Does coprescribing nonsteroidal anti‐inflammatory drugs and oral anticoagulants increase the risk of major bleeding, stroke and systemic embolism?
Leonie S. Penner; Sean P. Gavan; Darren M. Ashcroft; Niels Peek; Rachel Elliott · 2022 · British Journal of Clinical Pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
AIMS: To examine the risk of gastrointestinal (GI) bleeding, major bleeding, stroke and systemic embolism associated with prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) to adults receiving oral anticoagulant (OAC) therapy. METHODS: We conducted a population-based cohort study in adults receiving OAC therapy using linked primary care (Clinical Practice Research Datalink GOLD) and hospital (Hospital Episodes Statistics) electronic health records. We used cause-specific Cox regression models with time-dependent NSAID treatment in a propensity score matched population to estimate the in
Abstract by Leonie S. Penner; Sean P. Gavan; Darren M. Ashcroft; Niels Peek; Rachel Elliott, British Journal of Clinical Pharmacology (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1111/bcp.15371