Negative / Null Result ReportOpen accessImmunology and Microbiology
John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner et al. · 2026 · Nature Aging
Aging-associated inflammation, or 'inflammaging" is a driver of multiple age-associated diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to activate interferon response upon detecting viral DNA in the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alicja W. Wojciechowska, Jakub W. Wojciechowski, Gert Vriend et al. · 2026 · Scientific Reports
Abstract While three-dimensional structures of globular and transmembrane forms are available for many amyloid proteins, structures of their amyloid forms are scarce in the PDB. Amyloids pose major challenges for both experimental…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Avilash Singh Yadav, Lilan Hong, Patrick M. Klees et al. · 2026 · Current Biology
Nature exhibits organs of various shapes and forms, ranging from smooth to undulated morphologies. How cells coordinate their growth to produce smoothly shaped leaves and leaf-like organs such as sepals remains unclear. We identified a mutant, as2-7D, that exhibits ectopic expression of ASYMMETRIC LEAVES 2 (AS2) on the outer epidermis. Our analysis reveals that ectopic AS2 expression causes the outer epidermis of as2-7D sepals to buckle during early stages of sepal development. Buckling is caused by conflicting cell growth directions and unequal tissue stiffness across the epidermal layers. Ov
View details →Negative / Null Result ReportOpen accessMaterials Science
L L Sun, Yisa Zhao, Xiyu Caomeng et al. · 2026 · ChemistryOpen
Traditional blending electrospinning has a series of issues during implementation, and the corresponding monolithic nanofibers can always be updated through the intentional design of core-sheath nanostructures. In this study, a modified coaxial electrospinning approach was employed to refine the electrospinning process by eliminating abnormal phenomena, while simultaneously imparting core-sheath nanostructures and improved transdermal finasteride (FIN) delivery performance. Using an electrospinnable ethylcellulose (EC) solution containing FIN as the core fluid and an unspinnable polyvinylpyrro
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Qinghua Hou, Rajapakshalage Thashikala Nethmini, Feng Qi et al. · 2026 · Communications Biology
The leaf endosphere hosts diazotrophs vital for plant health and ecosystem resilience in saline environments. However, the geographic pattern and stability of the diazotrophic community in coastal salt marshes ecosystems are poorly…
View details →Negative / Null Result ReportOpen accessMedicine
Mitali Tyagi, Eric de Hoog, Matthew Grega et al. · 2026 · Cell
Abstract Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-to-cell 2 but the exact mechanisms of tau release and intercellular transmission remain poorly defined. Tau is released from neurons as free protein or in extracellular vesicles (EVs) 3–5 but the role of these different release mechanisms in intercellular tau transmission is unclear. Here, we show that the neuronal gene Arc is critical for packaging tau into EVs. Brain EVs purified from human tau
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Chang‐Wei Bai, Yi-Jiao Sun, Xin-Tong Huang et al. · 2026 · Nature Communications
Heterogeneous Fenton-like systems activated by peroxymonosulfate represent promising platforms for organic wastewater treatment but are significantly hampered by competing adsorption and catalytic oxidation processes at identical active…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Daniel S. Borrus, Raghav Sehgal, Judith Armstrong et al. · 2026 · Aging Cell
ABSTRACT Epigenetic clocks have emerged as potential biomarkers of aging due to their association with morbidity and mortality. They have recently gained traction as outcome measurements for anti‐aging interventions. However, as the number of new epigenetic clocks continues to grow, different clocks may not agree on the effect of an intervention. This raises the question of when researchers can trust epigenetic clock results. In this study, we find that when extending previously published single‐clock intervention studies to include additional clock models, no additional clocks reach statistic
View details →Negative / Null Result ReportOpen accessComputer Science
Thevin Senath, Kumuthu Athukorala, Ransika Costa et al. · 2025 · Natural Language Processing Journal
In this paper, we address the challenge of recipe personalization through ingredient substitution. We make use of Large Language Models (LLMs) to build an ingredient substitution system designed to predict plausible substitute ingredients within a given recipe context. Given that the use of LLMs for this task has been barely done, we carry out an extensive set of experiments to determine the best LLM, prompt, and the fine-tuning setups. We further experiment with methods such as multi-task learning, two-stage fine-tuning, and Direct Preference Optimization (DPO). The experiments are conducted
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kayla G. Townsley, S. H. Lee, Sarah Williams et al. · 2026 · Nature Communications
The immune environment influences neurodevelopment and subsequent clinical trajectories for psychiatric outcomes in childhood and adolescence. Yet it remains unclear if the impact of maternal and fetal immune activation varies with…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Laura Macchi, Francesco Poli, Laura Caravona et al. · 2019 · Europe’s Journal of Psychology
