Negative / Null Result ReportMedicine
Zhang Y, Wang J, Hao M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
PURPOSE: This proof-of-concept study aimed to detect preliminary signals of efficacy and assess the short-term safety of Esculin and Digitalis glycoside eye drops for the management of presbyopia. METHODS: This study was a 30-day,…
View details →Negative / Null Result ReportMedicine
Bovenberg C, Keeler JL, Cardi V et al. · 2026 · Journal of eating disorders
Background Anorexia nervosa (AN) is a severe psychiatric disorder (ED) with high mortality, marked functional impairment, and substantial phenotypical heterogeneity. Despite extensive research, treatment outcomes remain poor, and it is…
View details →Negative / Null Result ReportMedicine
Abbas Amanat M, Srichana T, Takahashi Yupanqui C et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Dry mouth is a condition associated with significant morbidity. It not only causes discomfort but also increases risk of many health and oral health problems. Objectives This study compared the efficacy and patient satisfaction…
View details →Negative / Null Result ReportMedicine
Rajendiran A, Maharjan A, Gerrard AD et al. · 2026 · Techniques in coloproctology
Introduction Radiofrequency ablation (RFA) for haemorrhoids has emerged as a minimally invasive treatment for grade II-III haemorrhoids, offering reduced postoperative pain and faster recovery compared with conventional surgery. However,…
View details →Negative / Null Result ReportMedicine
Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine
Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…
View details →Negative / Null Result ReportOpen accessMedicine
Wang J, Chen J, Zhao Y et al. · 2026 · Bone & joint research
Aims Ankle sprain (AS), a prevalent sports injury, often progresses to chronic ankle instability (CAI) and post-traumatic arthritis if inadequately treated. Despite known clinical manifestations, the molecular mechanisms driving poor…
View details →Negative / Null Result ReportOpen accessMedicine
Seok HG, Park SG · 2026 · Archives of orthopaedic and trauma surgery
INTRODUCTION: The recovery patterns following arthroscopic rotator cuff repairs are influenced by several factors, including the size of the tear and the degree of patient compliance. This study aimed to ascertain whether a correlation…
View details →Negative / Null Result ReportMedicine
Hassan AM, Elgarem HF, Sheta E et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective Balloon dilation of the Eustachian tube (BDET) is increasingly used to treat pediatric obstructive Eustachian tube dysfunction (OETD); however, its broader adoption is limited by the cost of commercially available devices.…
View details →Negative / Null Result ReportMedicine
Metry M, Bernard S · 2026 · JAAPA : official journal of the American Academy of Physician Assistants
Abstract Heart failure (HF) is one of the most common and consequential conditions encountered in clinical practice. It frequently coexists with chronic kidney disease (CKD), a highly prevalent and economically burdensome condition. The…
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Golz C, Gerlach M, Meichtry A et al. · 2026 · Preprint
Abstract Background: Presenteeism behaviour, defined as working while ill, can negatively affect employee health and productivity. Despite its high prevalence, targeted theory-based interventions remain scarce. This study evaluated a…
View details →Negative / Null Result ReportOpen accessMedicine
Flores Rodríguez JC, Morán Ortega MJ, Jimenez Ordoñez AC et al. · 2026 · Cureus
Postbiotics, defined as non-viable microbial cells and their metabolites, have emerged as topical therapies for inflammatory dermatoses and provide more clinical benefits than live postbiotics by eliminating infection risk and stability.…
View details →Negative / Null Result ReportOpen accessMedicine
Cangemi DJ, Laitman AP, Faiman O et al. · 2026 · Annals of medicine
Introduction Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately.…
View details →Negative / Null Result ReportMedicine
Gozde Ozdemir B, Avci F, Huseynli L et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.…
View details →Negative / Null Result ReportMedicine
Yang J, Han Y · 2026 · Food Hydrocolloids.
