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Browse the failure-mode index

21,247 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Chemoradiation ± Atezolizumab in Limited-Stage Small Cell Lung Cancer: Results of NRG Oncology/Alliance LU005

Kristin A. Higgins, Chen Hu, Helen J. Ross et al. · 2026 · Journal of Clinical Oncology

PURPOSE NRG Oncology/Alliance LU005 (ClinicalTrials.gov identifier: NCT03811002 ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial. METHODS Patients with limited-stage…

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Negative / Null Result ReportMedicine

Significant effects of lymph and blood vascular invasion on the prognosis of early‐stage cervical squamous cell carcinoma

Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research

AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…

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Negative / Null Result ReportOpen accessMedicine

Lack of benefit from hospitalization in patients with syncope: A propensity analysis

Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open

STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…

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Negative / Null Result Report

Nutraceutical and pharmaceutical cocktails did not improve muscle function or reduce histological damage in D2-mdx mice

Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology

Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…

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Negative / Null Result Report

Union-find quantum decoding without union-find

Sam J. Griffiths, Dan E. Browne · 2024 · Physical Review Research

The union-find decoder is a leading algorithmic approach to the correction of quantum errors on the surface code, achieving code thresholds comparable to minimum-weight perfect matching (MWPM) with amortized computational time scaling…

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Negative / Null Result ReportOpen accessMedicine

Erythrocytosis incidence and thromboembolic risk in heart failure with reduced ejection fraction treated with SGLT2 inhibitors: a nationwide register-based cohort study

Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology

BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…

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Negative / Null Result ReportOpen accessMedicine

Epidemiology of childhood acute kidney injury in England using e-alerts

Lucy Plumb, Anna Casula, Manish D. Sinha et al. · 2023 · Clinical Kidney Journal

ABSTRACT Background Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study…

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Negative / Null Result ReportOpen accessMedicine

Hepatic artery infusion of FOLFOX chemotherapy plus camrelizumab combined with sorafenib for advanced hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (Double-IA-001): a phase II trial

Lujun Shen, Fei Cao, Ying Liu et al. · 2025 · BMC Medicine

BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) with a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown excellent local control for patients with Barcelona Clinic Liver Cancer (BCLC) stage C…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses

Marcin A. Sowa, Haoyu Sun, Tricia T. Wang et al. · 2024 · JACC Basic to Translational Science

We investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y12 inhibitor, platelets from healthy volunteers receiving aspirin or…

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Null DatasetOpen accessMedicine

Causes and Outcomes of Admission and Investigation of Tuberculosis in Adults with Advanced HIV in South African Hospitals: Data from the TB Fast Track Trial

Peter Beckwith, Mpho Tlali, Salome Charalambous et al. · 2021 · American Journal of Tropical Medicine and Hygiene

Tuberculosis (TB) remains the leading cause of hospitalization and in-hospital mortality in HIV-positive adults. Using data from hospital and clinic files, research databases, and autopsy, we describe causes and outcomes of admissions, and…

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Negative / Null Result ReportOpen accessMedicine

Development of a tailored intervention targeting sedentary behavior and physical activity in people with stroke and diabetes: A qualitative study using a co-creation framework

Stefan Sjørslev Bodilsen, Mette Aadahl, Troels Wienecke et al. · 2023 · Frontiers in Rehabilitation Sciences

Purpose: Type 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity. Materials and methods: = 10) to develop the intervention. A content analysis was used to analyze data. Results: The developed "Everyday Life is Rehabilitation" (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention

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Negative / Null Result ReportOpen accessMedicine

The Price of Explainability in Machine Learning Models for 100-Day Readmission Prediction in Heart Failure: Retrospective, Comparative, Machine Learning Study

Amira Soliman, Björn Agvall, Kobra Etminani et al. · 2023 · Journal of Medical Internet Research

BACKGROUND: Sensitive and interpretable machine learning (ML) models can provide valuable assistance to clinicians in managing patients with heart failure (HF) at discharge by identifying individual factors associated with a high risk of readmission. In this cohort study, we delve into the factors driving the potential utility of classification models as decision support tools for predicting readmissions in patients with HF. OBJECTIVE: The primary objective of this study is to assess the trade-off between using deep learning (DL) and traditional ML models to identify the risk of 100-day readmi

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Negative / Null Result ReportOpen accessMedicine

Antineoplastic Drug Synergy of Artesunate with Navitoclax in Models of High-Grade Serous Ovarian Cancer

J. Robert McCorkle, Rebecca Ahn, Connie D. Cao et al. · 2024 · Cancers

) known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but has also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In the current study, we investigated the ability of navitoclax, an inhibitor of the antiapoptotic Bcl-2 protein family, to enhance artesunate efficacy in ovarian cancer cells. Artesunate and navitoclax both demonstrated antiproliferative effects on 2D and 3D ovarian cancer cell models as single

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Use of Beauveria bassiana to control northern fowl mites (Ornithonyssus sylviarum) on roosters in an agricultural research facility.

