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Browse the failure-mode index

21,300 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Association between short (≤ 30-day) dual antiplatelet therapy and 1-year major adverse cardiac events after drug-coated balloon-based non-stent percutaneous coronary intervention following optimal lesion preparation: a propensity score-based cohort study.

Kuroda S, Sawada T, Yui R et al. · 2026 · Cardiovascular intervention and therapeutics

Drug-coated balloon (DCB)-based non-stent percutaneous coronary intervention (PCI) may allow shorter dual antiplatelet therapy (DAPT), but whether a ≤ 30-day regimen is associated with worse outcomes remains unclear, particularly in…

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Negative / Null Result ReportOpen accessMedicine

The influence of different skeletal patterns on TMJ anatomy: a comprehensive CBCT study across various sagittal and vertical skeletal patterns in adults.

Eslami S, Sayahpour B, Tashakor A et al. · 2026 · Clinical oral investigations

Objective This study aimed to evaluate the impact of sagittal and vertical skeletal patterns as well as gender on temporomandibular joint (TMJ) morphology using Cone Beam Computed Tomography (CBCT). Methods A cross-sectional analysis was…

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Negative / Null Result ReportMedicine

Phacoemulsification Combined With 360° Gonioscopy-Assisted Transluminal Trabeculotomy: Prospective 12-Month Outcomes in Primary Open-Angle and Primary Angle-Closure Glaucoma.

Maheshwari D, Nagdev NG, Pillai MR et al. · 2026 · Journal of glaucoma

Precis This study concludes that combined gonioscopy assisted transluminal trabeculotomy-phacoemulsification have similar efficacy in terms of intraocular pressure and antiglaucoma medication reduction in primary open angle and primary…

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Negative / Null Result ReportMedicine

The Effect of Smoking History on Inflammatory Biomarkers in Synovial Fluid of Patients Undergoing Arthroscopic Knee Surgery for Meniscal Injury.

Kurtz JL, Ehlers M, Montgomery SR Jr et al. · 2026 · The American journal of sports medicine

Background Smoking has been linked to alterations in cellular inflammatory pathways and adverse outcomes in orthopaedic procedures. It is unclear how patient smoking affects the intra-articular microenvironment in the setting of…

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Negative / Null Result ReportOpen accessMedicine

Nano-magnolol enhances the modulatory effects of magnolol on cognitive performance and BACE1-related biochemical changes in an STZ-induced rat model of Alzheimer's disease.

Youssef B, Ibrahim EA, Moselhy SS et al. · 2026 · Discover nano

Background The Late-onset Alzheimer's disease (LOAD) is progressive cognitive deficits associated with different abnormalities as cholinergic dysfunction, amyloid accumulation, inflammation, and oxidative stress. Magnolol is a polyphenolic…

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Negative / Null Result ReportOpen accessMedicine

Clinical study on the efficacy comparison between ileotransverse colon overlap anastomosis and π-shaped anastomosis in laparoscopic radical right hemicolectomy.

Fangxin W, Bin L, Haocheng Z et al. · 2026 · Frontiers in surgery

Objective To compare the safety and efficacy of ileotransverse colon Overlap and π-shaped anastomosis in laparoscopic radical right hemicolectomy (LRRH). Methods A prospective RCT enrolled 120 right colon cancer patients (Dec 2022-Dec…

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Negative / Null Result ReportMedicine

Vision-related quality of life following trabeculectomy versus Baerveldt glaucoma implant: Five-year results from a randomized clinical trial.

Popescu-Giovanitsas I, Woudstra-de Jong JE, Vingerling JR et al. · 2026 · Acta ophthalmologica

Purpose To assess the vision-related quality of life (VRQoL) in glaucoma patients over 5 years after primary Baerveldt glaucoma implant (BGI) or trabeculectomy (TE) using a secondary analysis of a randomized clinical trial. Methods…

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Negative / Null Result ReportOpen accessMedicine

Comparative efficacy and safety of different posterior surgical approaches for Intra-articular distal humerus fractures.

