Negative / Null Result ReportMedicine
Bahaaldin Alsoufi, Cedric Manlhiot, Bahaa M. Fadel et al. · 2010 · European Journal of Cardio-Thoracic Surgery
OBJECTIVES: The Ross procedure is the aortic valve-replacement procedure of choice in children. Nonetheless, late autograft re-operation for dilatation and/or valve regurgitation is of concern. We examined whether preoperative haemodynamic…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Mieke Metzemaekers, Seppe Cambier, Marfa Blanter et al. · 2021 · Clinical & Translational Immunology
OBJECTIVES: Emerging evidence of dysregulation of the myeloid cell compartment urges investigations on neutrophil characteristics in coronavirus disease 2019 (COVID-19). We isolated neutrophils from the blood of COVID-19 patients receiving…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nolwazi Z. Khumalo, Melusi Sibanda · 2019 · Sustainability
Regardless of the steady increase in the economic growth of South Africa, poverty levels and food insecurity have not declined as one would have anticipated. Urban and peri-urban agriculture (UPA) presents an opportunity as a livelihood strategy to alleviate poverty and ensure household food security within the urban and peri-urban spheres. However, less research has been done in this area to discover the contribution of UPA on households’ food security. This paper assesses the food security status of households that practised any form of UPA activities (later on referred to the rest of this p
View details →Replication FailureOpen accessNeuroscience
Arnold Kochari, Monique Flecken · 2018 · Language Cognition and Neuroscience
An important question in predictive language processing is the extent to which prediction effects can reliably be measured on pre-nominal material (e.g. articles before nouns). Here, we present a large sample (N = 58) close replication of a study by Otten and van Berkum (2009). They report ERP modulations in relation to the predictability of nouns in sentences, measured on gender-marked Dutch articles. We used nearly identical materials, procedures, and data analysis steps. We fail to replicate the original effect, but do observe a pattern consistent with the original data. Methodological diff
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kristin M. Burkart, Tamar Sofer, Stephanie J. London et al. · 2018 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. Objectives Perform a GWAS of COPD phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. Methods GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies. Measurements and Main Results Among 11,
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Dajana Radujković, Erik Verbruggen, Bjarni D. Sigurðsson et al. · 2017 · FEMS Microbiology Ecology
Global change is expected to affect soil microbial communities through their responsiveness to temperature. It has been proposed that prolonged exposure to elevated temperatures may lead to progressively larger effects on soil microbial…
View details →Negative / Null Result ReportMedicine
Troy MacAvelia, Meisam Salahi, Michael Olsen et al. · 2012 · Journal of Biomechanical Engineering
Few experimental studies have examined surgical drilling in human bone, and no studies have inquired into this aspect for a popular commercially-available artificial bone used in biomechanical studies. Sixteen fresh-frozen human femurs and…
View details →Negative / Null Result ReportOpen accessDentistry
Valentina Lanteri, Gianguido Cossellu, Marco Farronato et al. · 2020 · Scientific Reports
The Palatal Rugae are considered a useful human identification marker for both orthodontists and forensic personnel. The principal aim of the present study was to evaluate the stability of palatal rugae with a 3D-3D superimposition procedure following Slow Maxillary Expansion (SME), in order to assess whether they kept their uniqueness and validity for human identification, even after a specific dental treatment. For this purpose, a sample of 27 digital dental models - belonging to growing patients (13 males and 14 females), aged between 8.5 and 15 years, who underwent SME therapy - was retros
View details →Negative / Null Result ReportOpen accessSocial Sciences
Josh Kinsler · 2012 · Quantitative Economics
Value-added models of teacher effectiveness yield consistent estimates of teacher quality under the assumption that students are randomly assigned to classrooms conditional on ability. Rothstein (2010) tested and rejected this underlying…
