Negative / Null Result ReportOpen accessMedicine
Memota Laishram, Krishnagopal Srikanth, AR Rajalakshmi et al. · 2017 · Journal of Clinical and Diagnostic Research
Introduction: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. Aim: To study the retinal sensitivity changes in macular diseases using microperimetry. Materials and Methods: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital. This study was started from December 2014 until June 2016, in all patients with m
View details →Negative / Null Result ReportOpen accessDiseases of the respiratory system
Amika K. Sood, Allison J. Burbank, Michael Lawson et al. · 2019 · Respiratory Research
Abstract Background Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways and in peripheral blood. Sputum induction is currently the only available method for assessing airway neutrophilia but is laborious and time-consuming. This analysis examined the correlation between systemic and airway inflammatory responses to endotoxin to determine if peripheral blood could serve as a surrogate marker for neutrophilic airway inflammation. Methods We
View details →Negative / Null Result ReportOpen accessNuclear engineering. Atomic power
Jun Yeong Jo, Chi Bum Bahn, Hwasung Yeom · 2024 · Nuclear Engineering and Technology
The dissolved oxygen in a coolant can affect the oxidation properties of structural materials. A desirable oxide phase formation is achieved by manipulating the oxygen level in the coolant, which can mitigate structural material degradation in nuclear power plants. Therefore, the role of dissolved oxygen in the corrosion of structural materials in aqueous environments needs to be understood. In this study, a short-term corrosion test (up to 300 h) of Ferritic/Martensitic steels (F/M steels; FeCrW model alloys), namely, Fe12Cr1W, Fe9Cr1W, and Fe9Cr, in stagnant water at 360 °C was performed in
View details →Negative / Null Result ReportOpen accessAnimal culture
C.D. Araújo, G.S. Sanches, F. Borek et al. · 2023 · Arquivo Brasileiro de Medicina Veterinária e Zootecnia
ABSTRACT KIT protein is associated with the etiology of canine mast cell tumors (MCT); however, the expression patterns of KIT are highly variable. The aim of this study was to determine if KIT patterns are related with eosinophil count in MCT. Hematoxylin eosin and May Grünwald-Giemsa stain techniques were applied, histological grading and eosinophil counting were performed in 48 MCT samples. Immunohistochemical evaluation was performed with IL-5, VEGFr, and c-KIT antibodies. The percentage of immunolabeling with IL-5 and VEGFr was determined, and the samples incubated with c-KIT were graded
View details →Negative / Null Result ReportOpen accessMedicine (General)
Manoochehr Nakhjavani, Firouzeh Asgarani, Fatemeh Esfahanian et al. · 2009 · Acta Medica Iranica
Accumulating evidence suggest that in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. To evaluate the association of oxidized low- density lipoprotein (ox-LDL) with the development of diabetic nephropathy, plasma level of ox-LDL were measured in 70 diabetic patients with macro and 63 patients with normoalbuminuria. The plasma oxidized- LDL level in patients with macroalbuminuria was higher than those in normoalbuminuric group, (85.72 ± 32.92 mu/L versus 75.07 ± 26.46 u/L, P= 0.041).
