e-ISSN: Pending

Browse the failure-mode index

21,191 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Board gender diversity, corporate governance and bank efficiency in Ghana: a two stage data envelope analysis (DEA) approach

David Adeabah, Agyapomaa Gyeke‐Dako, Charles Andoh · 2018 · Corporate Governance

Purpose This study aims to analyze the efficiency of banks under board gender diversity and to examine the determinants of bank efficiency. Design/methodology/approach Data for analysis were sourced from annual reports of 21 banks for the…

View details →
Negative / Null Result ReportChemistry

Reliable Identification of Significant Differences in Differential Hydrogen Exchange-Mass Spectrometry Measurements Using a Hybrid Significance Testing Approach

Tyler S. Hageman, David D. Weis · 2019 · Analytical Chemistry

Differential hydrogen exchange-mass spectrometry (HX-MS) measurements are valuable for identification of differences in the higher order structures of proteins. Typically, the data sets are large with many differential HX values…

View details →
Replication FailureMedicine

Long-Term Results of a Randomized, Observation-Controlled, Phase III Trial of Adjuvant Interferon Alfa-2b in Hepatocellular Carcinoma After Curative Resection

Li‐Tzong Chen, Miin-Fu Chen, Lung-An Li et al. · 2011 · Annals of Surgery

OBJECTIVE: To investigate the clinical efficacy of adjuvant interferon alfa-2b (IFNα-2b) therapy on recurrence-free survival (RFS) of patients with postoperative viral hepatitis-related hepatocellular carcinoma (HCC). BACKGROUND: Despite…

View details →
Negative / Null Result ReportOpen accessEnvironmental Science

Comparison of AOD between CALIPSO and MODIS: significant differences over major dust and biomass burning regions

Xiaoyan Ma, Kevin S. Bartlett, K. Harmon et al. · 2013 · Atmospheric measurement techniques

Abstract. Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) provide global vertical profiles of aerosol optical properties for the first time. In this study, we employed about 6 yr (2006–2011) of CALIPSO level 3 monthly mean gridded aerosol optical depth (AOD) products (daytime and nighttime) for cloud-free conditions, to compare with the Moderate Resolution Imaging Spectroradiometer (MODIS) Terra/Aqua level 3 monthly mean AOD dataset for the same time period. While the spatial distribution and seasonal variability of CALIPSO AOD is generally consistent with that of

View details →
Negative / Null Result ReportOpen accessMedicine

Impact of COVID‐19 pandemic on ST‐elevation myocardial infarction in a non‐COVID‐19 epicenter

Tarek A. Hammad, Melanie Parikh, Nour Tashtish et al. · 2020 · Catheterization and Cardiovascular Interventions

OBJECTIVES: We sought to study the impact of COVID-19 pandemic on the presentation delay, severity, patterns of care, and reasons for delay among patients with ST-elevation myocardial infarction (STEMI) in a non-hot-spot region.…

View details →
Negative / Null Result ReportMedicine

Robotic Resection is a Good Prognostic Factor in Rectal Cancer Compared with Laparoscopic Resection: Long-term Survival Analysis Using Propensity Score Matching

Jin Kim, Se Jin Baek, Dong-Woo Kang et al. · 2017 · Diseases of the Colon & Rectum

BACKGROUND: Robotic total mesorectal excision for rectal cancer has rapidly increased and has shown short-term outcomes comparable to conventional laparoscopic total mesorectal excision. However, data for long-term oncologic outcomes are…

View details →
Negative / Null Result ReportOpen accessPhysics and Astronomy

SEARCH FOR GRAVITATIONAL WAVES ASSOCIATED WITH GAMMA-RAY BURSTS DURING LIGO SCIENCE RUN 6 AND VIRGO SCIENCE RUNS 2 AND 3

J. Abadie, B. P. Abbott, R. Abbott et al. · 2012 · The Astrophysical Journal

We present the results of a search for gravitational waves associated with 154 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments in 2009-2010, during the sixth LIGO science run and the second and third…

View details →
Negative / Null Result ReportEconomics, Econometrics and Finance

Hedge Fund Crowds and Mispricing

Richard W. Sias, Harry J. Turtle, Blerina Bela Zykaj · 2015 · Management Science

Recent models and the popular press suggest that large groups of hedge funds follow similar strategies resulting in crowded equity positions that destabilize markets. Inconsistent with this assertion, we find that hedge fund equity…

View details →
Negative / Null Result ReportOpen accessMedicine

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

James Galea, Kayode Ogungbenro, Sharon Hulme et al. · 2017 · Journal of neurosurgery

OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the initial bleeding are likely to suffer further early brain injury arising from a…

View details →
Negative / Null Result ReportOpen accessSocial Sciences

INTERNAL FACTOR EFFECTS IN FORMING THE SUCCESS OF SMALL BUSINESSES

Achmad Daengs GS · 2020 · Sinergi Jurnal Ilmiah Ilmu Manajemen

ABSTRACT. The objective of this study to analyses the effects of entrepreneurial competency, marketing capability, financial resources, technology usage, knowledge sharing to business success on Small-Micro Enterprises built by Industrial…

View details →
Negative / Null Result ReportOpen accessSocial Sciences

Public attitudes toward COVID-19 vaccination: The role of vaccine attributes, incentives, and misinformation

Sarah Kreps, Nabarun Dasgupta, John S. Brownstein et al. · 2021 · npj Vaccines

While efficacious vaccines have been developed to inoculate against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; also known as COVID-19), public vaccine hesitancy could still undermine efforts to combat the pandemic. Employing a survey of 1096 adult Americans recruited via the Lucid platform, we examined the relationships between vaccine attributes, proposed policy interventions such as financial incentives, and misinformation on public vaccination preferences. Higher degrees of vaccine efficacy significantly increased individuals' willingness to receive a COVID-19 vaccine, whi

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri

Thomas R. Connor, Clare R. Barker, Kate S. Baker et al. · 2015 · eLife

Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the

View details →
Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

Cameron D. Palmer, Itsik Pe’er · 2017 · PLoS Genetics

Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery cohorts. This limited success of replication raises pervasive questions about the utility of the GWAS field. We identify all 332 studies of quantitative traits from the NHGRI-EBI GWAS Database with attempted replication. We find that the majority of studies provide insufficient data to evaluate repl

View details →
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Social capital and its effect on business performance in the Nigeria informal sector

Olamide Akintimehin, Anthony Abiodun Eniola, Oluwatobi Joseph Alabi et al. · 2019 · Heliyon

This study was aimed at investigating the effect of internal and external social capital on the financial and non-financial performance of businesses in the Nigerian informal sector. The study further investigated the controlling role of firm age. A cross-sectional survey of 650 informal business owners in the Ikeja region of Lagos state, Nigeria was carried out. The analysis was carried out using the partial least square method of the structural equation model (SEM). Findings revealed that without the controlling variable of firm age, social capital had a significant effect on business perfor

View details →
Negative / Null Result ReportOpen accessEnvironmental Science

Saharan dust and daily mortality in Emilia-Romagna (Italy)

Stefano Zauli Sajani, Rossella Miglio, Paolo Bonasoni et al. · 2010 · Occupational and Environmental Medicine

OBJECTIVE: To investigate the association between Saharan dust outbreaks and natural, cardiovascular and respiratory mortality. METHODS: A case-crossover design was adopted to assess the effects of Saharan dust days (SDD) on mortality in…

View details →
Negative / Null Result ReportOpen accessMaterials Science

Young’s equation revisited

Lasse Makkonen · 2016 · Journal of Physics Condensed Matter

Young's construction for a contact angle at a three-phase intersection forms the basis of all fields of science that involve wetting and capillary action. We find compelling evidence from recent experimental results on the deformation of a soft solid at the contact line, and displacement of an elastic wire immersed in a liquid, that Young's equation can only be interpreted by surface energies, and not as a balance of surface tensions. It follows that the a priori variable in finding equilibrium is not the position of the contact line, but the contact angle. This finding provides the explanatio

View details →
Negative / Null Result ReportSocial Sciences

Comparing the Undergraduate Experience of Engineers to All Other Majors: Significant Differences are Programmatic

Gary Lichtenstein, Alexander C. McCormick, Sheri Sheppard et al. · 2010 · Journal of Engineering Education

B ackground The authors partnered with the National Survey of Student Engagement (NSSE) to examine how persistence within the engineering major and engagement of undergraduate students in engineering compare to other majors. P urpose (H…

View details →
Negative / Null Result ReportOpen accessMedicine

Mortality due to cardiovascular disease, respiratory disease, and cancer in adults with cerebral palsy

Jennifer Ryan, Mark D. Peterson, Nicola Ryan et al. · 2019 · Developmental Medicine & Child Neurology

AIM: To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population. METHOD: A cohort study was conducted using data from adults with CP in England,…

View details →
Negative / Null Result ReportOpen accessMedicine

Traditional landmark versus ultrasound guided tracheal puncture during percutaneous dilatational tracheostomy in adult intensive care patients: a randomised controlled trial