The previous research attempts to reduce the influence of the belief bias on deductive thinking have often been unsuccessful and, when they succeeded, they failed to replicate. In this paper, we propose a new way to see an old problem. Instead of considering the analytical abilities of the respondent, we focus on the communicative characteristics of the experimental task. By changing the pragmatics into play through a subtle manipulation of the instruction of the syllogism problem, we obtained a strong improvement in the accuracy of the performance in both untrained and trained in logic respon
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Kasper Skytte Andersen, Kai Zhao, Alexander de Linde Agerskov et al. · 2025 · Nature Communications
Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of…
View details →Negative / Null Result ReportOpen accessMaterials Science
Luis E. Castro-Anaya, Eduardo Marese, Jaime A. Lozano et al. · 2025 · Journal of Chemical Information and Modeling
High Resolution Image Download MS PowerPoint Slide Traditionally, designing novel materials involves exploring new compositions guided by insights from previous work, relying on a trial-and-error approach, where continuous synthesis and characterization proceed until the properties meet the improvements. This method is inefficient due to the challenges of exploring vast chemical spaces. In this study, a machine-learning-based methodology is developed to assist the design from available data in the literature, allowing us to test in silico more than 1.2 million compositions. Two databases with
View details →Replication FailureOpen accessMedicine
Xueying Chen, Xi Liu, Ruogu Li et al. · 2026 · JAMA Cardiology
Importance: Left bundle-branch pacing (LBBP) has been proposed as an alternative to biventricular pacing (BiVP) for patients with heart failure with left bundle-branch block (LBBB). However, robust clinical evidence from randomized clinical trials is lacking. Objective: To evaluate the long-term clinical outcomes of LBBP and BiVP. Design, Setting, and Participants: This multicenter, prospective, randomized clinical trial enrolled 200 patients at 6 centers in China with a left ventricular ejection fraction (LVEF) of 35% or less and LBBB from October 2020 to March 2022. This study was took place
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Sadek Ahmed, Khaled M. Attallah, Marwa Eid Sayyed · 2026 · AAPS PharmSciTech
Abstract This research focuses on creating a novel Brijaluronic-based terpesomal system capable of transporting quercetin (QER) efficiently to the brain. The vesicles were fabricated through an ethanol-injection method and then refined using a structured optimization approach in Design-Expert® software. The influence of three main formulation parameters: terpene-to-drug ratio, surfactant type, and hyaluronic acid amount were evaluated. The optimization process was designed to maximize EE%, minimize VS, and maintain ZP within an acceptable stability range. The optimal formula hit a desirability
View details →Negative / Null Result ReportOpen accessSocial Sciences
Marcel Garz, Märt Ots · 2025 · Journal of Communication
Abstract News organizations have been under financial pressure to streamline their activities for decades. Critics argue that this pressure undermines the quality of news, posing a severe threat to democracy. However, the effects of media consolidation on news quality are theoretically ambiguous and empirical evidence is scarce. To address this gap, we study the case of the Swedish newspaper industry between 2014 and 2022, a period where more than half of the country’s newspapers changed their owners. We collect over 2 million articles from 108 newspapers and apply state-of-the-art computation
View details →Negative / Null Result ReportOpen accessNeuroscience
Eric A. Finkel, Yi-Ting Chang, Rajan Dasgupta et al. · 2024 · Cell Reports
The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects…
View details →Negative / Null Result ReportOpen accessEngineering
Zhaowei Yang, Wenqi Liu, Miwei Li et al. · 2025 · Energy Engineering
Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids. Although numerous studies have employed various methods to forecast wind power, there re... | Find, read and cite all the research you need on Tech Science Press
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Y C Shih · 2026 · Frontiers in Environmental Science
To assess the systematic integration of Marine Spatial Planning (MSP) and Other Effective Area-Based Conservation Measures (OECMs) into Taiwan’s coastal and marine governance frameworks to balance marine conservation and coastal development. The study adopts a comparative mixed-methods design that combines quantitative statistical analysis of spatial and ecological-economic data with qualitative policy analysis of the two selected governance frameworks. The comparative aspect of the research design explores the performance of multiple hub cases across temporal, spatial and multimodal aspects,
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fanzhuo Xu, Yu Xie, Weiwei Yu et al. · 2026 · Frontiers in Microbiology
Multidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration, serving as the core mechanism of resistance. This paper systematically analyses antimicrobial strategies targeting the outer membrane of Gram-negative bacteria, mainly including: (1) directly disrupting the outer membrane structure and enhancing drug permeability; (2) inhibiting the biosynthesis or transport pathways of key outer membrane com
