Negative / Null Result ReportOpen accessMedicine
Tiara Sekar Ayudhipasha, Menik Herdwiyanti, Sedayu Sedayu · 2025 · GHMJ (Global Health Management Journal)
Background: West Java ranks the highest Province with Human Immunodeficiency Virus (HIV) case in 2023. An estimated 1.648 patients estimated receive antiretroviral therapy (ART). Kidney disease contributes mortality amongst people living with HIV/AIDS (PLWH). Tenofovir disoproxil fumarate (TDF)-based ART was associated as risk factor of kidney disorders, indicate by declining glomerular filtration rate (GFR). However, there is limited study whether kidney disease among PLWH were related to ART use in Indonesia. Aims: To determine correlation between duration of antiretroviral therapy and glome
View details →Negative / Null Result ReportOpen accessGeneral. Including nature conservation, geographical distribution
Jennifer L. Reidy, Lisa O'Donnell, Frank R. Thompson III · 2015 · Wildlife Society Bulletin
ABSTRACT It is critically important to determine and understand relationships between endangered species populations and landscape and habitat features to effectively manage and conserve populations and the habitats they rely on. Several recent studies focused on the golden‐cheeked warbler (Setophaga chrysoparia), an endangered songbird that breeds exclusively in central Texas, USA, have used a reproductive index to link pairing and breeding success to various factors of interest. However, no field test has evaluated the performance of a reproductive index at estimating productivity of golden‐
View details →Negative / Null Result ReportOpen accessMedicine
Fithria Aldy, Gema Nazri Yanni, Jelita Siregar · 2024 · Majalah Kedokteran Bandung
Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study ap
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Filippo Mandelli, Filippo Mandelli, Filippo Mandelli et al. · 2021 · Frontiers in Neurology
Objective: Fatty infiltration of paraspinal muscle is associated with spinal disorders. It can be assessed qualitatively (i.e., Goutallier classification) and quantitatively using image processing software. The aims of this study were to compare paraspinal muscle fatty infiltration as assessed using the Goutallier classification vs. quantitative magnetic resonance images (MRI) measurements and to investigate the association between anthropometric parameters and paraspinal muscle morphology and fatty infiltration in patients with symptomatic lumbar spinal stenosis (LSS).Methods: Patients affect
View details →Negative / Null Result ReportOpen accessDentistry
Guven Kayaoglu, Mügem Gürel, Hüma Ömürlü et al. · 2009 · Journal of Applied Oral Science
OBJECTIVE: The aim of this study was to evaluate the degree of microbial contamination in packaged gutta-percha cones before and during use in clinical conditions. MATERIAL AND METHODS: Sealed packages of #15-40 gutta-percha cones were opened under aseptic laboratory conditions. Two gutta-percha cones from each size were randomly drawn and added to tubes containing glass beads and 750 µL of saline. The tubes were vortexed, serially diluted and samples of 250 µL were cultured on agar plates. The plates were incubated at 37ºC for 3 days and colonies were counted. The initially sampled packages w
View details →Negative / Null Result ReportOpen accessMedicine
Shreya Arora, Monica Gupta, Anita Tahlan et al. · 2022 · Journal of Dr. NTR University of Health Sciences
Background: Platelet count has been widely used to evaluate the severity, guide management and predict outcome in patients with dengue fever. This sole use, however, has prevented the utility of other platelet indices like Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) from being explored. Objectives: To study the association of MPV and PDW with the disease severity in patients with dengue fever. Materials and Methods: This prospective observational study was conducted in a tertiary care centre of Northern India for a period of one year. A total of 100 patients with confirmed
View details →Negative / Null Result ReportOpen accessMedicine
Zuraini Mohammad Nasir, Sethu Thakachy Subha · 2021 · International Archives of Otorhinolaryngology
Introduction Foreign body aspiration is a leading cause of accidental death in children. Clinical presentation varies from non-specific respiratory symptoms to respiratory failure making diagnosis challenging. Objective To review pediatric patients who underwent bronchoscopy due to suspicion of foreign body aspiration at a tertiary center in Malaysia. Methods We retrospectively studied patients < 11 years old who underwent bronchoscopy from 2008 to 2018. Results Over the 10-year period, 20 patients underwent bronchoscopy, and 16 were found to have foreign body aspiration with equal gender dist
