Carthamus tinctorius Suppresses LPS-Induced Anti-Inflammatory Responses by Inhibiting the MAPKs/NF-κB Signaling Pathway in HaCaT Cells
So-Yeon Kim; Minji Hong; Ponnuvel Deepa; Kandhasamy Sowndhararajan; Se Jin Park; SeonJu Park; Songmun Kim · 2023 · Scientia Pharmaceutica
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
This study aimed to elucidate the anti-inflammatory activity of C. tinctorius leaves by measuring inflammatory parameters such as nitric oxide (NO) production and mRNA expression of iNOS, interleukin-6 (IL-6), and IL-1β in lipopolysaccharide (LPS)-induced HaCaT cells. Further, the effect of C. tinctorius ethanol extract on the MAPKs/NF-κB signaling pathway was examined in HaCaT cells. The phytochemical profile of the ethanol extract of C. tinctorius leaves was determined using UPLC-QTOF-MS/MS. The results indicated that the ethanol extract of C. tinctorius effectively attenuated LPS-induced se
Abstract by So-Yeon Kim; Minji Hong; Ponnuvel Deepa; Kandhasamy Sowndhararajan; Se Jin Park; SeonJu Park; Songmun Kim, Scientia Pharmaceutica (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/scipharm91010014