View details →Negative / Null Result ReportOpen accessDentistry
Dewi Kania Intan Permatasari, Tenny Setiani Dewi, Dewi Marhaeni Diah Herawati · 2021 · Dental Journal
Background: Taste disorders often occur in the elderly, which can have serious consequences on their health status. Zinc and saliva volume have a role in maintaining taste acuity, especially in the elderly. Purpose: This study was to determine the correlation between salivary zinc levels, salivary volume, and taste disorders in elderly patients. Methods: This was a cross-sectional research. Elderly patients with and without taste disorders were included in this study. Salivary zinc levels were measured using the Atomic Absorption Spectrometry (AAS) method. Salivary volume was measured using th
View details →Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Dou Qu, Xiaoni Zhong, Guiyuan Xiao et al. · 2018 · International Journal of Infectious Diseases
Objective: To evaluate adherence to pre-exposure prophylaxis (PrEP) in a clinical trial of a population of men who have sex with men (MSM), to explore the influence of social psychology and objective factors (e.g., forgetting, too busy) on adherence, and to provide evidence for subsequent PrEP research. Methods: This study analyzed the data from the daily medication group within a PrEP study (a randomized placebo-controlled trial of oral tenofovir among MSM in Western China from April 2013 to March 2015). A total of 331 participants were analyzed. PrEP adherence was self-reported by the subjec
View details →Negative / Null Result ReportOpen accessMedicine
Fatemeh Moghadasi-Boroujeni, Mansoureh Adel Ghahraman · 2020 · مجله پژوهش در علوم توانبخشی
Introduction: Romberg test is one of the balance screening tests. Since this test does not require special equipment, it is widely used in the evaluation of people suffering from balance disorders. This study aimed to determine the sensitivity of the Romberg test for the diagnosis of peripheral vestibular dysfunction compared with the caloric test that is the gold standard for the diagnosis of horizontal semicircular canal/superior vestibular nerve disorders.Materials and Methods: This study was a cross-sectional-comparative study and the sample was selected from those who referred to the audi
View details →Negative / Null Result ReportOpen accessMedicine (General)
Joel Del Bel Pádua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro et al. · 2024 · Biomarker Insights
Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. Objective and design: This retrospective cohort study aimed to evaluate mRNA expression and promoter methylation of some homologous recombination-related genes in this neoplasm. Methods: We evaluated mRNA expression and methylation of RAD51 , ATM , ATR , BRCA1 , and BRCA2 in tumor and non-tumor frozen samples from gastrectomy specimens by RT-qPCR and MS-HRM, correlating our results with previous i
View details →Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Aves Editorial Aves Editorial · 2019 · Urology Research and Practice
Abstract Introduction: Lower urinary tract symptoms (LUTS) associated with BPH and erectile dysfunction (ED) are common problems in aging male. In this study, we aimed to determine the causes of the relationship between LUTS and ED, and the possible effects of body mass index (BMI), serum leptin, free testosterone (fT) and lipid levels on LUTS and ED etiology. Materials and Methods: Between June 2003 and February 2004, 46 patients were recruited in this study. All patients underwent physical examination including digital rectal examination, urine analysis, uroflowmetry and residual urine volum
View details →Negative / Null Result ReportOpen accessGeneral. Including nature conservation, geographical distribution
Jennifer L. Reidy, Lisa O'Donnell, Frank R. Thompson III · 2015 · Wildlife Society Bulletin
ABSTRACT It is critically important to determine and understand relationships between endangered species populations and landscape and habitat features to effectively manage and conserve populations and the habitats they rely on. Several recent studies focused on the golden‐cheeked warbler (Setophaga chrysoparia), an endangered songbird that breeds exclusively in central Texas, USA, have used a reproductive index to link pairing and breeding success to various factors of interest. However, no field test has evaluated the performance of a reproductive index at estimating productivity of golden‐
View details →Negative / Null Result ReportOpen accessMedicine
Fithria Aldy, Gema Nazri Yanni, Jelita Siregar · 2024 · Majalah Kedokteran Bandung
Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study ap
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Filippo Mandelli, Filippo Mandelli, Filippo Mandelli et al. · 2021 · Frontiers in Neurology