View details →Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Pedro Boal Carvalho, Bruno Rosa, Maria João Moreira et al. · 2014 · Gastroenterology Research and Practice
Objectives. Small bowel capsule endoscopy (SBCE) plays a decisive role in the obscure gastrointestinal bleeding (OGIB) diagnosis. Antithrombotics may increase bleeding risk in patients with preexistent lesions or through direct mucosal aggression. We aimed to correlate antithrombotics usage with lesions with bleeding potential found in SBCE. Methods. Retrospective single-center study including 274 consecutive SBCE performed over 7 years for OGIB. The lesions were classified as P0 (no bleeding potential), P1 (uncertain bleeding potential: erosions), and P2 (high bleeding potential: angioectasia
View details →Negative / Null Result ReportOpen accessPediatrics
Nevzat Gönder, Cansu Öztürk, Rabia Taşdemir et al. · 2025 · Children
Background: A precise radiographic evaluation of adolescent idiopathic scoliosis (AIS) is essential for effective treatment planning and follow-up. The pelvic axial rotation (PAR) and horizontal balance of the pelvis are critical factors to consider throughout the treatment and monitoring of AIS. While some previous studies have examined spinal curvature in relation to PAR direction and the direction of the major curve (DMC) in AIS patients, this study aims to explore the relationship between scoliosis morphology, pelvic axial rotation (PAR), and the direction of the major curve in patients wi
View details →Negative / Null Result ReportOpen accessMedicine
Derya Koyun, Gokhan Nergizoglu, Kemal Metin Kir · 2018 · Saudi Journal of Kidney Diseases and Transplantation
The loss of muscle mass and cachexia is commonly seen in hemodialysis (HD) patients and contribute to morbidity and mortality. The exact mechanism of this fact is multifactorial and still unclear. Myostatin, a transforming growth factor-ß family ligand, is released from the skeletal and heart muscle and may be responsible for muscle degradation and atrophy. The aim of this study is evaluation of the relationship between muscle mass and serum myostatin level in chronic HD patients. One hundred and forty HD patients (79 males, 28 diabetic, mean age; 53.96 ± 13.6) were included in this cross-sect
View details →Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities
Lalić Bojan R., Ranđelović Dušan J. · 2013 · Zbornik Radova Filozofskog Fakulteta u Prištini
The aim of this research was to identify relations between level of religiosity and level of contact on one side and social attitudes towards members of religious out-groups in conflict environment on the other side. This research was conducted on the sample of Christian Orthodox students in Kosovska Mitrovica (which is partially conflict environment) and the Muslims were the out-group towards whom attitudes were analyzed. Attitudes measures we used were social distance scale and semantic differential. Likert type scale was used for religiosity measure, quantity and quality of contact. Control
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Inga Marte Charlott Seuthe, Markus Ruwe, Franz Mitze et al. · 2025 · Discover Oncology
Abstract Objectives VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC. Methods The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed. Results High VCP/p97 express
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Erica Anna Gumpert Herlofson, Francesca Tavola, Karolina Siri Engdahl et al. · 2023 · Acta Veterinaria Scandinavica
Abstract Background Pre-emptive local analgesia with the use of lidocaine is practised increasingly in veterinary medicine as part of applied multimodal analgesia, despite its controversial impact on wound healing. The purpose of this prospective, randomised, double-blinded, placebo-controlled clinical study was to evaluate if preoperative subcutaneous infiltration of lidocaine has a negative impact on primary wound healing of surgical incisions. Fifty-two companion animals (3 cats and 49 dogs) were enrolled in the study. The inclusion criteria were as follows: American Society of Anaesthesiol
View details →Negative / Null Result ReportOpen accessAgriculture
Yosuke Kuroda, Kazuyuki Okazaki, Kenji Takashino et al. · 2025 · Agrosystems, Geosciences & Environment
