Neuronal complex I deficiency occurs throughout the Parkinson’s disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage
Irene H. Flønes; Erika Fernández‐Vizarra; Maria Lykouri; Brage Brakedal; Geir Skeie; Hrvoje Miletić; Peer K. Lilleng; Guido Alves · 2017 · Acta Neuropathologica
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mitochondrial complex I deficiency occurs in the substantia nigra of individuals with Parkinson's disease. It is generally believed that this phenomenon is caused by accumulating mitochondrial DNA damage in neurons and that it contributes to the process of neurodegeneration. We hypothesized that if these theories are correct, complex I deficiency should extend beyond the substantia nigra to other affected brain regions in Parkinson's disease and correlate tightly with neuronal mitochondrial DNA damage. To test our hypothesis, we employed a combination of semiquantitative immunohistochemical an
Abstract by Irene H. Flønes; Erika Fernández‐Vizarra; Maria Lykouri; Brage Brakedal; Geir Skeie; Hrvoje Miletić; Peer K. Lilleng; Guido Alves, Acta Neuropathologica (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s00401-017-1794-7