Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sarah J. Higgins, Katharine He Xing, Hani Kim et al. · 2013 · Malaria Journal
BACKGROUND: Severe falciparum malaria (SM) pathogenesis has been attributed, in part, to deleterious systemic host inflammatory responses to infection. High mobility group box 1 (HMGB1) protein is an important mediator of inflammation implicated in sepsis pathophysiology. METHODS: Plasma levels of HMGB1 were quantified in a cohort of febrile Ugandan children with Plasmodium falciparum infection, enrolled in a prospective observational case-controlled study, using a commercial enzyme-linked immunosorbent assay. The utility of HMGB1 to distinguish severe malaria (SM; n = 70) from uncomplicated m
View details →Negative / Null Result ReportOpen accessMedicine
Miles Piper, Benjamin Van Court, Adam Mueller et al. · 2021 · Clinical Cancer Research
PURPOSE: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular…
View details →Negative / Null Result ReportOpen accessMedicine
Ivo M.B. Francischetti, Emile B. Gordon, Bruna Bizzarro et al. · 2014 · PLoS ONE
BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopo
View details →Negative / Null Result ReportMedicine
Ian R. Nelson, Jason Chen, Rebecca Love et al. · 2016 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Anterior cruciate ligament reconstructions (ACLRs) in skeletally immature patients are increasing. The purpose of this study is to describe the demographics, graft usage, revision, and re-operation rates in skeletally immature…
View details →Negative / Null Result ReportOpen accessMedicine
Khurum Khan, David Cunningham, Clare Peckitt et al. · 2016 · Oncotarget
// Khurum Khan 1 , David Cunningham 1 , Clare Peckitt 1 , Sarah Barton 1 , Diana Tait 1 , Maria Hawkins 1,2 , David Watkins 1 , Naureen Starling 1 , Sheela Rao 1 , Ruwaida Begum 1 , Janet Thomas 1 , Jacqui Oates 1 , Vincenza Guzzardo 3 , Matteo Fassan 3 , Chiara Braconi 1,4 and Ian Chau 1 1 Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK 2 CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK 3 Department of Medicine, University of Padua, Padua, IT 4 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutt
View details →Negative / Null Result ReportOpen accessMedicine
Hye Jun Lee, Jae Eun Lee, Seung‐Yup Ku et al. · 2013 · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
OBJECTIVE: To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS: We retrospectively studied 43 infertile women with…
View details →Negative / Null Result ReportOpen accessMedicine
Bengt Sorbe, CHRISTIAN JURESTA, Cecilia Ahlin · 2014 · Oncology Letters
The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma…
View details →Negative / Null Result ReportOpen accessMedicine
Ziad S. Saad, Derrek P. Hibar, Maggie Fedgchin et al. · 2020 · The International Journal of Neuropsychopharmacology
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has…
View details →Negative / Null Result ReportOpen accessMedicine
Anna C. Navis, Sanne A. M. van Lith, Sander M. J. van Duijnhoven et al. · 2015 · Acta Neuropathologica
MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors are in clinical trials. We here describe a novel variant of MET that is expressed in 6% of high-grade gliomas. Characterization of this mutation in a glioma cell line revealed that it consists of an intronic deletion, resulting in a splice event connecting an intact splice donor site in exon 6 with
View details →Negative / Null Result ReportOpen accessMedicine
Gonçalo N. Petrucci, Joaquim Henriques, Hugo Gregório et al. · 2020 · Journal of Feline Medicine and Surgery
Objectives Although feline mammary carcinomas (FMCs) are highly metastatic, the literature and treatment options pertaining to advanced tumours are scarce. This study aimed to investigate the clinical outcome of metastatic FMC with or…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Kalijn F. Bol, Gerty Schreibelt, Martine Bloemendal et al. · 2024 · Nature Communications
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall surv
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kyle J. Bednar, Elena Shanina, Romain Ballet et al. · 2017 · The Journal of Immunology
Abstract CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas…
View details →Negative / Null Result ReportOpen accessMedicine
Ji‐Feng Feng, Liang Wang, Xun Yang et al. · 2019 · Cancer Management and Research
