Assessment of cancer risk associated with 7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine‐contaminated sitagliptin use: A retrospective cohort study
Takehiro Sugiyama; Takashi Furuno; Yuichi Ichinose; Masao Iwagami; Noriko Ihana‐Sugiyama; Kenjiro Imai; Tamaki Kakuwa; Ryoko Rikitake · 2024 · Journal of Diabetes Investigation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its safety profile. The present study aimed to determine if the use of NTTP‐contaminated sitagliptin, in comparison with other dipeptidyl peptidase‐4 (DPP‐4) inhibitors, is associated with an increased cancer risk. Materials and Methods This retrospective cohort study secondarily used the National Database of Health Insurance Claims and S
Abstract by Takehiro Sugiyama; Takashi Furuno; Yuichi Ichinose; Masao Iwagami; Noriko Ihana‐Sugiyama; Kenjiro Imai; Tamaki Kakuwa; Ryoko Rikitake, Journal of Diabetes Investigation (2024) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Lack of effect of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed type 1 diabetes: a randomised controlled trial
Negative / Null Result ReportEvaluation of ketoconazole as a treatment for Cushing’s disease in a retrospective cohort
Negative / Null Result ReportThe Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
Negative / Null Result ReportExpression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
Negative / Null Result ReportThe effect of preoperative short-term octreotide treatment to surgery in thyrotropin-secreting pituitary adenomas: a retrospective cohort study
Negative / Null Result ReportAssociation between adjusted body size index and abdominal aortic calcification among US older adults aged 40 years and above from a cross-sectional survey of the NHANES 2013-2014
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1111/jdi.14281