Negative / Null Result ReportOpen accessMedicine
Mark Thalgott, Thomas Horn, Matthias Heck et al. · 2014 · Journal of Hematology & Oncology
BACKGROUND: Patients with locally advanced and high-risk prostate cancer (LAPC) are prone to experience biochemical recurrence despite radical prostatectomy (RP). We evaluated feasibility, safety and activity of a neoadjuvant chemohormonal therapy (NCHT) with 3-weekly full dose docetaxel and complete androgen blockade (CAB) in locally advanced and high-risk prostate cancer patients (LAPC) undergoing RP. METHODS: Patients (n = 30) were selected by Kattans' preoperative score and received trimestral buserelin 9,45 mg, bicalutamide 50 mg/day and 3 cycles docetaxel (75 mg/m²) followed by RP. Prima
View details →Negative / Null Result ReportOpen accessMedicine
Brigitte Leeners, Tillmann H. C. Krüger, Kirsten Geraedts et al. · 2017 · Frontiers in Behavioral Neuroscience
Background: Interpretation of observational studies on associations between prefrontal cognitive functioning and hormone levels across the female menstrual cycle is complicated due to small sample sizes and poor replicability. Methods: This observational multisite study comprised data of n=88 menstruating women from Hannover, Germany, and Zurich, Switzerland, assessed during a first cycle and n=68 re-assessed during a second cycle to rule out practice effects and false-positive chance findings. We assessed visuospatial working memory, attention, cognitive bias and hormone levels at four consec
View details →Negative / Null Result ReportOpen accessSocial Sciences
Alexis V. Knaub, Kathleen Foote, Charles Henderson et al. · 2016 · International Journal of STEM Education
The characteristics of the classroom environment play an important role in shaping teaching practices and supporting research-based instructional strategies. One instructional strategy that has reimagined the classroom is the Student-Centered Active Learning Environment with Upside-Down Pedagogies (SCALE-UP). SCALE-UP uses studio-style instruction to facilitate student collaboration. Although there is significant interest in studio-style instruction, there is not much research-based guidance available for institutions interested in setting up a classroom, especially for secondary users interes
View details →Negative / Null Result ReportOpen accessMedicine
Agatha Lenartowicz, Holly Truong, Giulia C. Salgari et al. · 2019 · Journal of Child Psychology and Psychiatry
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in…
View details →Failed Experiment ReportPhysics and Astronomy
V. K. Dixit, S. Porwal, S. D. Singh et al. · 2014 · Journal of Physics D Applied Physics
Temperature dependence of the photoluminescence (PL) peak energy of bulk and quantum well (QW) structures is studied by using a new phenomenological model for including the effect of localized states. In general an anomalous S-shaped…
View details →Replication FailureDecision Sciences
Marc-André Goulet, Denis Cousineau · 2019 · Advances in Methods and Practices in Psychological Science
When running statistical tests, researchers can commit a Type II error, that is, fail to reject the null hypothesis when it is false. To diminish the probability of committing a Type II error (β), statistical power must be augmented.…
View details →Negative / Null Result ReportOpen accessComputer Science
Marco Roccetti, Giovanni Delnevo, Luca Casini et al. · 2021 · Journal Of Big Data
Abstract Deep learning models are tools for data analysis suitable for approximating (non-linear) relationships among variables for the best prediction of an outcome. While these models can be used to answer many important questions, their utility is still harshly criticized, being extremely challenging to identify which data descriptors are the most adequate to represent a given specific phenomenon of interest. With a recent experience in the development of a deep learning model designed to detect failures in mechanical water meter devices, we have learnt that a sensible deterioration of the
View details →Replication FailureOpen accessMedicine
Benjamin Baker, Ashish Bhalla, Brett Doleman et al. · 2016 · Medical Teacher
INTRODUCTION: Simulation-based training (SBT) has become an increasingly important method by which doctors learn. Stress has an impact upon learning, performance, technical, and non-technical skills. However, there are currently no studies that compare stress in the clinical and simulated environment. We aimed to compare objective (heart rate variability, HRV) and subjective (state trait anxiety inventory, STAI) measures of stress theatre with a simulated environment. METHODS: HRV recordings were obtained from eight anesthetic trainees performing an uncomplicated rapid sequence induction at pr
View details →Replication FailureSocial Sciences
John P. Crowley, Ryan Allred, Julianna Follon et al. · 2018 · Communication Studies
Research on the mere presence hypothesis shows mixed findings for the effects of cell phone presence on various conversation outcomes. The current study performed a partial replication of Przybylski and Weinstein’s (2013) study, which…
View details →Failed Experiment ReportOpen accessMedicine
Arafat Tfayli, Majd Al Assaad, Ghina Fakhri et al. · 2020 · Cancer Medicine
