Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dan Li, Shu-Gao Yang, Cheng-Wen He et al. · 2020 · BMC Biology
BACKGROUND: When stressed, eukaryotic cells produce triacylglycerol (TAG) to store nutrients and mobilize autophagy to combat internal damage. We and others previously reported that in yeast, elimination of TAG synthesizing enzymes inhibits autophagy under nitrogen starvation, yet the underlying mechanism has remained elusive. RESULTS: Here, we show that disruption of TAG synthesis led to diacylglycerol (DAG) accumulation and its relocation from the vacuolar membrane to the endoplasmic reticulum (ER). We further show that, beyond autophagy, ER-accumulated DAG caused severe defects in the endom
View details →Negative / Null Result ReportOpen accessMedicine
Shruti Agashe, David B. Burkholder, Keith Starnes et al. · 2022 · Frontiers in Human Neuroscience
There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy (GGE). Centromedian nucleus of the thalamus (CM) deep brain stimulation (DBS) may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic (GTC) seizures. At baseline she had 4-8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve stimulation. A multidisciplin
View details →Negative / Null Result ReportOpen accessMedicine
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann et al. · 2019 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) like erlotinib are effective for treating patients with EGFR mutant lung cancer; however, drug resistance inevitably emerges. Approaches to combine immunotherapies and targeted therapies to overcome or delay drug resistance have been hindered by limited knowledge of the effect of erlotinib on tumor-infiltrating immune cells. METHODS: Using mouse models, we studied the immunological profile of mutant EGFR-driven lung tumors before and after erlotinib treatment. RESULTS: We found that erlotinib triggered the re
View details →Negative / Null Result ReportOpen accessMedicine
Sahir Javed, Stéphane Benoist, Patrick Devos et al. · 2022 · World Journal of Surgical Oncology
BACKGROUND: BRAF V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than BRAF wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains difficult due to the scarce literature. The aim was to study a large cohort of BRAF V600E-mutant CRLM patients in order to see if surgery extend overall survival among others prognostic factors. METHODS: BRAF V600E-mutant CRCs diagnosed with liver-only metastases, resected or not, were retrospectively identified between April 2008 and December 2017, in 25 French centers. Clinic
View details →Negative / Null Result ReportMedicine
Helmut Schoellnast, Ajita Deodhar, Meier Hsu et al. · 2012 · Acta Radiologica
BACKGROUND: Radiofrequency ablation (RFA) is a potential application as a salvage tool after failure of surgery, chemotherapy, or radiotherapy of non-small cell lung cancer (NSCLC). Although several studies have evaluated the use of RFA in…
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Lucinda M Hilliard, Katrina M Mirabito, Kate M Denton · 2013 · Clinical and Experimental Pharmacology and Physiology
Summary Major sex differences exist in the development and progression of hypertension and cardiovascular disease. Prior to menopause, women have lower arterial pressure and, furthermore, are protected from hypertension and cardiovascular…
View details →Negative / Null Result ReportOpen accessMedicine
Narendra Kumar, Pankaj Kumar, Shabab Angurana et al. · 2013 · Journal of Neurosciences in Rural Practice
AIMS: We present retrospective analysis of patients of glioblastoma multiforme (GBM) and discuss clinical characteristics, various treatment protocols, survival outcomes, and prognostic factors influencing survival. MATERIALS AND METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Miklós Lipcsey, Mia Furebring, Sten Rubertsson et al. · 2010 · Upsala Journal of Medical Sciences
BACKGROUND: Renal dysfunction is associated with increased morbidity and mortality in intensive care patients. In most cases the glomerular filtration rate (GFR) is estimated based on serum creatinine and the Modification of Diet in Renal Disease (MDRD) formula, but cystatin C-estimated GFR is being used increasingly. The aim of this study was to compare creatinine and MDRD and cystatin C-estimated GFR in intensive care patients. METHODS: Retrospective observational study was performed, on patients treated within the general intensive care unit (ICU) during 2004-2006, in a Swedish university h
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Simran Thakkar, Aditi Chopra, Lakshmi Nagendra et al. · 2023 · touchREVIEWS in Endocrinology
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition characterized by the irreversible destruction of the β cells of the pancreas, which leads to a lifelong dependency on exogenous insulin. Despite the advancements in insulin…