Background: We firstly identified a combination of lactate dehydrogenase (LDH) along with albumin (ALB), which was defined as LAR (LDH/ALB ratio). The purpose of our study here was initially to explore the prognostic role of LAR in…
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Anwaar Saeed, Robin Park, Harsh B. Pathak et al. · 2024 · Nature Communications
CAMILLA is a basket trial (NCT03539822) evaluating cabozantinib plus the ICI durvalumab in chemorefractory gastrointestinal cancer. Herein, are the phase II colorectal cohort results. 29 patients were evaluable. 100% had confirmed pMMR/MSS tumors. Primary endpoint was met with ORR of 27.6% (95% CI 12.7-47.2%). Secondary endpoints of 4-month PFS rate was 44.83% (95% CI 26.5-64.3%); and median OS was 9.1 months (95% CI 5.8-20.2). Grade≥3 TRAE occurred in 39%. In post-hoc analysis of patients with RAS wild type tumors, ORR was 50% and median PFS and OS were 6.3 and 21.5 months respectively. Explo
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Jing Wang, Ting Xu, Lirong Wu et al. · 2022 · JTO Clinical and Research Reports
IntroductionDurvalumab after concurrent chemoradiation (CCRT) for NSCLC improves survival, but only in a subset of patients. We investigated the effect of severe radiation-induced lymphopenia (sRIL) on survival in these…
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Koji Matsuo, Muneaki Shimada, Harushige Yokota et al. · 2017 · Oncotarget
// Koji Matsuo 1, 2, * , Muneaki Shimada 3, 4, * , Harushige Yokota 5 , Toyomi Satoh 6 , Hidetaka Katabuchi 7 , Shoji Kodama 8, 9 , Hiroshi Sasaki 10, 11 , Noriomi Matsumura 12, 13 , Mikio Mikami 14 and Toru Sugiyama 15 1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA 2 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA 3 Department of Obstetrics and Gynecology, Tottori University, Tottori, Japan 4 Current affiliation: Department of Obstetrics and Gynecology, Tohoku Univ
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Bertrand Sauneuf, Benoît Champigneulle, Alexis Soummer et al. · 2013 · Critical Care
INTRODUCTION: The overall outcome of septic shock has been recently improved. We sought to determine whether this survival gain extends to the high-risk subgroup of patients with cirrhosis. METHODS: Cirrhotic patients with septic shock admitted to a medical intensive care unit (ICU) during two consecutive periods (1997-2004 and 2005-2010) were retrospectively studied. RESULTS: Forty-seven and 42 cirrhotic patients presented with septic shock in 1997-2004 and 2005-2010, respectively. The recent period differed from the previous one by implementation of adjuvant treatments of septic shock includ
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Mats Enlund, Anders Berglund, Anna Enlund et al. · 2023 · EClinicalMedicine
Background: Anaesthesia may impact long-term cancer survival. In the Cancer and Anaesthesia study, we hypothesised that the hypnotic drug propofol will have an advantage of at least five percentage points in five-year survival over the inhalational anaesthetic sevoflurane for breast cancer surgery. Methods: From 2118 eligible breast cancer patients scheduled for primary curable, invasive breast cancer surgery, 1764 were recruited after ethical approval and individual informed consent to this open label, single-blind, randomised trial at four county- and three university hospitals in Sweden and
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Kristen Starbuck, Linah Al-Alem, David A. Eavarone et al. · 2018 · Oncotarget
// Kristen Starbuck 1, 4 , Linah Al-Alem 1, 4 , David A. Eavarone 2 , Silvia Fatima Hernandez 1, 4 , Chiara Bellio 1, 4 , Jillian M. Prendergast 2 , Jenna Stein 2 , Daniel T. Dransfield 2 , Bianca Zarrella 1 , Whitfield B. Growdon 1, 3, 4 , Jeff Behrens 2 , Rosemary Foster 1, 3, 4, * and Bo R. Rueda 1, 3, 4, * 1 Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA 2 Siamab Therapeutics, Inc., Newton, MA, USA 3 Division of Gynecologic Oncology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hosp
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fengling Zhang, Xingjia Xiang, Yuanqiu Dong et al. · 2020 · Animals
Intestinal bacterial communities form an integral component of the organism. Many factors influence gut bacterial community composition and diversity, including diet, environment and seasonality. During seasonal migration, birds use many habitats and food resources, which may influence their intestinal bacterial community structure. Hooded crane (Grus monacha) is a migrant waterbird that traverses long distances and occupies varied habitats. In this study, we investigated the diversity and differences in intestinal bacterial communities of hooded cranes over the migratory seasons. Fecal sample
