Increased Circulating H3 Histone in Response to Repeated Bouts of Exercise Does Not Associate with Parallel Alterations of Cell-Free DNA
Robert Stawski; Konrad Walczak; Ewelina Perdas; Anna Prymont-Przymińska; Anna Zwolińska; Piotr Kosielski; Tomasz Budlewski; Gianluca Padula · 2021 · Biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond
Abstract by Robert Stawski; Konrad Walczak; Ewelina Perdas; Anna Prymont-Przymińska; Anna Zwolińska; Piotr Kosielski; Tomasz Budlewski; Gianluca Padula, Biology (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/biology10030181