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Browse the failure-mode index

21,245 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Investigating the quadrupedal abilities of Scutellosaurus lawleri and its implications for locomotor behavior evolution among dinosaurs

Lilian Anderson, Charlotte Brassey, Stuart Pond et al. · 2023 · The Anatomical Record

A reversion to secondary quadrupedality is exceptionally rare in nature, yet the convergent re-evolution of this locomotor style occurred at least four separate times within Dinosauria. Facultative quadrupedality, an intermediate state between obligate bipedality and obligate quadrupedality, may have been an important transitional step in this locomotor shift, and is proposed for a range of basal ornithischians and sauropodomorphs. Advances in virtual biomechanical modeling and simulation have allowed for the investigation of limb anatomy and function in a range of extinct dinosaurian species,

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Negative / Null Result ReportOpen accessMedicine

Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: results from a multicenter study in China

Danfeng Xu, Rong Na, Da Huang et al. · 2020 · Asian Journal of Andrology

To evaluate whether prostate volume (PV) would provide additional predictive utility to the prostate health index (phi) for predicting prostate cancer (PCa) or clinically significant prostate cancer, we designed a prospective,…

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Negative / Null Result ReportOpen accessMedicine

Nonopioid vs opioid analgesics after impacted third-molar extractions

Cecile A. Feldman, Janine Fredericks-Younger, Paul J. Desjardins et al. · 2025 · The Journal of the American Dental Association

BACKGROUND: Opioids are still being prescribed to manage acute postsurgical pain. Unnecessary opioid prescriptions can lead to addiction and death, as unused tablets are easily diverted. METHODS: To determine whether combination nonopioid analgesics are at least as good as opioid analgesics, a multisite, double-blind, randomized, stratified, noninferiority comparative effectiveness trial was conducted, which examined patient-centered outcomes after impacted mandibular third-molar extraction surgery. Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioi

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Negative / Null Result Report

WHERE DOES AVICENNA DEMONSTRATE THE EXISTENCE OF GOD?

Daniel D. De Haan · 2016 · Arabic Sciences and Philosophy

Abstract This study examines a number of different answers to the question: where does Avicenna demonstrate the existence of God within the Metaphysics of the Healing ? Many interpreters have contended that there is an argument for God's…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Harnessing genotype-by-environment interaction to determine adaptability of advanced cowpea lines to multiple environments in Uganda

Abiriga Francis, O. Ongom Patrick, Rubaihayo Patrick et al. · 2020 · Journal of Plant Breeding and Crop Science

This study was conducted to determine the yield stability of advanced cowpea lines in diverse agro-ecological zones of Uganda in order to facilitate documentation requirements for national performance trials (NPT). Thirty cowpea genotypes were evaluated against six checks in three localities, over three growing seasons, making a total of 9 unique environments. The trials were laid in a 6x6 alpha lattice design with three replications and grain yield was the principal trait measured. Single-site and multi-location data were summarized using analysis of variance. Further analysis of stability wa

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Negative / Null Result ReportOpen accessComputer Science

Improving SAT-solving with Machine Learning

Haoze Wu · 2017

In this project, we aimed to improve the runtime of Minisat, a Conflict-Driven Clause Learning (CDCL) solver that solves the Propositional Boolean Satisfiability (SAT) problem. We first used a logistic regression model to predict the…

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Negative / Null Result Report

Effect of methionine hydroxy analog feed supplements: Significant alteration and enrichment of rumen microbiota and metabolome in Hu sheep

Shujie Li, Hanfang Zeng, Changjian Wang et al. · 2022 · Frontiers in Veterinary Science

Methionine hydroxy analogs (MHA) are widely used as the main sources of methionine in ruminant feed production. The purpose of this study was to explore the effect of using MHA supplements such as MHA as a salt of calcium (MHA-Ca) and…

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Negative / Null Result ReportOpen accessEngineering

Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn’s from Ulcerative Colitis, in Children

Rachael Slater, Kukatharmini Tharmaratnam, Salma Belnour et al. · 2024 · Sensors

The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn's disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography-sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a

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Negative / Null Result ReportOpen accessHealth Professions

Gait Characteristics and Cognitive Function in Middle-Aged Adults with and without Type 2 Diabetes Mellitus: Data from ENBIND

Pieter M. R. Herings, Adam H. Dyer, Seán Kennelly et al. · 2022 · Sensors

Type 2 Diabetes Mellitus (T2DM) in midlife is associated with a greater risk of dementia in later life. Both gait speed and spatiotemporal gait characteristics have been associated with later cognitive decline in community-dwelling older adults. Thus, the assessment of gait characteristics in uncomplicated midlife T2DM may be important in selecting-out those with T2DM at greatest risk of later cognitive decline. We assessed the relationship between Inertial Motion Unit (IMUs)-derived gait characteristics and cognitive function assessed via Montreal Cognitive Assessment (MoCA)/detailed neuropsy

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Negative / Null Result ReportOpen accessMedicine

Significant association factors of bone mineral density in Taiwan adults

Yuh‐Feng Wang, Tzyy‐Ling Chuang, Mei‐Hua Chuang et al. · 2019 · Tzu Chi Medical Journal

OBJECTIVE: To examine the biofactors associated with bone mineral density (BMD) in southern Taiwanese adults. MATERIALS AND METHODS: The medical records of 3242 adults who underwent health examinations between June 2014 and February 2018…

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Negative / Null Result ReportOpen accessMedicine