View details →Negative / Null Result ReportOpen accessMaterials Science
Rosalie Cresswell, Parveen Kumar Deralia, Yoshihisa Yoshimi et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide The structure of plant cellulose microfibrils remains elusive, despite the abundance of cellulose and its utility in industry. Using 2D solid-state NMR of 13 C-labeled never-dried plants, six major glucose environments are resolved, which are common to the cellulose of softwood, hardwood, and grasses. These environments are maintained in isolated holocellulose nanofibrils, allowing more detailed microfibril characterization. We show that there are only two glucose environments that reside within the microfibril core. These have the same NMR 13
View details →Negative / Null Result ReportMedicine
Han Sang Kim, Jung Yong Hong, Jaekyung Cheon et al. · 2020 · Journal of Clinical Oncology
4584 Background: Previously, two phase III clinical trials of immune checkpoint inhibitors (ICI) failed to meet their primary endpoints, leading to doubts regarding the clinical activity of ICI monotherapy in patients with aHCC. Here, we…
View details →Negative / Null Result ReportOpen accessMedicine
Fiona McPhee, Joseph Ueland, Vincent Vellucci et al. · 2019 · Antimicrobial Agents and Chemotherapy
[tested DAAs] of >5,000 nM) and were detected in evaluated GT-6b and -6f sequences. NS5A-L28A-R30A, observed in GT-6r, did not replicate. In conclusion, HCV GT-6b, GT-6f, and GT-6r sequences harbored highly resistant RASs to all evaluated…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nannan Li, Guoliang Li, Xiaofang Huang et al. · 2026 · Nature Plants
The rhizosphere microbiome plays a crucial role in determining plant performance and fitness. Nevertheless, regulatory mechanisms linking host genetic variation, root gene regulation and microbiome assembly-and their collective influence on plant nutritional traits-remain poorly understood. Here we generated and integrated 1,341 paired datasets, including root transcriptomes, rhizosphere bacterial 16S rRNA profiles and root ionomes, across 175 resequenced Brassica napus ecotypes grown at two contrasting field sites. We identified 203 highly heritable bacterial amplicon sequence variants (ASVs)
View details →Negative / Null Result ReportOpen accessMedicine
Xinyi Chen, Mu Yang, Yongbiao Huang et al. · 2025 · Therapeutic Advances in Medical Oncology
Abscopal immunity—the regression of distant, non-irradiated lesions after localized radiotherapy (RT)—signals conversion of focal DNA damage into systemic antitumor immunity. This review advances a unifying three-stage…
View details →Negative / Null Result ReportOpen accessMedicine
Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Junhua Dang, Zeynep E. Ekim, Sarah Ohlsson et al. · 2020 · BMC Psychology
BACKGROUND: Previous studies showed that anger, rather than sadness, created automatic intergroup bias in a minimal group context. METHODS: The current research reports a single study (N = 99) aiming to replicate this finding and further to test whether the intergroup bias manifests as ingroup favoritism, outgroup derogation, or both. RESULTS: Our results failed to replicate the effect of anger on automatic bias. Intriguingly, participants across all emotion conditions exhibited high level of ingroup favoritism, but there was little evidence of outgroup derogation. CONCLUSION: These results su
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Marcello Candelli, Marta Sacco Fernandez, Gloria Rozzi et al. · 2025 · Diagnostics
Background and Objectives: Despite major advances in medical science and critical care, sepsis remains a leading cause of morbidity and mortality worldwide: it arises from dysregulated host response to infections and may culminate in organ dysfunction. A hallmark of its pathogenesis is the cytokine storm, in which interleukins (ILs) serve as central mediators of both protective and deleterious immune responses. This review summarizes the current knowledge on the role of ILs in sepsis, emphasizing their potential as biomarkers and therapeutic targets. Material and Methods: We analyzed recent cl
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Andrei Kudriashov, Xiong Zhou, Razmik A. Hovhannisyan et al. · 2025 · Science Advances
Josephson junctions (JJs) are key to superconducting quantum technologies and the search for self-conjugate quasiparticles potentially useful for fault-tolerant quantum computing. In topological insulator (TI)–based JJs, measuring the current-phase relation (CPR) can reveal unconventional effects such as Majorana bound states (MBS) and nonreciprocal transport. However, reconstructing CPR as a function of magnetic field has not been attempted. Here, we present a platform for field-dependent CPR measurements in planar JJs made of NbSe 2 and few-layer Bi 2 Se 3 . When a flux quantum Φ 0 thr
View details →Negative / Null Result ReportOpen accessNeuroscience
James Downar, James Downar, Julie Lapenskie et al. · 2024 · Palliative Medicine
Background: Psychological and existential suffering affects many people with advanced illness, and current therapeutic options have limited effectiveness. Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective therapy…
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