Negative / Null Result ReportOpen accessMedicine
Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Xinyi Zhang, Liangjie Wang, Jian Wei et al. · 2026 · Nature Communications
Oxygen vacancies (Ov) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully…
View details →Negative / Null Result ReportOpen accessEngineering
Rui Zhao, Qiushi Feng, Yangyang Xia et al. · 2025 · Pharmaceuticals
The inherent complexity and heterogeneity of tumors pose substantial challenges for the development of effective oncology therapeutics. Organoids, three-dimensional (3D) in vitro models, have become essential tools for predicting therapeutic responses and advancing precision oncology, with established correlations to clinical outcomes in patient-derived models. These systems have transformed preclinical drug screening by bridging the gap between conventional two-dimensional (2D) cultures and in vivo models, preserving tumor histopathology, cellular heterogeneity, and patient-specific molecular
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Zhendong Zhao, Huiwang Dai, Tiantian Nie et al. · 2025 · Nature Communications
High-valent iron-oxo species (FeIV=O) have garnered increasing attention for water purification, while the selective generation of FeIV = O in Fenton-like reactions still lacks an effective control protocol at the atomic level. Here, we…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Muhammad Asif, Long Yun-rong, Muhammad Azam Zia et al. · 2025 · Energy & Environment
Climate change, caused by the burning of fossil fuels, has emerged as an acute world problem, especially in the Group of Twenty (G20), where CO 2 emissions and other greenhouse gases are accumulating. This research examines how energy…
View details →Negative / Null Result ReportOpen accessMedicine
Mengting Zhu, Jonathan Lee · 2025 · Nutraceuticals
Short-chain fatty acids (SCFAs) are metabolites derived from the fermentation of dietary fibre by gut bacteria. SCFAs function as essential regulators of host-microbiome interactions by participating in numerous physiological and pathological processes within the gastrointestinal (GI) tract. In recent years, the depletion of SCFAs has been increasingly linked to the pathogenesis of GI diseases. In this review, we summarize the current understanding of the therapeutic mechanisms of SCFAs in GI diseases, including inflammatory bowel disease, irritable bowel syndrome, metabolic dysfunction-associ
View details →Replication FailureOpen accessMedicine
Julien Vionnet, Jorge P. Torres-Yaguana, Rosa Miquel et al. · 2024 · American Journal of Transplantation
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jing Zeng, Ali Punjwani · 2025 · Sustainability
Achieving environmental sustainability remains a critical challenge for governments worldwide, particularly within the G20 bloc, due to rapid urbanization, resource-intensive industrial activities, and the environmental pressures associated with globalization. Despite various efforts, ecological degradation continues to escalate, necessitating a deeper understanding of the factors influencing environmental sustainability. This study investigates the role of technological innovation (TLI), education (EDU), human capital (HMC), and natural resources (NTS) in shaping ecological sustainability, wh
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras et al. · 2026 · Nature Medicine
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome. In multivariable confounder-adjusted regression models, antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant asso
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jong Won Shin, Minh Nguyen Thien, Sun Ha Jee · 2025 · Healthcare
Background: Bilirubin is a potent endogenous antioxidant that plays a key role in regulating oxidative stress and inflammation, both closely linked to lung carcinogenesis. This study reinterprets the ALBI (Albumin–Bilirubin) and PALBI (Platelet–Albumin–Bilirubin) indices as composite markers of antioxidant and inflammatory status and evaluates their associations with lung cancer risk by sex, including stratified analyses by major lifestyle factors such as smoking and alcohol use. Methods: This study utilized data from the Korean Cancer Prevention Study-II (KCPS-II) cohort, which included 133,6
View details →Negative / Null Result ReportOpen accessMedicine
Sherry S. Y. Nyeo, Erin M. Cumming, Oliver S. Burren et al. · 2026 · Nature
Abstract Epstein–Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence following primary exposure remain poorly understood, although human genetic variation partially contributes to this phenotypic spectrum 1–3 . Here we demonstrate that existing whole genome sequencing (WGS) data of human populations can be used to quantify persistent EBV D
View details →Negative / Null Result ReportOpen accessMedicine
Jörg Matthes, Anne Reinhardt, Selma Hodzic et al. · 2026 · Journal of Medical Internet Research
Background: The rise of generative artificial intelligence (AI) tools such as ChatGPT is rapidly transforming how people access information online. In the health context, generative AI is seen as a potentially disruptive information source due to its low entry barriers, conversational style, and ability to tailor content to users' needs. However, little is known about whether and how individuals use generative AI for health purposes, and which groups may benefit or be left behind, raising important questions of digital health equity. Objective: This study aimed to assess the current relevance
View details →Negative / Null Result ReportOpen accessMedicine
Steven D. Nathan, Victoria Lacasse, Heidi Bell et al. · 2024 · Pulmonary Circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →Negative / Null Result ReportOpen accessMedicine
Fanjing Kong, Yanru Zhao, Weiming Zhang et al. · 2026 · Nature Communications
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were initially approved for type 2 diabetes mellitus. Recent evidence suggests their therapeutic potential in various diseases, though their efficacy and safety remain incompletely…
View details →Negative / Null Result ReportOpen accessMedicine
Joe M. Butler, Hessel Peters Sengers, Tom D. Y. Reijnders et al. · 2025 · EBioMedicine
BACKGROUND: Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI). METHODS: RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-
