21,681 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Grazia Crescimanno, Oreste Marrone, Andrea Vianello · 2011 · Respirology
BACKGROUND AND OBJECTIVE: Although non-invasive ventilation is widely used for the management of patients with neuromuscular disease, it remains unclear which ventilatory mode is associated with optimal patient-ventilator interaction and…
View details →Catarina Dinis Fernandes, Cuong V. Dinh, Iris Walraven et al. · 2018 · Physics and Imaging in Radiation Oncology
BACKGROUND AND PURPOSE: High-risk prostate cancer patients are frequently treated with external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15-35% will experience biochemical recurrence (BCR) within five years. Magnetic…
View details →Anouk Wouters, Gerda Croiset, Nienke R. Schripsema et al. · 2017 · Advances in Health Sciences Education
Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct admission based on top pre-university grade point averages (≥8 out of 10; top-pu-GPA). We also considered whether students had participated in selection, prior to being admitted through weighted lottery. Year-1 (pre-clinical) and Year-4 (clinical) stude
View details →Shun‐Long Weng, Wenjun Wu, Yi‐Hsuan Hsiao et al. · 2018 · International Journal of Medical Sciences
Up to date, no study explores the relationship of single nucleotide polymorphisms (SNPs) of long non-coding RNAs HOTAIR (lncRNAs HOTAIR) with cancer recurrence and patient survival in uterine cervical cancer for Taiwanese women. We…
View details →John T. Kanegaye, Jennifer M. Jacob, Denise Malicki · 2014 · PEDIATRICS
OBJECTIVE: The performance of automated flow cytometric urinalysis is not well described in pediatric urinary tract infection. We sought to determine the diagnostic performance of automated cell counts and emergency department…
View details →Mariama Jaiteh, Ismael Rodríguez‐Espigares, Jana Selent et al. · 2020 · PLoS Computational Biology
Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small number of available atomic resolution structures. We assessed the use of homology modeling to predict the structures of two therapeutically relevant GPCRs and strategies to improve the performance of virtual screening against modeled binding sites. Homology models of the D2 dopamine (D2R) and serotonin 5-HT2A receptors (5-HT2AR) were generated based on crystal structures of 16 different GPCRs. Comparison of the homology models to D2R and 5-HT2AR crystal structures showed that accurate predictions could be obta
View details →Jack Grieve · 2021 · Linguistics
Abstract In this paper, I propose that replication failure in linguistics may be due primarily to inherent issues with the application of experimental methods to analyze an inextricably social phenomenon like language, as opposed to poor…
View details →Fulya Akpinar, Andrea C. Timm, John Yin · 2015 · Journal of Virology
UNLABELLED: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth. In coinfections with helper virus, the diversion of viral proteins to the replication and packaging of DIP genomes can interfere…
View details →Mürşide Değirmenci, Yılmaz Kemal Yüce, Matjaž Perc et al. · 2023 · Frontiers in Human Neuroscience
In recent studies, in the field of Brain-Computer Interface (BCI), researchers have focused on Motor Imagery tasks. Motor Imagery-based electroencephalogram (EEG) signals provide the interaction and communication between the paralyzed patients and the outside world for moving and controlling external devices such as wheelchair and moving cursors. However, current approaches in the Motor Imagery-BCI system design require effective feature extraction methods and classification algorithms to acquire discriminative features from EEG signals due to the non-linear and non-stationary structure of EEG
View details →Jussi Palomäki, Anton Kunnari, Marianna Drosinou et al. · 2018 · Heliyon
The uncanny valley (UV) effect refers to an eerie feeling of unfamiliarity people get while observing or interacting with robots that resemble humans almost but not quite perfectly. The effect is not well understood, and it is also unclear…
View details →Sung-Min Kim, Yosoon Choi · 2017 · International Journal of Environmental Research and Public Health
To develop appropriate measures to prevent soil contamination in abandoned mining areas, an understanding of the spatial variation of the potentially toxic trace elements (PTEs) in the soil is necessary. For the purpose of effective soil sampling, this study uses hot spot analysis, which calculates a z-score based on the Getis-Ord Gi* statistic to identify a statistically significant hot spot sample. To constitute a statistically significant hot spot, a feature with a high value should also be surrounded by other features with high values. Using relatively cost- and time-effective portable X-r
View details →Vikram M. Narayan, Shreyas Gandhi, Kristin Chrouser et al. · 2018 · British Journal of Urology
OBJECTIVES: To use the Fragility Index to evaluate the robustness of statistically significant findings from urological randomised controlled trials (RCTs). MATERIALS AND METHODS: The 'Fragility Index' is defined as the minimum number of…
View details →Scott J. Young, Matteo Bertucco, Rebecca Sheehan-Stross et al. · 2012 · Journal of Child Neurology
Studies suggest that dystonia is associated with increased motor cortex excitability. Cathodal transcranial direct current stimulation can temporarily reduce motor cortex excitability. To test whether stimulation of the motor cortex can…
View details →Olenka Kacperczyk, Peter Younkin · 2021 · Organization Science
There is both widespread interest in encouraging entrepreneurship and universal recognition that the vast majority of these founders will fail, which raises an important unanswered question: What happens to ex-founders when they apply for…
