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Browse the failure-mode index

21,245 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Large-scale multi-omics unveils host–microbiome interactions driving root development and nitrogen acquisition

Nannan Li, Guoliang Li, Xiaofang Huang et al. · 2026 · Nature Plants

The rhizosphere microbiome plays a crucial role in determining plant performance and fitness. Nevertheless, regulatory mechanisms linking host genetic variation, root gene regulation and microbiome assembly-and their collective influence on plant nutritional traits-remain poorly understood. Here we generated and integrated 1,341 paired datasets, including root transcriptomes, rhizosphere bacterial 16S rRNA profiles and root ionomes, across 175 resequenced Brassica napus ecotypes grown at two contrasting field sites. We identified 203 highly heritable bacterial amplicon sequence variants (ASVs)

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

What Is the Cost of Privatization for Workers?

Martin Olsson, Joacim Tå̊g · 2025 · The Journal of Finance

ABSTRACT Privatization of state‐owned enterprises is on the agenda across the globe. Using Swedish data covering two decades, we show that productivity gains and headcount reductions are associated with economic costs for incumbent…

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Negative / Null Result ReportOpen accessSocial Sciences

Examining the effects of the killing of George Floyd by police in the United States on attitudes of Black Londoners: a replication

Amy Nivette, Christof Nägel, Emily Gilbert · 2023 · Police Practice and Research

High-profile incidents of police misconduct can have serious consequences for public trust in the police. A recent study in the British Journal of Political Science found that Eric Garner’s death in NYC lead to more negative attitudes towards the police in London among Black residents compared to White and Asian residents. The current study aimed to replicate this transnational effect by assessing the impact of George Floyd’s death on Londoners’ perceptions of police. Using the same data and methodological approach, we did not replicate the immediate effect on Black Londoners’ attitudes. We di

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Negative / Null Result ReportMedicine

Different organ-specific response to nivolumab to determine the survival outcome of patients with advanced hepatocellular carcinoma (aHCC).

Han Sang Kim, Jung Yong Hong, Jaekyung Cheon et al. · 2020 · Journal of Clinical Oncology

4584 Background: Previously, two phase III clinical trials of immune checkpoint inhibitors (ICI) failed to meet their primary endpoints, leading to doubts regarding the clinical activity of ICI monotherapy in patients with aHCC. Here, we…

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Negative / Null Result ReportOpen accessMaterials Science

Using Solid-State NMR to Understand the Structure of Plant Cellulose

Rosalie Cresswell, Parveen Kumar Deralia, Yoshihisa Yoshimi et al. · 2025 · Journal of the American Chemical Society

High Resolution Image Download MS PowerPoint Slide The structure of plant cellulose microfibrils remains elusive, despite the abundance of cellulose and its utility in industry. Using 2D solid-state NMR of 13 C-labeled never-dried plants, six major glucose environments are resolved, which are common to the cellulose of softwood, hardwood, and grasses. These environments are maintained in isolated holocellulose nanofibrils, allowing more detailed microfibril characterization. We show that there are only two glucose environments that reside within the microfibril core. These have the same NMR 13

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Negative / Null Result ReportOpen accessMedicine

Conduction System vs Biventricular Pacing in Heart Failure

André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology

Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf

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Failed Experiment ReportOpen accessPhysics and Astronomy

Physics basis for the reference flat-top plasma scenario in the ST–E1 fusion power plant

Steven McNamara, S. Abouelazayem, А. И. Алиева et al. · 2026 · Nuclear Fusion

Abstract As part of the U.S. Department of Energy’s Milestone-Based Fusion Energy Development Program, Tokamak Energy has completed the pre-concept design of the ST–E1 fusion power plant. ST–E1 is envisaged to operate in two phases: a pilot plant phase, targeting sustained net power production of 300 − 500 MWe for a duration > 1 hr , followed by a commercial power plant phase targeting steady-state operations and a normalised overnight capital cost of ⩽ 12 000 $ / kWe . The design process adopted was highly iterative, integrating all major plant systems and progressing i

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Negative / Null Result ReportOpen accessSocial Sciences

Efficacy of an appropriate point-of-use water treatment intervention for low-income communities in India utilizing Moringa oleifera, sari-cloth filtration and solar UV disinfection

Syed Imran Ali, Morgan C. MacDonald, J. Jincy et al. · 2011 · Journal of Water Sanitation and Hygiene for Development

This study investigated the efficacy of a POU water treatment system featuring sari-cloth filtration and/or Moringa oleifera coagulation as pre-treatments for solar disinfection (SODIS). Surface water from a peri-urban slum in Chennai,…

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Negative / Null Result Report

Impact of lifestyle intervention in primary prevention of Type 2 diabetes did not differ by baseline age and BMI among Asian‐Indian people with impaired glucose tolerance

