Negative / Null Result ReportOpen accessMedicine
Seyed Seifollah Beladi Mousavi, Abbasali Zeraati, Sajad Moradi et al. · 2015 · Saudi Journal of Kidney Diseases and Transplantation
Hemodialysis‐associated muscle cramps (HAMC) are a common complication during hemodialysis (HD) sessions. A number of pharmacologic agents have been evaluated to prevent and or diminish HAMC; however, none of them has an established role. To the best of our knowledge, this is the first study to evaluate the possible effect of gabapentin on HAMC. In a double-blinded clinical trial, we compared the possible effect of gabapentin with a placebo in prevention and or diminishing episodes of HAMC in HD patients who had experienced frequent intradialytic muscle cramps. At first, placebo was given befo
View details →Negative / Null Result ReportOpen accessMedicine
Annikka Polster, Lena Öhman, Julien Tap et al. · 2021 · Scientific Reports
Abstract Although incompletely understood, microbiota-host interactions are assumed to be altered in irritable bowel syndrome (IBS). We, therefore, aimed to develop a novel analysis pipeline tailored for the integrative analysis of microbiota-host interactions and association to symptoms and prove its utility in a pilot cohort. A multilayer stepwise integrative analysis pipeline was developed to visualize complex variable associations. Application of the pipeline was demonstrated on a dataset of IBS patients and healthy controls (HC), using the R software package to analyze colonic host mRNA a
View details →Negative / Null Result ReportOpen accessEnvironmental technology. Sanitary engineering
Han Wu, Baofa Jiang, Ping Zhu et al. · 2018 · Environmental Research Letters
When discussing the association between birth weight and air pollution, previous studies mainly focus on the maternal trimester-specific exposures during pregnancy, whereas the possible associations between birth weight and weekly-specific exposures have been largely neglected. We conducted a nested 1:4 matched case-control study in Jinan, China to examine the weekly-specific associations during pregnancy between maternal fine particulate matter (aerodynamic diameter < 2.5 μm, PM _2.5 ), nitrogen dioxide (NO _2 ), and sulfur dioxide (SO _2 ) exposure and birth weight, which is under a represen
View details →Negative / Null Result ReportOpen access
L. L. D. Paiva, Tatiane Kelly Barbosa de Azevedo, A. Pimenta et al. · 2023 · Revista Árvore
ABSTRACT This research aimed to evaluate the effect of thinning on the wood volumes per hectare on the tannin content in the bark of Mimosa caesalpiniifolia. The planting was subdivided into two plots, one thinned at 12 and 55 months of…
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Bolte John, Schipper Maarten, Kelfkens Gert et al. · 2011 · BMC Public Health
Abstract Background Evidence about a possible causal relationship between non-specific physical symptoms (NSPS) and exposure to electromagnetic fields (EMF) emitted by sources such as mobile phone base stations (BS) and powerlines is insufficient. So far little epidemiological research has been published on the contribution of psychological components to the occurrence of EMF-related NSPS. The prior objective of the current study is to explore the relative importance of actual and perceived proximity to base stations and psychological components as determinants of NSPS, adjusting for demograph
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Asher Shafrir, Asher Shafrir, Asher Shafrir et al. · 2022 · Frontiers in Pharmacology
Background and Aims: There is conflicting evidence regarding the association between proton pump inhibitors (PPI) and the risk of acquisition and severity of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Aim: To evaluate the association between PPI exposure and infection and development of severe disease in patients infected with SARS-CoV2in a large population-based historical cohort.Methods: Data were extracted from a health maintenance organization database in Israel that insures over 1,200,000 individuals from across the country. All patients who underwent SARS-CoV-2 testi
View details →Negative / Null Result ReportOpen accessMedicine
Rob Janssen, Jef Serré, Ianthe Piscaer et al. · 2020 · ERJ Open Research
Background Vitamin D supplementation lowers exacerbation frequency in severe vitamin D-deficient patients with COPD. Data regarding the effect of vitamin D on elastin degradation are lacking. Based on the vitamin's anti-inflammatory properties, we hypothesised that vitamin D supplementation reduces elastin degradation, particularly in vitamin D-deficient COPD patients. We assessed the effect of vitamin D status and supplementation on elastin degradation by measuring plasma desmosine, a biomarker of elastin degradation. Methods Desmosine was measured every 4 months in plasma of 142 vitamin D-na