View details →Sarah J. Higgins, Katharine He Xing, Hani Kim et al. · 2013 · Malaria Journal
BACKGROUND: Severe falciparum malaria (SM) pathogenesis has been attributed, in part, to deleterious systemic host inflammatory responses to infection. High mobility group box 1 (HMGB1) protein is an important mediator of inflammation implicated in sepsis pathophysiology. METHODS: Plasma levels of HMGB1 were quantified in a cohort of febrile Ugandan children with Plasmodium falciparum infection, enrolled in a prospective observational case-controlled study, using a commercial enzyme-linked immunosorbent assay. The utility of HMGB1 to distinguish severe malaria (SM; n = 70) from uncomplicated m
View details →Miles Piper, Benjamin Van Court, Adam Mueller et al. · 2021 · Clinical Cancer Research
PURPOSE: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular…
View details →Ivo M.B. Francischetti, Emile B. Gordon, Bruna Bizzarro et al. · 2014 · PLoS ONE
BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopo
View details →Ian R. Nelson, Jason Chen, Rebecca Love et al. · 2016 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Anterior cruciate ligament reconstructions (ACLRs) in skeletally immature patients are increasing. The purpose of this study is to describe the demographics, graft usage, revision, and re-operation rates in skeletally immature…
View details →Khurum Khan, David Cunningham, Clare Peckitt et al. · 2016 · Oncotarget
// Khurum Khan 1 , David Cunningham 1 , Clare Peckitt 1 , Sarah Barton 1 , Diana Tait 1 , Maria Hawkins 1,2 , David Watkins 1 , Naureen Starling 1 , Sheela Rao 1 , Ruwaida Begum 1 , Janet Thomas 1 , Jacqui Oates 1 , Vincenza Guzzardo 3 , Matteo Fassan 3 , Chiara Braconi 1,4 and Ian Chau 1 1 Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK 2 CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK 3 Department of Medicine, University of Padua, Padua, IT 4 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutt
View details →Hye Jun Lee, Jae Eun Lee, Seung‐Yup Ku et al. · 2013 · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
OBJECTIVE: To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS: We retrospectively studied 43 infertile women with…
View details →Bengt Sorbe, CHRISTIAN JURESTA, Cecilia Ahlin · 2014 · Oncology Letters
The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma…
View details →Ziad S. Saad, Derrek P. Hibar, Maggie Fedgchin et al. · 2020 · The International Journal of Neuropsychopharmacology
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has…
View details →Anna C. Navis, Sanne A. M. van Lith, Sander M. J. van Duijnhoven et al. · 2015 · Acta Neuropathologica
MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors are in clinical trials. We here describe a novel variant of MET that is expressed in 6% of high-grade gliomas. Characterization of this mutation in a glioma cell line revealed that it consists of an intronic deletion, resulting in a splice event connecting an intact splice donor site in exon 6 with
View details →Gonçalo N. Petrucci, Joaquim Henriques, Hugo Gregório et al. · 2020 · Journal of Feline Medicine and Surgery
Objectives Although feline mammary carcinomas (FMCs) are highly metastatic, the literature and treatment options pertaining to advanced tumours are scarce. This study aimed to investigate the clinical outcome of metastatic FMC with or…
View details →Kalijn F. Bol, Gerty Schreibelt, Martine Bloemendal et al. · 2024 · Nature Communications
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall surv
View details →Kyle J. Bednar, Elena Shanina, Romain Ballet et al. · 2017 · The Journal of Immunology
Abstract CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas…
View details →Ji‐Feng Feng, Liang Wang, Xun Yang et al. · 2019 · Cancer Management and Research
Background: We firstly identified a combination of lactate dehydrogenase (LDH) along with albumin (ALB), which was defined as LAR (LDH/ALB ratio). The purpose of our study here was initially to explore the prognostic role of LAR in…
View details →Anwaar Saeed, Robin Park, Harsh B. Pathak et al. · 2024 · Nature Communications
CAMILLA is a basket trial (NCT03539822) evaluating cabozantinib plus the ICI durvalumab in chemorefractory gastrointestinal cancer. Herein, are the phase II colorectal cohort results. 29 patients were evaluable. 100% had confirmed pMMR/MSS tumors. Primary endpoint was met with ORR of 27.6% (95% CI 12.7-47.2%). Secondary endpoints of 4-month PFS rate was 44.83% (95% CI 26.5-64.3%); and median OS was 9.1 months (95% CI 5.8-20.2). Grade≥3 TRAE occurred in 39%. In post-hoc analysis of patients with RAS wild type tumors, ORR was 50% and median PFS and OS were 6.3 and 21.5 months respectively. Explo
View details →Jing Wang, Ting Xu, Lirong Wu et al. · 2022 · JTO Clinical and Research Reports
IntroductionDurvalumab after concurrent chemoradiation (CCRT) for NSCLC improves survival, but only in a subset of patients. We investigated the effect of severe radiation-induced lymphopenia (sRIL) on survival in these…
View details →Koji Matsuo, Muneaki Shimada, Harushige Yokota et al. · 2017 · Oncotarget
// Koji Matsuo 1, 2, * , Muneaki Shimada 3, 4, * , Harushige Yokota 5 , Toyomi Satoh 6 , Hidetaka Katabuchi 7 , Shoji Kodama 8, 9 , Hiroshi Sasaki 10, 11 , Noriomi Matsumura 12, 13 , Mikio Mikami 14 and Toru Sugiyama 15 1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA 2 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA 3 Department of Obstetrics and Gynecology, Tottori University, Tottori, Japan 4 Current affiliation: Department of Obstetrics and Gynecology, Tohoku Univ
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