Negative / Null Result ReportMedicine
Joanna J. Wykrzykowska, Scot Garg, Yoshinobu Onuma et al. · 2011 · Circulation Cardiovascular Interventions
BACKGROUND: The age, creatinine, and ejection fraction (ACEF) score (age/left ventricular ejection fraction+1 if creatinine >2.0 mg/dL) has been established as an effective predictor of clinical outcomes in patients undergoing elective…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Floor Bennebroek Evertsz, Pythia T. Nieuwkerk, Pieter Stokkers et al. · 2012 · Journal of Crohn s and Colitis
AIM: To develop a patient-based Simple Clinical Colitis Activity Index (P-SCCAI) of ulcerative colitis (UC) activity and to compare it with the clinician-based SCCAI, C-reactive protein (CRP) and Physician's Global Assessment (PGA) of UC…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Davidson Heath, Daniele Macciocchi, Roni Michaely et al. · 2023 · European Finance Review
Abstract Using micro-level data, we examine the behavior of socially responsible investment (SRI) funds. SRI funds select firms with lower pollution, more board diversity, higher employee satisfaction, and better workplace safety. Yet,…
View details →Negative / Null Result ReportOpen accessMedicine
Petra Langerbeins, Michael Hallek · 2022 · Blood
The coronavirus infectious disease (COVID-19) shows a remarkable symptomatic heterogeneity. Several risk factors including advanced age, previous illnesses, and a compromised immune system contribute to an unfavorable outcome. In patients…
View details →Negative / Null Result ReportSocial Sciences
Andrew Rojecki, Sharon Meraz · 2014 · New Media & Society
The World Wide Web has changed the dynamics of information transmission and agenda-setting. Facts mingle with half-truths and untruths to create factitious informational blends (FIBs) that drive speculative politics. We specify an…
View details →Negative / Null Result ReportOpen accessMedicine
Yukinori Kurokawa, Mitsuru Sasako, Takeshi Sano et al. · 2015 · British journal of surgery
BACKGROUND: The optimal surgical approach for treatment of oesophagogastric junction (OGJ) cancer is controversial. A randomized clinical trial (JCOG9502) comparing transhiatal (TH) and left thoracoabdominal (LTA) approaches was stopped…
View details →Failed Experiment ReportOpen accessPhysics and Astronomy
Eric M Kenney, Brenden R Ortiz, Chennan Wang et al. · 2021 · Journal of Physics Condensed Matter
Abstract We have carried out muon spin relaxation and rotation measurements on the newly discovered kagome metal KV 3 Sb 5 , and find a local field dominated by weak magnetic disorder which we associate with the nuclear moments present,…
View details →Negative / Null Result ReportMedicine
Wim Van Paesschen, Édouard Hirsch, Martin Johnson et al. · 2012 · Epilepsia
PURPOSE: To evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV), a novel high-affinity synaptic vesicle protein 2A ligand that also displays inhibitory activity at neuronal voltage-dependent sodium channels, in adult…
View details →Negative / Null Result ReportOpen accessMedicine
Timothy F. Cloughesy, Kevin Petrecca, Tobias Walbert et al. · 2020 · JAMA Oncology
Importance: New treatments are needed to improve the prognosis of patients with recurrent high-grade glioma. Objective: To compare overall survival for patients receiving tumor resection followed by vocimagene amiretrorepvec (Toca 511)…
View details →Negative / Null Result ReportSocial Sciences
Sandra E. Black, Paul J. Devereux, Kjell G. Salvanes · 2015 · American Economic Journal Applied Economics
Using population data from Norway, we examine the effects of stress induced by the death of the mother's parent during pregnancy on both the short-run and the long-run outcomes of the infant. Using a variety of empirical strategies to…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yuchao Zhang, Atahualpa Castillo-Morales, Min Jiang et al. · 2013 · Molecular Biology and Evolution
In female mammals most X-linked genes are subject to X-inactivation. However, in humans some X-linked genes escape silencing, these escapees being candidates for the phenotypic aberrations seen in polyX karyotypes. These escape genes have…
View details →Negative / Null Result ReportPsychology
Robyn L. Gobin, Jennifer J. Freyd · 2013 · Psychological Trauma Theory Research Practice and Policy
Early experiences of violation perpetrated by close others, or betrayal traumas, may interfere with developing social capacities, including the ability to make healthy decisions about whom to trust. Betrayal trauma theory posits that…
View details →Negative / Null Result ReportOpen accessPsychology
Clare Sutherland, Xizi Liu, Lingshan Zhang et al. · 2017 · Personality and Social Psychology Bulletin
People form first impressions from facial appearance rapidly, and these impressions can have considerable social and economic consequences. Three dimensions can explain Western perceivers' impressions of Caucasian faces: approachability,…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Alexander M. Aiken, Calum Davey, James Hargreaves et al. · 2015 · International Journal of Epidemiology
BACKGROUND: Helminth (worm) infections cause morbidity among poor communities worldwide. An influential study conducted in Kenya in 1998-99 reported that a school-based drug-and-educational intervention had benefits regarding worm…
View details →Negative / Null Result ReportOpen accessMedicine
Mark W. Becker, Nora M. Bello, Raghav Prashant Sundar et al. · 2015 · Food Policy
OBJECTIVES: 1) To assess whether Front-of-Pack (FOP) nutrition labels garner attention more readily than more complete, mandated nutrition information (the Nutrition Facts Panel (NFP), required in the US), and 2) To determine whether label…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Oisín Tansey · 2015 · Democratization
Recent scholarship has increasingly focused on the international dimensions of authoritarian rule, and the idea of autocracy promotion has gained considerable academic currency. While the literature on autocracy promotion has identified…
View details →Negative / Null Result ReportOpen accessMedicine
Daniel J. Renouf, Jonathan M. Loree, Jennifer J. Knox et al. · 2022 · Nature Communications