View details →Negative / Null Result ReportOpen accessPediatrics
Karl Ove Hufthammer, Trond Markestad, Claus Klingenberg et al. · 2022 · BMJ Paediatrics Open
Objective To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks.Setting All neonatal intensive care units (NICUs) in Norway during 2012–2018.Methods Defined population-based data were prospectively entered into a national registry. We compared LISA infants with all non-LISA infants and with non-LISA infants who received surfactant following intubation. We used propensity score (PS) matching to identify non-LISA infants who were similar regarding potential confounders.Main outco
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Takehiro Sugiyama, Takashi Furuno, Yuichi Ichinose et al. · 2024 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its safety profile. The present study aimed to determine if the use of NTTP‐contaminated sitagliptin, in comparison with other dipeptidyl peptidase‐4 (DPP‐4) inhibitors, is associated with an increased cancer risk. Materials and Methods This retrospective cohort study secondarily used the National Database of Health Insurance Claims and S
View details →Negative / Null Result ReportOpen accessMedicine
Luis M. Pérez-Belmonte, José David Torres-Peña, María D. López-Carmona et al. · 2020 · BMC Medicine
Abstract Background Limited evidence exists on the role of glucose-lowering drugs in patients with COVID-19. Our main objective was to examine the association between in-hospital death and each routine at-home glucose-lowering drug both individually and in combination with metformin in patients with type 2 diabetes mellitus admitted for COVID-19. We also evaluated their association with the composite outcome of the need for ICU admission, invasive and non-invasive mechanical ventilation, or in-hospital death as well as on the development of in-hospital complications and a long-time hospital st
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Mostafa Shahraki Jazinaki, Mostafa Shahraki Jazinaki, Mohammad Safarian et al. · 2024 · Frontiers in Nutrition
Background and aimThe Global Leadership Initiative on Malnutrition (GLIM) recently proposed a new malnutrition diagnostic tool known as the GLIM criteria. The GLIM criteria need confirmed validation before being widely used in each population or healthcare system. This study aimed to investigate the validation of the GLIM criteria for malnutrition diagnosis in hospitalized patients.MethodsThe content validity was assessed by calculating the content validity ratio (CVR) and content validity index (CVI). Subjective global assessment (SGA) is considered the reference tool to diagnose malnutrition
View details →Negative / Null Result ReportOpen accessSports medicine
Stian Kjennvold MD, Jan Harald Røtterud MD, PhD, Magnus Forssblad MD, PhD et al. · 2025 · Orthopaedic Journal of Sports Medicine
Background: It is well-established that patients undergoing anterior cruciate ligament reconstruction (ACLR) have a less favorable prognosis if a concomitant full-thickness cartilage lesion is present at the time of surgery. However, the long-term benefits of surgically addressing these cartilage lesions remain uncertain. Purpose: To evaluate whether the most used surgical treatments for cartilage lesions influenced patient-reported outcomes 10 years after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: This study was based on a cohort of all patients with primary unilateral A
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Louis Okeibunor Odeigah, Yahkub Babatunde Mutalub, Olalekan Ayodele Agede et al. · 2022 · PLOS Global Public Health
Safe and effective vaccination remains the mainstay of control of COVID-19 because there is still no universally recommended treatment. This strategy is however being threatened by vaccine hesitancy and resistance due to fear of adverse events and safety concerns. It is, therefore, necessary to study post-vaccination adverse events (AE) in various populations and geographical areas. The objective of this study was to analyze the adverse events following COVID-19 vaccination in five major immunization centers of Kwara State Nigeria. A retrospective descriptive study of the adverse events follow
View details →Negative / Null Result ReportOpen accessPsychiatry
Junjun Liu, Junjun Liu, Junjun Liu et al. · 2023 · Frontiers in Psychiatry
ObjectiveTriglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG index and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim of this study was to investigate the relationship between TyG index and SA in Chinese patients with first-episode drug-naïve (FEDN) MDD.MethodsThis cross-sectional study enrolled 1,718 patients with FEDN MDD aged 34.9 ± 12.4 years from the First Hospital of Shanxi Medical University (Taiyuan, Shanxi Province, China) from September 2016 to December 2018. Mul
