Negative / Null Result ReportOpen accessMedicine
Rosalyn Chi, Anthony J. Perkins, Yara Khalifeh et al. · 2024 · American Journal of Critical Care
BACKGROUND: Hypoalbuminemia has been associated with an increased risk of in-hospital delirium. However, the relationship between serum albumin levels and the duration and severity of delirium is not well defined. OBJECTIVE: To investigate…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ali Ghasemi, Amaia Martínez-Usatorre, Yang Liu et al. · 2025 · Nature Communications
Cancer immunotherapy using dendritic cells (DC) pulsed ex vivo with tumour antigens is considered safe, but its clinical efficacy is generally modest. Here we engineer DC progenitors (DCP), which can replenish conventional type 1 DCs…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Leah Zuroff, Vista Farkhondeh, Riley Bove et al. · 2025 · Drugs
Despite major advances in multiple sclerosis (MS) treatment, disability accumulation independent of relapse activity remains a significant challenge. Chronic demyelination is a key driver of neurodegeneration and disease progression,…
View details →Negative / Null Result ReportOpen accessMedicine
Atul Malhotra, R GRUNSTEIN, Ali Azarbarzin et al. · 2026 · Nature Medicine
Obstructive sleep apnea (OSA) is associated with obesity and cardiovascular risk. The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated…
View details →Replication FailureOpen accessMedicine
Xueying Chen, Xi Liu, Ruogu Li et al. · 2026 · JAMA Cardiology
Importance: Left bundle-branch pacing (LBBP) has been proposed as an alternative to biventricular pacing (BiVP) for patients with heart failure with left bundle-branch block (LBBB). However, robust clinical evidence from randomized clinical trials is lacking. Objective: To evaluate the long-term clinical outcomes of LBBP and BiVP. Design, Setting, and Participants: This multicenter, prospective, randomized clinical trial enrolled 200 patients at 6 centers in China with a left ventricular ejection fraction (LVEF) of 35% or less and LBBB from October 2020 to March 2022. This study was took place
View details →Negative / Null Result ReportOpen accessMedicine
Edoardo Cipolletta, Tatiana Zverkova Sandström, D. Rozza et al. · 2026 · JAMA Internal Medicine
Importance: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in patients with gout is unknown. Objectives: To evaluate the association between achieving a serum urate treatment target lower than 6 mg/dL and cardiovascular events among patients with gout who were newly prescribed ULT. Design, Setting, and Participants: This new-user cohort study using emulated target trial framework with up to 5-year follow-up was performed using primary care data from the C
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Callum T. Donnan, Mark Dickinson, Anthony J. Taylor et al. · 2025 · The Astrophysical Journal
Abstract We present JWST/NIRSpec PRISM observations of three luminous ( M UV < −20) galaxies at z ∼ 10 observed with the CANDELS-Area Prism Epoch of Reionization Survey (CAPERS) Cycle 3 program. These galaxies exhibit extreme UV slopes compared to typical galaxies at z = 10. Of the three sources, two of them are a close pair (0 . ″ 22) of blue galaxies at z = 9.800 ± 0.003 and z = 9.808 ± 0.002 with UV slopes of β = −2.87 ± 0.15 and β = −2.46 ± 0.10, respectively, selected from PRIMER COSMOS NIRCam imaging. We perform spectrophotometric modeling of the galaxies, which suggests extre
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Amina Hamdouni · 2025 · International Journal of Financial Studies
This study examines the association between Saudi banks’ internal adoption of AI-enabled FinTech-related digital tools and their financial performance, sustainability performance, and financial stability over the period 2015–2024. Using a panel dataset of 10 banks, the analysis investigates how the adoption of AI-driven technologies—such as machine-learning credit assessment, robo-advisory systems, and automated compliance tools—is related to market performance (Tobin’s Q), accounting performance (ROA and ROE), financial stability (Z-Score), and sustainability outcomes measured by both Bloombe
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Kasper Skytte Andersen, Kai Zhao, Alexander de Linde Agerskov et al. · 2025 · Nature Communications
Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of…
View details →Negative / Null Result ReportOpen accessEngineering
Lianpeng Dai, Xin Zhao, Yishan Pan et al. · 2026 · Journal of Rock Mechanics and Geotechnical Engineering
Strainburst is a type of severe dynamic hazard frequently encountered in underground excavation, involving violent rock ejection. It is caused by the release of elastic strain energy stored in the surrounding rocks. Hence, the burst energy…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jeremy Bowles, Kevin Croke, Horacio Larreguy et al. · 2025 · American Political Science Review
Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to durably reduce susceptibility to misinformation, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. Sustained exposure to these fact-checks induced substantial internalization of fact-checked content, while increasing participants’ ability to discern new political and health misinformation upon
View details →Negative / Null Result ReportOpen accessMedicine
Shivani Baisiwala, Elisa Fazzari, Matthew Li et al. · 2026 · Cell Reports
