Negative / Null Result ReportOpen accessMedicine
Donna R. Rivera, Solange Peters, Orestis A. Panagiotou et al. · 2020 · Cancer Discovery
Abstract Among 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. Logistic…
View details →Negative / Null Result ReportOpen accessMedicine
Priyanka Sharma, William E. Barlow, Andrew K. Godwin et al. · 2017 · Annals of Oncology
Background: Homologous recombination deficiency (HRD)-causing alterations have been reported in triple-negative breast cancer (TNBC). We hypothesized that TNBCs with HRD alterations might be more sensitive to anthracycline plus…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Celso Brunetti, Bahattin Büyükşahin, Jeffrey H. Harris · 2016 · Journal of Financial and Quantitative Analysis
We use data from 2005–2009 that uniquely identify categories of traders to test how speculators such as hedge funds and swap dealers relate to volatility and price changes. In examining various subperiods where price trends are strong, we…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lee S. Katz, Aaron Petkau, John Beaulaurier et al. · 2013 · mBio
UNLABELLED: Prior to the epidemic that emerged in Haiti in October of 2010, cholera had not been documented in this country. After its introduction, a strain of Vibrio cholerae O1 spread rapidly throughout Haiti, where it caused over 600,000 cases of disease and >7,500 deaths in the first two years of the epidemic. We applied whole-genome sequencing to a temporal series of V. cholerae isolates from Haiti to gain insight into the mode and tempo of evolution in this isolated population of V. cholerae O1. Phylogenetic and Bayesian analyses supported the hypothesis that all isolates in the sample
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Kevin J. Gaston, Daniel T. C. Cox, Sonia B. Canavelli et al. · 2018 · BioScience
Although there is a diversity of concerns about recent persistent declines in the abundances of many species, the implications for the associated delivery of ecosystem services to people are surprisingly poorly understood. In principle, there are a broad range of potential functional relationships between the abundance of a species or group of species and the magnitude of ecosystem-service provision. Here, we identify the forms these relationships are most likely to take. Focusing on the case of birds, we review the empirical evidence for these functional relationships, with examples of suppor
View details →Negative / Null Result ReportOpen accessPsychology
Julia Depa, Juan Ramón Barrada, María Roncero · 2019 · Nutrients
Recent research points to the bidimensional nature of orthorexia, with one dimension related to interest in healthy eating (healthy orthorexia) and another dimension related to a pathological preoccupation with eating healthily (orthorexia nervosa). Research was needed to provide further support for this differentiation. We examined the food-choice motives related to both aspects of orthorexia. Participants were 460 students from a Spanish university who completed the Teruel Orthorexia Scale and the Food Choice Questionnaire. By means of structural equation modeling, we analyzed the relationsh
View details →Negative / Null Result ReportOpen accessSocial Sciences
Alessandro Gavazza, Mattia Nardotto, Tommaso Valletti · 2018 · The Review of Economic Studies
Abstract We empirically study the effects of broadband internet diffusion on local election outcomes and on local government policies using rich data from the U.K. Our analysis shows that the internet has displaced other media with greater…
View details →Replication FailureOpen accessDecision Sciences
Pepijn Obels, Daniël Lakens, Nicholas A. Coles et al. · 2020 · Advances in Methods and Practices in Psychological Science
Ongoing technological developments have made it easier than ever before for scientists to share their data, materials, and analysis code. Sharing data and analysis code makes it easier for other researchers to reuse or check published research. However, these benefits will emerge only if researchers can reproduce the analyses reported in published articles and if data are annotated well enough so that it is clear what all variable and value labels mean. Because most researchers are not trained in computational reproducibility, it is important to evaluate current practices to identify those tha
View details →Negative / Null Result ReportOpen accessMedicine
Sherief Abd‐Elsalam, Eslam Saber Esmail, Mai Khalaf et al. · 2020 · American Journal of Tropical Medicine and Hygiene
The COVID-19 pandemic is showing an exponential growth, mandating an urgent need to develop an effective treatment. Indeed, to date, a well-established therapy is still lacking. We aimed to evaluate the safety and efficacy of…
View details →Negative / Null Result ReportOpen accessPsychology
Nia Plamenova Djourova, Isabel Rodríguez, Núria Tordera et al. · 2019 · Journal of Leadership & Organizational Studies