Objective: Fatty infiltration of paraspinal muscle is associated with spinal disorders. It can be assessed qualitatively (i.e., Goutallier classification) and quantitatively using image processing software. The aims of this study were to compare paraspinal muscle fatty infiltration as assessed using the Goutallier classification vs. quantitative magnetic resonance images (MRI) measurements and to investigate the association between anthropometric parameters and paraspinal muscle morphology and fatty infiltration in patients with symptomatic lumbar spinal stenosis (LSS).Methods: Patients affect
View details →Negative / Null Result ReportOpen accessDentistry
Guven Kayaoglu, Mügem Gürel, Hüma Ömürlü et al. · 2009 · Journal of Applied Oral Science
OBJECTIVE: The aim of this study was to evaluate the degree of microbial contamination in packaged gutta-percha cones before and during use in clinical conditions. MATERIAL AND METHODS: Sealed packages of #15-40 gutta-percha cones were opened under aseptic laboratory conditions. Two gutta-percha cones from each size were randomly drawn and added to tubes containing glass beads and 750 µL of saline. The tubes were vortexed, serially diluted and samples of 250 µL were cultured on agar plates. The plates were incubated at 37ºC for 3 days and colonies were counted. The initially sampled packages w
View details →Negative / Null Result ReportOpen accessMedicine
Shreya Arora, Monica Gupta, Anita Tahlan et al. · 2022 · Journal of Dr. NTR University of Health Sciences
Background: Platelet count has been widely used to evaluate the severity, guide management and predict outcome in patients with dengue fever. This sole use, however, has prevented the utility of other platelet indices like Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) from being explored. Objectives: To study the association of MPV and PDW with the disease severity in patients with dengue fever. Materials and Methods: This prospective observational study was conducted in a tertiary care centre of Northern India for a period of one year. A total of 100 patients with confirmed
View details →Negative / Null Result ReportOpen accessMedicine
Zuraini Mohammad Nasir, Sethu Thakachy Subha · 2021 · International Archives of Otorhinolaryngology
Introduction Foreign body aspiration is a leading cause of accidental death in children. Clinical presentation varies from non-specific respiratory symptoms to respiratory failure making diagnosis challenging. Objective To review pediatric patients who underwent bronchoscopy due to suspicion of foreign body aspiration at a tertiary center in Malaysia. Methods We retrospectively studied patients < 11 years old who underwent bronchoscopy from 2008 to 2018. Results Over the 10-year period, 20 patients underwent bronchoscopy, and 16 were found to have foreign body aspiration with equal gender dist
View details →Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Pedro Boal Carvalho, Bruno Rosa, Maria João Moreira et al. · 2014 · Gastroenterology Research and Practice
Objectives. Small bowel capsule endoscopy (SBCE) plays a decisive role in the obscure gastrointestinal bleeding (OGIB) diagnosis. Antithrombotics may increase bleeding risk in patients with preexistent lesions or through direct mucosal aggression. We aimed to correlate antithrombotics usage with lesions with bleeding potential found in SBCE. Methods. Retrospective single-center study including 274 consecutive SBCE performed over 7 years for OGIB. The lesions were classified as P0 (no bleeding potential), P1 (uncertain bleeding potential: erosions), and P2 (high bleeding potential: angioectasia
View details →Negative / Null Result ReportOpen accessScience (General)
Xin Wang, Chen Li, Ming Li et al. · 2024 · Heliyon
Objective: Serum lactate (LA) and lactate dehydrogenase (LDH) levels have a major impact on the clinical treatment of malignant tumors and critically ill patients. Nevertheless, the assessment of disease severity in oncology patients admitted to the intensive care unit (ICU) remains incomplete when considering the serum LA and LDH levels. This study aimed to investigate the significance of serum LDH and LA levels in assessing disease severity and predicting clinical outcomes in patients with colorectal cancer (CRC) admitted to the ICU. Methods: This retrospective study included patients with C
View details →Negative / Null Result ReportOpen accessMedicine
Janan G. Hasan · 2010 · The Medical Journal of Basrah University
ABSTRACT Background: Abnormal blood lipid profiles have been associated with many malignant diseases especially in children with acute lymphoblastic leukemia on L-asparaginase therapy Objective: To investigate the frequency and clinical significance of altered lipid profiles in children with Acute lymphoblastic leukemia (ALL) on L-asparaginase therapy Patients and Methods: A prospective study was carried out between February 2008 till January 2009 on a total of 50 patients with recently diagnosed and non-treated acute lymphoblastic leukemia who were admitted to pediatric oncology unit at Basra