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Dulharie T. Wijeratne, Samitha Fernando, Laksiri Gomes et al. · 2019 · Immunity, Inflammation and Disease
Abstract Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied. We sought to investigate how the functionality of DENV–NS3 and DENV–NS5 protein‐specific T cells differ in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Methods Using intracellular cytokine assays, we assessed the production of interferon γ (IFNγ), tumor necrosis factor‐α (TNF‐α), macrophage inflammatory protein‐1β (MIP‐1β), a
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Pankaj Puar, Nikhil Mistry, Kim A. Connelly et al. · 2023 · ESC Heart Failure
Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. Methods and results The EMPA‐HEART CardioLink‐6 trial used gold‐standard cardiac magnetic resonance imaging to detect change in left ventricular mass
View details →Negative / Null Result ReportOpen accessMedicine
Mina Niusha, Seyed Ali Rahmani, Leila Kohan et al. · 2023 · Asian Pacific Journal of Reproduction
Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 embryos from 62 couples were screened for chromosomes 13, 21, 18, X, and Y by fluorescence insitu hybridization. For biopsy of blastomere, a laser was used to remove a significantly smaller portion of the zona pellucida. One blastomere was gently biopsied by an aspiration pipette through the hole. After biopsy, the embryo was immediately returned to
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Baravan Al-Kassou, Hasanin Al-Shaikh, Adem Aksoy et al. · 2023 · International Journal of Cardiology: Heart & Vasculature
Background: Vascular injury and bleeding complications remain frequent after transcatheter aortic valve replacement (TAVR). Whether the access-site of preprocedural coronary angiography (CAG) affects TAVR-related complications is not known. The aim of this study was to evaluate the impact of transradial (TRA) versus transfemoral access (TFA) for preprocedural CAG on outcomes in patients undergoing subsequent TAVR. Methods: The study cohort included 1002 patients undergoing transfemoral TAVR, of whom 39.4% (395/1002) had undergone radial and 60.6% (607/1002) femoral access for pre-TAVR CAG. The
View details →Negative / Null Result ReportOpen accessBusiness
Choudhury Mousumi, Singh Ranjit · 2016 · Acta Universitatis Sapientiae: Economics and Business
Bancassurance has evolved as a strong distribution channel in India. Bancassurance means that the insurance company and the bank come together to offer insurance products from the counter of the banks to the bank’s customer. The present study attempts to analyse customers’ perception regarding assurance of bancassurance channel in providing insurance-related services. The study also tries to find out the impact of various demographic variables on customers’ perception regarding assurance of bancassurance channel. The study finds that customers consider bancassurance channel having high assuran
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shih-Wei Lai, Shih-Wei Lai, Cheng-Li Lin et al. · 2017 · Frontiers in Pharmacology
Background/Objectives: Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study purpose was to examine the association between HCC risk and zolpidem use in Taiwan.Methods: Using the database from the Taiwan National Health Insurance Program, we designed a case-control study which consisted of 77986 subjects aged 20 years or older with newly diagnosed HCC as the case group, and 77986 subjects without HCC as the control group, from 2000 to 2011. Ever use of zolpidem wa
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Sonia Oveisi, Roghaye Keshavarz Sadegh, Sina Hosainzade et al. · 2025 · Discover Social Science and Health
Abstract Background Parenting self-efficacy (PSE) describes the beliefs and attitudes of parents on their capabilities to perform well on parenting tasks. Considering its direct relation to the physical and mental development of the children, we evaluated PSE in Iranian parents and investigated its potential effects on children's growth as a reflection of their self-regulation. Methods This investigation was conducted in 2019 in Takestan, Iran, and aimed to assess PSE in 300 parents of children under 2 years old. Families filled out a demographic questionnaire and a PSE questionnaire containin
View details →Negative / Null Result ReportOpen accessMedicine
Zainab Almussa · 2021 · The Medical Journal of Basrah University
Abstract: Introduction: Low birth weight is the best indicator of the impact in the health system and the best predictor of mortality and morbidity in the neonatal, post neonatal and childhood periods. Objectives: This study was planned to study the association between birth weight and selected risk factors in Basrah governorate with special reference to: Socio demographic factors, Present obstetric history, Past obstetric history, History of Ante Natal Care, and Medical history. Methods: This is hospital- based cross sectional study was conducted on 362 infants delivered and /or admitted to A
