Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights
Stanley E. Lazic; Elizaveta Semenova; Dominic P. Williams · 2020 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Regulatory authorities require animal toxicity tests for new chemical entities. Organ weight changes are accepted as a sensitive indicator of chemically induced organ damage, but can be difficult to interpret because changes in organ weight might reflect chemically-induced changes in overall body weight. A common solution is to calculate the relative organ weight (organ to body weight ratio), but this inadequately controls for the dependence on body weight - a point made by statisticians for decades, but which has not been widely adopted. The recommended solution is an analysis of covariance (
Abstract by Stanley E. Lazic; Elizaveta Semenova; Dominic P. Williams, Scientific Reports (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-020-63465-y