Yao H, Chen W, Lin Z et al. · 2026 · Journal of orthopaedic surgery and research

Objective To systematically compare the clinical efficacy and safety of four posterior surgical approaches-olecranon osteotomy (OO), triceps-reflecting approach (TRA), triceps-splitting approach (TS), and triceps tongue approach (TT)-for…

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Negative / Null Result ReportOpen accessMedicine

Reporting of patient-reported outcomes (PROs) in randomized controlled trials of anemia treatments for people with CKD: a scoping review.

Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes

BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…

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Negative / Null Result ReportOpen accessMedicine

Amniotic Membrane Versus Platelet-Rich Fibrin for the Treatment of Gingival Recession Using the Vestibular Incision Subperiosteal Tunnel Access Technique: A Randomized Controlled Clinical Trial.

Advani H, Dixit A, Kumar S et al. · 2026 · Cureus

Background Gingival recession (GR) results in significant functional and cosmetic concerns and manifests as a disintegration of soft and hard tissues. Recently, clinical research has increasingly focused on the development of minimally…

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Negative / Null Result ReportOpen accessMedicine

Accuracy of Marginal and Internal Adaptation of Advanced Lithium Disilicate Crowns Using Different Margin Designs (In Vitro Study).

Mohamed HA, Azer A, AboElHassan RG · 2026 · International journal of dentistry

Background Advanced lithium disilicate glass ceramics offer excellent esthetics, but conservative crown preparations are not always the preferred choice. Various margin designs are available; however, more conservative vertical…

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Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer

Lilla Bűdi, Dániel Hammer, Rita Varga et al. · 2025 · Pathology and Oncology Research

ObjectivesSpingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circulating S1P and anti-ceramide antibody as biomarkers in non-small cell lung cancer (NSCLC).MethodsWe recruited 66 subjects (34 controls and 32 patients with NSCLC). Patient history and clinical variables were taken from all participants. Venous blood samples were collected to evaluate plasma biomarkers. If bronchoscopy was performed, bronchial washing fluid

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Negative / Null Result ReportOpen accessDentistry

The Effectiveness of Using Pulpotec® in Treatment of Pulpitis by Pulpotomy of Vital Deciduous Molar and Vital Immature Permanent Molar

Khudhair A Al- Salman, Baydaa A Al-Rawi, Omar S Rahawi · 2012 · Al-Rafidain Dental Journal

Aims: To evaluate the effect of two types of disinfectant solutions(2% alkaline glutaraldehyde, 1% sodium hypochlorite) in wettability of three types of elastomeric impression materials (light body) which are used in crown and bridge restorations at different times of immersion. Materials and me-thods: Three types of elastomeric impression materials (light body) were formed on a flat acrylic resin block and allowed to set(five specimens of each impression material was done for each immersion time(15,30 and60 minutes)of each disinfectant solution in addition to control groups). The wettability

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Negative / Null Result ReportOpen accessPharmacy and materia medica

Carthamus tinctorius Suppresses LPS-Induced Anti-Inflammatory Responses by Inhibiting the MAPKs/NF-κB Signaling Pathway in HaCaT Cells

So-Yeon Kim, Minji Hong, Ponnuvel Deepa et al. · 2023 · Scientia Pharmaceutica

This study aimed to elucidate the anti-inflammatory activity of C. tinctorius leaves by measuring inflammatory parameters such as nitric oxide (NO) production and mRNA expression of iNOS, interleukin-6 (IL-6), and IL-1β in lipopolysaccharide (LPS)-induced HaCaT cells. Further, the effect of C. tinctorius ethanol extract on the MAPKs/NF-κB signaling pathway was examined in HaCaT cells. The phytochemical profile of the ethanol extract of C. tinctorius leaves was determined using UPLC-QTOF-MS/MS. The results indicated that the ethanol extract of C. tinctorius effectively attenuated LPS-induced se

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Negative / Null Result ReportOpen accessSports medicine

Do Ankle Sleeves And Lace-Up Braces Effect Neuromuscular Control And Athletic Performance?