View details →Negative / Null Result ReportOpen accessMedicine
Francesco Fortunato, Francesco D’Amico, Anny Votano et al. · 2025 · Epilepsia
OBJECTIVE: To estimate the proportion of individuals with focal epilepsy treated with at least one among carbamazepine (CBZ), oxcarbazepine (OXC), or eslicarbazepine (ESL), who were hospitalized due to hyponatremia-related symptoms in 2024, and to test the hypothesis that there is an association with climatic variables. METHODS: We undertook a prospective study in which people with focal epilepsy treated with at least one of the target drugs and at least one attendance in 2024 formed the study cohort. Individuals who were admitted or seen as outpatients for hyponatremia in 2024 were considered
View details →Negative / Null Result ReportOpen accessMedicine
Marwah Karim, Manjari Mishra, Chieh‐Wen Lo et al. · 2025 · Nature Communications
In search for broad-spectrum antivirals, we discover a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrate selective inhibition of…
View details →Negative / Null Result ReportOpen accessPsychology
Raeanna Kilby, Kristin D. Mickelson · 2025 · Frontiers in Psychiatry
Social media movements centered on body positivity and body neutrality both encourage healthy attitudes toward the physical body; however, these movements are conceptually distinct and may have unique influences on body image. This study examined how brief exposure to different types of body acceptance and weight-stigmatizing content affects body image and mood. Participants consisted of women and gender-diverse individuals (N = 326) who completed an online survey and were randomly assigned to view one of four TikTok video compilations: body neutrality, body positivity, weight-stigmatizing, or
View details →Negative / Null Result ReportOpen accessMedicine
Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species
View details →Replication FailureOpen accessMedicine
Jean‐Christophe Rozé, Gilles Cambonie, Cyril Flamant et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Controversies persist about management of the ductus arteriosus by nonsteroidal anti-inflammatory drugs in extremely preterm infants. Acetaminophen (paracetamol) appears to be a promising alternative with possibly fewer adverse…
View details →Negative / Null Result ReportOpen accessMaterials Science
Ran Dong, Yingao Ru, Xi Zhang et al. · 2026 · ACS Omega
Abstract Batch nanofabrication of complex nanostructures remains a critical challenge, restricting their translation from laboratory design to industrial application. To address this, we report a conceptual and methodological advance by…
View details →Replication FailureOpen accessMedicine
Hideaki Bando, Jun Watanabe, Yusuke Takahashi et al. · 2026 · Nature Medicine
Tumor-informed circulating tumor DNA (ctDNA) enables detection of molecular residual disease (MRD) after curative resection of colorectal cancer (CRC), but whether early intervention improves outcomes remains uncertain. ALTAIR was a…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Gongwei Guo, Zhihui Tang, Honggang Liu · 2026 · European Journal of Education
ABSTRACT Although the proliferation of artificial intelligence (AI) and digital tools has facilitated AI‐enhanced and informal digital learning of English, traditional classroom ecology remains a central context for adolescent English‐as‐a‐foreign‐language (EFL) learners' language learning and development. Additionally, while the importance of achievement emotions among tertiary‐level EFL learners has been well established, research on retrospective outcome emotions (e.g., pride and shame) among non‐tertiary EFL learners remains scarce. As such, the study investigated whether and how language
View details →Negative / Null Result ReportOpen accessMathematics
Michelle Pistner Nixon, Kyle C. McGovern, Maxwell A. Konnaris et al. · 2026 · The Annals of Applied Statistics
Many scientific fields, including human gut microbiome science, collect multivariate count data where the sum of the counts is unrelated to the scale of the underlying system being measured (e.g., total microbial load in a subject’s…
View details →Failed Experiment ReportOpen accessAgricultural and Biological Sciences
Irene Dini · 2026 · Molecules
Fermented foods and probiotics represent complementary yet distinct components of human nutrition. Fermented foods are shaped by biochemical transformations driven by microbial metabolism, whereas probiotics are live microorganisms that may confer health benefits to the host. In both cases, bacteria, yeasts, and filamentous fungi mediate key metabolic activities that generate bioactive compounds and modulate host-microbiota interactions. During fermentation, microbial communities synthesize organic acids, peptides, exopolysaccharides, vitamins, and other metabolites that enhance food safety, s
View details →Negative / Null Result ReportOpen accessEnergy
Ahmed M. Khalil, Samir M. Kamel, Mohamed S. Mohy Eldin · 2026 · Scientific Reports
This work used a simple technique to prepare a novel cerium titanate nano-rods embedded in a cellulose-based hydrogel with high photo catalytic degradation activity. The composite hydrogel was prepared by embedding different amounts of cerium titanate nano-rods (Ce/Ti-NRs) into a crosslinked carboxymethyl cellulose/polyacrylamide polyelectrolyte complex (CMC/PAM) as a matrix material. The physico-chemical properties of the Ce/Ti-NRs, CMC/PAM, and cerium titanate nano-rods embedded in a cellulose-based hydrogel (Ce/Ti-NRs/CMC/PAM) were investigated by FT-IR, XRD, BET, TEM, SEM, and EDX techniqu
View details →Negative / Null Result ReportOpen accessEngineering
Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production
The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics
Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather
View details →Negative / Null Result ReportOpen accessMedicine
Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine
Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc
View details →Negative / Null Result ReportOpen accessDecision Sciences
Yuan Tao, Yu Z, Tianxue Chen et al. · 2026 · iScience
Phytomedicine extraction-process optimization often relies on regression or machine learning models, but model choice is commonly judged by goodness of fit alone. Here, we assembled 1,148 structurally eligible extraction datasets from…
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