Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy
Suborov Evgeny V; Smetkin Alexey A; Kondratiev Timofey V; Valkov Andrey Y; Kuzkov Vsevolod V; Kirov Mikhail Y; Bjertnaes Lars J · 2012 · BMC Anesthesiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Methods Anesthetized sheep underwent right pn
Abstract by Suborov Evgeny V; Smetkin Alexey A; Kondratiev Timofey V; Valkov Andrey Y; Kuzkov Vsevolod V; Kirov Mikhail Y; Bjertnaes Lars J, BMC Anesthesiology (2012) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1471-2253-12-10