A major obstacle to identifying effective therapies for the aggressive brain tumor glioblastoma is the lack of human-specific, immunocompetent models that reflect the human tumor microenvironment. To address this, we developed the…
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Sadek Ahmed, Khaled M. Attallah, Marwa Eid Sayyed · 2026 · AAPS PharmSciTech
Abstract This research focuses on creating a novel Brijaluronic-based terpesomal system capable of transporting quercetin (QER) efficiently to the brain. The vesicles were fabricated through an ethanol-injection method and then refined using a structured optimization approach in Design-Expert® software. The influence of three main formulation parameters: terpene-to-drug ratio, surfactant type, and hyaluronic acid amount were evaluated. The optimization process was designed to maximize EE%, minimize VS, and maintain ZP within an acceptable stability range. The optimal formula hit a desirability
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Jing Mai, Ying Ning, Zhonglong Lin et al. · 2025 · Industrial Crops and Products
Many bacteria such as Bacillus , Pseudomonas , and Lactobacillus are widely present in flue-cured tobacco leaves during the aging process, indicating they play important roles in improving tobacco quality. In this study, we aimed to screen…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Laura Macchi, Francesco Poli, Laura Caravona et al. · 2019 · Europe’s Journal of Psychology
The previous research attempts to reduce the influence of the belief bias on deductive thinking have often been unsuccessful and, when they succeeded, they failed to replicate. In this paper, we propose a new way to see an old problem. Instead of considering the analytical abilities of the respondent, we focus on the communicative characteristics of the experimental task. By changing the pragmatics into play through a subtle manipulation of the instruction of the syllogism problem, we obtained a strong improvement in the accuracy of the performance in both untrained and trained in logic respon
View details →Negative / Null Result ReportOpen accessNeuroscience
Clara E. James · 2012 · Frontiers in Psychology
A commentary on Musical expertise and statistical learning of musical and linguistic structures by Schön, D., and François, C. (2011). Front. Psychology 2:167. doi: 10.3389/ fpsyg.2011.00167 Both language and music consist of discrete elements organized in embedded hierarchical structures. Schön and François nicely expose in this review that musical expertise facilitates learning of both linguistic and musical structures. At the behavioral level, the musicians did not outperform the nonmusicians. However, ERP analyses showed that acquisition of boundary perception (segmentation) between units
View details →Negative / Null Result ReportOpen accessSocial Sciences
Eelco Harteveld, Lars Erik Berntzen, Andrej Kokkonen et al. · 2026 · European Journal of Political Research
Abstract Affective polarization (or antipathy between supporters of opposing political camps) is considered a threat to societal cohesion and democratic stability worldwide. However, causal evidence of its impact remains scarce, especially outside the United States. Our study examines the individual-level consequences of affective polarization by manipulating it in a survey experiment in nine countries (Brazil, France, Germany, Italy, Poland, Spain, Sweden, the United Kingdom, and the United States; N ≈ 18,000) and subsequently assessing the downstream consequences for social avoidance and dis
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Gonzalo Morrás, G. Pratten, P. Schmidt · 2026 · The Astrophysical Journal Letters
Abstract The observation of gravitational waves (GWs) from merging black holes and neutron stars provides a unique opportunity to discern information about their astrophysical environment. Two signatures that are considered powerful tracers to distinguish between different binary formation channels are general relativistic spin-induced orbital precession and orbital eccentricity. Both effects leave characteristic imprints in the GW signal that can be extracted from observations. To date, neither precession nor eccentricity has been confidently discerned in merging neutron star–black hole binar
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Yuliya Semenova, Ademi Yergaliyeva, Ainur Aimurziyeva et al. · 2024 · Antibiotics
BACKGROUND/OBJECTIVES: There has been a lack of a holistic approach to evaluating antibiotic consumption in Kazakhstan over the past few years using an internationally recognized methodology. Therefore, this study aimed to provide a nationwide evaluation of antibiotic consumption in Kazakhstan during the period 2019-2023. METHODS: Defined daily doses per 1000 inhabitants per day (DIDs) were calculated for systemic antibiotics (J01 code of the Anatomical Therapeutic Chemical Classification System (ATC)) following the methodology established by the Global Antimicrobial Resistance and Use Surveil
View details →Negative / Null Result ReportOpen accessMaterials Science
Yangjian Cai, Ming Lu, Xian Qin et al. · 2025 · Nature Communications
Shell coating is known to suppress luminescence quenching in spherical upconversion nanoparticles. However, the emergence of anisotropic nanoparticles with facet-selective, directional growth complicates the coating process, and the use of…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shanwen Gu, Adil Javed · 2025 · Sustainability
