Negative / Null Result Report
C Länger, P Ernst, M Bender et al. · 2021 · New Journal of Physics
Abstract Hydrogen-covered Si(001) surfaces were exposed to swift heavy ions (SHI) and slow highly charged ions (HCI). Using scanning tunneling microscopy as analysis tool, the ion-induced modifications on the surface were resolved on the…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Cedric Popa, Karel Holvoet, Tessa Van Montfort et al. · 2018 · Frontiers in Pharmacology
Background: Profits in the biopharmaceutical industry have been scrutinized in social debate. However, drawing conclusions based on industry profitability only is inappropriate as such an analysis does not account for risks faced by investors. This study aims to measure risks and returns in the biopharmaceutical industry and investigates whether risk-adjusted return on investment in the biopharmaceutical industry is higher than that in other industries. Methods: To enable appropriate comparison, we identified six benchmark industries with characteristics that match those of the biopharmaceutic
View details →Negative / Null Result ReportOpen accessMedicine
Jacobien H. F. Oosterhoff, Anne de Hond, Rinne M Peters et al. · 2024 · Clinical Orthopaedics and Related Research
BACKGROUND: Estimating the risk of revision after arthroplasty could inform patient and surgeon decision-making. However, there is a lack of well-performing prediction models assisting in this task, which may be due to current conventional…
View details →Negative / Null Result Report
Jan Reinhard, Melanie Schindler, Franziska Leiss et al. · 2023 · Archives of Orthopaedic and Trauma Surgery
Abstract Introduction Enhanced recovery after surgery (ERAS) leads to less morbidity, faster recovery, and, therefore, shorter hospital stays. The expected increment of primary total hip arthroplasty (THA) in the U.S. highlights the need…
View details →Negative / Null Result Report
Amanda Sundberg, Anna Carin Wahlberg, Niklas Zethraeus et al. · 2021 · BMJ Open
Objectives Telephone advice nursing is introduced in many countries with one key aim being a reduction of avoidable healthcare visits. The aim of this study was to explore whether callers to a telephone advice nursing service followed the…
View details →Negative / Null Result ReportOpen accessComputer Science
Conor Hanrahan · 2019 · ARROW@Dublin Institute of Technology (Dublin Institute of Technology)
The presence of noise in electroencephalography (EEG) signals can significantly reduce the accuracy of the analysis of the signal. This study assesses to what extent stacked autoencoders designed using one-dimensional convolutional neural…
View details →Negative / Null Result Report
Youn-Goo Kang, Taeyoung Lee, Jaeyoung Ro et al. · 2023 · Nutrients
Obesity is a major global health problem which is associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity and gut microbiota has led to a worldwide effort to use…
View details →Negative / Null Result Report
Rae Morris, Fiona Lewis, Nancy Baker et al. · 2021 · Health & Social Work
Abstract Homelessness is a long-standing issue at the forefront of healthcare globally, and discharge of homeless patients from hospital settings can exacerbate gaps and burdens in healthcare systems. In hospitals, social workers often…
View details →Negative / Null Result Report
Kaoru Ochi, Tamaki Mizuno, Prosenjit Samanta et al. · 2021 · mSphere
Cholera is an acute diarrheal disease caused by pathogenic strains of V. cholerae generated by lysogenization of the filamentous cholera toxin phage CTXΦ. The analysis revealed that recent isolates possessed altered CTXΦ prophage array of…
View details →Negative / Null Result ReportComputer Science
Pertti Vakkari · 2011 · Online Information Review
Purpose This paper seeks to evaluate to what extent Google retrieved correct answers to queries inferred from factual and topical requests in a digital Ask‐a‐Librarian service. Design/methodology/approach In total, 100 factual and 100…
View details →Replication FailureOpen accessMedicine
Daniela Achkova, Richard Beatson, John Maher · 2022 · Cells
Macrophage colony-stimulating factor receptor (M-CSFR) is found in cells of the mononuclear phagocyte lineage and is aberrantly expressed in a range of tumours, in addition to tumour-associated macrophages. Consequently, a variety of cancer therapies directed against M-CSFR are under development. We set out to engineer chimeric antigen receptors (CARs) that employ the natural ligands of this receptor, namely M-CSF or interleukin (IL)-34, to achieve specificity for M-CSFR-expressing target cells. Both M-CSF and IL-34 bind to overlapping regions of M-CSFR, although affinity of IL-34 is significa
View details →Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Dennis Poel, Elske C. Gootjes, Lotte Bakkerus et al. · 2020 · Cancer Medicine
BACKGROUND: Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed. Therefore, a previously developed tissue-derived microRNA profile to predict clinical benefit from chemotherapy was evaluated in tissue biopsies and serum from patients with mCRC. METHODS: Samples were prospectively collected from patients (N = 132) who were treated with capecitabine or 5-FU/LV with oxaliplatin ± bevacizumab. Response evaluation wa
View details →Negative / Null Result ReportOpen accessMedicine
Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed
BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…
View details →Negative / Null Result Report
Sarah C. Moudy, Brian T. Peters, Torin K. Clark et al. · 2024 · Frontiers in Physiology
The perceptual and motor coordination problems experienced following return from spaceflight reflect the sensory adaptation to altered gravity. The purpose of this study was to develop a ground-based analog that replicates similar…
View details →Negative / Null Result ReportSocial Sciences
Qian Xu, Shi Chen, Lida Safarnejad · 2020 · Health Communication