Abstract Sugar beet (Beta vulgaris) production in Japan faces major challenges from virus yellows (VY), caused by beet leaf yellowing virus (BLYV) and transmitted by aphids. Outbreaks have reduced sugar yields, and breeding for tolerant varieties has not been conducted in Japan. This study marks the first step toward developing VY‐tolerant varieties by testing three hypotheses: (1) leaf yellowing can be induced by artificial inoculation, (2) tolerance varies among breeding materials, and (3) differences in tolerance to yellowing disease can be evaluated. From 2017 to 2020, four sugar beet mate
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Kun Wang, Yuanyuan Shen, Chen Hu et al. · 2025 · Clinical and Translational Science
ABSTRACT While PD‐L1 antibodies have demonstrated efficacy in small cell lung cancer, the therapeutic benefits remain limited. To address this unmet medical need, serplulimab was developed as an innovative monoclonal antibody targeting PD‐1. This study evaluated the pharmacokinetic (PK) properties of serplulimab and their relationship with efficacy and safety in patients with extensive‐stage small cell lung cancer (ES‐SCLC), using population pharmacokinetics (PopPK) and exposure–response (E–R) analysis to inform dose selection. Data from 1144 patients across eight Phase I–III clinical trials s
View details →Negative / Null Result ReportOpen accessScience (General)
Xin Wang, Chen Li, Ming Li et al. · 2024 · Heliyon
Objective: Serum lactate (LA) and lactate dehydrogenase (LDH) levels have a major impact on the clinical treatment of malignant tumors and critically ill patients. Nevertheless, the assessment of disease severity in oncology patients admitted to the intensive care unit (ICU) remains incomplete when considering the serum LA and LDH levels. This study aimed to investigate the significance of serum LDH and LA levels in assessing disease severity and predicting clinical outcomes in patients with colorectal cancer (CRC) admitted to the ICU. Methods: This retrospective study included patients with C
View details →Negative / Null Result ReportOpen accessMedicine
Janan G. Hasan · 2010 · The Medical Journal of Basrah University
ABSTRACT Background: Abnormal blood lipid profiles have been associated with many malignant diseases especially in children with acute lymphoblastic leukemia on L-asparaginase therapy Objective: To investigate the frequency and clinical significance of altered lipid profiles in children with Acute lymphoblastic leukemia (ALL) on L-asparaginase therapy Patients and Methods: A prospective study was carried out between February 2008 till January 2009 on a total of 50 patients with recently diagnosed and non-treated acute lymphoblastic leukemia who were admitted to pediatric oncology unit at Basra
View details →Negative / Null Result ReportOpen accessBiology (General)
Robert Stawski, Konrad Walczak, Ewelina Perdas et al. · 2021 · Biology
Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond
View details →Negative / Null Result ReportOpen accessPsychiatry
O. Elleuch, M. Maalej, W. Guidara et al. · 2023 · European Psychiatry
Introduction The pathophysiology of bipolar disorder (BD) is complex and remains uncertain to this day. Several hypotheses have been suggested, including the involvement of inflammatory mechanisms in its pathogenesis and in eventual cognitive impairment. C-reactive protein (CRP) is one of the most commonly used inflammatory markers. High-sensitivity CRP (hs- CRP) is a more sensitive marker. Objectives We aimed to examine hs-CRP levels in patients with BD, and to investigate its relationship with cognitive functions. Methods We conducted a cross-sectional study between June 2016 and July 2018 o
View details →Negative / Null Result ReportOpen accessMedicine
Amer Imraish, Tuqa Abu-Thiab, Tareq Alhindi et al. · 2022 · PLoS ONE
Background Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators, such as histamine and prostaglandins, from mast cells in asthmatic patients. Objective In this study, single nucleotide polymorphisms of GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C
View details →Negative / Null Result ReportOpen accessGeophysics. Cosmic physics
Liyu ZHANG, Donghua YOU, Rong LI et al. · 2025 · Shiyou shiyan dizhi
