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Browse the failure-mode index

21,257 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Comparison of the Efficacy of Intra-Articular Polyacrylamide Hydrogel and the Cross-Linked Hyaluronic Acid/Chondroitin Sulfate Combination in Treating Advanced-Stage Knee Osteoarthritis.

Altıntaş M, Ateş O, Soy F et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Polyacrylamide hydrogel (PAAG) is still underresearched, and few human studies have validated its efficacy in knee osteoarthritis (OA), particularly in advanced stages. The aim of this study was to compare the…

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Negative / Null Result ReportMedicine

Improving Operative Note Documentation in Vascular Surgery: A Two-Cycle Closed-Loop Audit Following Introduction of Standardised Procedure-Specific Templates.

Mersal M, Amin A, Embaby OM et al. · 2026 · Annals of vascular surgery

Objective To evaluate completeness of operative note documentation in a vascular surgery service and to assess whether introduction of standardised procedure-specific templates was associated with improved documentation in a repeat audit…

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Negative / Null Result ReportMedicine

The effect of glandular frenulectomy on refractory lifelong premature ejaculation: a pilot study.

Roaiah MF, El Khayat YI, Saad El Din OA et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Purpose Premature ejaculation (PE) is one of the most common male sexual disorders and is influenced by both psychological and biological factors. Despite available treatments, including psychosexual therapy and pharmacological…

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Negative / Null Result ReportMedicine

Impact of an 8-Week Targeted Potentiation Phase in the RAMP Warm-Up Protocol on Agility Performance in Female Police Officers.

Janković D, Kukić F, Radić I et al. · 2026 · Journal of strength and conditioning research

Abstract Janković, D, Kukić, F, Radić, I, Čvorović, A, Dawes, J, and Dopsaj, M. Impact of an 8-week targeted potentiation phase in the RAMP warm-up protocol on agility performance in female police officers. J Strength Cond Res XX(X):…

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Negative / Null Result ReportMedicine

ST-Elevation Myocardial Infarction Complicated by Ventricular Septal Defect Is Associated With Very High Mortality Without Improvement Over Time.

Movahed MR, Rasti A, Hashemzadeh M · 2026 · Reviews in cardiovascular medicine

Background This study aimed to examine mortality trends among patients who presented with ST-elevation myocardial infarction (STEMI) complicated by ventricular septal defect (VSD) between 2016 and 2022. Methods Using the Nationwide…

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Negative / Null Result ReportMedicine

Prediction of Clinically Significant Improvements During the Interdisciplinary Intensive Outpatient Program for Traumatic Brain Injury Using Machine Learning.

Srikanchana R, Samuel D, Powell J et al. · 2025 · Annals of biomedical engineering

Purpose The aim of this research was to assess the potential for machine learning to predict clinically significant patient improvement during a four-week interdisciplinary Intensive Outpatient Program (IOP) for traumatic brain injury…

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Negative / Null Result ReportOpen accessMedicine

Non-Pharmacological Interventions for Symptom Cluster Management in Women with Cancer: A Scoping Review of Multicomponent and Mechanism-Based Approaches.

Irmala N, Solehati T, Sukmawati S · 2026 · International journal of women's health

Background Women with cancer frequently experience co-occurring symptoms, including cancer-related fatigue, sleep disturbance, and psychological distress, which negatively impact quality of life. Despite the increasing use of…

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Negative / Null Result ReportMedicine

Similar performance with electrochemically deposited hydroxyapatite coating versus plasma porous spray in press-fit acetabular components for primary total hip arthroplasty: a randomised controlled study of early outcomes with DEXA.

Liu D, Turner D, Cadman J et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background Hydroxyapatite (HA) is an osteo-inductive material commonly added to the surface of components to enhance bone implant fixation; however, clinical studies have demonstrated inferior performance of HA coated acetabular cups in…

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Negative / Null Result ReportMedicine

Absent Bone Marrow Edema on MRI in a Patient with Acute Vertebral Compression Fractures: Implications for Vertebral Augmentation.

