Iteration of Tumor Organoids in Drug Development: Simplification and Integration
Rui Zhao; Qiushi Feng; Yangyang Xia; Lingzi Liao; Shang Xie · 2025 · Pharmaceuticals
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The inherent complexity and heterogeneity of tumors pose substantial challenges for the development of effective oncology therapeutics. Organoids, three-dimensional (3D) in vitro models, have become essential tools for predicting therapeutic responses and advancing precision oncology, with established correlations to clinical outcomes in patient-derived models. These systems have transformed preclinical drug screening by bridging the gap between conventional two-dimensional (2D) cultures and in vivo models, preserving tumor histopathology, cellular heterogeneity, and patient-specific molecular
Abstract by Rui Zhao; Qiushi Feng; Yangyang Xia; Lingzi Liao; Shang Xie, Pharmaceuticals (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ph18101540