Blake Bodendorfer, Gary Stover, Christopher Ryan James MD et al. · 2015 · Orthopaedic Journal of Sports Medicine

Objectives: Athletes commonly wear fitted silicone ankle sleeves (SAS) and lace-up ankle braces (LAB). There is limited data about their effect on neuromuscular control or athletic performance. Our goal is to evaluate their efficacy in a young, active population during athletic tasks using motion analysis. Methods: Ten subjects (5 males, 5 females) without prior musculoskeletal injury were recruited. They were asked to perform the Drop Vertical Jump test (DVJ), 45 degree bound, and cutting maneuvers under three conditions: No brace, SAS, LAB. DVJ was used as a surrogate for neuromuscular contr

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Negative / Null Result ReportOpen accessZoology

Ambient Air Temperature Does Not Predict whether Small or Large Workers Forage in Bumble Bees (Bombus impatiens)

Margaret J. Couvillon, Ginny Fitzpatrick, Anna Dornhaus · 2010 · Psyche: A Journal of Entomology

Bumble bees are important pollinators of crops and other plants. However, many aspects of their basic biology remain relatively unexplored. For example, one important and unusual natural history feature in bumble bees is the massive size variation seen between workers of the same nest. This size polymorphism may be an adaptation for division of labor, colony economics, or be nonadaptive. It was also suggested that perhaps this variation allows for niche specialization in workers foraging at different temperatures: larger bees might be better suited to forage at cooler temperatures and smaller

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Negative / Null Result ReportOpen accessAnesthesiology

Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Suborov Evgeny V, Smetkin Alexey A, Kondratiev Timofey V et al. · 2012 · BMC Anesthesiology

Abstract Background Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Methods Anesthetized sheep underwent right pn

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Negative / Null Result ReportOpen accessVeterinary medicine

Effects of different environmental enrichments on the behavioral patterns, growth performance, hematological, and hormonal changes in Japanese quail.

Mohamed Morsy, Souad abdemoaty, essam ahmed et al. · 2022 · Benha Veterinary Medical Journal

The current study was carried out to estimate the effect of environmental enrichments (EE) on behavioral patterns, growth performance, hematological, and hormonal changes in Japanese quail. A total number of 216 healthy Japanese quails 1 month old with an average body weight of 135.66±1.32 g were randomly assigned to three groups (72 birds each) and each group was divided into 3 replicates (24 birds each) with a sex ratio 1 male to 3 females according to the environmental enrichment within the pen. The first group had no environmental enrichment (control group), the second group was subjected

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Negative / Null Result ReportOpen accessBusiness

PENGARUH ASPEK PAJAK DAN ASPEK LAINNYA TERHADAP TINGKAT HUTANG

Stephanie Soerodjo · 2020 · Jurnal Ekonomi dan Bisnis Airlangga

As a developing country, Indonesia shows a quite interesting phenomenon, which is the high rate of debt of many companies in Indonesia. This fact shows that the policy of leverage plays an important role for the viability of the company. The main purpose of this research was to test empirically factors influencing leverage, for there are still inconsistencies in research results from the prior studies. Based on the data of the mining companies listed on BEI for period 2009-2011, in addition of using tax factors that consisted of Corporate tax rate and Non-debt tax shield, influencing the lever

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Negative / Null Result ReportOpen accessMedicine

Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis.

William Coley, Sree Rayavarapu, Jack H van der Meulen et al. · 2013 · PLoS ONE

BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle

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Negative / Null Result ReportOpen accessGeneral Works

Increasing Heat Tolerance in Wheat to Counteract Recent and Projected Increases in Heat Stress

Najeeb Ullah, Behnam Ababaei, Karine Chenu · 2020 · Proceedings

The frequency of heat shocks during grain filling of wheat crops across the Australian wheatbelt has significantly increased over the last 30 years. These post-flowering heat events significantly reduce wheat yields with a relatively greater impact on grain size than grain number. A controlled environment study was conducted to assess the impact of post-flowering heat shocks on wheat recombinant inbred lines SB062 and SB003. Plants were submitted to 7-day heat shocks (33/21 °C day/night temperature) at different periods during grain filling. Heat shocks significantly accelerated leaf senescenc

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