Negative / Null Result ReportMedicine
Steven Boonen, Dennis M. Black, Cathleen Colón‐Emeric et al. · 2010 · Journal of the American Geriatrics Society
OBJECTIVES: To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women. DESIGN: A post hoc…
View details →Negative / Null Result ReportMedicine
T.J. Karpanen, A.L. Casey, Peter A. Lambert et al. · 2011 · Infection Control and Hospital Epidemiology
OBJECTIVE: To determine whether copper incorporated into hospital ward furnishings and equipment can reduce their surface microbial load. DESIGN: A crossover study. SETTING: Acute care medical ward with 19 beds at a large university…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Kaoping Zhang, Manuel Delgado‐Baquerizo, Yong‐Guan Zhu et al. · 2020 · mSystems
Both space and time are key factors that regulate microbial community, but microbial temporal variation is often ignored at a large spatial scale. In this study, we compared spatial and seasonal effects on bacterial and fungal diversity variation across an 878-km transect and found direct evidence that space is far more important than season in regulating the soil microbial community. Partitioning the effect of season, space and environmental variables on microbial community, we further found that fast-changing environmental factors contributed to microbial temporal variation.
View details →Negative / Null Result ReportMedicine
Rogier M. Thurlings, Marie Boumans, Janneke Tekstra et al. · 2010 · Arthritis & Rheumatism
OBJECTIVE: To analyze the relationship between the type I interferon (IFN) signature and clinical response to rituximab in rheumatoid arthritis (RA) patients. METHODS: Twenty RA patients were treated with rituximab (cohort 1). Clinical…
View details →Negative / Null Result ReportOpen accessMedicine
Jordan Spatz, E. E. Fields, Elaine W Yu et al. · 2012 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin. However, few studies have reported changes in serum sclerostin in humans…
View details →Negative / Null Result ReportOpen accessMedicine
Brendan McMullan, Catriona Halliday, Tania C. Sorrell et al. · 2012 · PLoS ONE
BACKGROUND: Cryptococcus neoformans causes life-threatening meningitis. A recently introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is reportedly more rapid and convenient than standard latex agglutination (LA), but has not yet been evaluated in a diagnostic laboratory setting. METHODS: One hundred and six serum, 42 cerebrospinal fluid (CSF), and 20 urine samples from 92 patients with known or suspected cryptococcosis were tested by LA and LFA, and titres were compared. Results were correlated with laboratory-confirmed cryptococcosis. Serial samples were tested i
View details →Negative / Null Result ReportOpen accessMedicine
Man‐Fung Yuen, Ingolf Schiefke, Jung‐Hwan Yoon et al. · 2019 · Hepatology
BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV)…
View details →Negative / Null Result ReportSocial Sciences
Mark Umbricht, Frank Fernandez, Justin C. Ortagus · 2015 · Educational Policy
Previous studies have shown that state performance funding policies do not increase baccalaureate degree production, but higher education scholarship lacks a rigorous, quantitative analysis of the unintended consequences of performance…
View details →Negative / Null Result ReportOpen accessMedicine
Jochen Klucken, Anne-Maria Poehler, Darius Ebrahimi‐Fakhari et al. · 2012 · Autophagy
Synucleinopathies like Parkinson disease and dementia with Lewy bodies (DLB) are characterized by α-synuclein aggregates within neurons (Lewy bodies) and their processes (Lewy neurites). Whereas α-synuclein has been genetically linked to…
View details →Replication FailurePsychology
Enda M. Byrne, Philip Gehrman, Sarah E. Medland et al. · 2013 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Several aspects of sleep behavior such as timing, duration and quality have been demonstrated to be heritable. To identify common variants that influence sleep traits in the population, we conducted a genome-wide association study of six…
View details →Negative / Null Result ReportSocial Sciences
Daantje Derks, Lieke L. ten Brummelhuis, Dino Zecic et al. · 2012 · European Journal of Work and Organizational Psychology
This study examines the impact of work-related smartphone use on daily recovery from work-related efforts. The literature shows that work–home interference (WHI) is an important inhibitor of the recovery process. We propose that the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Stephen E. Alway, Jean L. McCrory, Kalen Kearcher et al. · 2017 · The Journals of Gerontology Series A
Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took either a placebo or resveratrol (RSV) (500 mg/d) to test the hypothesis that RSV treatment combined with exercise would increase mitochondrial…
View details →Negative / Null Result ReportOpen accessMathematics
Stanley E. Lazic, Elizaveta Semenova, Dominic P. Williams · 2020 · Scientific Reports
Regulatory authorities require animal toxicity tests for new chemical entities. Organ weight changes are accepted as a sensitive indicator of chemically induced organ damage, but can be difficult to interpret because changes in organ weight might reflect chemically-induced changes in overall body weight. A common solution is to calculate the relative organ weight (organ to body weight ratio), but this inadequately controls for the dependence on body weight - a point made by statisticians for decades, but which has not been widely adopted. The recommended solution is an analysis of covariance (
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jaana Hartiala, Brian J. Bennett, W.H. Wilson Tang et al. · 2014 · Arteriosclerosis Thrombosis and Vascular Biology
OBJECTIVE: Elevated levels of plasma trimethylamine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Patrick N. Osakwe, Amelia U. Santos‐Paulino, Berna Doğan · 2018 · Journal of African Trade
This paper explores the relationship between trade, trade liberalization, and exports diversification in developing and Sub-Saharan African (SSA) countries. The non-parametric analyses indicate that developing countries that are more open…
View details →Negative / Null Result ReportMedicine
Catalina Medina, Sı́món Barquera, Ian Janssen · 2013 · PubMed
OBJECTIVE: To determine the test-retest reliability and validity of the Spanish version of the short-form International Physical Activity Questionnaire (IPAQ) among adults in Mexico. METHODS: This was a cross-sectional study of a…
View details →Negative / Null Result ReportMedicine