Máté Rudas, Ian Seppelt, Robert Herkes et al. · 2014 · Critical Care

INTRODUCTION: Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been proposed to decrease complications and improve the accuracy of the tracheal puncture. We aimed to compare the procedural safety and efficacy of real-time ultrasound guidance with the traditional landmark approach during percutaneous dilatational tracheostomy (PDT). METHODS: A total of 50 patients undergoing PDT for clinical indications were randomly assigned, after obtaining infor

View details →
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Phenotypic plasticity of thermal tolerance contributes to the invasion potential of Mediterranean fruit flies ( Ceratitis capitata )

Casper Nyamukondiwa, Elsje Kleynhans, John S. Terblanche · 2010 · Ecological Entomology

1. The invasion success of Ceratitis capitata probably stems from physiological, morphological, and behavioural adaptations that enable them to survive in different habitats. However, it is generally poorly understood if variation in acute…

View details →
Negative / Null Result Report

Progressive resistance training did not improve walking but can improve muscle performance, quality of life and fatigue in adults with multiple sclerosis: a randomized controlled trial

KJ Dodd, NF Taylor, N Shields et al. · 2011 · Multiple Sclerosis Journal

Background: Few high-quality trials have examined the effects of progressive resistance training (PRT) on people with multiple sclerosis (MS). Objective: To determine the effectiveness of PRT for people with MS, focusing on improving the…

View details →
Negative / Null Result ReportOpen accessEarth and Planetary Sciences

The floatingSargassum(Phaeophyceae) of the South Atlantic Ocean – likely scenarios

Marina Nasri Sissini, Maria Beatriz Barbosa de Barros Barreto, Maria Teresa Menezes de Széchy et al. · 2017 · Phycologia

:This study represents the efforts of a network of researchers to characterise the large, floating Sargassum (Fucales, Phaeophyceae) biomass that had reached the Brazilian coast in 2014 and 2015. Material collected during these events was…

View details →
Negative / Null Result ReportOpen accessNursing

Breadth of tuning in taste afferent neurons varies with stimulus strength

An Wu, Gennady Dvoryanchikov, Elizabeth Pereira et al. · 2015 · Nature Communications

Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory afferent neurons. Whether each taste quality (sweet, bitter and so on) is encoded by separate neurons ('labelled lines') remains controversial. We used mice expressing GCaMP3 in geniculate ganglion sensory neurons to investigate taste-evoked activity. Using confocal calcium imaging, we recorded responses to oral stimulation with prototypic taste stimuli. Up to 69% of neurons respond to multiple tastants. Moreover, neurons tuned to a single taste quality at low concentration become more broadly tuned when

View details →
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts

Dana A. Opulente, Abigail L. LaBella, Marie‐Claire Harrison et al. · 2024 · Science

Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth and (ii) the joint influence of extrinsic (environmental) and intrinsic (genomic) factors. We assembled genomic, metabolic, and ecological data from nearly all known species of the ancient fungal subphylum Saccharomycotina (1154 yeast strains from 1051 species), grown in 24 different environmental conditions, to examine niche breadth evolution.

View details →
Negative / Null Result ReportOpen accessMedicine

Markers of Celiac Disease and Gluten Sensitivity in Children with Autism

Nga M. Lau, Peter H.R. Green, Annette K. Taylor et al. · 2013 · PLoS ONE

OBJECTIVE: Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity. However, studies to date regarding the immune response to gluten in autism and its association with celiac disease have been inconsistent. The aim of this study was to assess immune reactivity to gluten in pediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and celiac disease. METHODS: Study participants included children (with or without gastrointestinal sym

View details →
Negative / Null Result ReportOpen accessMedicine

Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa et al. · 2017 · BMC Cancer

BACKGROUND: Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to estimate the incidence and survival rates. Furthermore, limited information is available on the efficacy of various treatment modalities in relation to primary tumor sites. METHODS: The data for this retrospective study were drawn from the Surveillance, Epidemiology and End Resu

View details →
Negative / Null Result ReportOpen accessMedicine

Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia—a multicenter, double‐blind, randomized, placebo‐controlled study

Hidekazu Suzuki, Juntaro Matsuzaki, Yasushi Fukushima et al. · 2014 · Neurogastroenterology & Motility

BACKGROUND: Rikkunshito, a standardized Japanese herbal medicine, is thought to accelerate gastric emptying and relieve dyspepsia, although no large-scale, randomized, placebo-controlled trials of rikkunshito have been conducted. This…

View details →