21,222 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Glenn I. Roisman, Cathryn Booth‐LaForce, Jay Belsky et al. · 2013 · Attachment & Human Development
This paper advises caution in relation to the increasing interest in molecular-genetic association studies in developmental psychology based on a set of empirical examples from the NICHD Study of Early Child Care and Youth Development…
View details →Fei Tian, Yanting Shen, Zhenzhu Chen et al. · 2017 · BioMed Research International
BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that are involved in many biological regulation processes. Studies have reported that miRNAs are enriched in human plasma and plasma-derived exosome as novel diagnostic biomarkers. The aim of this study was to determine whether the miRNA expression levels are different between plasma and plasma-derived exosome. METHODS: We sequenced and quantified the miRNAs in plasma and exosome from healthy blood samples and validated three miRNAs in the two groups of lung cancer samples by qRT-PCR. RESULTS: The sequencing results showed that only sever
View details →Jessica E. Salvatore, Alexis C. Edwards, Jeanette N. McClintick et al. · 2015 · Translational Psychiatry
Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case-control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumi
View details →Amparo Ferrero, Ana Esplugues, Marisa Estarlich et al. · 2017 · Environmental Pollution
derived from a lifetime risk of leukemia above 1/100 000. Monitoring season, maternal country of birth and parental tobacco consumption were associated with residential benzene exposure (indoor and outdoors). Additionally, indoor levels…
View details →Chunyan Wang, Bernardo A. Huberman · 2012 · Scientific Reports
The massive amounts of data that social media generates has facilitated the study of online human behavior on a scale unimaginable a few years ago. At the same time, the much discussed apparent randomness with which people interact online…
View details →Sarah Cockayne, Caroline Fairhurst, Joy Adamson et al. · 2017 · Trials
BACKGROUND: Randomised controlled trials are generally regarded as the 'gold standard' experimental design to determine the effectiveness of an intervention. Unfortunately, many trials either fail to recruit sufficient numbers of participants, or recruitment takes longer than anticipated. The current embedded trial evaluates the effectiveness of optimised patient information sheets on recruitment of participants in a falls prevention trial. METHODS: A three-arm, embedded randomised methodology trial was conducted within the National Institute for Health Research-funded REducing Falls with ORth
View details →Juliane Jaitner, Tanja Morath, Robert A. Byrne et al. · 2012 · Circulation Cardiovascular Interventions
BACKGROUND: The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T,…
View details →Lisa M. DeBruine, Benedict C. Jones, David A. Frederick et al. · 2010 · Evolutionary Psychology
Over the last decade, a growing literature has shown that women in the fertile phase of the menstrual cycle demonstrate stronger preferences for men with masculine traits than they do when in the non-fertile phases of the cycle (see…
View details →Matthew A. Thomas, Benjamin B. Mirus, Joel B. Smith · 2020 · Hydrological Processes
Abstract The devastating impacts of the widespread flooding and landsliding in Puerto Rico following the September 2017 landfall of Hurricane Maria highlight the increasingly extreme atmospheric disturbances and enhanced hazard potential…
View details →Daisuke Hamada, Masataka Nakayama, Jun Saiki · 2020 · Cognitive Research Principles and Implications
BACKGROUND: The wisdom of crowds and collective decision-making are important tools for integrating information between individuals, which can exceed the capacity of individual judgments. They are based on different forms of information integration. The wisdom of crowds refers to the aggregation of many independent judgments without deliberation and consensus, while collective decision-making is aggregation with deliberation and consensus. Recent research has shown that collective decision-making outperforms the wisdom of crowds. Additionally, many studies have shown that metacognitive knowled
View details →Susanne R. Youngren-Ortiz, David B. Hill, Peter Hoffmann et al. · 2017 · Journal of Aerosol Medicine and Pulmonary Drug Delivery
BACKGROUND: Aerosol delivery of chemotherapeutic nanocarriers represents a promising alternative for lung cancer therapy. This study optimized gemcitabine (Gem)-loaded gelatin nanocarriers (GNCs) cross-linked with genipin (Gem-GNCs) to…