Kevin C. Huoh, David W. Eisele · 2011 · Otolaryngology
OBJECTIVES: The purpose of this study was to investigate etiologic factors for sialolithiasis in a population of patients from the United States. STUDY DESIGN: Retrospective, cohort study. SETTING: Tertiary university. MATERIALS AND…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jaap Brand, Stef van Buuren, Saskia le Cessie et al. · 2018 · Statistics in Medicine
In healthcare cost-effectiveness analysis, probability distributions are typically skewed and missing data are frequent. Bootstrap and multiple imputation are well-established resampling methods for handling skewed and missing data.…
View details →Negative / Null Result ReportMedicine
Kevin W. Eva, Harold Reiter, Jack Rosenfeld et al. · 2012 · JAMA
CONTEXT: There has been difficulty designing medical school admissions processes that provide valid measurement of candidates' nonacademic qualities. OBJECTIVE: To determine whether students deemed acceptable through a revised admissions…
View details →Negative / Null Result ReportOpen accessMedicine
Teruko Tashiro, Sorin V. Pislaru, Jodi M Blustin et al. · 2014 · European Heart Journal
AIMS: Severe aortic stenosis (SAS) is a major risk factor for death after non-cardiac surgery, but most supporting data are from studies over a decade old. We evaluated the risk of non-cardiac surgery in patients with SAS in contemporary…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Clelia Gasparini, Leigh W. Simmons, Maxine Beveridge et al. · 2010 · PLoS ONE
Sperm competition is expected to favour the evolution of traits that influence the performance of sperm when they compete to fertilize a female's eggs. While there is considerable evidence that selection favours increases in sperm numbers, much less is known about how sperm quality contributes towards competitive fertilization success. Here, we determine whether variation in sperm quality influences competitive fertilization success in the green swordtail Xiphophorus helleri, a highly promiscuous livebearing fish. We use artificial insemination as a method of controlled sperm delivery and show
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Tariq M. Butt, Bethany P. J. Greenfield, Carolyn Greig et al. · 2013 · PLoS ONE
Metarhizium anisopliae, a fungal pathogen of terrestrial arthropods, kills the aquatic larvae of Aedes aegypti, the vector of dengue and yellow fever. The fungus kills without adhering to the host cuticle. Ingested conidia also fail to germinate and are expelled in fecal pellets. This study investigates the mechanism by which this fungus adapted to terrestrial hosts kills aquatic mosquito larvae. Genes associated with the M. anisopliae early pathogenic response (proteinases Pr1 and Pr2, and adhesins, Mad1 and Mad2) are upregulated in the presence of larvae, but the established infection proces
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Dion Bongaerts, Frank de Jong, Joost Driessen · 2017 · Review of Financial Studies
We use an asset pricing approach to compare the effects of the liquidity level and liquidity risk on expected U.S. corporate bond returns. Using signed transaction data, we estimate effective transaction costs for bond portfolios by a…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mareike Albert, Sandra U. Schmitz, Susanne M. Kooistra et al. · 2013 · PLoS Genetics
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cranial nerves, defects in eye development, and increased incidences of exencephaly. Moreover, in line
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Tim Jenkinson, Howard Jones, José Vicente Martinez · 2015 · The Journal of Finance
ABSTRACT Investment consultants advise institutional investors on their choice of fund manager. Focusing on U.S. actively managed equity funds, we analyze the factors that drive consultants’ recommendations, what impact these…
View details →Negative / Null Result ReportOpen accessMedicine
Alan K. Burnett, Nigel H. Russell, Ann E. Hunter et al. · 2013 · Blood
Better treatment is required for older patients with acute myeloid leukemia (AML) not considered fit for intensive chemotherapy. We report a randomized comparison of low-dose Ara-C (LDAC) vs the novel nucleoside, clofarabine, in untreated…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Frida Magda Sumual, David Paul Elia Saerang, Herman Karamoy et al. · 2021 · Accounting
This present study intends to analyze the factors affecting the performance of the local government of North Sulawesi. The population of this study includes the members of the Regional People’s Representative Assembly and the leaders of Regional Apparatus Organizations managing the Regional Revenue and Expenditure Budget (APBD). Those Regional Apparatus Organizations include Education and Culture Office, Health Office, Regional Revenue Service, Tourism Office, Public Works Office, and Auditor Inspectorate of North Sulawesi Province. The sampling technique used is the saturated sampling techniq
View details →Negative / Null Result ReportOpen accessDecision Sciences
Mukelabai M. Musheke, Jackson Phiri · 2021 · Open Journal of Business and Management
Communication is a very crucial and significant element in an organization, and it is necessary for creating collaboration within the work environment that has effects on organizational performance and decision making. This study on effects of effective communications on organizational performance using the systems theory is thus essential. The objectives of this study were to firstly identify the factors affecting effective communication based on the systems theory and secondly to devise a communication model that addresses these factors to improve organisational performance. A quantitative a
View details →Negative / Null Result ReportOpen accessEngineering
Payam Jalili, Ali Ahmadi Azar, Bahram Jalili et al. · 2023 · Results in Physics
This paper studies the effect of thermo-diffusion, electrical field, and nonlinear thermal radiation. Thermal radiant heat transfer has several industrial applications, and the analysis of radiation heat transfer in non-Newtonian fluids…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Bo Xiong, John C. Beghin · 2011 · European Review of Agricultural Economics
We provide an ex post econometric examination of the harmonisation and tightening of the EU maximum residue limit (MRL) on aflatoxins in 2002, and its impact on African exports of groundnut products. We find no evidence of the EU MRL…
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