The E-7 nations face significant challenges in harmonizing artificial intelligence (AI) adoption with sustainable economic and environmental goals. While AI holds transformative potential to revolutionize energy structures, modernize infrastructure, broaden financial inclusion, and reduce carbon emissions, its effective integration is frequently hindered by policy inertia, economic limitations, and long-standing institutional barriers. Using the multi-level perspective (MLP), this study employs the method of moments quantile regression (MMQREG) on panel data from 2004 to 2024 to investigate th
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nikola Pavlović, Petar Todorović, Mirko Maglica et al. · 2025 · Biomolecules
The heart’s relentless contractile activity depends critically on mitochondrial function to meet its extraordinary bioenergetic demands. Mitochondria, through oxidative phosphorylation, not only supply ATP but also regulate metabolism, calcium homeostasis, and apoptotic signaling, ensuring cardiomyocyte viability and cardiac function. Mitochondrial dysfunction is a hallmark of cardiomyopathies and heart failure, characterized by impaired oxidative phosphorylation, excessive production of reactive oxygen species (ROS), dysregulated calcium handling, and disturbances in mitochondrial dynamics an
View details →Negative / Null Result ReportOpen accessNeuroscience
Alice Mason, Casimir J. H. Ludwig, Simon Farrell · 2016 · Quarterly Journal of Experimental Psychology
Reward is thought to enhance episodic memory formation via dopaminergic consolidation. Bunzeck, Dayan, Dolan, and Duzel [(2010). A common mechanism for adaptive scaling of reward and novelty. Human Brain Mapping, 31, 1380-1394] provided functional magnetic resonance imaging (fMRI) and behavioural evidence that reward and episodic memory systems are sensitive to the contextual value of a reward-whether it is relatively higher or lower-as opposed to absolute value or prediction error. We carried out a direct replication of their behavioural study and did not replicate their finding that memory p
View details →Negative / Null Result ReportOpen accessMedicine
Jia-Jie Guo, Qi-Qi Hang, Ting Xu et al. · 2025 · Lipids in Health and Disease
BACKGROUND: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited. METHODS: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using
View details →Negative / Null Result ReportOpen accessEngineering
Yue Cheng, Jian Wang, Mingwang Shao et al. · 2025 · Advanced Composites and Hybrid Materials
Hybrid polymer composites with carbon fillers are of great interest for applications requiring specific mechanical, electrical, and thermal properties. However, studies on hybrid polymer composite fiber (HPCF) with multiple carbon fillers…
View details →Negative / Null Result ReportOpen accessMedicine
M.a Cruces Souto-Gallardo, Arturo Jiménez–Cruz, Montserrat Bacardí‐Gascón · 2026 · Archivos Latinoamericanos de Nutrición
The aim of this study was to evaluate the ability of parents to estimate the weight status of preschool children attending the Instituto Mexicano del Seguro Social (IMSS) day-care centers using three different tools. A total of 100…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Marcel Garz, Märt Ots · 2025 · Journal of Communication
Abstract News organizations have been under financial pressure to streamline their activities for decades. Critics argue that this pressure undermines the quality of news, posing a severe threat to democracy. However, the effects of media consolidation on news quality are theoretically ambiguous and empirical evidence is scarce. To address this gap, we study the case of the Swedish newspaper industry between 2014 and 2022, a period where more than half of the country’s newspapers changed their owners. We collect over 2 million articles from 108 newspapers and apply state-of-the-art computation
View details →Negative / Null Result ReportOpen accessMaterials Science
Luis E. Castro-Anaya, Eduardo Marese, Jaime A. Lozano et al. · 2025 · Journal of Chemical Information and Modeling
High Resolution Image Download MS PowerPoint Slide Traditionally, designing novel materials involves exploring new compositions guided by insights from previous work, relying on a trial-and-error approach, where continuous synthesis and characterization proceed until the properties meet the improvements. This method is inefficient due to the challenges of exploring vast chemical spaces. In this study, a machine-learning-based methodology is developed to assist the design from available data in the literature, allowing us to test in silico more than 1.2 million compositions. Two databases with
View details →Negative / Null Result ReportOpen accessMedicine
Lígia Ramos dos Santos, Jucimara Ferreira Figueiredo Almeida, Lúcia Helena Sagrillo Pimassoni et al. · 2019 · Genetics and Molecular Biology
Genome-wide associations studies (GWAS) are detecting new variants associated with late-onset of Alzheimer's disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU and rs3764650 ABCA7 uncovered by GWAS led to different AD pathways, such as metabolism, trafficking and endocytosis of lipids and inflammation. However, most of the association studies did not replicate these variants with significance. This could be due to a small power effect evident when these variants are tested independently with LOAD. Therefore, we aimed to investigate whether t
View details →Negative / Null Result ReportOpen accessMedicine
Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature
The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…
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