The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…
View details →Negative / Null Result ReportMedicine
Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…
View details →Negative / Null Result ReportMedicine
Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science
Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…
View details →Negative / Null Result ReportMedicine
Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…
View details →Negative / Null Result Report
EL-Husseiny AM, Salem HH, Abdelfatah AM et al. · 2026 · Preprint
Abstract Background Chronic pain imposes significant impact on individuals and the health system as it is often accompanied by significant physical, emotional and social burden. It is frequently associated with anxiety disorders,…
View details →Negative / Null Result ReportMedicine
Saito T, Hirose T, Haruna T et al. · 2026 · The Journal of laryngology and otology
Objective. To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for…
View details →Negative / Null Result Report
Erbas A, Duman S, Onder M et al. · 2026 · Preprint
Abstract Introduction: Comparative data for regenerative techniques in osteochondral lesions of the talus (OLT) remain limited. We compared the outcomes of a three-layered cell-free scaffold (ChondRoD) with osteochondral autograft…
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Awatade NT, Budden KF, Pathinayake PS et al. · 2026 · Preprint
Increasing evidence suggests that acquired dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel occurs as a result of cigarette smoke exposure in Chronic obstructive pulmonary disease (COPD).…
View details →Negative / Null Result ReportOpen accessMedicine
Song X, Wang Y, Chen H · 2026 · International journal of cardiology. Cardiovascular risk and prevention
Objective To identify distinct multi-year cognitive function trajectories in middle-aged and older Chinese adults with established cardiovascular disease (CVD) and evaluate their independent associations with all-cause mortality. Methods…
View details →Negative / Null Result ReportOpen accessMedicine
Pham VX, Gilbertson E · 2026 · Cureus
This case report describes an 83-year-old female who developed severe psoriasiform lesions suspected to be induced by dupilumab. The patient initially presented with eczematous papules affecting her back, arms, torso, and scalp, and a…
View details →Negative / Null Result ReportMedicine
Espehana A, Macfarlane G, Garden EM et al. · 2026 · Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
Objectives Tumour Necrosis factor antagonists is a potent anti-inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in…
View details →Negative / Null Result Report
Lin B, Schneider K, Ozgul M et al. · 2026 · Preprint
Abstract This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression in Royal College of Surgeons (RCS) rats with retinal…
View details →Negative / Null Result ReportMedicine
Liu X, Shi J, Wang T · 2026 · Reproduction (Cambridge, England)
Polycystic ovary syndrome (PCOS) is a prevalent multifactorial disorder characterized by hormone dysregulation and follicular development defects. Asialoglycoprotein receptor 1 (ASGR1), a C-type lectin predominantly expressed on the…
View details →Negative / Null Result Report
Grilc N, Cocks A, Kal E et al. · 2026 · Preprint
Falls in older adults are a significant public health concern. Action simulation interventions involving action observation and/or motor imagery have been proposed as alternative or adjunct strategies to physical exercise for reducing fall…
View details →Negative / Null Result ReportMedicine
Yilmaz Ü, Çalişkan BB · 2026 · Gerontology & geriatrics education
Ageism remains a global challenge that undermines the quality of care for older adults. Nursing students, as future healthcare professionals, are in a key position to prevent age-related discrimination through educational interventions.…
View details →Negative / Null Result ReportOpen accessMedicine
Vuurberg G, Maria PA, Baalbaki R et al. · 2026 · Orthopaedic journal of sports medicine
Background Lateral ligament repair is a reliable surgical approach for the treatment of chronic ankle instability (CAI). Although the open technique has shown success over time, technological advancements have enabled the increasing use of…
View details →Negative / Null Result ReportOpen accessMedicine
Lewis E, Smalley CM, Kostura M · 2026 · The western journal of emergency medicine
As climate-related health impacts intensify, emergency physicians (EP) increasingly encounter patients whose conditions are influenced by environmental change. To provide care for climate- vulnerable patients in the emergency department…
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