In recent years, multiple wells in the Sichuan Basin have produced industrial gas from the marlstone/marl-bearing limestone strata in the first member of the Middle Permian Maokou Formation (Mao 1), demonstrating promising exploration potential. Previous studies have suggested that the marlstone/marl-bearing limestone in Mao 1 exhibits self-generation and self-storage characteristics, forming low-porosity, low-permeability fracture-porosity type tight carbonate reservoirs with diverse storage spaces. Notably, diagenetic shrinkage pores and fractures formed during the transformation of sepiolit
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yingpu Cui, Yingpu Cui, Yaobin Lin et al. · 2022 · Frontiers in Immunology
PurposeTo develop a comprehensive PET radiomics model to predict the pathological response after neoadjuvant toripalimab with chemotherapy in resectable stage III non-small-cell lung cancer (NSCLC) patients.MethodsStage III NSCLC patients who received three cycles of neoadjuvant toripalimab with chemotherapy and underwent 18F-FDG PET/CT were enrolled. Baseline 18F-FDG PET/CT was performed before treatment, and preoperative 18F-FDG PET/CT was performed three weeks after the completion of neoadjuvant treatment. Surgical resection was performed 4–5 weeks after the completion of neoadjuvant treatm
View details →Negative / Null Result ReportOpen accessMedicine
Ni Luh Kadek Alit Arsani, Luh Ari Arini, Luh Yenny Armayanti et al. · 2026 · Althea Medical Journal
Background: During perimenopause, declining estrogen levels often lead to altered menstrual patterns and other age-related health concerns. Consequently, the role of physical activity warrants closer examination. This study investigated the correlation between exercise frequency and menstrual cycle characteristics in premenopausal women Methods: A cross-sectional observational study was conducted in Singaraja City, Indonesia, from July to October 2024. A total of 150 premenopausal women aged 45–50 years were recruited through random sampling. Exercise frequency was measured using the World Hea
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Kimberly Williams, Valerie MacDonald-Dickinson, Arata Matsuyama · 2024 · Journal of Feline Medicine and Surgery
Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between
View details →Negative / Null Result ReportOpen accessMedicine
Yayuan Deng, Hongxuan Wu, Tingning Zhao et al. · 2025 · Scientific Reports
Abstract Atmospheric dustfall is solid air pollutant, which is mainly influenced by local sources, so it has a major impact on the local environment and the health of local residents. The objective of this study was to investigate the distribution characteristics of dustfall fluxes and particle size, and the meteorological factors affected them. Atmospheric dustfall was collected in an open-pit coal mining area and surrounding areas in the arid desert area of Northwest China from March to December 2018. Dustfall fluxes was measured, particle size was measured by using graphical methods and gra
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Nicola Manta, Laura Mangiavini, Cristiana Balbino et al. · 2021 · BMC Musculoskeletal Disorders
Abstract Background Suction drainage is commonly applied after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) to reduce hematoma, swelling and to favor surgical wound healing. However, its efficacy remains controversial; thus, the purpose of this study is to evaluate drainage efficiency in the management of postoperative bleeding in TKA and UKA. Methods The cohort comprised 134 clinical records of patients affected by knee osteoarthritis (OA) who underwent either TKA or UKA. All the patients were subdivided into 2 groups: the first one with drainage and the second o
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Evangelia Maniaki, Carmen Pineda, Angie Hibbert et al. · 2024 · Frontiers in Veterinary Science
ObjectivesThis case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.MethodsHypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained.
View details →Replication Failure
Anisatul Fauziah · 2023 · SIGNIFICANT : Journal Of Research And Multidisciplinary
Persaingan dalam lingkungan kerja saat ini semakin ketat, ini menuntut perusahaan terus menerus mengembangkan usahanya untuk dapat bersaing dengan perusahaan lain. Oleh karena itu dibutuhkan pengelola manajemen perusahaan yang biasa…
View details →Negative / Null Result ReportOpen accessMedicine
M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology
BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…
View details →Negative / Null Result ReportOpen accessMedicine
V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research
CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…
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