View details →Negative / Null Result ReportOpen accessMedicine
John Ly, David Minarik, Lars Edenbrandt et al. · 2019 · EJNMMI Research
The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and reference organs may differ which affects DS classification and therefore medical treatment. The EANM Research Ltd. (EARL) harmonization program from the European Association of Nuclear Medicine (EANM) partly mi
View details →Negative / Null Result ReportOpen accessMedicine
Terence Fullerton, Brendon Binneman, William David et al. · 2018 · Alzheimer s Research & Therapy
Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in humans at a dose of 30 mg. This was a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial evaluating the efficacy and safety of SAM-760 30 mg once daily (QD) for 12 weeks in subjects with AD on a stable regimen of donepezil 5 to 10 mg QD. The study included an interim analysis with stopping rules for futility or efficacy after 180 subjects comp
View details →Negative / Null Result ReportOpen accessMedicine
Péter Kupó, T Riesz, László Sághy et al. · 2023 · Journal of Cardiovascular Electrophysiology
INTRODUCTION: Routine ultrasound (US) guidance for femoral venous access to decrease vascular complications of atrial fibrillation (AF) ablation procedures has been advocated. However, the benefit has not been unequivocally demonstrated by randomized-trial data. METHODS: Consecutive patients undergoing pulmonary vein isolation (PVI) on uninterrupted anticoagulant treatment were included. A quasi-random allocation to either US-guided or conventional puncture group was based on which of the two procedure rooms the patient was scheduled in, with only one of the rooms equipped with a US machine in
View details →Negative / Null Result ReportOpen accessSocial Sciences
Stefan Stieger, Sabine Wunderl · 2022 · Computers in Human Behavior
In adolescence, smartphone use in general and social media use in particular has often been associated with negative effects, such as higher anxiety levels and body dissatisfaction. Other outcomes – such as fundamental cognitive abilities and skills (e.g., intelligence, information processing, spatial perception) – have rarely been the focus of research. Here, we analysed data from a large sample of adolescents (12–16 years; N > 12,000) who performed a series of psychometric tests ranging from intelligence, spatial perception, and information processing, to practical numeracy, and compared the
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Igor Calzada · 2020 · Smart Cities
This article addresses the problem of replication among smart cities in the European Commission’s Horizon 2020: Smart Cities and Communities (EC-H2020-SCC) framework programme. This article initially sets the general policy context by…
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David Houdoux, Axelle Amon, David Marsan et al. · 2021 · Communications Earth & Environment
Abstract Memory effects in seismology—such as the occurrence of aftershock sequences—are implicitly assumed to be governed by the time since the main event. However, experiments are yet to identify if memory effects are structural or…
View details →Negative / Null Result ReportMedicine
Sarah Moody, Leire Escudero‐Ibarz, Ming Wang et al. · 2017 · The Journal of Pathology
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends…
View details →Negative / Null Result ReportOpen accessMedicine
Janet M. Boekhout, Brenda Berendsen, Denise A. Peels et al. · 2018 · International Journal of Environmental Research and Public Health
This study explores the effectiveness of the Active Plus65 intervention designed to stimulate physical activity among single older adults with a chronic physical impairment. A quasi-experimental pre-test post-test study was performed. The intervention group (n = 411; mean age = 76.75; SD = 7.75) was assessed at baseline, three months, and six months. Data of comparable older adults who completed the original Active Plus intervention served as reference group (n = 87; mean age = 74.36; SD = 6.26). Multilevel regression analyses were applied: outcome measures were weekly minutes of moderate to v
View details →Negative / Null Result ReportPsychology
Chung-Yuan Hsu, Chin‐Chung Tsai · 2012 · Interactive Learning Environments
Abstract Educational researchers have indicated that although computer games have the potential to promote students' motivation and engagement, the work on how to design effective games that fulfil educational purposes is still in its…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Satoru Sugie, Shoichiro Mukai, Koji Yamasaki et al. · 2016 · PubMed
BACKGROUND/AIM: Up-regulation of caveolin (CAV)-1 is associated with aggressive prostate cancer. Recently, it has been inferred that CAV2, a co-factor sub-type of CAV1, cross-talks with CAV1 and promotes tumor growth. We previously…
