High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma
Inga Marte Charlott Seuthe; Markus Ruwe; Franz Mitze; Steffi Silling; Eric Ehrke-Schulz; Sabine Eichhorn; Jonas Jae-Hyun Park · 2025 · Discover Oncology
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Abstract
Abstract Objectives VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC. Methods The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed. Results High VCP/p97 express
Abstract by Inga Marte Charlott Seuthe; Markus Ruwe; Franz Mitze; Steffi Silling; Eric Ehrke-Schulz; Sabine Eichhorn; Jonas Jae-Hyun Park, Discover Oncology (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1007/s12672-025-03839-8