21,691 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jean‐Christophe Marine, Osnat Bartok, Shira Sagie et al. · 2026 · Cell
Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate…
View details →Chengjiao Yang, Ruici Yang, Binbin Zheng et al. · 2026 · Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of "Lactylation Switch in Cancer Vulnerabilities." We dissect the dominant enzymatic pathways (AARS1/2, KATs, HDACs) and non-enzymatic mechanisms (MGO/LGSH), alongside their critical structural underpinnings. Furthermore, we delineate how lactylation signals are interpreted by specific readers (e.g., TRIM33), directly reprogram non-histone protein function through s
View details →Matthew Bourke, Claudia I. Maddren, Franziska Sippel et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Understanding the within-person association between daily screen use and sleep can help clarify whether this association reflects potentially causal effects or confounding factors. Objective: To synthesize evidence on the…
View details →Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species
View details →Jean‐Christophe Rozé, Gilles Cambonie, Cyril Flamant et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Controversies persist about management of the ductus arteriosus by nonsteroidal anti-inflammatory drugs in extremely preterm infants. Acetaminophen (paracetamol) appears to be a promising alternative with possibly fewer adverse…
View details →Michelle Pistner Nixon, Kyle C. McGovern, Maxwell A. Konnaris et al. · 2026 · The Annals of Applied Statistics
Many scientific fields, including human gut microbiome science, collect multivariate count data where the sum of the counts is unrelated to the scale of the underlying system being measured (e.g., total microbial load in a subject’s…
View details →Irene Dini · 2026 · Molecules
Fermented foods and probiotics represent complementary yet distinct components of human nutrition. Fermented foods are shaped by biochemical transformations driven by microbial metabolism, whereas probiotics are live microorganisms that may confer health benefits to the host. In both cases, bacteria, yeasts, and filamentous fungi mediate key metabolic activities that generate bioactive compounds and modulate host-microbiota interactions. During fermentation, microbial communities synthesize organic acids, peptides, exopolysaccharides, vitamins, and other metabolites that enhance food safety, s
View details →Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production
The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…
View details →Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics
Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather
View details →Cailin Plunkett, S. Vitale, T. A. Callister et al. · 2026 · Physical Review Letters
Repeated black-hole mergers in dense stellar clusters are a plausible mechanism to populate the predicted gap in black hole masses due to the pair-instability supernova process. These hierarchical mergers carry distinct spin…
View details →Jennifer L. Havens, Sergei L. Kosakovsky Pond, Jordan D. Zehr et al. · 2026 · Cell
Using a phylogenetic framework to characterize natural selection, we investigate the hypothesis that zoonotic viruses require adaptation prior to zoonosis to sustain human-to-human transmission. Examining the zoonotic emergence of Ebola…
View details →Vania Stavrakeva, JENNY TANG · 2026 · The Journal of Finance
ABSTRACT Conventional wisdom holds that lowering a home country's interest rate relative to another's will depreciate the domestic currency. We document that, at business‐cycle frequencies, U.S. forward guidance monetary policy easings had…
View details →Suli Yu, Zhen Pang, Hong Fang et al. · 2026 · Molecular Biomedicine
Ferroptosis, a regulated cell death modality driven by iron accumulation and lipid peroxidation, has emerged as a pivotal pathophysiological mechanism across a broad spectrum of cardiovascular diseases (CVDs), which remain the leading cause of global mortality. Although robust preclinical evidence indicates that modulation of ferroptosis attenuates myocardial and vascular injury, clinical translation is constrained by incomplete understanding of context-specific roles, the paucity of validated biomarkers, and the absence of targeted therapeutics with acceptable safety profiles. In this Review,
View details →Jiahui Xiang, Jiayi Li, Zizhao Guo et al. · 2026 · Biomarker Research
Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a paradigm-shifting therapeutic strategy in oncology, demonstrating significant synthetic lethality in tumors characterized by homologous recombination deficiency. Due to their…
View details →Joe M. Butler, Hessel Peters Sengers, Tom D. Y. Reijnders et al. · 2025 · EBioMedicine
BACKGROUND: Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI). METHODS: RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-
View details →Janine Kutzsche, Nicoleta Carmen Cosma, Gunther Kauselmann et al. · 2025 · Nature Communications
Self-replicating amyloid beta (Aβ) oligomers are considered as one of the major drivers for disrupted synaptic function and plasticity, leading to impaired neuronal viability and progression of Alzheimer's disease (AD). Here, we investigated the safety, tolerability and pharmacokinetics of the anti-oligomeric peptide PRI-002, which was developed to disassemble toxic Aβ oligomers into non-toxic monomers. In a randomized, double-blind, single-center phase 1b trial, 20 patients aged between 50 and 80 years, with mild neurocognitive impairment (MCI) or mild dementia due to AD were recruited. Eligi
View details →Sylwia Sumińska, Andrzej Rynkiewicz · 2025 · PLoS ONE
INTRODUCTION: Mindfulness-Based Stress Reduction (MBSR) helps counteract the negative consequences of stress. An essential aspect of mind-body therapies is learning to be mindful of emotional reactions and bodily sensations, a process defined as interoceptive awareness. This awareness can also be enhanced by providing physiological feedback from a smartwatch. However, the impact of using smartwatch-generated physiological signals during mindfulness training has not been studied yet. The study aims at verifying, whether physiological signals from a smartwatch would support the MBSR. METHODS: We
View details →Maximilian Roithmeier, Simon Geck, Markus Bühner et al. · 2025 · Schizophrenia
