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WASTE Journal

Browse the failure-mode index

21,733 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Feasibility of Individualized Homoeopathic Treatment in Temporomandibular Joint Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial.

Bhattacharjee B, Ghosh S, Basu N et al. · 2026 · Journal of integrative and complementary medicine

Objectives To assess the feasibility of conducting a randomized controlled trial and to explore preliminary effects of individualized homoeopathic medicines (IHMs) compared with placebo in patients with temporomandibular joint dysfunction…

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Negative / Null Result Report

The Inflation Reduction Act’s Impact Upon Late-Stage R&D

Bowen HP, O’Loughlin G, Schleicher C et al. · 2026 · Preprint

Background The impact of the Inflation Reduction Act (IRA) upon late-stage developments has been assumed to be limited. The Congressional Budget Office’s IRA analysis excluded post-approval innovation, potentially overlooking substantial…

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Negative / Null Result ReportMedicine

Association between short-term air pollution exposure and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke: a time-stratified case-crossover study.

Gu X, Liu J, Wang H et al. · 2026 · Frontiers in public health

Objective To analyze the association between short-term exposure to air pollutants and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke, to provide scientific basis for health management…

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Negative / Null Result ReportOpen accessMedicine

Associations between fat distribution and obstructive sleep apnea severity among individuals with type 2 diabetes: an MRI-based study.

Ahtola K, Ulander M, Agholme J et al. · 2026 · Scientific reports

Obstructive Sleep Apnea (OSA) affects 1 billion people globally, with a male-to-female ratio of 2:1. While obesity is a major risk factor, sex differences in fat distribution may influence OSA risk. This study examined the relationship…

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Negative / Null Result ReportMedicine

Knowledge, attitudes, and practices of occupational health and safety measures among nurses at Bolgatanga Regional Hospital of Ghana.

Ti-Enkawol Nachinab G, Alem JN, Coffie GB · 2026 · BMC health services research

Introduction Occupational health and safety are major concerns for health workers worldwide. Nurses working in resource-constrained areas are at higher risk of occupational hazards. The purpose of the study was to assess the knowledge,…

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Negative / Null Result ReportMedicine

Proximal femoral bionic nail is associated with lower postoperative complication risk and better early functional recovery in older patients with intertrochanteric fractures: a retrospective cohort study.

Luo X, Ma N, Yang Y et al. · 2026 · BMC surgery

Objective Proximal femoral bionic nail (PFBN) represents a novel biomechanical design for the internal fixation of intertrochanteric fractures in older adults. However, comparative real-world evidence between PFBN and the conventional…

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Negative / Null Result ReportMedicine

Role of Prenatal Ultrasound and Fetal MRI in Diagnosing Congenital Anomalies of the Kidney and Urinary Tract: A Comparative Diagnostic Study.

Thompson GE, Wesemann LB, Ogundipe EA et al. · 2026 · Fetal diagnosis and therapy

Prenatal diagnoses of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are critical for counseling families about potential postnatal outcomes. While ultrasound (US) remains the gold standard for prenatal diagnosis of CAKUT,…

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Negative / Null Result ReportMedicine

Comparative efficacy of intraoperative wound irrigation with aqueous chlorhexidine versus normal saline to prevent surgical site infections: a double-blind randomized controlled trial.

Kultanaruangnonth M, Chatrung L, Tansawet A et al. · 2026 · World journal of emergency surgery : WJES

Background Surgical site infections (SSIs) remain a major concern after abdominal surgery, with incidences of 15-22%. Intraoperative wound irrigation (IOWI) before closure is routinely performed to reduce bacterial contamination, but the…

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Negative / Null Result ReportMedicine

[Comparative analysis of the efficacy between endoscopic submucosal dissection combined with low-dose radiotherapy and direct surgical resection for T1a-MM/T1b-SM stage esophageal squamous cell carcinoma].

Geng YQ, Ding Y, Fu CG et al. · 2026 · Zhonghua yi xue za zhi

Objective: To compare the efficacy between endoscopic submucosal dissection (ESD) combined with low-dose radiotherapy and direct surgical resection in patients with T1a-MM/T1b-SM stage esophageal squamous cell carcinoma. Methods: A…

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Negative / Null Result ReportOpen accessMedicine

Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.

Bader SE, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an adjunct in haemorrhagic shock (HS) to restore proximal perfusion. Its cerebral metabolic effects during haemorrhagic shock, particularly in the…

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Negative / Null Result ReportMedicine

Comparison of the Impact of Different Dacryocystorhinostomy Techniques on Patient Quality of Life in Lacrimal Duct Obstruction.

Hakkani Öznay Ç, Findik H, Uzun F et al. · 2026 · Journal of clinical medicine

Objectives : To prospectively compare the outcomes of external dacryocystorhinostomy (EX-DCR), endonasal dacryocystorhinostomy (EN-DCR), and laser-assisted transcanalicular dacryocystorhinostomy (TL-DCR) in patients with nasolacrimal duct…

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Negative / Null Result ReportOpen accessMedicine

Association of Driver Oncogenic Alterations with SUVmax, Preoperative Serum Calcium, and Smoking Status in Surgically Resected Non-Small-Cell Lung Cancer: A Retrospective Single-Center Study.

Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Journal of clinical medicine

Background: Non-small-cell lung cancer (NSCLC) is driven by distinct oncogenic alterations with important therapeutic and prognostic implications. Noninvasive biomarkers that predict molecular status in surgically resectable disease may…

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Negative / Null Result ReportOpen accessMedicine

Impact of oral health education program in children suffering from attention deficit hyperactivity disorder: A cross-sectional study.

Mahajan A, Haideri S, Kumar VVH et al. · 2026 · Journal of education and health promotion

Background The oral health is an integral part of general well-being in children suffering from attention deficit hyperactivity disorder (ADHD). The present study aimed to analyze the impact of oral health education program on children…

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Negative / Null Result ReportMedicine

Delayed initiation of GnRH antagonist in PCOS patients undergoing IVF: a retrospective cohort study of premature ovulation and embryological outcomes.

Peker N, Yücetürk A, Tığlı E et al. · 2026 · Journal of ovarian research

Background We aimed to evaluate whether delayed initiation of gonadotropin hormone-releasing hormone (GnRH) antagonist treatment affects premature ovulation and the number of good-quality blastocysts. We retrospectively reviewed the…

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Negative / Null Result ReportOpen accessMedicine

The Gut-Disc Axis: Mendelian Randomization Study Reveals Causal Effects of Gut Microbiota on Intervertebral Disc Degeneration Not Mediated by Systemic Inflammation.

Yan Z, Jiang Q, Lu Z et al. · 2026 · International journal of general medicine

Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Observational studies suggest a link with gut microbiota (GM), possibly mediated by systemic inflammation, but causality remains unclear. Objective To…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Clinical Outcomes of INBONE II Total Ankle Arthroplasty in Patients Under 50 and Over 65 Years: A 4-Year Retrospective Study.

Xu X, Zhang B, Wang X et al. · 2026 · Orthopaedic surgery

Objective There is no consensus on the age restriction for total ankle arthroplasty (TAA) patients. The aim of our study was to analyze the clinical function, radiographic outcomes, patient satisfaction, and complications between patients…

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Negative / Null Result ReportOpen accessMedicine

An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial.

Lopresti AL, Smith SJ, Ferdinands FR · 2026 · Frontiers in reproductive health

Background Khaya senegalensis is a tree species that has traditional use for the alleviation of menstrual and hormonal symptoms in women. Moreover, supplementation with a Khaya senegalensis preparation (Khapregesic®) was associated with…

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