The objective of this article is to test the roles of self-efficacy and resilience as consecutive mediators in the relationship between the four dimensions of transformational leadership and well-being (operationalized as psychosomatic complaints and psychological distress). The sample consists of 225 social services employees in Spain. Data were gathered at two time points with a time-lag of 6 months. We used path analysis to test the hypothesized model and Monte Carlo confidence intervals to check the significance of the indirect effects. Our results showed that only two of the four transfor
View details →Negative / Null Result ReportOpen accessMedicine
Colin Steer, George Davey Smith, Pauline Emmett et al. · 2010 · PLoS ONE
BACKGROUND: Breastfeeding is important for child cognitive development. A study by Caspi et al has suggested that rs174575 within the FADS2 gene moderates this effect so that children homozygous in the minor allele (GG genotype) have similar IQs irrespective of feeding method. METHODS AND PRINCIPAL FINDINGS: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575. However, an interaction with this polymorphism was observed such that breastfed GG children performed better than their formula fed counterparts by an additional 5.8 points [1.4, 10.1] (inter
View details →Replication FailureOpen accessPsychology
Eric‐Jan Wagenmakers, Josine Verhagen, Alexander Ly · 2015 · Behavior Research Methods
We present a suite of Bayes factor hypothesis tests that allow researchers to grade the decisiveness of the evidence that the data provide for the presence versus the absence of a correlation between two variables. For concreteness, we apply our methods to the recent work of Donnellan et al. (in press) who conducted nine replication studies with over 3,000 participants and failed to replicate the phenomenon that lonely people compensate for a lack of social warmth by taking warmer baths or showers. We show how the Bayes factor hypothesis test can quantify evidence in favor of the null hypothes
View details →Negative / Null Result ReportOpen accessMedicine
Amy J. Schuh, Melissa J. Ward, Andrew Brown et al. · 2013 · PLoS neglected tropical diseases
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important etiologic agent of epidemic encephalitis worldwide, and is primarily maintained between vertebrate reservoir hosts (avian and swine) and culicine mosquitoes. There are five genotypes of JEV: GI-V. In recent years, GI has displaced GIII as the dominant JEV genotype and GV has re-emerg
View details →Negative / Null Result ReportOpen accessMedicine
Stijn van Roessel, Eran van Veldhuisen, Sjors Klompmaker et al. · 2020 · JAMA Oncology
IMPORTANCE: The benefit of adjuvant chemotherapy after resection of pancreatic cancer following neoadjuvant combination treatment with folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) is unclear. OBJECTIVE: To assess…
View details →Negative / Null Result ReportOpen accessMedicine
Weijun Xuan, Fatma Vatansever, Liyi Huang et al. · 2013 · PLoS ONE
Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of transcranial LLLT to treat stroke and traumatic brain injury (TBI). We developed a mouse model of severe TBI induced by controlled cortical impact and explored the effect of different treatment schedules. Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI sham-treatment, (b) real-TBI sham-treatment, and (c) real-TBI active-treatmen
View details →Negative / Null Result ReportOpen accessMedicine
Nohra Chalouhi, Robert M. Starke, Steven Yang et al. · 2013 · Stroke
BACKGROUND AND PURPOSE: Flow diverters are currently indicated for treatment of large and complex intracranial aneurysms. The purpose of this study was to determine whether the indications of flow diversion can be safely extended to…
View details →Negative / Null Result ReportMedicine
Clarissa Capp, Simone Magagnin Wajner, Débora Rodrigues Siqueira et al. · 2010 · Thyroid
BACKGROUND: Vascular endothelial growth factor (VEGF-A) expression is upregulated in the majority of human tumors, where it stimulates proliferation, migration, and survival of endothelial cells. Studies have suggested that VEGF inhibitors…
View details →Negative / Null Result ReportSocial Sciences
David A. Tandberg, Nicholas Hillman · 2014 · Journal of education finance
As states explore strategies for increasing educational attainment levels, attention is being paid to performance funding. This study asks, “Does the introduction of performance funding programs affect degree completion among participating…
View details →Negative / Null Result ReportOpen accessMedicine
Leonie S. Penner, Sean P. Gavan, Darren M. Ashcroft et al. · 2022 · British Journal of Clinical Pharmacology
AIMS: To examine the risk of gastrointestinal (GI) bleeding, major bleeding, stroke and systemic embolism associated with prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) to adults receiving oral anticoagulant (OAC) therapy. METHODS: We conducted a population-based cohort study in adults receiving OAC therapy using linked primary care (Clinical Practice Research Datalink GOLD) and hospital (Hospital Episodes Statistics) electronic health records. We used cause-specific Cox regression models with time-dependent NSAID treatment in a propensity score matched population to estimate the in