Customized Prediction of Short Length of Stay Following Elective Cardiac Surgery in Elderly Patients Using a Genetic Algorithm

Joon Lee, Sapna Govindan, Leo Anthony Celi et al. · 2013 · World Journal of Cardiovascular Surgery

OBJECTIVE: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. DESIGN: Utilization of a machine learning algorithm in a prospectively collected STS database consisting of patients who received cardiac surgery between January 2002 and June 2011. SETTING: Urban tertiary-care center. PARTICIPANTS: Geriatric patients aged 70 years or older at the time of cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Predefined morbidity and mortality events were collec

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Negative / Null Result ReportComputer Science

The Effect of 360-Degree Video Authentic Materials on EFL Learners' Listening Comprehension

Suhe Ji, Ke Li, Linfeng Zou · 2019 · 2019 International Joint Conference on Information, Media and Engineering (IJCIME)

Although the increased use of authentic materials in listening comprehension teaching has become general practice, it is crucial to find out whether or not the new technology-supported authentic material could be beneficial to English as a…

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Negative / Null Result ReportMedicine

Differential susceptibility to effects of the home environment on motor developmental outcomes of preschool children: low birthweight status as a susceptibility factor

Jennifer Chun-Li Wu, Tung‐liang Chiang · 2015 · Early Child Development and Care

Low birthweight (LBW) children tend to have higher risks of developmental problems. According to differential susceptibility hypothesis, these putatively vulnerable children may also disproportionately benefit from positive environmental…

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Negative / Null Result Report

Orthognathic Surgery Has a Significant Positive Effect on Perceived Personality Traits and Perceived Emotional Facial Expressions in Subjects with Primary Maxillary Deficiency

Jeffrey C. Posnick, Brian E. Kinard · 2019 · Plastic and Reconstructive Surgery - Global Open

Background: Crowdsourcing is increasingly being used in medical research to obtain the opinion of laypeople. The investigators hypothesized that a layperson’s perception of a primary maxillary deficiency (PMD) dentofacial deformity (DFD)…

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Negative / Null Result ReportOpen accessPsychology

Perception of English phonetic contrasts by Dutch children: How bilingual are early-English learners?

Claire Goriot, James M. McQueen, Sharon Unsworth et al. · 2020 · PLoS ONE

The aim of this study was to investigate whether early-English education benefits the perception of English phonetic contrasts that are known to be perceptually confusable for Dutch native speakers, comparing Dutch pupils who were enrolled in an early-English programme at school from the age of four with pupils in a mainstream programme with English instruction from the age of 11, and English-Dutch early bilingual children. Children were 4-5-year-olds (start of primary school), 8-9-year-olds, or 11-12-year-olds (end of primary school). Children were tested on four contrasts that varied in diff

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Negative / Null Result Report

Erector spinae plane block did not improve postoperative pain-related outcomes and recovery after video-assisted thoracoscopic surgery : a randomised controlled double-blinded multi-center trial

A. Clairoux, A. Moore, M. Caron-Goudreault et al. · 2024 · BMC Anesthesiology

Abstract Introduction There is a sizable niche for a minimally invasive analgesic technique that could facilitate ambulatory video-assisted thoracoscopic surgery (VATS). Our study aimed to determine the analgesic potential of a single-shot…

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Negative / Null Result Report

Actis: A Strictly Local Union–Find Decoder

Tim Chan, Simon C. Benjamin · 2023 · Quantum

Fault-tolerant quantum computing requires classical hardware to perform the decoding necessary for error correction. The Union–Find decoder is one of the best candidates for this. It has remarkably organic characteristics, involving the…

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Negative / Null Result Report

Smoking Cessation Intention and Its Association with Advice to Quit from Significant Others and Medical Professionals

Jun Hyun Hwang, Soon-Woo Park · 2021 · International Journal of Environmental Research and Public Health

Few studies have simultaneously considered the effects of significant others and medical professionals’ advice to quit smoking on smoking cessation intention. The present study involved 3841 current adult Korean smokers, divided into four…

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Negative / Null Result Report

Change in sagittal alignment after decompression alone in patients with lumbar spinal stenosis without significant deformity: a prospective cohort study

Jamal Bech Bouknaitir, Leah Y. Carreon, Stig Brorson et al. · 2022 · Journal of Neurosurgery: Spine

OBJECTIVE The authors’ objective was to investigate whether sagittal balance improves in patients with spinal stenosis after decompression alone. METHODS This prospective longitudinal cohort study compared preoperative and 6-month…

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Negative / Null Result Report

Is AI Better than Humans? Unveiling the Boundary Conditions Under Which Virtual Influencers Outperform Human Influencers in Endorsing Sustainable Products

Xu Yan, Hon Tat Huam, Abu Bakar Sade · 2024 · Sustainability

With the rising trend toward sustainable consumption and the pivotal role of social media in the buying behavior, brands are keen to promote sustainable products through these platforms. Virtual influencers (VIs) have emerged as lower-cost…

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Negative / Null Result Report

Fibre supplementation to pre‐weaning piglet diets did not improve the resilience towards a post‐weaning enterotoxigenic E. coli challenge

Hubèrt van Hees, Dominiek Maes, Sam Millet et al. · 2020 · Journal of Animal Physiology and Animal Nutrition

Abstract Dietary fibre (DF) is implicated in gastrointestinal health of weaned piglets, either through its physiochemical properties, through modulation of gut microbiota and (or) improved gut integrity. We aimed to study the effect of DF…

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