Abstract The Positive and Negative Syndrome Scale (PANSS) is widely used to assess schizophrenia symptoms. Initially designed with three subscales, Marder et al.´s 5-factor-Model (M5M) first proposed in 1997 has been frequently used in treatment trials, but it has never been systematically reviewed for its measurement properties. We utilized the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline for systematic reviews and meta-analytical procedures to assess the psychometric properties of the M5M-PANSS. COSMIN comprises several steps: literature se
View details →Bálint Soczó, Ildikó Pethes · 2025 · Journal of Molecular Liquids
Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations . Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction potential model for water. In various studies, the models have been evaluated based on their ability to reproduce different properties of water. This work focuses on the atomic-scale structure in the liquid phase of water. Forty-four classical water potential models are compared to identify those that can accurately describe the structure in alignment with experim
View details →Lihua Liang, Xiaodong Li, Shutong Liu et al. · 2026 · Buildings
This study develops and applies an integrated methodology that combines deep learning-based computer vision and spatial statistics to automate the large-scale identification and analysis of morphological features in vernacular courtyard dwellings. Focusing on Liangshuaixiu dwellings in Wu’an, southern Hebei, we trained an HRNetV2 semantic segmentation model on high-resolution satellite imagery to identify and extract contours for 134,280 courtyard spaces. Core morphological parameters (area, orientation) were calculated and analyzed using GIS spatial statistics and the geographic detector mode
View details →R. Abbasi, M. Ackermann, J. Adams et al. · 2026 · The Astrophysical Journal Letters
Abstract Recently, IceCube reported neutrino emission from the Seyfert galaxy NGC 1068. Using 13.1 yr of IceCube data, we present a follow-up search for neutrino sources in the northern sky. NGC 1068 remains the most significant neutrino source among 110 preselected gamma-ray emitters while also being spatially compatible with the most significant location in the northern sky. Its energy spectrum is characterized by an unbroken power-law with spectral index γ = 3.4 ± 0.2. Consistent with previous results, the observed neutrino flux exceeds its gamma-ray counterpart by at least 2 orders of magn
View details →Dawn Finzi, Eshed Margalit, Kendrick Kay et al. · 2026 · Nature Communications
Human visual cortex is organized into dorsal, lateral, and ventral streams. A long-standing hypothesis is that the functional organization into streams emerged to support distinct visual behaviors. Here, we compare neural network-based…
View details →Weiye Chen, Yige Zeng, Jinxin Zheng et al. · 2026 · Nature Medicine
Antimicrobial resistance (AMR) poses a major global health threat, yet the effectiveness of national action plans (NAPs) remains uncertain. Here we developed a multidimensional One Health governance index through a structured Delphi expert…
View details →Muhammad Dawood, Kim Branson, Sabine Tejpar et al. · 2026 · Nature Biomedical Engineering
Deep learning models that infer clinically relevant biomarker status from tissue images are being explored as rapid and low-cost alternatives to molecular testing. Here we show, through statistical analysis across multiple cancer types, datasets and modelling approaches, that the datasets used to train these models contain strong dependencies between biomarkers and clinicopathological features, which prevent models from isolating the effect of a single biomarker and lead them to learn confounded signals. Consequently, their prediction accuracy varies substantially with the status of codependen
View details →Toni K. Choueiri, R Motzer, Jose A. Karam et al. · 2026 · Journal of Clinical Oncology
LBA418 Background: Adjuvant pembrolizumab is a standard of care for patients with ccRCC at increased risk of recurrence following nephrectomy based on the phase 3 KEYNOTE-564 study (N Engl J Med 385:683; N Engl J Med 390:1359). Combination…
View details →Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →John M. Carey, Brian J. Fogarty, Marília Gehrke et al. · 2025 · Science Advances
We investigate how to counter misinformation about voter and election fraud using data from the US and Brazil. Our study first compares two types of messages countering claims of widespread fraud: (i) retrospective corrections from…
View details →Davide Faccialà, M. Bonanomi, Bruno Nunes Cabral Tenorio et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide We report a study of the electronic and nuclear relaxation dynamics of the photoexcited RNA base uracil in the gas phase using time-resolved core-level photoelectron spectroscopy together with high-level calculations. The dynamics was investigated by trajectory surface hopping calculations, and the core ionization energies were calculated for geometries sampled from these. The molecule was excited by a UV laser and dynamics probed on the oxygen, nitrogen, and carbon sites by core electron spectroscopy. We find that the main de-excitation chann
View details →Jonas Schmidinger, Viacheslav Barkov, Sebastian Vogel et al. · 2025 · Computers and Electronics in Agriculture
Machine learning and geostatistics are two fundamentally different frameworks for the prediction and spatial mapping of soil properties. Geostatistics leverages the spatial structure of soil properties, whereas machine learning models capture the relationship between available environmental features and soil properties. We propose a hybrid framework that augments machine learning with spatial context through the engineering of ‘spatial lag’ features derived from ordinary kriging. We call this approach ‘kriging prior regression’ (KpR), as it reverses the logic of regression kriging by incorpera
View details →Ghassan M. Khairallah, Samar Al‐Hajj, Hani O. Mowafi et al. · 2025 · BMC Public Health
BACKGROUND: Healthcare workers (HCWs) are exposed to a multitude of hazards in the hospital environment, increasing their risks of sustaining injuries at a higher rate compared to workers in other sectors and resulting in substantial level…
View details →