View details →Marcos S. Lopes, H. Bovenhuis, Maren van Son et al. · 2017 · Journal of Animal Science
The first attempts of applying marker-assisted selection (MAS) in animal breeding were not very successful because the identification of markers closely linked to QTL using low-density microsatellite panels was difficult. More recently,…
View details →Janet H. Hsiao, Jeehye An, Yueyuan Zheng et al. · 2021 · Cognition
Recent research has suggested the importance of part-based information in face recognition in addition to global, whole-face information. Nevertheless, face drawing experience was reported to enhance selective attention to the eyes but did…
View details →Subin Park, Ki Kyoung Yi, Riji Na et al. · 2013 · Behavioral and Brain Functions
BACKGROUND: Previous research on serum total cholesterol and suicidality has yielded conflicting results. Several studies have reported a link between low serum total cholesterol and suicidality, whereas others have failed to replicate these findings, particularly in patients with major affective disorders. These discordant findings may reflect the fact that studies often do not distinguish between patients with bipolar and unipolar depression; moreover, definitions and classification schemes for suicide attempts in the literature vary widely. METHODS: Subjects were patients with one of the th
View details →Vanessa Pitz, Mary B. Makarious, Sara Bandrés‐Ciga et al. · 2024 · npj Parkinson s Disease
Although many rare variants have been reportedly associated with Parkinson's disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants. We assessed a total of 27,590 PD cases, 6701 PD proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, and AMP-PD. Based on well-known PD genes, 834 variants of interest were selected from the ClinVar annotated 23andMe dataset. We performed a meta-analysis using summary statistics of all three studies. The meta-analysis resulted in five significant variants
View details →Maximilian J. Mair, Barbara Kiesel, Katharina Feldmann et al. · 2021 · Journal of Neuro-Oncology
PURPOSE: Immune modulatory therapies including immune checkpoint inhibitors have so far failed to result in clinically meaningful efficacy in glioma. We aimed to investigate lymphocyte activation gene 3 (LAG-3), an inhibitory receptor on immune cells and target of second-generation immune checkpoint inhibitors, in glioma. METHODS: 97 patients with diffuse glioma (68 with glioblastoma, 29 with WHO grade II-III glioma) were identified from the Neuro-Biobank of the Medical University of Vienna. LAG-3 expression in the inflammatory microenvironment was assessed by immunohistochemistry (monoclonal
View details →James E. Hines, James D. Nichols, Jaime A. Collazo · 2014 · Methods in Ecology and Evolution
Summary Occupancy surveys collecting data from adjacent (sometimes correlated) spatial replicates have become relatively popular for logistical reasons. Hines et al . ( ) presented one approach to modelling such data for single‐season…
View details →Lingjun Zuo, Xiangyang Zhang, Fei Wang et al. · 2012 · Alcoholism Clinical and Experimental Research
BACKGROUND: Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors. METHODS: We searched for significant risk genomic regions…
View details →Teshome Elshaday, Debela Kenenisa, Sultan Mohammed · 2018 · AFRICAN JOURNAL OF BUSINESS MANAGEMENT
This study aims at examining the determinants of the financial performance of private commercial banks in Ethiopia. The study uses secondary data for eight private banks which are in the industry for more than ten years. These banks are chosen from sixteen private commercial banks which are currently functional in Ethiopia banking industry. The data for this study is obtained from annual reports of the banks, minutes and the national bank report. Correlation and multiple linear regressions of panel data for the eight banks for the years 2007 to 2016 is analyzed using random effect model. E-Vie
View details →Rishikesh Kankesh Patel, James Brouner, Owen Spendiff · 2015 · Journal of the International Society of Sports Nutrition
BACKGROUND: Dark chocolate (DC) is abundant in flavanols which have been reported to increase the bioavailability and bioactivity of nitric oxide (NO). Increasing NO bioavailability has often demonstrated reduced oxygen cost and performance enhancement during submaximal exercise. METHODS: Nine moderately-trained male participants volunteered to undertake baseline (BL) measurements that comprised a cycle V̇O(2max) test followed by cycling at 80% of their established gas exchange threshold (GET) for 20-min and then immediately followed by a two-minute time-trial (TT). Using a randomised crossove
