Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria
Sarah J. Higgins; Katharine He Xing; Hani Kim; Dylan Kain; Feng Wang; Aggrey Dhabangi; Charles Musoke; Christine Cserti‐Gazdewich · 2013 · Malaria Journal
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Severe falciparum malaria (SM) pathogenesis has been attributed, in part, to deleterious systemic host inflammatory responses to infection. High mobility group box 1 (HMGB1) protein is an important mediator of inflammation implicated in sepsis pathophysiology. METHODS: Plasma levels of HMGB1 were quantified in a cohort of febrile Ugandan children with Plasmodium falciparum infection, enrolled in a prospective observational case-controlled study, using a commercial enzyme-linked immunosorbent assay. The utility of HMGB1 to distinguish severe malaria (SM; n = 70) from uncomplicated m
Abstract by Sarah J. Higgins; Katharine He Xing; Hani Kim; Dylan Kain; Feng Wang; Aggrey Dhabangi; Charles Musoke; Christine Cserti‐Gazdewich, Malaria Journal (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1475-2875-12-105