Pre-Diagnostic Circulating Metabolites and Colorectal Cancer Risk in the Cancer Prevention Study-II Nutrition Cohort
Marjorie L. McCullough; Rebecca A. Hodge; Peter T. Campbell; Victoria L. Stevens; Ying Wang · 2021 · Metabolites
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Untargeted metabolomic studies have identified potential biomarkers of colorectal cancer risk, but evidence is still limited and broadly inconsistent. Among 39,239 Cancer Prevention Study II Nutrition cohort participants who provided a blood sample between 1998–2001, 517 newly diagnosed colorectal cancers were identified through 30 June 2015. In this nested case–control study, controls were matched 1:1 to cases on age, sex, race and date of blood draw. Mass spectroscopy-based metabolomic analyses of pre-diagnostic plasma identified 886 named metabolites, after quality control exclusions. Condi
Abstract by Marjorie L. McCullough; Rebecca A. Hodge; Peter T. Campbell; Victoria L. Stevens; Ying Wang, Metabolites (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/metabo11030156