View details →Robert Z. Tashjian, Rahul Banerjee, Michael P. Bradley et al. · 2010 · The Journal of Knee Surgery
Sixty-eight patients undergoing outpatient knee arthroscopy for treatment of meniscal tears or loose bodies were divided into three treatment groups (zolpidem [24 patients], control [24 patients], and placebo [20 patients]). All groups…
View details →Tia Stevens Andersen · 2015 · Criminal Justice and Behavior
Missing from the considerable body of literature on disproportionate minority contact is an examination of the factors that influence risk of juvenile arrest. Using the National Longitudinal Survey of Youth 1997, the author examines…
View details →Zhiyong Liu, Weitao Yao, Yao Zhao et al. · 2021 · Cancer Management and Research
PURPOSE: Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients with advanced soft tissue sarcomas (STS) in China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The…
View details →Yoon‐Koo Kang, Yung‐Jue Bang, Shunsuke Kondo et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Patients with advanced gastric/gastroesophageal junction cancer (GC/GEJC) have limited treatment options after first-line therapy. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the…
View details →Wenshu Tang, Cario W. S. Lo, Wei Ma et al. · 2024 · Cell & Bioscience
BACKGROUND: Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1-4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and their complex interplays within the glioma environment remain poorly understood, and reliable prognostic markers remain elusive. Therefore, in-depth exploration of the tumor microenvironment (TME) and identification of predictive markers are crucial for improving the clinical management of glioma patients. RE
View details →Cristian Ricci, Jeannine Baumgartner, Manja Zec et al. · 2018 · British Journal Of Nutrition
Accumulating evidence indicates that saturated fat intake is related to mortality risk increase, whereas unsaturated fat intake is associated with reduced mortality risk. The aim of the present study was to estimate the mortality risk…
View details →Chetan Shenoy, Judy Boura, Pamela Orshaw et al. · 2010 · PLoS ONE
BACKGROUND: Chronic kidney disease (CKD) is strongly associated with adverse outcomes after percutaneous coronary intervention (PCI). There are limited data on the effectiveness of drug-eluting stents (DES) in patients with CKD. METHODOLOGY/PRINCIPAL FINDINGS: Of 3,752 consecutive patients enrolled in the Guthrie PCI Registry between 2001 and 2006, 436 patients with CKD - defined as a creatinine clearance <60 mL/min - were included in this study. Patients who received DES were compared to those who received bare metal stents (BMS). Patients were followed for a mean duration of 3 years after th
View details →Kanan Patel, Gregg C. Fonarow, Dalane W. Kitzman et al. · 2012 · European Journal of Heart Failure
AIMS: To examine the clinical effectiveness of angiotensin receptor blockers (ARBs) in older patients with heart failure and preserved ejection fraction (HF-PEF). METHODS AND RESULTS: Of the 10 570 hospitalized HF-PEF patients, aged ≥ 65…
View details →Sabrina Arnold, A. Richard Kitching, Véronique Witko‐Sarsat et al. · 2024 · The Lancet Rheumatology
Myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (MPO-ANCA-associated vasculitis) is one of two major ANCA-associated vasculitis variants characterised by systemic necrotising vasculitis with few or no immune deposits. MPO-ANCA-associated vasculitis predominantly affects small blood vessels and, in contrast to its counterpart proteinase 3-ANCA-associated vasculitis, is generally not associated with granulomatous inflammation. The kidneys and lungs are the most commonly affected organs. The pathogenesis of MPO-ANCA-associated vasculitis is characte
View details →Henrik Falconer, Ulrika Joneborg, Kamilla Krawiec et al. · 2020 · Gynecologic Oncology
OBJECTIVE: Ultra-radical surgery to achieve complete resection in advanced epithelial ovarian cancer (EOC) has been widely accepted without strong supporting data. Our objective was to assess overall survival after a structured shift to an ultra-radical upfront surgical treatment algorithm and to investigate changes in the distribution of primary treatments after this shift. PATIENTS AND METHODS: In this population-based cohort study, all women with suspected EOC in the Stockholm-Gotland region of Sweden reported to the Swedish Quality Registry for Gynecologic Cancer (SQRGC) and National Cance
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