By taking the 2016 Zika outbreak as a case study, this research examines how information veracity (true information vs. misinformation) interacted with message frames to influence the dissemination of information about Zika through retweet…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Yumei Luo, Quan Chen, Fan Liu et al. · 2023 · Frontiers in Ecology and Evolution
Introduction Plant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal. Methods In this study, six emergent plant species categorized into slender type ( Schoenoplectus tabernaemontani, Typha orientalis ), fan type ( Iris sibirica, Acorus calamus ) and la
View details →Negative / Null Result Report
Z. F. LIU, G. ZHAO, Y. H. CHENG et al. · 2012 · Journal of Mechanics in Medicine and Biology
The purpose of this work is to evaluate the heating effect of thermally significant blood vessels (TSBVs) during cryosurgery process. A theoretical model is developed to describe the heat transfer of perfused tissue containing a 6…
View details →Negative / Null Result ReportOpen accessEngineering
Luisa Hopp, Barbara Glaser, Julian Klaus et al. · 2019 · Hydrological Processes
Abstract The occurrence of preferential flow in the subsurface has often been shown in field experiments. However, preferential flow is rarely included in models simulating the hydrological response at the catchment scale. If it is…
View details →Negative / Null Result ReportOpen accessChemistry
Santosh Lohumi, Lalit Mohan Kandpal, Young Wook Seo et al. · 2016 · Journal of Biosystems Engineering
Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it…
View details →Negative / Null Result ReportOpen accessMedicine
C. Elizabeth Shaaban, Caterina Rosano, Xiaonan Zhu et al. · 2023 · The Journals of Gerontology Series A
BACKGROUND: Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA. METHODS: To make our approach clinically accessible, we created…
View details →Negative / Null Result ReportEarth and Planetary Sciences
Camille Zaug, John D. Carter · 2021 · Studies in Applied Mathematics
Abstract Ocean swell plays an important role in the transport of energy across the ocean, yet its evolution is not well understood. In the late 1960s, the nonlinear Schrödinger (NLS) equation was derived as a simplified model for the…
View details →Negative / Null Result ReportOpen accessNeuroscience
David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology
Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.
View details →Negative / Null Result ReportMedicine
Carlos González‐Alayón, Esteban Porrini, Sergio Luis‐Lima et al. · 2021 · Liver International
BACKGROUND & AIMS: In cirrhosis, the reliability of formulas that estimate renal function, either those specifically developed in this population or the classic equations, has not been properly quantified. We studied the agreement between…
View details →Negative / Null Result Report
Li Wang, Jiting Zhang, Li Zhang et al. · 2022 · Frontiers in Cellular and Infection Microbiology
Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Liza Van der Laan, Kyle Parmley, Mojdeh Saadati et al. · 2025 · The Plant Genome
Developments in genomics and phenomics have provided valuable tools for use in cultivar development. Genomic prediction (GP) has been used in commercial soybean [Glycine max L. (Merr.)] breeding programs to predict grain yield and seed…
View details →Negative / Null Result ReportDecision Sciences
Dapeng Liu, Heinz Roland Weistroffer · 2020 · Journal of Computer Information Systems
Trust, such as trust in a technology or believing that a technology has trustworthy utility, manifests its importance by affecting user behaviors toward information systems (IS). There is no dearth of evidence showing that the effect of…
View details →Negative / Null Result ReportOpen accessMedicine
Chang Yu, Ning Zhang, Weikang Zhu et al. · 2019 · Evidence-based Complementary and Alternative Medicine
Objectives . To evaluate the safety of moxa smoke, especially to provide quantitative information and details for the occupational prevention of acupuncturists. Methods . We combined the questionnaire-based cross-sectional survey and lung function testing-based historical retrospective cohort research to investigate the safety of moxa smoke exposure (MSE) among acupuncturists. A mathematical regression model was established to quantitatively evaluate the relationship between moxa smoke exposure and the respiratory health of the acupuncturist. The smoke exposure time of the acupuncturist and th
View details →Negative / Null Result ReportOpen accessPsychology
Ioana M. Latu, Sean Duffy, Vaani Pardal et al. · 2017 · Comprehensive Results in Social Psychology
In the current study, we sought to replicate the finding that adopting an open/expansive body posture increases subjective feelings of power, while also investigating how these body postures influence the processing of persuasive messages.…
View details →Negative / Null Result ReportOpen accessMedicine
Zofia Strojny, Rafał Rutkowski, Alina Kanikowska et al. · 2021 · Nutrients
Background: Chronotype is the pattern of the circadian rhythm that allows an individual to optimize times of sleep and activity. It has been observed that chronotypes may associate with some conditions and diseases, including obesity. It is not known, however, whether chronotypes determine the effectiveness of weight loss regimens. Therefore, in the present study, we compared the outcomes of a 3-week moderate calorie restriction undertaken by individuals with obesity under the same controlled hospital conditions. Methods: A total of 131 participants with obesity (median BMI 40.0) were studied.
View details →Negative / Null Result ReportMaterials Science
Shanshan Jiang, Jaka Sunarso, Wei Zhou et al. · 2013 · Journal of Materials Chemistry A
Layered oxides of Sr4Fe4Co2O13 (SFC2) which contains alternating perovskite oxide octahedral and polyhedral oxide double layers are attractive for their mixed ionic and electronic conducting and oxygen reduction reaction properties. In…
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