21,247 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Nikoletta Symeonidou, Beatrice G. Kuhlmann · 2021 · Cognition & Emotion
Emotion-enhanced memory (EEM) describes the robust memory advantage of emotional over non-emotional stimuli. While extensively investigated with emotional items, it is unclear whether the EEM effect extends to source memory for a neutral…
View details →Andreea Geambașu, Sybren Spit, Daan van Renswoude et al. · 2022 · Developmental Science
We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.'s study has
View details →Lewend Mayiwar, Linda Lai · 2019 · Social Psychology
Abstract. We performed an independent, direct, and better powered ( N = 295) replication of Study 1, an experiment ( N = 113) by Lammers, Stoker, and Stapel (2009) . Lammers and colleagues distinguished between social power (influence over…
View details →A. Archidona-Yuste, I. Clavero-Camacho, A. N. Ruiz-Cuenca et al. · 2024 · Zoological Letters
Abstract The ring nematode genus Xenocriconemella De Grisse and Loof, 1965 comprises only one nominal species, Xenocriconemella macrodora (Taylor, 1936) De Grisse and Loof, 1965. The initial objective of the present study was to…
View details →Sara R. Rashkin, Mario A. Cleves, Gary M. Shaw et al. · 2022 · American Journal of Medical Genetics Part A
Abstract Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures,…
View details →Simon Holmbacka, Robert Müller · 2017
Current benchmark suites for evaluating energy efficiency of modern computer systems fail to replicate real-world streaming applications accurately enough because of indeterministic load pattern which depends heavily on the input data of…
View details →Emanuela S. Gritti, Gregory J. Meyer, Robert F. Bornstein et al. · 2020 · Journal of Personality Assessment
We used self-reported narcissistic grandiosity and vulnerability and a component derived from 11 potential grandiosity and narcissism variables (GNVs) coded from Rorschach behavior to predict fluctuations in self-esteem and their links to…
View details →Breanne Cuddington, Meghan L. Verschoor, Ali A. Ashkar et al. · 2015 · Molecular Therapy — Oncolytics
Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the…
View details →Sue M Hudson, Kathie Binysh, Stephen W Duffy · 2022 · Journal of Medical Screening
Objective The Covid-19 pandemic created a backlog of women awaiting an invitation for breast screening in the UK. To recover in a timely fashion, the National Health Service programme opted to issue open invitations (OI) to women rather…
View details →Justin J. Robert, Sarah M. Larocque, Steven J. Cooke · 2012 · North American Journal of Fisheries Management
Abstract Catch and release is a common practice among recreational anglers. In instances when fish are deeply hooked, the proper techniques for promoting survival are poorly understood, although evidence suggests that the fishing line…
View details →Divya Narayanan, John David Rodriguez, Garrick Wallstrom et al. · 2020 · BMC Ophthalmology
BACKGROUND: To prevent irreversible vision loss in age-related macular degeneration (AMD), it is critical to detect retinal dysfunction before permanent structural loss occurs. In the current study we evaluated a series of visual function tests to identify potential endpoints to detect visual dysfunction in non-advanced AMD. METHODS: A series of visual function tests were performed on 23 non-advanced AMD subjects (AREDS grade 1-4 on simplified scale) and 34 age-matched normals (AREDS grade 0). Tests included some commonly used endpoints such as ETDRS visual acuity (VA), low luminance (LL) 2.0N
View details →Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery
Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…
View details →Ecaterina E. Dumbrava, Thomas E. Stinchcombe, Mrinal M. Gounder et al. · 2025 · Clinical Cancer Research
PURPOSE: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that degrades the tumor suppressor p53. In cancers, MDM2 amplification (MDM2amp) leads to overexpression of MDM2, inducing p53 degradation and a p53-null phenotype even in the…
View details →Louis Pechmajou, Éloi Marijon, Olivier Varenne et al. · 2020 · Circulation Cardiovascular Interventions
Background: Conflicting data exist regarding the benefit of urgent coronary angiogram and percutaneous coronary intervention (PCI) after sudden cardiac arrest, particularly in the absence of ST-segment elevation. We hypothesized that the…
View details →Jung Hyun Yoon, Jin Young Kwak, Hee Jung Moon et al. · 2019 · Ultrasound Quarterly
Abstract In this study, we evaluated the role of ultrasonography-guided core needle biopsy (US-CNB) in deciding upon management for prior atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)…
View details →Jianbo Wang, Hussein A. Tawbi · 2021 · Neuro-Oncology Advances
Brain metastases from solid tumors are increasing in incidence, especially as outcomes of systemic therapies continue to extend patients' overall survival. The long-held notion that the brain is an immune sanctuary has now been largely…
View details →James M. Barron, Nathan R. Jensen, Paul J. Anders et al. · 2013 · North American Journal of Aquaculture
Abstract The survival and percentage of North American Burbot Lota lota maculosa larvae and metamorphosing larvae presumed to have been cannibalized during a 15-d period immediately following a size-grading event were compared with those of fish in nongraded control groups. In larvae (mean TL, 11.8 mm), grading immediately produced a size distinction, as the group that passed the grader was significantly narrower and shorter than the group retained by the grader. The mean coefficient of variation of the length of larvae in the retained group was significantly lower than that of the control gro
