finetti et al. · 2021 · Neurobiology of Disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since…
View details →Failed Experiment ReportComputer Science
Jihan Yang, Shusheng Yang, Anjali Gupta et al. · 2025
Humans possess the visual-spatial intelligence to remember spaces from sequential visual observations. However, can Multimodal Large Language Models (MLLMs) trained on million-scale video datasets also "think in space" from videos? We…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Guohao Xie, Glenn C Duff, L.W. Hall et al. · 2013 · Journal of Animal Science
The effects of bacitracin methylene disalicylate (BMD) and scours on the fecal microbiome, animal performance, and health were studied in Holstein bull calves. Holstein bull calves (n = 150) were obtained from a single source at 12 to 24 h…
View details →Negative / Null Result ReportOpen accessNeuroscience
Susan G. Brown, Ryan K.M. Ikeuchi, Daniel R. Lucas · 2014 · Health Psychology and Behavioral Medicine
The interaction between the behavioral and physiological immune systems provides fertile ground for research. Here, we examine the interactions between fear of disease, collectivism/individualism, disgust, visual perception and salivary…
View details →Negative / Null Result ReportOpen accessComputer Science
Kirsty Kitto, Ben Hicks, Simon Buckingham Shum · 2023 · British Journal of Educational Technology
Abstract An extraordinary amount of data is becoming available in educational settings, collected from a wide range of Educational Technology tools and services. This creates opportunities for using methods from Artificial Intelligence and…
View details →Negative / Null Result ReportOpen accessPsychology
on behalf of the Pediatric Imaging Neurocognition Genetics study, John D. Eicher, Angela Montgomery et al. · 2015 · Brain Imaging and Behavior
Dyslexia and language impairment (LI) are complex traits with substantial genetic components. We recently completed an association scan of the DYX2 locus, where we observed associations of markers in DCDC2, KIAA0319, ACOT13, and FAM65B with reading-, language-, and IQ-related traits. Additionally, the effects of reading-associated DYX3 markers were recently characterized using structural neuroimaging techniques. Here, we assessed the neuroimaging implications of associated DYX2 and DYX3 markers, using cortical volume, cortical thickness, and fractional anisotropy. To accomplish this, we examin
View details →