Multiple randomized studies have shown that combination of chemotherapy and immune checkpoint inhibitors (ICIs) leads to better response rates and survival as compared to chemotherapy alone in the advanced stage of NSCLC. Data suggesting a benefit to using ICIs in the neoadjuvant therapy of patients with early stage NSCLC are emerging. Eligible subjects were treatment naïve patients with stage IB, II, and resectable IIIA NSCLC. Patients received three cycles of neoadjuvant chemotherapy with four doses of avelumab every 2 weeks. Patients with squamous cell cancer received cisplatin or carboplat
View details →Negative / Null Result ReportOpen accessMedicine
Kayleigh N. McCarty, David H. Morris, Laura E. Hatz et al. · 2017 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: The UPPS-P model posits that impulsivity comprises five factors: positive urgency, negative urgency, lack of planning, lack of perseverance, and sensation seeking. Negative and positive urgency are the traits most consistently…
View details →Negative / Null Result ReportPsychology
Stephen R. Shirk, Anne P. DePrince, Patrice S. Crisostomo et al. · 2013 · Psychotherapy
Four clinical trials have shown that a history of interpersonal trauma is associated with diminished response to cognitive-behavioral therapy (CBT) for adolescent depression. An efficacious CBT protocol for adolescent depression was…
View details →Negative / Null Result ReportOpen accessMedicine
Sara Galimberti, Mario Petrini, Claudia Baratè et al. · 2020 · Frontiers in Oncology
SARS-CoV-2 is the viral agent responsible for the pandemic that in the first months of 2020 caused about 400,000 deaths. Among compounds proposed to fight the SARS-CoV-2-related disease (COVID-19), tyrosine kinase inhibitors (TKIs), already effective in Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML), have been proposed on the basis of their antiviral action already demonstrated against SARS-CoV-1. Very few cases of COVID-19 have been reported in Ph+ ALL and in CML Italian cohorts; authors suggested that this low rate of infections might depend f
View details →Negative / Null Result ReportOpen accessNeuroscience
Colin Quirk, Kirsten Adam, Edward K. Vogel · 2020 · eNeuro
Visual working memory is the ability to hold visual information temporarily in mind. A key feature of working memory is its starkly limited capacity, such that only a few simple items can be remembered at once. Prior work has shown that this capacity limit cannot be circumvented by providing additional encoding time, whether providing just 200 ms or up to 1300 ms, capacity is still limited to only three to four items. In contrast, Brady et al. (2016) hypothesized that real-world objects, but not simple items used in prior research, benefit from additional encoding time and are not subject to t
View details →Negative / Null Result ReportOpen accessMedicine
Charles Sharp, Huzaifa Adamali, Ann Millar · 2017 · ERJ Open Research
Idiopathic pulmonary fibrosis (IPF) has an unpredictable course and prognostic factors are incompletely understood. We aimed to identify prognostic factors, including multidimensional indices from a significant IPF cohort at the Bristol…
View details →Negative / Null Result ReportMedicine
Soenke Böettger, David García Núñez, Rafael Meyer et al. · 2017 · Palliative & Supportive Care
BACKGROUND: In the intensive care setting, delirium is a common occurrence that comes with subsequent adversities. Therefore, several instruments have been developed to screen for and detect delirium. Their validity and psychometric…
View details →Negative / Null Result ReportOpen accessMedicine
Karin Bammann, Nicola K. Thomson, Birte Marie Albrecht et al. · 2021 · PLoS ONE
The study of physical activity in older adults is becoming more and more relevant. For evaluation of physical activity recommendations, intensity-specific accelerometer cut-points are utilized. However, research on accelerometer cut-points for older adults is still scarce. The aim of the study was to generate placement-specific cut-points of ActiGraph GT3X+ activity counts and raw measures of acceleration to determine physical activity intensity in older adults. A further aim was to compare the validity of the generated cut-points for a range of different physical activities. The study was a s
View details →Negative / Null Result ReportOpen accessComputer Science
Xinsong Du, John Novoa-Laurentiev, Joseph M. Plasek et al. · 2024 · EBioMedicine
BACKGROUND: Large language models (LLMs) have shown promising performance in various healthcare domains, but their effectiveness in identifying specific clinical conditions in real medical records is less explored. This study evaluates LLMs for detecting signs of cognitive decline in real electronic health record (EHR) clinical notes, comparing their error profiles with traditional models. The insights gained will inform strategies for performance enhancement. METHODS: This study, conducted at Mass General Brigham in Boston, MA, analysed clinical notes from the four years prior to a 2019 diagn
View details →Negative / Null Result ReportOpen accessComputer Science
Zongyao Li, Kazuhiro Kitajima, Kenji Hirata et al. · 2021 · EJNMMI Research
Abstract Background To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[ 18 F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep-learning technologies. Materials and methods Two clinicians and the new AI system retrospectively analyzed and diagnosed 414 axillae of 407 patients with biopsy-proven breast cancer who had undergone 2-[ 18 F]FDG-PET/CT before a mastectomy or breast-conserving surgery with a sentinel lymph node (LN) biopsy and/or axillary LN dissection. We designed and trained a
View details →Negative / Null Result Report