View details →Negative / Null Result ReportOpen accessBiology (General)
Robert Stawski, Konrad Walczak, Ewelina Perdas et al. · 2021 · Biology
Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond
View details →Negative / Null Result ReportOpen accessPsychiatry
O. Elleuch, M. Maalej, W. Guidara et al. · 2023 · European Psychiatry
Introduction The pathophysiology of bipolar disorder (BD) is complex and remains uncertain to this day. Several hypotheses have been suggested, including the involvement of inflammatory mechanisms in its pathogenesis and in eventual cognitive impairment. C-reactive protein (CRP) is one of the most commonly used inflammatory markers. High-sensitivity CRP (hs- CRP) is a more sensitive marker. Objectives We aimed to examine hs-CRP levels in patients with BD, and to investigate its relationship with cognitive functions. Methods We conducted a cross-sectional study between June 2016 and July 2018 o
View details →Negative / Null Result ReportOpen accessMedicine
Amer Imraish, Tuqa Abu-Thiab, Tareq Alhindi et al. · 2022 · PLoS ONE
Background Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators, such as histamine and prostaglandins, from mast cells in asthmatic patients. Objective In this study, single nucleotide polymorphisms of GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C
View details →Negative / Null Result ReportOpen accessGeophysics. Cosmic physics
Liyu ZHANG, Donghua YOU, Rong LI et al. · 2025 · Shiyou shiyan dizhi
In recent years, multiple wells in the Sichuan Basin have produced industrial gas from the marlstone/marl-bearing limestone strata in the first member of the Middle Permian Maokou Formation (Mao 1), demonstrating promising exploration potential. Previous studies have suggested that the marlstone/marl-bearing limestone in Mao 1 exhibits self-generation and self-storage characteristics, forming low-porosity, low-permeability fracture-porosity type tight carbonate reservoirs with diverse storage spaces. Notably, diagenetic shrinkage pores and fractures formed during the transformation of sepiolit
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yingpu Cui, Yingpu Cui, Yaobin Lin et al. · 2022 · Frontiers in Immunology
PurposeTo develop a comprehensive PET radiomics model to predict the pathological response after neoadjuvant toripalimab with chemotherapy in resectable stage III non-small-cell lung cancer (NSCLC) patients.MethodsStage III NSCLC patients who received three cycles of neoadjuvant toripalimab with chemotherapy and underwent 18F-FDG PET/CT were enrolled. Baseline 18F-FDG PET/CT was performed before treatment, and preoperative 18F-FDG PET/CT was performed three weeks after the completion of neoadjuvant treatment. Surgical resection was performed 4–5 weeks after the completion of neoadjuvant treatm
View details →Negative / Null Result ReportOpen accessMedicine
M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology
BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…
View details →Negative / Null Result ReportOpen accessMedicine
V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research
CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…
View details →Negative / Null Result ReportOpen access
Ali Md. Yeakub, Fatimah Md. Yusoff, Natrah Fatin Mohd. Ikhsan et al. · 2023 · Pertanika Journal of Tropical Agricultural Science
Marine fish larvae are an integral part of the marine environment because their abundance can become an ecological indicator. The abundance is dependent on the environmental variations that include but are not limited to lunar phases and…
View details →Negative / Null Result ReportOpen accessMedicine
S. Lipshultz, Paige L. Williams, B. Zeldow et al. · 2015 · AIDS (London)
Objectives:We evaluated the potential cardiac effects of in-utero exposures to antiretroviral drugs in HIV-exposed but uninfected (HEU) children. Design and methods:We compared echocardiographic parameters of left ventricular function…
View details →Negative / Null Result ReportMedicine
James K. Gabriels, M. Abdelrahman, Lakshmi Nambiar et al. · 2021 · Heart Rhythm
BACKGROUND Electrocardiographic (ECG) criteria have been proposed to localize the site of origin (SOO) of outflow region ventricular arrhythmias (VAs). Many factors influence the QRS morphology of VAs and may limit the accuracy of these…
View details →Negative / Null Result ReportMedicine
J. Stoeckle, S. Poland, H. Maynard et al. · 2024 · JCO Precision Oncology
PURPOSE Previous studies document underuse of next-generation sequencing (NGS). We examined the impact to oncology care for veterans of incorporating NGS ordering into the Veterans Affairs (VA) electronic medical record (EMR) at two New…
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