A. Nanditha, C. Snehalatha, J. Ram et al. · 2016 · Diabetic Medicine

Abstract Aim To investigate whether the effectiveness of lifestyle interventions on the incidence of diabetes was influenced by the baseline age and BMI of the Asian‐Indian participants with prediabetes. Methods Pooled data, obtained from…

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Negative / Null Result Report

No significant change of tibiofemoral rotation after femoral rotational osteotomy in patients with patellofemoral instability

Lukas Jud, Vanessa Klenecky, Georgios Neopoulos et al. · 2024 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose An increased value of tibiofemoral rotation is frequently observed in patients with patellofemoral instability or maltracking. Nevertheless, the appropriate approach for addressing this parameter remains unclear so far.…

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Negative / Null Result Report

WHERE DOES AVICENNA DEMONSTRATE THE EXISTENCE OF GOD?

Daniel D. De Haan · 2016 · Arabic Sciences and Philosophy

Abstract This study examines a number of different answers to the question: where does Avicenna demonstrate the existence of God within the Metaphysics of the Healing ? Many interpreters have contended that there is an argument for God's…

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Negative / Null Result Report

Change in sagittal alignment after decompression alone in patients with lumbar spinal stenosis without significant deformity: a prospective cohort study

Jamal Bech Bouknaitir, Leah Y. Carreon, Stig Brorson et al. · 2022 · Journal of Neurosurgery: Spine

OBJECTIVE The authors’ objective was to investigate whether sagittal balance improves in patients with spinal stenosis after decompression alone. METHODS This prospective longitudinal cohort study compared preoperative and 6-month…

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Negative / Null Result Report

Actis: A Strictly Local Union–Find Decoder

Tim Chan, Simon C. Benjamin · 2023 · Quantum

Fault-tolerant quantum computing requires classical hardware to perform the decoding necessary for error correction. The Union–Find decoder is one of the best candidates for this. It has remarkably organic characteristics, involving the…

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Negative / Null Result Report

Is AI Better than Humans? Unveiling the Boundary Conditions Under Which Virtual Influencers Outperform Human Influencers in Endorsing Sustainable Products

Xu Yan, Hon Tat Huam, Abu Bakar Sade · 2024 · Sustainability

With the rising trend toward sustainable consumption and the pivotal role of social media in the buying behavior, brands are keen to promote sustainable products through these platforms. Virtual influencers (VIs) have emerged as lower-cost…

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Negative / Null Result Report

Smoking Cessation Intention and Its Association with Advice to Quit from Significant Others and Medical Professionals

Jun Hyun Hwang, Soon-Woo Park · 2021 · International Journal of Environmental Research and Public Health

Few studies have simultaneously considered the effects of significant others and medical professionals’ advice to quit smoking on smoking cessation intention. The present study involved 3841 current adult Korean smokers, divided into four…

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Negative / Null Result Report

Erector spinae plane block did not improve postoperative pain-related outcomes and recovery after video-assisted thoracoscopic surgery : a randomised controlled double-blinded multi-center trial

A. Clairoux, A. Moore, M. Caron-Goudreault et al. · 2024 · BMC Anesthesiology

Abstract Introduction There is a sizable niche for a minimally invasive analgesic technique that could facilitate ambulatory video-assisted thoracoscopic surgery (VATS). Our study aimed to determine the analgesic potential of a single-shot…

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Negative / Null Result Report

Cholesterol Control Among Uninsured Adults Did Not Improve From 2001‐2004 to 2009‐2012 as Disparities With Both Publicly and Privately Insured Adults Doubled

Brent M. Egan, Jiexiang Li, Sara M. Sarasua et al. · 2017 · Journal of the American Heart Association

Background Low‐density lipoprotein cholesterol (LDL‐C) control is higher among insured than uninsured adults, but data on time trends and contributing factors are incomplete and important for improving health equity. Methods and Results…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Ex vivo infection model for Francisella using human lung tissue

Kristin Köppen, Diana Fatykhova, Gudrun Holland et al. · 2023 · Frontiers in Cellular and Infection Microbiology

Introduction Tularemia is mainly caused by Francisella tularensis ( Ft ) subsp. tularensis ( Ftt ) and Ft subsp. holarctica ( Ftt ) in humans and in more than 200 animal species including rabbits and hares. Human clinical manifestations depend on the route of infection and range from flu-like symptoms to severe pneumonia with a mortality rate up to 60% without treatment. So far, only 2D cell culture and animal models are used to study Francisella virulence , but the gained results are transferable to human infections only to a certain extent. Method In this study, we firstly established an ex

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Negative / Null Result ReportOpen accessMedicine

Pharmacological Treatment of Intermittent Claudication Does Not Have a Significant Effect on Gait Impairments During Claudication Pain

Jennifer M. Yentes, Jessie M. Huisinga, Sara A. Myers et al. · 2012 · Journal of Applied Biomechanics

Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our…

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