Rajesh R. Shrestha, Daniel L. Peters, Markus A. Schnorbus · 2013 · Hydrological Processes
Abstract It is a common practice to employ hydrologic models for assessing alterations to streamflow as a result of anthropogenically driven changes, such as riverine, land use, and climate change. However, the ability of the models to…
View details →Negative / Null Result ReportOpen accessMedicine
Christoph Rochlitz, Martin Bigler, Roger von Moos et al. · 2016 · BMC Cancer
BACKGROUND: Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS: This multicenter, randomized phase III trial compared bevacizumab with either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide (arm B) as first-line treatment in patients with HER2-negative advanced breast cancer. The primary endpoint was the incidence of selected grade 3-5 adverse events (AE) including: febrile
View details →Negative / Null Result ReportOpen accessMedicine
Qinfeng Huang, Junjie Shao, Shuiyun Lan et al. · 2015 · Journal of Virology
UNLABELLED: Arenaviruses cause severe hemorrhagic fever diseases in humans, and there are limited preventative and therapeutic measures against these diseases. Previous structural and functional analyses of arenavirus nucleoproteins (NPs)…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Adam K. Fetterman, Kai Sassenberg · 2015 · PLoS ONE
Scientists are dedicating more attention to replication efforts. While the scientific utility of replications is unquestionable, the impact of failed replication efforts and the discussions surrounding them deserve more attention. Specifically, the debates about failed replications on social media have led to worry, in some scientists, regarding reputation. In order to gain data-informed insights into these issues, we collected data from 281 published scientists. We assessed whether scientists overestimate the negative reputational effects of a failed replication in a scenario-based study. Sec
View details →Negative / Null Result ReportOpen accessSocial Sciences
Janina Molina Dargo, Michelle Dimas · 2021 · JETL (Journal Of Education Teaching and Learning)
Due to Covid-19 pandemic, schools, particularly in the rural areas employed Modular Distance Learning (MDL) to ensure education continuity. This study seeks to investigate the effects of MDL in the academic performance of learners whether…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Linda M. Polfus, Jennifer A. Smith, Lawrence C. Shimmin et al. · 2013 · PLoS ONE
Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than interactions with environmental factors (GxE). Identification of GxE interactions is particularly important for coronary heart disease (CHD), a major preventable source of morbidity and mortality with strong non-genetic risk factors. Atherosclerosis is the major cause of CHD, and coronary artery calcification (CAC) is directly correlated with quantity of coronary atherosclerotic plaque. In the current study, we tested for genetic variants influe
View details →Negative / Null Result ReportOpen accessEngineering
Seong Ki Yoo, Simon L. Cotton, Robert W. Heath et al. · 2017 · IEEE Wireless Communications Letters
In this letter, we report the results of a series of experiments which were performed to examine the impact of terminal handling and movement upon the user equipment (UE) to evolved NodeB (eNB) communications channel at 60 GHz. Three key utilization scenarios, in which a user imitated making a voice call, sending a text message or simply carrying the device in a pocket, are investigated. Each of these three user cases were studied under line of sight (LOS) and non-LOS (NLOS) channel conditions when the user was mobile in a range of different indoor and outdoor small cell scenarios. It is shown
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Mary Garvey · 2023 · Infectious Disease Reports
The antimicrobial resistance crisis is an ongoing major threat to public health safety. Low- and middle-income countries are particularly susceptible to higher fatality rates and the economic impact of antimicrobial resistance (AMR). As an…
View details →Negative / Null Result ReportMedicine
Larisa I. Labzin, Keng Yih Chew, Kathrin Eschke et al. · 2023 · Science Signaling
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on a subset of macrophages at sites of SARS-CoV-2 infection in…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Kaustubh Thirumalai, Julie N. Richey, Terrence M. Quinn et al. · 2014 · Scientific Reports
Planktic foraminifer Globigerinoides ruber (G. ruber), due to its abundance and ubiquity in the tropical/subtropical mixed layer, has been the workhorse of paleoceanographic studies investigating past sea-surface conditions on a range of…
View details →Negative / Null Result ReportOpen accessMedicine
Jessica J. Harrison, David Warrilow, Breeanna J. McLean et al. · 2016 · Viruses
The discovery and characterisation of new mosquito-borne viruses provides valuable information on the biodiversity of vector-borne viruses and important insights into their evolution. In this study, a broad-spectrum virus screening system, based on the detection of long double-stranded RNA in inoculated cell cultures, was used to investigate the presence of novel viruses in mosquito populations of northern Australia. We detected and isolated a new virus (tentatively named Parry's Lagoon virus, PLV) from Culex annulirostris, Culex pullus, Mansonia uniformis and Aedes normanensis mosquitoes that
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