Matthew S W Rassette, Elizabeth I. Pierpont, Tina Wahl et al. · 2011 · PubMed

Treatment of Northern fowl mite (Ornithonyssus sylviarum) infestation on poultry in research facilities can be challenging. The mite has a rapid reproductive cycle (egg to adult in 5 to 7 d), and chemical treatments can be toxic to birds,…

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Negative / Null Result ReportOpen accessComputer Science

A Hybrid K-Means++ and Particle Swarm Optimization Approach for Enhanced Document Clustering

Eisha Hassan, Fazila‐Tun‐Nesa Malik, Qazi Waqas Khan et al. · 2025 · IEEE Access

Document Clustering has attracted the interest of many researchers who have created several solutions to this problem by combining different techniques, models, and algorithms. While famous for its simplicity, the most commonly used algorithm, K-Means, suffers from issues such as finding the optimal value for k and random initialization of the centroids. In this paper, we propose a hybrid methodology combining K-Means++ with the metaheuristic algorithm PSO to overcome the challenges of both these algorithms. K-Means++ is a smart initialization technique that selects clusters based on probabili

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Negative / Null Result ReportOpen accessMedicine

Prediction of Radiation-Induced Hypothyroidism Using Radiomic Data Analysis Does Not Show Superiority over Standard Normal Tissue Complication Models

Urszula Smyczyńska, Szymon Grabia, Zuzanna Nowicka et al. · 2021 · Cancers

State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was development of radiomic NTCP model for radiation-induced hypothyroidism (RIHT) using imaging biomarkers (radiomics). We gathered CT images and clinical data from 98 patients, who underwent intensity-modulated radiation therapy (IMRT) for head and neck cancers with a planned total dose of 70.0 Gy (33–35 fractions). During the 28-month (median) follow-up 27 pat

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Negative / Null Result ReportOpen accessMedicine

Effect of the index of cardiac electrophysiological balance on major adverse cardiovascular events in patients with diabetes complicated with coronary heart disease

Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ

Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Accurate prediction of quantitative traits with failed SNP calls in canola and maize

Sven E. Weber, Harmeet Singh Chawla, Lennard Ehrig et al. · 2023 · Frontiers in Plant Science

In modern plant breeding, genomic selection is becoming the gold standard to select superior genotypes in large breeding populations that are only partially phenotyped. Many breeding programs commonly rely on single-nucleotide polymorphism (SNP) markers to capture genome-wide data for selection candidates. For this purpose, SNP arrays with moderate to high marker density represent a robust and cost-effective tool to generate reproducible, easy-to-handle, high-throughput genotype data from large-scale breeding populations. However, SNP arrays are prone to technical errors that lead to failed al

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Negative / Null Result ReportOpen accessMedicine

On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations

Simone Conti, Edmond Y. Lau, Victor Ovchinnikov · 2022 · Antibodies

The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging despite advances in computer hardware and algorithms, primarily because proteins are flexible molecules, and thus, require explicit or implicit incorporation of multiple conformational states into the computational procedure. The astronomical size of the amino acid sequence space further compounds the challenge by requiring predictions to be computed

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

A D-vine copula-based quantile regression towards merging satellite precipitation products over rugged topography: a case study in the upper Tekeze–Atbara Basin

Mohammed Abdallah, Ke Zhang, Lijun Chao et al. · 2024 · Hydrology and earth system sciences

Abstract. Precipitation is a vital key element in various studies of hydrology, flood prediction, drought monitoring, and water resource management. The main challenge in conducting studies over remote regions with rugged topography is that weather stations are usually scarce and unevenly distributed. However, open-source satellite-based precipitation products (SPPs) with a suitable resolution provide alternative options in these data-scarce regions, which are typically associated with high uncertainty. To reduce the uncertainty of individual satellite products, we have proposed a D-vine copul

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