View details →Negative / Null Result ReportOpen accessDentistry
Patrícia Petromilli Nordi Sasso Garcia, Camila Pinelli, Juliana dos Reis Derceli et al. · 2015 · Brazilian Journal of Oral Sciences
Aim: This study assessed the risk factors of undergraduate students to develop musculoskeletal disorders (MSD) in the upper limbs, regarding gender, type of dental clinical procedure, mouth region treated, and the four-handed dentistry practice. Methods: Dental students enrolled in the 8th semester in the Araraquara School of Dentistry, UNESP, Brazil, were photographed while practicing 283 dental procedures. The Rapid Upper Limb Assessment (RULA) method was used to evaluate the working postures of each student. The photographs were evaluated and a final risk score was attributed to each analyz
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki et al. · 2002 · BMC Neurology
Abstract Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. Methods Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mansour S Almetwazi, Ahmad O Noor, Diena M Almasri et al. · 2017 · Saudi Pharmaceutical Journal
Objective: To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes. Research design and method: We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin
View details →Negative / Null Result ReportOpen accessMedicine
Xin Zhao, Chaoxuan Wang, Jian Wang et al. · 2026 · Scientific Reports
Abstract Sarcopenia, the progressive loss of muscle mass and function, is a significant health concern in middle-aged and older adults, potentially linked to adverse outcomes like falls and fractures. A cohort study was conducted utilizing participants aged ≥ 45 years from CHARLS. Sarcopenia was defined using established criteria. Primary outcomes were isolated falls, isolated hip fractures, and composite outcomes. Associations were assessed using multivariable Cox regression (adjusted for confounders), propensity score matching (PSM), and inverse probability weighting (IPW), reporting hazard
View details →Negative / Null Result ReportOpen accessPsychiatry
Ahmed Kamil Toman, Ahmed Kamil Toman, Ahmed Kamil Toman et al. · 2025 · Frontiers in Psychiatry
IntroductionCo-occurring conditions are common in children with autism spectrum disorder (ASD) and have important negative impacts on the children and their families. For Iraqi children, local healthcare systems tend to place more emphasis on the management of ASD itself while neglecting co-occurring conditions.ObjectivesThis study aims to investigate the prevalence, characteristics, and potential risk factors of co-occurring epilepsy, sleep, and weight issues among Iraqi children with ASD.MethodsA multicenter cross-sectional study was conducted from January 24 to August 7, 2024, including chi
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Sharmin Chowdhury, Sheikh Joly Ferdous Ara, Shirazum Monira Mili et al. · 2022 · Advances in Cancer Biology - Metastasis
Background: Colorectal carcinoma (CRC) is the third most common cancer in the world and incidences are on the rise in Bangladesh. KRAS, NRAS, BRAF, PIK3CA, and AKTI gene mutations are predictive markers of biological therapies, monoclonal antibodies targeting EGFR. The purpose of this study was to detect KRAS, NRAS, BRAF, PIK3CA, and AKT1 genes mutation in CRC patients by multiplex real-time Polymerase Chain Reaction (PCR) and evaluate the association of the mutations with clinicopathological features. Methodology: This cross-sectional study was carried out in the Department of Microbiology &
View details →Negative / Null Result ReportMedicine
H. Henjum, Karoline Mo Feten, Erlend Hartvigsen et al. · 2025 · Acta oncologica
Background and purpose Proton Arc Therapy (PAT) is an emerging proton therapy treatment modality with the potential to reduce radiation exposure to healthy tissues compared to conventional Intensity-Modulated Proton Therapy (IMPT) with…
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Sanjay B Tripathi, Vishakha K Kapadia · 2015 · National Journal of Community Medicine
Objectives: To evaluate the clinical profile and the factors influencing treatment outcome of TB patients co-infected with HIV attending DOT centers of Southeast area of Ahmedabad, Gujarat Methodology: A Prospective observation study was conducted to assess the treatment outcome of TB in TB-HIV co-infected patients on DOTs conducted at L.G. Hospital and tuberculosis units (TUs) of south and east region of Ahmedabad. TB patients started DOTS were registered and were followed till treatment outcome was declared. Results: The treatment success rate was found to be 84.17% (101 of 120 patients). Tr
View details →