Immunotherapy-based monotherapy treatment in metastatic pancreatic ductal adenocarcinoma (mPDAC) has shown limited benefit outside of the mismatch repair deficiency setting, while safety and efficacy of combining dual-checkpoint inhibitor immunotherapy with chemotherapy remains uncertain. Here, we present results from the CCTG PA.7 study (NCT02879318), a randomized phase II trial comparing gemcitabine and nab-paclitaxel with and without immune checkpoint inhibitors durvalumab and tremelimumab in 180 patients with mPDAC. The primary endpoint was overall survival. Secondary endpoints included pr
View details →Negative / Null Result ReportOpen accessMedicine
Floris Dammeijer, Lysanne A. Lievense, Margaretha E. Kaijen-Lambers et al. · 2017 · Cancer Immunology Research
Abstract New immunotherapeutic strategies are needed to induce effective antitumor immunity in all cancer patients. Malignant mesothelioma is characterized by a poor prognosis and resistance to conventional therapies. Infiltration of…
View details →Negative / Null Result ReportOpen accessPsychology
Philip T. Yanos, David Roe, Michelle L. West et al. · 2012 · Psychological Services
Elevated internalized stigma is common and is linked to subjective and objective outcomes for severe mental illness. The authors developed a manualized group-based intervention (Narrative Enhancement/Cognitive Therapy; NECT) to address…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Kenneth Younge, Tony W. Tong, Lee Fleming · 2014 · Strategic Management Journal
This study draws on strategic factor market theory and argues that acquirers' decisions regarding whether to bid for a firm reflect their expectations about employee departure from the firm post‐acquisition, suggesting a negative…
View details →Negative / Null Result ReportOpen accessMedicine
David C. Wheeler, Gérard M. London, Patrick S. Parfrey et al. · 2014 · Journal of the American Heart Association
BACKGROUND: Premature cardiovascular disease limits the duration and quality of life on long-term hemodialysis. The objective of this study was to define the frequency of fatal and nonfatal cardiovascular events attributable to…
View details →Negative / Null Result ReportOpen accessHealth Professions
Andrew M. Ryan, Sam Krinsky, Kristin A. Maurer et al. · 2017 · New England Journal of Medicine
BACKGROUND: Starting in fiscal year 2013, the Hospital Value-Based Purchasing (HVBP) program introduced quality performance-based adjustments of up to 1% to Medicare reimbursements for acute care hospitals. METHODS: We evaluated whether…
View details →Negative / Null Result ReportOpen accessNeuroscience
Vincent O. Nyasembe, Peter E. A. Teal, Wolfgang R Mukabana et al. · 2012 · Parasites & Vectors
BACKGROUND: Sugar feeding is critical for survival of malaria vectors and, although discriminative plant feeding previously has been shown to occur in Anopheles gambiae s.s., little is known about the cues mediating attraction to these plants. In this study, we investigated the role of olfaction in An. gambiae discriminative feeding behaviour. METHODS: Dual choice olfactometer assays were used to study odour discrimination by An. gambiae to three suspected host plants: Parthenium hysterophorus (Asteraceae), Bidens pilosa (Asteraceae) and Ricinus communis (Euphorbiaceae). Sugar content of the t
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Rachel Griffith, Gareth Macartney · 2013 · The Review of Economics and Statistics
Abstract The theoretical effects of labor regulations, such as employment protection legislation (EPL), on innovation is ambiguous. EPL increases job security, and the greater enforceability of job contracts may increase worker investment…
View details →Negative / Null Result ReportOpen accessMedicine
Céline Grégoire, Caroline Ritacco, Muriel Hannon et al. · 2019 · Frontiers in Immunology
Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft-versus-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. MSCs from different tissue origins display different characteristics, but their therapeutic benefits have never been directly compared in GVHD. Here, we compared the impact of BM-, umbilical cord (UC-), and adipose-tissue (AT-) derived MSCs on T-cell function in
View details →Negative / Null Result ReportOpen accessMedicine
Emily C. LaVoy, Christopher P. Fagundes, Robert Dantzer · 2026 · PubMed
Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer…
View details →Negative / Null Result ReportOpen accessMedicine
Donna R. Rivera, Solange Peters, Orestis A. Panagiotou et al. · 2020 · Cancer Discovery
Abstract Among 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. Logistic…
View details →Negative / Null Result ReportOpen accessMedicine
Priyanka Sharma, William E. Barlow, Andrew K. Godwin et al. · 2017 · Annals of Oncology
Background: Homologous recombination deficiency (HRD)-causing alterations have been reported in triple-negative breast cancer (TNBC). We hypothesized that TNBCs with HRD alterations might be more sensitive to anthracycline plus…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Celso Brunetti, Bahattin Büyükşahin, Jeffrey H. Harris · 2016 · Journal of Financial and Quantitative Analysis
We use data from 2005–2009 that uniquely identify categories of traders to test how speculators such as hedge funds and swap dealers relate to volatility and price changes. In examining various subperiods where price trends are strong, we…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lee S. Katz, Aaron Petkau, John Beaulaurier et al. · 2013 · mBio
UNLABELLED: Prior to the epidemic that emerged in Haiti in October of 2010, cholera had not been documented in this country. After its introduction, a strain of Vibrio cholerae O1 spread rapidly throughout Haiti, where it caused over 600,000 cases of disease and >7,500 deaths in the first two years of the epidemic. We applied whole-genome sequencing to a temporal series of V. cholerae isolates from Haiti to gain insight into the mode and tempo of evolution in this isolated population of V. cholerae O1. Phylogenetic and Bayesian analyses supported the hypothesis that all isolates in the sample
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