View details →Negative / Null Result ReportMedicine
Hasan Akın, Aysun Ölçmen, Özgür İşgörücü et al. · 2011 · The Thoracic and Cardiovascular Surgeon
Mediastinal lymph node dissection, an important part of surgery for non-small cell lung cancer, is associated with a risk of chylothorax. Although mortality has significantly decreased in recent years, it still worries thoracic surgeons.…
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Joji Suzuki, Jeffrey DeVido, Inder Kalra et al. · 2015 · American Journal on Addictions
BACKGROUND AND OBJECTIVES: Opioid dependent patients are hospitalized frequently. We aimed to determine if initiation of buprenorphine treatment during hospitalization facilitates entry into treatment following discharge. METHODS:…
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Peter C. Banacos, Michael L. Ekster · 2010 · Weather and Forecasting
Abstract The occurrence of rare but significant severe weather events associated with elevated mixed-layer (EML) air in the northeastern United States is investigated herein. A total of 447 convective event days with one or more…
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Yue Du, Ying‐Ping Wang, Dafeng Hui et al. · 2022 · Global Change Biology
Abstract Global warming intensifies the hydrological cycle, which results in changes in precipitation regime (frequency and amount), and will likely have significant impacts on soil respiration ( R s ). Although the responses of R s to…
View details →Negative / Null Result ReportSocial Sciences
Jolanda Jetten, S. Alexander Haslam, Fiona Kate Barlow · 2012 · Social Psychological and Personality Science
Why are conservatives happier than liberals? Napier and Jost (2008) argue that this is because conservative ideology has a palliative (system-justifying) function that protects conservatives’ (but not liberals’) happiness. We develop…
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Haidong Zheng, Yue Zhang · 2016 · Chinese Management Studies
Purpose The purpose of this paper is to explore the relationship between firm size, the nature of ownership and corporate social responsibility (CSR) performance in China and to figure out the reason that state-owned enterprises (SOEs)…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Salim Khan, Wang Yahong · 2021 · Frontiers in Environmental Science
Several researchers have studied the relationship between poverty and environmental degradation, as these concerns are remained at top priority in achieving Sustainable Development Goals (SDGs). However, the symmetric and asymmetric impact of poverty and income inequality along with population and economic growth on carbon emissions (CO 2 e) has not been studied in the case of Pakistan. For this purpose, the short and long-run impact of poverty, income inequality, population, and GDP per capita on CO 2 e investigated by applying the Autoregressive Distributive Lag (ARDL) along with Non-linear
View details →Negative / Null Result ReportOpen accessHealth Professions
Hamzah Abdul Rahman, Mu’taman Jarrar, Mohammad Sobri Don · 2015 · Global Journal of Health Science
BACKGROUND AND OBJECTIVE: Nursing knowledge and skills are required to sustain quality of care and patient safety. The numbers of nurses with Bachelor degrees in Malaysia are very limited. This study aims to predict the impact of nurse level of education on quality of care and patient safety in the medical and surgical wards in Malaysian private hospitals. METHODOLOGY: A cross-sectional survey by questionnaire was conducted. A total 652 nurses working in the medical and surgical wards in 12 private hospitals were participated in the study. Multistage stratified simple random sampling performed
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Reina Yamaji, Shinya Yamada, Mai Quynh Le et al. · 2015 · Journal of Virology
UNLABELLED: Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Ulrike Fasbender, Anne Burmeister, Mo Wang · 2023 · Journal of Vocational Behavior
In this paper, we investigate the risks and side effects of workplace friendships for coworkers. Combining the dialectical perspective on workplace friendships with a self-regulatory perspective, we argue that workplace friendships can…
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