View details →Replication FailureBiochemistry, Genetics and Molecular Biology
Kyle M. Walsh, Erik L. Anderson, Helen M. Hansen et al. · 2012 · Genetic Epidemiology
Genomewide association studies (GWAS) and candidate-gene studies have implicated single-nucleotide polymorphisms (SNPs) in at least 45 different genes as putative glioma risk factors. Attempts to validate these associations have yielded…
View details →Negative / Null Result ReportOpen accessMedicine
Loes F.M. van der Zanden, Iris A.L.M. van Rooij, Wout Feitz et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Hypospadias is a common congenital malformation of the male external genitalia with a multifactorial etiology. Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in…
View details →Negative / Null Result ReportOpen accessMedicine
Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Luíz Felipe Pinho Moreira et al. · 2018 · Scientific Reports
Transforming growth factor-β1 (TGF-β1) is a potent inducer of fibroblast to myofibroblast differentiation and contributes to the pro-fibrotic microenvironment during cardiac remodeling. Fibroblast growth factor-2 (FGF-2) is a growth factor secreted by adipose tissue-derived stromal cells (ASC) which can antagonize TGF-β1 signaling. We hypothesized that TGF-β1-induced cardiac fibroblast to myofibroblast differentiation is abrogated by FGF-2 and ASC conditioned medium (ASC-CMed). Our experiments demonstrated that TGF-β1 treatment-induced cardiac fibroblast differentiation into myofibroblasts, as
View details →Negative / Null Result ReportOpen accessNeuroscience
Samuel Murray, Nathan Liang, Nicholaus P. Brosowsky et al. · 2021 · Psychology of Aesthetics Creativity and the Arts
A primary aim of mind-wandering research has been to understand its influence on task performance. While this research has typically highlighted the costs of mind wandering, a handful of studies have suggested that mind wandering may be…
View details →Negative / Null Result ReportOpen accessMedicine
Changhee Park, Tae Min Kim, Jeong Mo Bae et al. · 2020 · Cancer Research and Treatment
PURPOSE: The treatment outcomes and genomic profiles of diffuse midline glioma (DMG) in adult patients are rarely characterized. We performed a retrospective study to evaluate the clinicogenomic profiles of adult patients with brain DMG.…
View details →Negative / Null Result ReportOpen accessMedicine
Andrew Orton, Jonathan Frandsen, Randy L. Jensen et al. · 2017 · Journal of neurosurgery
OBJECTIVE Anaplastic meningiomas represent 1%-2% of meningioma diagnoses and portend a poor prognosis. Limited information is available on practice patterns and optimal management. The purpose of this study was to define treatment patterns…
View details →Negative / Null Result ReportOpen accessMedicine
Brian Martin, Beth A. Gabris-Weber, Rajiv P. Reddy et al. · 2018 · PLoS ONE
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive
View details →Negative / Null Result ReportOpen accessMedicine
Pradeesh Sivapalan, Charlotte Suppli Ulrik, Thérèse Lapperre et al. · 2021 · European Respiratory Journal
Background Combining the antibiotic azithromycin and hydroxychloroquine induces airway immunomodulatory effects, with the latter also having in vitro antiviral properties. This may improve outcomes in patients hospitalised for coronavirus…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
J Prazák, Luca G. Valente, Manuela Iten et al. · 2021 · The Journal of Infectious Diseases
BACKGROUND: The optimal method for delivering phages in the context of ventilator-associated pneumonia (VAP) is unknown. In the current study, we assessed the utility of aerosolized phages (aerophages) for experimental…
View details →Negative / Null Result ReportOpen accessMedicine
Hiroki Nishikawa, Akira Arimoto, Tomoko Wakasa et al. · 2012 · International Journal of Oncology
The aim of the present study was to evaluate the influence of preoperative transcatheter arterial chemoembolization (TACE) on survival after surgical resection (SR) for hepatocellular carcinoma (HCC). Two hundred and thirty-five HCC…
View details →Negative / Null Result ReportOpen accessMedicine
Maria Juárez, Nieves Díaz, Geoffrey I. Johnston et al. · 2020 · Lara D. Veeken
OBJECTIVES: This phase 2 proof-of-concept study (NCT02610543) assessed efficacy, safety and effects on salivary gland inflammation of seletalisib, a potent and selective PI3Kδ inhibitor, in patients with moderate-to-severe primary…