View details →Negative / Null Result ReportMedicine
Alexis F. Turgeon, Dean A Fergusson, Lucy Clayton et al. · 2024 · New England Journal of Medicine
BACKGROUND: The effect of a liberal transfusion strategy as compared with a restrictive strategy on outcomes in critically ill patients with traumatic brain injury is unclear. METHODS: We randomly assigned adults with moderate or severe…
View details →Negative / Null Result ReportBusiness, Management and Accounting
Justin Paul, Shailja Bhakar · 2017 · Journal of Promotion Management
We examine whether image congruence (IC) of celebrities have significant effect on purchase intention (PI) and whether attitude towards brand and attitude towards advertisement mediate the relationships in a developing country, based on…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Heidi Edmonds, Julie Lovell, C. A. Knox Lovell · 2020 · Ecological Indicators
The earth’s climate is changing, with global warming attributable to anthropogenic greenhouse gas emissions driven by economic and population growth. Human systems and ecosystems vary in their exposure, mitigation and adaptive capacity,…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Christopher Redding, Thomas M. Smith · 2016 · American Educational Research Journal
Alternative certification programs are now commonplace in the credentialing of new teachers. We complement the growing evidence base for these teachers by exploring their turnover patterns in four waves of the nationally representative…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jonathan Beauchamp, David Cesarini, Magnus Johannesson et al. · 2011 · The Journal of Economic Perspectives
The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all,…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Kabir Peay, Sabrina E. Russo, Krista L. McGuire et al. · 2015 · Ecology Letters
Plants interact with a diversity of microorganisms, and there is often concordance in their community structures. Because most community-level studies are observational, it is unclear if such concordance arises because of host specificity,…
View details →Negative / Null Result ReportOpen accessNeuroscience
Dana M. Brantley‐Sieders, Aixiang Jiang, Krishna Sarma et al. · 2011 · PLoS ONE
Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated eph and ephrin expression in human breast cancer relative to endpoints of overall and/or recurrence-f
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
D. Rubin, G. Aldering, M. Betoule et al. · 2025 · The Astrophysical Journal
Abstract Type Ia supernovae (SNe Ia) were instrumental in establishing the acceleration of the Universe’s expansion. By virtue of their combination of distance reach, precision, and prevalence, they continue to provide key cosmological constraints, complementing other cosmological probes. Individual SN surveys cover only over about a factor of 2 in redshift, so compilations of multiple SN data sets are strongly beneficial. We assemble an up-to-date “Union” compilation of 2087 cosmologically useful SNe Ia from 24 data sets (“Union3”). We take care to put all SNe on the same distance scale and u
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Imran Yousaf, Larisa Yarovaya · 2022 · Finance research letters
We examine the static and time-varying herding behavior in three cryptocurrency classes: ‘conventional’ cryptocurrencies, non-fungible tokens, and DeFi assets during the most recent cryptocurrency bubble of 2021. While static herding analysis failed to demonstrate any evidence of herding, the time-varying herding has been identified in conventional cryptocurrencies and DeFi assets for the short investment horizons. The herding asymmetry analysis reveals that herding is not evident in conventional cryptocurrencies and NFT during up/down market, high/low volatility days, and high/low trading day
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Annika Wahl, Michel Charifzadeh, Fabian E. Diefenbach · 2020 · Business Strategy and the Environment
Abstract This study investigates how integrated reporting (IR) creates value for investors. It examines how providers of financial capital benefit from an improved firm information environment provided by IR. Specifically, this study investigates the effect of voluntary IR disclosure on analyst earnings forecast accuracy as well as on firm value. To do so, we use an international sample of 167 listed companies that voluntarily publish an integrated report. Our analysis shows no significant effect of a voluntary IR publication on analyst earnings forecast accuracy and no significant effect on f
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Kamalesh Mishra, Mary J. Metilda · 2015 · IIMB Management Review
This paper aims at studying the impact of investment experience, gender, and level of education on two specific biases—overconfidence and self-attribution, and exploring the relationship between the two biases. Data collected from a sample…
View details →