Singh S, Galperin M, Waghray-Penmetcha T · 2026 · Pain medicine case reports

Background Vertebral compression fractures (VCFs) are a common and debilitating consequence of multiple myeloma (MM). Acute VCFs often benefit from percutaneous vertebral augmentation (PVA), indicated by bone marrow edema (BME) on MRI. We…

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Negative / Null Result Report

Improvement in Beetroot’s ( Beta vulgaris ) Growth and Yield Parameters in Soils Fertilized with Maize ( Zea mays ) Biochar Under Drip Irrigation with Treated Wastewater

Mathapa BG, Gaba T, Mmolawa K · 2026 · Preprint

Global water scarcity due to climate change coupled with environmental pollution from artificial fertilizers threatens sustainable agricultural productivity. To address these challenges, innovative circular and sustainable agricultural…

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Negative / Null Result ReportMedicine

No clinical and functional benefit after medial congruent compared to ultra congruent total knee arthroplasty at 1 year: A prospective randomized controlled study.

Schrednitzki D, Sina J, Lamarche A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose Various conforming bearing designs are used during total knee arthroplasty (TKA), yet their impact on clinical outcomes remains uncertain. In recent years, the use of medial congruent (MC) and ultra congruent (UC) onlays has gained…

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Negative / Null Result ReportOpen accessMedicine

Clinical and Radiographic Factors Affecting the Outcomes of Decompression Surgery in Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Classification Type C Degenerative Lumbar Spondylolisthesis.

Kawano A, Tarukado K, Yokota K et al. · 2026 · Cureus

Introduction The optimal surgical strategy for Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Type C remains controversial, particularly regarding decompression alone versus fusion surgery. Evidence focusing on outcomes…

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Negative / Null Result ReportMedicine

Does the ACR/EULAR Total Improvement Score reflect how individuals with autoimmune inflammatory myopathies feel and function?

Leclair V, Berger C, Bouchard-Marmen M et al. · 2026 · The Journal of rheumatology

Objective Little is known as to whether the American College of Rheumatology/European Alliance of Associations for Rheumatology Total Improvement Score (TIS) reflects how patients in the autoimmune inflammatory myopathies (AIM) spectrum…

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Negative / Null Result ReportMedicine

Intraocular foreign bodies in the posterior segment: Clinical characteristics, management, and visual outcomes.

Phogat J, Prabha C, Nada M et al. · 2026 · Chinese journal of traumatology = Zhonghua chuang shang za zhi

Purpose To analyze the clinical characteristics, management, and visual outcomes of patients with retained posterior segment intraocular foreign bodies (IOFBs). Methods This was a retrospective, non-comparative, single-institutional case…

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Negative / Null Result ReportMedicine

Use of Expected Utility to Evaluate Artificial Intelligence-Enabled Rule-out Devices for Mammography Screening.

Fan KL, Thompson YLE, Chen W et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundAn artificial intelligence (AI)-enabled rule-out device may autonomously remove patient images unlikely to have cancer from radiologist review. Many published studies evaluate this type of device by retrospectively applying the…

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Negative / Null Result ReportMedicine

Evaluation of text- and image-based generative artificial intelligence for simulating impacted third molar extraction.

Hamada M, Nishiyama K, Ichiyama S et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background Recent advances in generative artificial intelligence (AI) have opened new opportunities in procedural simulation. However, its clinical accuracy for simulating impacted mandibular third molar extraction remains unclear.…

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Negative / Null Result ReportMedicine

A critical analysis of the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) and the European Carotid Surgery Trial (ECST)-2.

Paraskevas KI, Zeebregts CJ, Blecha M et al. · 2026 · Seminars in vascular surgery

The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) concluded that addition of transfemoral carotid artery stenting to intensive medical therapy (IMT) among patients with high-grade…

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Negative / Null Result ReportOpen accessMedicine

Clinical impact of the angiosome concept: is it applicable in femoropopliteal bypasses, limb salvage, and wound healing in critical pathologic limb-threatening ischemia?

Mazurova T, Sengul I, Sengul D et al. · 2026 · Revista da Associacao Medica Brasileira (1992)

Introduction The global burden of peripheral artery disease is increasing worldwide. A subset of 5% of these patients ultimately reach the final stage with trophic defects, a condition clinically defined as critical limb-threatening…

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