View details →Negative / Null Result ReportMedicine
Wei Qiu, Sonja Raven, Jing-Kun Wu et al. · 2010 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: To determine the frequency of hypothalamic lesions in patients with multiple sclerosis (MS) using conventional MRI (cMRI) protocols. METHODS: Brain cMRI (1.5 Tesla) scans of 105 Caucasian patients with classical MS (50 with…
View details →Negative / Null Result ReportOpen accessMedicine
Antoine Bouquegneau, Emmanuelle Vidal‐Petiot, François Vrtovsnik et al. · 2013 · Nephrology Dialysis Transplantation
BACKGROUND: Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD). Accurate estimation of glomerular filtration rate (GFR) is thus important in these patients. We tested the…
View details →Negative / Null Result Report
Swati Agarwal, Faisal A Alzahrani, Asif Ahmed · 2018 · International Journal of Molecular Sciences
Background: Throughout history, menopause has been regarded as a transition in a woman’s life. With the increase in life expectancy, women now spend more than a third of their lives in menopause. During these years, women may experience…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fabio Morgante, Wen Huang, Peter Sørensen et al. · 2020 · G3 Genes Genomes Genetics
Abstract The ability to accurately predict complex trait phenotypes from genetic and genomic data are critical for the implementation of personalized medicine and precision agriculture; however, prediction accuracy for most complex traits is currently low. Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. We found that expression levels (r
View details →Negative / Null Result ReportOpen accessMedicine
Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić et al. · 2023 · Blood Cancer Journal
Currently, the International Prognostic Index (IPI) is the most used and reported model for prognostication in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). IPI-like variations have been proposed, but only a few have been validated in different populations (e.g., revised IPI (R-IPI), National Comprehensive Cancer Network IPI (NCCN-IPI)). We aimed to validate and compare different IPI-like variations to identify the model with the highest predictive accuracy for survival in newly diagnosed DLBCL patients. We included 5126 DLBCL patients treated with immunochemotherapy wit
View details →Negative / Null Result ReportOpen accessMaterials Science
Jack Cavanaugh, Michael Whittaker, Derk Joester · 2019 · Chemical Science
In situ observation of amorphous calcium carbonate (ACC) confined in ∼500 pL emulsion droplets allows determination of the timing of individual crystal nucleation events. Statistical analysis of events in hundreds of droplets establishes…
View details →Negative / Null Result Report
Jacob Schewe, Anders Levermann · 2012 · Environmental Research Letters
Abstract Indian monsoon rainfall is vital for a large share of the world’s population. Both reliably projecting India’s future precipitation and unraveling abrupt cessations of monsoon rainfall found in paleorecords require improved…
View details →Negative / Null Result ReportOpen accessVeterinary
Zhen Wang, Shuangshan Wang, Qingmin Wu · 2014 · FEMS Microbiology Letters
Brucella melitensis is a facultative intracellular pathogen that mainly resides within macrophages. The mechanisms employed by Brucella to adapt to harsh intracellular environments and survive within host macrophages are not clearly…
View details →Negative / Null Result ReportOpen accessMedicine
Martin Urner, Peter Jüni, L. Paloma Rojas-Saunero et al. · 2023 · Critical Care Medicine
OBJECTIVES: Previous studies reported an association between higher driving pressure (∆P) and increased mortality for different groups of mechanically ventilated patients. However, it remained unclear if sustained intervention on ∆P, in…
View details →Negative / Null Result ReportOpen accessSocial Sciences
M.B. Ogunniyi, Christiana Ogonna Igberi · 2014 · VNU Journal of Science: Natural Sciences and Technology (Vietnam National University)
Many developing countries are competing to attract foreign direct investment with a belief that it can be a tool for poverty reduction because it serves as supplements to domestic savings and it is often accompanied with technology and…
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