View details →Negative / Null Result ReportNeuroscience
Fanxing Meng, Cristy Ho, Rob Gray et al. · 2014 · Ergonomics
Three experiments were conducted to assess the effectiveness of dynamic vibrotactile warning signals with different spatial patterns and to compare dynamic towards-torso and towards-head vibrotactile warnings in a simulated driving task.…
View details →Negative / Null Result Report
Timothy J. Layton, Andrew M. Ryan · 2015 · Health Services Research
Objective To evaluate the effects of the size of financial bonuses on quality of care and the number of plan offerings in the Medicare Advantage Quality Bonus Payment Demonstration. Data Sources Publicly available data from CMS from 2009…
View details →Negative / Null Result ReportOpen accessMedicine
Jawed Alam, Sankar Maiti, Prachetash Ghosh et al. · 2012 · Journal of Medical Microbiology
A novel virulence factor, duodenal ulcer-promoting gene A (dupA), in Helicobacter pylori has been found to be associated with disease in certain populations but not in others. This study analysed a South-east Indian population as part of…
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André S. Pereira, Eithne Kavanagh, Catherine Hobaiter et al. · 2020 · Biology Letters
Abstract Speech is a human hallmark, but its evolutionary origins continue to defy scientific explanation. Recently, the open–close mouth rhythm of 2–7 Hz (cycles/second) characteristic of all spoken languages has been identified in the…
View details →Negative / Null Result Report
Mikhail Ponomarenko, Dmitry Rasskazov, Olga Arkova et al. · 2015 · BioMed Research International
The use of biomedical SNP markers of diseases can improve effectiveness of treatment. Genotyping of patients with subsequent searching for SNPs more frequent than in norm is the only commonly accepted method for identification of SNP…
View details →Negative / Null Result Report
Karen Cristine Gonçalves dos Santos, Isabel Desgagné-Penix, Hugo Germain · 2020 · BMC Genomics
Abstract Background RNA sequencing allows the measuring of gene expression at a resolution unmet by expression arrays or RT-qPCR. It is however necessary to normalize sequencing data by library size, transcript size and composition, among…
View details →Negative / Null Result Report
Shuichi Matsuda, Hideki Mizu‐uchi, Shingo Fukagawa et al. · 2010 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract A prospective study was performed to compare the clinical and radiological results of mobile‐ and fixed‐bearing total knee arthroplasty with specific attention to rotational alignment and range of motion. Sixty‐one knees were…
View details →Negative / Null Result ReportOpen accessNursing
Todd W. Rice, D. Clark Files, Peter E. Morris et al. · 2018 · Journal of Parenteral and Enteral Nutrition
BACKGROUND: Enteral nutrition (EN) increases hyperglycemia due to high carbohydrate concentrations while providing insufficient protein. The study tested whether an EN formula with very high-protein- and low-carbohydrate-facilitated…
View details →Negative / Null Result ReportOpen accessMedicine
Arjan Kol, Anton Terwisscha van Scheltinga, Martin Pool et al. · 2017 · Oncotarget
// Arjan Kol 1 , Anton Terwisscha van Scheltinga 2 , Martin Pool 1 , Christian Gerdes 3 , Elisabeth de Vries 1 , Steven de Jong 1 1 Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 3 Roche Pharma Research & Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland Correspondence to: Steven de Jong, email: s.de.jong@umcg.nl Keywords: non-small cell lung cancer,
View details →Negative / Null Result ReportMedicine
Daisuke Nakamura, Tomohiro Suzuki, Mikinobu Yasumatsu et al. · 2011 · The Journal of Strength and Conditioning Research
Several investigators have reported the effects of reduced training and interrupted training on athletic performance, but few reports are available for soccer players. The purpose of this study was to examine, using the Yo-Yo intermittent…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sindrila Dutta Banik, Nilashis Nandi · 2012 · Journal of Biomolecular Structure and Dynamics
In the present work we report, for the first time, a novel difference in the molecular mechanism of the activation step of aminoacylation reaction between the class I and class II aminoacyl tRNA synthetases (aaRSs). The observed difference is in the mode of nucleophilic attack by the oxygen atom of the carboxylic group of the substrate amino acid (AA) to the αP atom of adenosine triphosphate (ATP). The syn oxygen atom of the carboxylic group attacks the α-phosphorous atom (αP) of ATP in all class I aaRSs (except TrpRS) investigated, while the anti oxygen atom attacks in the case of class II aa
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