View details →Dana Lengel, Paul J. Kenny · 2023 · Addiction Neuroscience
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence.…
View details →Zeev Elkoshi · 2021 · Frontiers in Immunology
A binary model for the classification of chronic diseases has formerly been proposed. The model classifies chronic diseases as “high Treg” or “low Treg” diseases according to the extent of regulatory T cells (Treg) activity (frequency or function) observed. The present paper applies this model to severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2) infection. The model correctly predicts the efficacy or inefficacy of several immune-modulating drugs in the treatment of severe coronavirus disease 2019 (COVID-19) disease. It also correctly predicts the class of pathogens mostly associ
View details →Adam Brufsky, Michael T. Lotze · 2020 · Journal of Medical Virology
Muller's ratchet1 predicts that when mutation rates are high and a significant proportion of mutations are deleterious, a kind of irreversible ratchet mechanism will gradually decrease the mean fitness of small populations of asexual organisms.2 In cell culture, serial passage of genetically bottlenecked vesicular stomatitis virus, which grew quite rapidly on HeLa cells, severely reduced in fitness and virulence within 20 passages in a novel BHK host cell.2 Genetic bottlenecks are likely important in intraspecies viral transmission.3 RNA-based viruses are particularly prone to repeated bottlen
View details →Devika Sindu, Deepika Razia, Katherine Grief et al. · 2023 · Transplantation Direct
Background. Lung transplant recipients (LTRs) have an increased risk of COVID-19–related morbidity and mortality. Tixagevimab-cilgavimab (tix-cil) is a long-acting monoclonal antibody combination granted Emergency Use Authorization…
View details →Xiaolin Yu, Jie Zhu, Xiang‐meng Liu et al. · 2020 · British Journal of Pharmacology
BACKGROUND AND PURPOSE: Immunotherapeutic intervention is one of the most promising strategies for the prevention and treatment of Alzheimer's disease (AD). Although they showed great success in AD mouse models, the clinical trials of many…
View details →Adrian K. Davison, Graham Dinsdale, Paul New et al. · 2022 · Rheumatology Advances in Practice
Objective: Clinical trials assessing systemic sclerosis (SSc)-related digital ulcers have been hampered by a lack of reliable outcome measures of healing. Our objective was to assess the feasibility of patients collecting high-quality mobile phone images of their digital lesions as a first step in developing a smartphone-based outcome measure. Methods: Patients with SSc-related digital (finger) lesions photographed one or more lesions each day for 30 days using their smartphone and uploaded the images to a secure Dropbox folder. Image quality was assessed using six criteria: blurriness, shadow
View details →M. Müllner, K. Zwintz, E. Corsaro et al. · 2021 · Astronomy & Astrophysics
Context. In recent years, our understanding of solar-like oscillations from main sequence to red giant stars has improved dramatically thanks to pristine data collected from space telescopes. One of the remaining open questions focuses on…
View details →Rebecca D. Dodd, Amanda Scherer, Wesley Huang et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New…
View details →Sk. Kayum Alam, Li Wang, Zhu Zhu et al. · 2023 · npj Precision Oncology
Non-small cell lung cancer (NSCLC) accounts for 80-85% cases of lung cancer cases. Diagnosis at advanced stages is common, after which therapy-refractory disease progression frequently occurs. Therefore, a better understanding of the molecular mechanisms that control NSCLC progression is necessary to develop new therapies. Overexpression of IκB kinase α (IKKα) in NSCLC correlates with poor patient survival. IKKα is an NF-κB-activating kinase that is important in cell survival and differentiation, but its regulation of oncogenic signaling is not well understood. We recently demonstrated that IK
View details →Leah Amundson, Brandon Boelts, Vivek Kataria et al. · 2021 · Infectious Diseases in Clinical Practice
To the Editor: Coronavirus disease 2019 (COVID-19) has resulted in a widespread pandemic in which various therapeutics have been studied. Targeted therapies focus on either the viral or the inflammatory phase to ultimately reduce disease…
View details →H. R. Spaulding, T. Quindry, J. C. Quindry et al. · 2020 · Experimental Physiology
New Findings What is the central question of this study? We previously demonstrated that quercetin transiently preserved respiratory function in dystrophin‐deficient mice. To gain lasting therapeutic benefits, we tested quercetin in…
View details →Vasileios Angelis, Alicia Okines · 2023 · Cancers
Despite recent advances, HER2-positive advanced breast cancer (ABC) remains a largely incurable disease, with resistance to conventional anti-HER2 drugs ultimately unavoidable for all but a small minority of patients who achieve an enduring remission and possibly cure. Over the past two decades, significant advances in our understanding of the underlying molecular mechanisms of HER2-driven oncogenesis have translated into pharmaceutical advances, with the developing of increasingly sophisticated therapies directed against HER2. These include novel, more potent selective HER2 tyrosine kinase in
View details →S. Lot Aronson, Bram Thijssen, Marta López‐Yurda et al. · 2025 · Nature Communications
While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, their efficacy in high-grade serous ovarian cancer (HGSOC) remains limited. Some patients, however, achieve lasting responses, emphasizing the need to…
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